Selenium Supplementation in Patients with Autoimmune Thyroiditis Decreases Thyroid Peroxidase Antibodies Concentrations

2002 ◽  
Vol 87 (4) ◽  
pp. 1687-1691 ◽  
Author(s):  
R. Gartner
Keyword(s):  
Autoimmune Thyroiditis ◽  
Selenium Supplementation ◽  
Thyroid Peroxidase ◽  
Thyroid Peroxidase Antibodies

scholarly journals Expression of Cytokines and Cytokine Receptors-Genes in Patients with Different Forms of Thyroid Pathology in Ukrainian Population

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Iryna Kamyshna ◽  
Aleksandr Kamyshnyi
Keyword(s):  
Autoimmune Thyroiditis ◽  
Interleukin 6 ◽  
Interleukin 1 ◽  
White Blood Cells ◽  
Elevated Serum ◽  
Interleukin 10 ◽  
Thyroid Peroxidase ◽  
Thyroid Peroxidase Antibodies ◽  
Interleukin 6 Receptor ◽  
Peripheral White Blood Cells

Abstract Multiple susceptibility genes can be involved in the development of Hashimoto’s thyroiditis. Some of these genes are implicated in other autoimmune diseases, while others are specific to thyroid autoimmune response. 153 patients with thyroid pathology were enrolled in the study (152 women and 1 man, the average age was 46,02±14,3). They were divided into 3 groups: 16 patients with postoperative hypothyroidism; 65 patients with hypothyroidism resulting from autoimmune thyroiditis, and 72 patients with both AIT and elevated serum an anti-thyroglobulin and anti-thyroid peroxidase antibodies. We used a pathway-specific real-time Polymerase chain reaction array to identify and verify cytokines and receptor pathway-associated gene expression in peripheral white blood cells in randomly selected 12 individuals from each group. In the patients with postoperative hypothyroidism and those with hypothyroidism resulting from autoimmune thyroiditis, the expression of Chemokine (C-X3-C motif) receptor 1, Chemokine (C-X-C motif) receptor 4, Interleukin 6, and Interleukin 6 receptor significantly decreased, while the expression of IL6ST and IL10RA increased. In contrast, mRNA levels of Chemokine (C-X3-C motif) receptor 1, Chemokine (C-X-C motif) receptor 4, Interleukin 6, and Interleukin 6 receptor increased in the autoimmune thyroiditis patients with elevated serum anti-thyroglobulin and anti-thyroid peroxidase antibodies, while the expression of Interleukin 6 signal transducer and Interleukin 10 receptor, alpha decreased in this group of patients. The patients with hypothyroidism resulting from autoimmune thyroiditis and patients with elevated serum anti-thyroglobulin and anti-thyroid peroxidase antibodies had significantly lowered expression of Interleukin 10, while the expression of Interleukin 1, beta and Interleukin 1 receptor, type I was elevated. autoimmune thyroiditis and hypothyroidism affect the mRNA-level expression of cytokines and cytokine receptor genes in a gene-specific manner, and these changes to gene expression can be among the triggers of autoimmune inflammation progression in the thyroid gland. Transcriptional activity of cytokines, inducer, and receptor genes in the peripheral white blood cells can be used as an important minimally invasive prognostic marker of the autoimmune thyroid disease severity.

scholarly journals Selenium Supplementation May Decrease Thyroid Peroxidase Antibody Titer via Reducing Oxidative Stress in Euthyroid Patients with Autoimmune Thyroiditis

2020 ◽  
Vol 2020 ◽  
pp. 1-7
Author(s):  
Xun Tian ◽  
Ning Li ◽  
Rui Su ◽  
Chenyang Dai ◽  
Ruiguo Zhang
Keyword(s):  
Oxidative Stress ◽  
Clinical Study ◽  
Autoimmune Thyroiditis ◽  
Selenium Supplementation ◽  
Thyroid Peroxidase ◽  
Sod Activity ◽  
Group I ◽  
Thyroid Peroxidase Antibody ◽  
Selenium Treatment ◽  
Group Ii

