scholarly journals Poor sleep is associated with CSF biomarkers of amyloid pathology in cognitively normal adults

Neurology ◽  
2017 ◽  
Vol 89 (5) ◽  
pp. 445-453 ◽  
Author(s):  
Kate E. Sprecher ◽  
Rebecca L. Koscik ◽  
Cynthia M. Carlsson ◽  
Henrik Zetterberg ◽  
Kaj Blennow ◽  
...  
Keyword(s):  
Sleep Quality ◽  
Sleep Problems ◽  
Self Report ◽  
Csf Biomarkers ◽  
Poor Sleep ◽  
Subjective Sleep Quality ◽  
Parental History ◽  
Cognitively Normal ◽  
T Tau ◽  
The Relationship

Objective:To determine the relationship between sleep quality and CSF markers of Alzheimer disease (AD) pathology in late midlife.Methods:We investigated the relationship between sleep quality and CSF AD biomarkers in a cohort enriched for parental history of sporadic AD, the Wisconsin Registry for Alzheimer's Prevention. A total of 101 participants (mean age 62.9 ± 6.2 years, 65.3% female) completed sleep assessments and CSF collection and were cognitively normal. Sleep quality was measured with the Medical Outcomes Study Sleep Scale. CSF was assayed for biomarkers of amyloid metabolism and plaques (β-amyloid 42 [Aβ42]), tau pathology (phosphorylated tau [p-tau] 181), neuronal/axonal degeneration (total tau [t-tau], neurofilament light [NFL]), neuroinflammation/astroglial activation (monocyte chemoattractant protein–1 [MCP-1], chitinase-3-like protein 1 [YKL-40]), and synaptic dysfunction/degeneration (neurogranin). To adjust for individual differences in total amyloid production, Aβ42 was expressed relative to Aβ40. To assess cumulative pathology, CSF biomarkers were expressed in ratio to Aβ42. Relationships among sleep scores and CSF biomarkers were assessed with multiple regression, controlling for age, sex, time between sleep and CSF measurements, and CSF assay batch.Results:Worse subjective sleep quality, more sleep problems, and daytime somnolence were associated with greater AD pathology, indicated by lower CSF Aβ42/Aβ40 and higher t-tau/Aβ42, p-tau/Aβ42, MCP-1/Aβ42, and YKL-40/Aβ42. There were no significant associations between sleep and NFL or neurogranin.Conclusions:Self-report of poor sleep was associated with greater AD-related pathology in cognitively healthy adults at risk for AD. Effective strategies exist for improving sleep; therefore sleep health may be a tractable target for early intervention to attenuate AD pathogenesis.

scholarly journals Risk Perception, Perception of Collective Efficacy and Sleep Quality in Chinese Adults During COVID-19 Pandemic in Hong Kong: A Cross-sectional Study

2021 ◽  
Author(s):  
Shiang-Yi Lin ◽  
Kevin Kien Hoa Chung
Keyword(s):  
Hong Kong ◽  
Risk Perception ◽  
Sleep Quality ◽  
Sleep Problems ◽  
Self Report ◽  
Poor Sleep ◽  
Chinese Adults ◽  
Poor Sleep Quality ◽  
Risk Appraisals ◽  
The Relationship

Background: Only few studies have studied the link between risk perception and sleep in the context of the COVID-19 pandemic. This study investigates the effect of two distinct risk appraisals—risk perception and perception of collective coordinated defense (PCCD) on Chinese adults’ sleep quality during the COVID-19 pandemic, and tested COVID-19-related fear and rumination as potential mediators of the relationships. Methods: Data were collected using a self-report online questionnaire from a sample of 224 Chinese adults during the fourth wave of the COVID-19 pandemic in Hong Kong. Results: COVID-19 risk perception and PCCD were related to poor sleep quality. Mediation analysis showed that both fear and rumination mediated the relationship between risk perception and sleep quality, whereas only fear mediated the relationship between PCCD and sleep quality. The model showed an excellent fit to the data and accounted for 44% of the variance in sleep quality in Chinese adults. Conclusions: This study demonstrates the distinct perceptual processes—risk appraisals in particular—contributed to poor sleep quality in Chinese adults during the COVID-19 public emergencies. These findings would be helpful for policy makers to address the sleep problems induced by psychological consequences of the pandemic.

scholarly journals Risk Perception, Perception of Collective Efficacy and Sleep Quality in Chinese Adults during COVID-19 Pandemic in Hong Kong: A Cross-Sectional Study