Objective. Selenium, as an antioxidant, has been implicated in the development of autoimmune thyroiditis (AIT). Many studies showed selenium supplementation could decrease thyroid autoantibodies in patients with AIT. However, the underlying mechanisms have not been well determined. Therefore, we performed a clinical study to investigate the possible mechanism of beneficial effects of selenium treatment on AIT patients. Methods. Forty euthyroid patients with AIT were randomized into two groups. Group I was treated with 200 μg/day selenium supplementation, and group II received a placebo over a 3-month period. Thyroid stimulating hormone (TSH), thyroid peroxidase antibody (TPOAb), antithyroglobulin antibody (TgAb), malondialdehyde (MDA), total antioxidant capacity (TAC), and superoxide dismutase (SOD) were measured before and 3 months after treatments. Additionally, twenty healthy volunteers also served as a control group for the evaluation of such parameters in basic condition. Results. Totally, 32 patients (group I, n = 18; group II, n = 14) completed the clinical study and were incorporated into the statistics. MDA level was higher and SOD activity and TAC were lower in patients compared to healthy individuals. After 3 months, TPOAb titer significantly decreased within group I (P<0.001) but did not change within group II (P=0.001). There were also no statistically significant changes in TSH and TgAb titers within the two groups (all P>0.05). Additionally, decreased MDA level (from 6.8 ± 1.3 nmol/ml to 4.9 ± 0.7 nmol/ml; P<0.001) and increased TAC (from 10.0 ± 1.9 mmol/l to 12.9 ± 3.1 mmol/l; P=0.003) and SOD activity (from 72.3 ± 10.3 U/ml to 84.3 ± 13.2 U/ml; P=0.007) were simultaneously observed after 3 months’ selenium treatment. Moreover, there was a negative correlation between TAC and TgAb/TPOAb and a positive correlation between MDA and TgAb/TPOAb in AIT patients. Conclusions. Our findings support the hypothesis that selenium treatment could decrease TPOAb titer via enforcing the defense against oxidative stress in euthyroid patients with AIT, which may be a potential underlying mechanism.

Thyroid cytotoxic antibodies in atrophic and goitrous autoimmune thyroiditis

1995 ◽  
Vol 132 (1) ◽  
pp. 69-74 ◽  
Author(s):  
Ulrich Bogner ◽  
Laszlo Hegedüs ◽  
Jens Molholm Hansen ◽  
Reinhard Finke ◽  
Horst Schleusener
Keyword(s):  
Autoimmune Thyroiditis ◽  
Confidence Limit ◽  
Thyroid Volume ◽  
Human Thyroid ◽  
Thyroid Peroxidase ◽  
Chronic Lymphocytic Thyroiditis ◽  
Lymphocytic Thyroiditis ◽  
Cytotoxic Antibodies ◽  
Thyroid Peroxidase Antibodies ◽  
Blocking Antibodies

Bogner U, Hegedüs L, Hansen JM, Finke R, Schleusener H. Thyroid cytotoxic antibodies in atrophic and goitrous autoimmune thyroiditis. Eur J Endocrinol 1995;132:69–74. ISSN 0804–4643 It is unknown whether in chronic lymphocytic thyroiditis the goitrous (Hashimoto's thyroiditis) and atrophic forms (primary myxedema) are variants of the same disease or different pathogenic entities. Conventional thyroid-related autoimmune parameters are unable to separate both diseases serologically. It is assumed that cellular and humoral cytotoxic events induce gland atrophy and thus should be detectable more often in non-goitrous than goitrous autoimmune thyroiditis. We determined antibody-dependent cell-mediated cytotoxicity in 67 patients with autoimmune thyroiditis, using a 51chromium-release assay against human thyroid cells. Thyroid volume had been measured by ultrasonography. Other thyroid-specific antibodies, like TSH binding-inhibiting antibodies, TSH function-blocking antibodies, thyroglobulin antibodies and thyroid peroxidase antibodies, were determined. Cytotoxic antibody activity was 20.5% (median, range 0–54.5%) in patients with autoimmune thyroiditis and 8.3% (median, range 0–18.4%) in controls (p < 0.0001). Analysis of cytotoxicity regarding thyroid size showed a high incidence of cytotoxic antibodies in atrophic disease (median thyroid volume 6 ml), where cytotoxic antibodies were detectable in 80% versus 39% (x2 = 9.6; p < 0.0001) in goitrous disease (median thyroid volume 36 ml). The specific lysis of 30% (median; 95% confidence limit 23.9–32.9) in non-goitrous thyroiditis patients was significantly higher than in goitrous patients (16.9%; 95% confidence limit 13.2–20.4) (p = 0.0006). Prevalence of thyroglobulin and thyroid peroxidase antibodies were equally distributed in both groups, with slightly higher levels of thyroid peroxidase antibodies in goitrous thyroiditis (p < 0.05). Both TSH binding-inhibiting and TSH function-blocking antibodies were rarely positive in either atrophic or goitrous disease. Our study shows for the first time a striking association of thyroid cytotoxic antibodies with the atrophic variant of autoimmune thyroiditis. We suggest that the occurrence of cytotoxic antibodies in the pathogenesis of chronic lymphocytic thyroiditis is the decisive event that favors the development of the atrophic rather than goitrous form of the disease. Ulrich Bogner, Thyroid Research Unit, Freie Universität Berlin, Kurfürstenstr. 126, 10785 Berlin, Germany

scholarly journals Are zinc transporter type 8 antibodies a marker of autoimmune thyroiditis in non-obese adults with new-onset diabetes?

2014 ◽  
Vol 170 (4) ◽  
pp. 651-658 ◽  
Author(s):  
Anita Rogowicz-Frontczak ◽  
Dorota Zozulińska-Ziółkiewicz ◽  
Monika Litwinowicz ◽  
Paweł Niedźwiecki ◽  
Krystyna Wyka ◽  
...  
Keyword(s):  
Autoimmune Thyroiditis ◽  
Autoimmune Diabetes ◽  
Zinc Transporter ◽  
Islet Autoantibodies ◽  
Thyroid Peroxidase ◽  
Diabetic Patients ◽  
Obese Adults ◽  
Thyroid Peroxidase Antibodies ◽  
Onset Diabetes ◽  
New Onset

ObjectiveThe diagnosis of autoimmune diabetes in non-obese adults is based on the detection of glutamic acid decarboxylase autoantibodies (GADA), islet cell antibodies (ICA) and antibodies to tyrosine phosphatase (IA-2A). Zinc transporter 8 (ZnT8) has been identified as a new autoantigen in patients with type 1 diabetes mellitus. The coincidence of autoimmune thyroiditis (AITD) with diabetes is common; therefore, screening of TSH and thyroid peroxidase antibodies (ATPO) is recommended during the diagnosis of diabetes. In this study, we determined whether the occurrence of islet autoantibodies is associated with a positive titre of ATPO in newly diagnosed adult-onset autoimmune diabetic patients.Design and methodsThe study involved 80 non-obese adults aged 44 (interquartile range (IQR): 37–51) years with a BMI of 24.0 (IQR: 22.2–26.0) kg/m2and new-onset diabetes. The markers of autoimmune diabetes (GADA, ICA, IA-2A and ZnT8A), TSH and thyroid peroxidase antibodies (ATPO) were evaluated.ResultsIn the study population, 70% (n=56) of the subjects were positive for at least one of the four assessed markers of autoimmune diabetes (83.9% GADA, 62.5% ICA, 42.8% IA-2A and 33% ZnT8A) and 37.5% of the subjects were positive for ATPO. The ZnT8A-positive subjects had higher ATPO titres than the ZnT8A-negative subjects (172.7 (IQR: 0.36–410.4) vs 92.4 (IQR: 0–23.7) IU/ml,P=0.001). Based on the assessed islet autoantibodies, the occurrence of positive ZnT8A and GADA was found to be related to a positive titre of ATPO using logistic regression (OR=5.48, 95% CI: 1.65–18.14,P=0.006 and OR=3.42, 95% CI: 1.09–10.71,P=0.03 respectively).ConclusionsIn non-obese adults with new-onset diabetes, the presence of GADA and especially ZnT8 autoantibodies increases the risk of AITD.

scholarly journals Selenium Supplementation does not Decrease Thyroid Peroxidase Antibody Concentration in Children and Adolescents with Autoimmune Thyroiditis

2010 ◽  
Vol 10 ◽  
pp. 990-996 ◽  
Author(s):  
W. Bonfig ◽  
R. Gäertner ◽  
H. Schmidt
Keyword(s):  
Children And Adolescents ◽  
Autoimmune Thyroiditis ◽  
Sodium Selenite ◽  
Selenium Supplementation ◽  
Antibody Concentration ◽  
Thyroid Peroxidase ◽  
Thyroid Peroxidase Antibody ◽  
Significant Difference ◽  
Group A ◽  
Group B

In adults, selenium supplementation decreases thyroid peroxidase antibody (TPO Ab) concentrations in patients with autoimmune thyroiditis (AIT). Our aim in this study was to investigate if selenium supplementation decreased TPO Ab and thyroglobulin antibody (Tg Ab) concentrations in children with AIT. Forty-nine patients (33 females) with newly diagnosed AIT and hypothyroidism were randomized to daily oral therapy with levothyroxine alone (group A, n = 18), levothyroxine plus 100 µg sodium-selenite (group B, n = 13), or levothyroxine plus 200 µg sodium-selenite (group C, n = 18). Mean age at diagnosis was 12.2 ± 2.2 years. All 49 patients needed a mean levothyroxine dose of 1.6 ± 0.5 µg/kg body weight to lower TSH to the treatment goal of 1–2 µU/ml, with no significant difference between groups. At study entry and after 12 months, TPO Ab concentrations were comparable in all three groups. Tg Ab concentrations decreased significantly after 12 months in group A and group C (p= 0.03 andp= 0.01), but not in group B (p= 0.06). It is our conclusion that selenium supplementation with sodium-selenite does not decrease TPO Ab concentrations in children and adolescents, neither given in the reduced dose of 100 µg daily nor given in the “adult” supplementation dose of 200 µg daily.

scholarly journals Thyroid peroxidase antibodies in children with autoimmune thyroiditis.

1992 ◽  
Vol 45 (2) ◽  
pp. 106-109 ◽  
Author(s):  
A Vakeva ◽  
S Kontiainen ◽  
A Miettinen ◽  
A Schlenzka ◽  
J Maenpaa
Keyword(s):  
Autoimmune Thyroiditis ◽  
Thyroid Peroxidase ◽  
Thyroid Peroxidase Antibodies

scholarly journals Cytological Evaluation of Thyroid and its Correlation with Thyroid Function Test and Anti-Thyroid Peroxidase in a Patient of Hashimoto’s Thyroiditis

2019 ◽  
Vol 8 (2) ◽  
pp. 57-61
Author(s):  
Manish Kumar Das ◽  
Meenakshi Basnet
Keyword(s):  
Thyroid Gland ◽  
Thyroid Function ◽  
Autoimmune Thyroiditis ◽  
Malignant Tumors ◽  
Thyroid Function Test ◽  
Thyroid Peroxidase ◽  
Thyroid Peroxidase Antibodies ◽  
Number Of Patients ◽  
Function Test ◽  
The Mean

Background: A thyroid swelling is an enlargement of thyroid glands causes by iodine deficiency, ageing, autoimmune disease and benign or malignant tumors. Autoimmune thyroiditis is the second most common thyroid lesion diagnosed after goiter. Materials and Methods: To find out the distribution of thyroid gland swelling in patients visiting otorhinolaryngology department of Nobel medical college and correlate serum thyroid function test and anti-thyroid peroxidase level with fine needle aspiration cytology reports. Results: The mean age of patient with thyroid gland lesions was 40.47 ± 13.05 years. Out of 87 patients studied, the highest number of patients (37, 42.5%) was diagnosed with colloid goiter followed by autoimmune thyroiditis (29, 33.3%). The mean age of patients with autoimmune thyroiditis was found to be 38.66 ± 12.31 years. The sensitivity and specificity of anti-thyroid peroxidase antibodies for diagnosing autoimmune thyroiditis was 89.7% and 94.8% respectively. Conclusion: Autoimmune thyroiditis has statistical correlation with serum anti-thyroid peroxidase antibodies and it can be effectively used as an alternative tool in diagnosing autoimmune thyroiditis with acceptable diagnostic accuracy.

scholarly journals Selenium Supplementation in Patients with Autoimmune Thyroiditis Decreases Thyroid Peroxidase Antibodies Concentrations

2002 ◽  
Vol 87 (4) ◽  
pp. 1687-1691 ◽  
Author(s):  
Roland Gärtner ◽  
Barbara C. H. Gasnier ◽  
Johannes W. Dietrich ◽  
Bjarne Krebs ◽  
Matthias W. A. Angstwurm
Keyword(s):  
Placebo Group ◽  
Autoimmune Thyroiditis ◽  
Selenium Deficiency ◽  
Thyroid Peroxidase ◽  
Free T4 ◽  
Autoimmune Thyroid Diseases ◽  
Thyroid Cells ◽  
Autoimmune Thyroid ◽  
Thyroid Peroxidase Antibodies ◽  
The Mean

Abstract In areas with severe selenium deficiency there is a higher incidence of thyroiditis due to a decreased activity of selenium-dependent glutathione peroxidase activity within thyroid cells. Selenium-dependent enzymes also have several modifying effects on the immune system. Therefore, even mild selenium deficiency may contribute to the development and maintenance of autoimmune thyroid diseases. We performed a blinded, placebo-controlled, prospective study in female patients (n = 70; mean age, 47.5 ± 0.7 yr) with autoimmune thyroiditis and thyroid peroxidase antibodies (TPOAb) and/or Tg antibodies (TgAb) above 350 IU/ml. The primary end point of the study was the change in TPOAb concentrations. Secondary end points were changes in TgAb, TSH, and free thyroid hormone levels as well as ultrasound pattern of the thyroid and quality of life estimation. Patients were randomized into 2 age- and antibody (TPOAb)-matched groups; 36 patients received 200 μg (2.53 μmol) sodium selenite/d, orally, for 3months, and 34 patients received placebo. All patients were substituted with l-T4 to maintain TSH within the normal range. TPOAb, TgAb, TSH, and free thyroid hormones were determined by commercial assays. The echogenicity of the thyroid was monitored with high resolution ultrasound. The mean TPOAb concentration decreased significantly to 63.6% (P = 0.013) in the selenium group vs. 88% (P = 0.95) in the placebo group. A subgroup analysis of those patients with TPOAb greater than 1200 IU/ml revealed a mean 40% reduction in the selenium-treated patients compared with a 10% increase in TPOAb in the placebo group. TgAb concentrations were lower in the placebo group at the beginning of the study and significantly further decreased (P = 0.018), but were unchanged in the selenium group. Nine patients in the selenium-treated group had completely normalized antibody concentrations, in contrast to two patients in the placebo group (by χ2 test, P = 0.01). Ultrasound of the thyroid showed normalized echogenicity in these patients. The mean TSH, free T4, and free T3 levels were unchanged in both groups. We conclude that selenium substitution may improve the inflammatory activity in patients with autoimmune thyroiditis, especially in those with high activity. Whether this effect is specific for autoimmune thyroiditis or may also be effective in other endocrine autoimmune diseases has yet to be investigated.

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