2021 ◽  
Vol 18 (21) ◽  
pp. 11533
Author(s):  
Shiang-Yi Lin ◽  
Kevin Kien Hoa Chung
Keyword(s):  
Hong Kong ◽  
Risk Perception ◽  
Sleep Quality ◽  
Self Report ◽  
Poor Sleep ◽  
Chinese Adults ◽  
Subjective Sleep Quality ◽  
Convenience Sample ◽  
Subjective Sleep ◽  
The Relationship

Background: Only a few studies have studied the link between risk perception and sleep in the context of the COVID-19 pandemic. The purpose of our study is to propose and test a theoretical model to understand the relationships between COVID-19 risk appraisals—risk perception and perception of collective coordinated defense (PCCD) in particular—and subjective sleep quality in Chinese adults in Hong Kong during the COVID-19 pandemic. COVID-19-related fear and rumination were examined as potential mediators of the relationships. Methods: Data were collected using a self-report online questionnaire from a convenience sample of 224 Chinese adults during the fourth wave of the COVID-19 pandemic in Hong Kong. Results: Risk perception and PCCD were found to predict poor sleep quality. Mediation analysis showed that both fear and rumination mediated the relationship between risk perception and sleep quality, whereas only fear mediated the relationship between PCCD and sleep quality. The model was an excellent fit to the data and accounted for 44% of the variance in sleep quality in Chinese adults. This study indicated that both perception of high risks of contracting COVID-19 and anticipations of collective disease preventive efforts had adverse effects on subjective sleep quality via increasing COVID-19-related fear. Conclusions: These findings underscore the need for addressing sleep problems induced by psychological consequences of the pandemic. While policy makers often deliver public messaging campaigns that frame disease prevention as a collective goal, developing evidence-based coping strategies to combat COVID-19 adverse impacts on psychological health is equally important.

scholarly journals The relationship between sleep hygiene and sleep quality among residents of an elderly care institution in DKI Jakarta

2020 ◽  
Vol 4 (1) ◽  
Author(s):  
Mutia Annisa ◽  
Dwi Nurviyandari Kusuma Wati
Keyword(s):  
Sleep Quality ◽  
Sleep Problems ◽  
Elderly Care ◽  
Sleep Hygiene ◽  
Poor Sleep ◽  
Poor Sleep Quality ◽  
Cross Sectional ◽  
Cross Sectional Design ◽  
The Relationship ◽  
Purposive Sample

<p class="AbstractContent"><strong>Objective:</strong> Elderly are at risk of poor slepp quality and other health problems due to reduced sleep satisfaction. The objective of this study was to explore the association between sleep hygiene and sleep quality in elderly.</p><p class="AbstractContent"><strong>Methods: </strong>This was a descriptive study with cross sectional design. The study was conducted in four elderly care institutions in Jakarta, Indonesia, involving a purposive sample of 103 elderly aged 60 to 111 years old. Data were collected using Sleep Hygiene Index (SHI) and Pittsburgh Sleep Quality Index (PSQI).</p><p class="AbstractContent"><strong>Results:</strong> Over half of the residents had poor sleep hygiene (51.5%) and more than three quarter (81.6%) had poor sleep quality. The study revealed that there was a highly significant relationship between sleep hygiene and sleep quality (p = 0.001). The study also showed that those with poor sleep hygiene were 7.834 times more likely to have poor sleep quality.<strong></strong></p><p class="AbstractContent"><strong>Conclusion: </strong>Nurses need to include interventions that may address residents’ sleep problems. They also need to promote sleep hygiene and improve residents’ sleep quality.<strong></strong></p><strong>Keywords: </strong>elderly, institution, sleep hygiene, sleep quality

scholarly journals Sleep Quality and Self-Control: The Mediating Roles of Positive and Negative Affects

2020 ◽  
Vol 11 ◽  
Author(s):  
Jinru Liu ◽  
Lin Zhu ◽  
Conghui Liu
Keyword(s):  
Negative Affect ◽  
Sleep Quality ◽  
Positive Affect ◽  
Self Control ◽  
Self Report ◽  
Poor Sleep ◽  
Poor Sleep Quality ◽  
Negative Affects ◽  
The Relationship ◽  
Positive And Negative Affects

This study examined the mediating roles of both positive and negative affects in the relationship between sleep quality and self-control. A sample of 1,507 Chinese adults (37% men; mean age = 32.5 years) completed self-report questionnaires measuring sleep quality, positive and negative emotions, and self-control. Poor sleep quality was positively correlated with negative affect and negatively correlated with positive affect and self-control. Positive affect was positively correlated with self-control, while negative affect was negatively correlated with self-control. Both positive and negative affects significantly mediated the relationship between sleep quality and self-control. Improving individuals’ sleep qualities may lead to more positive emotions and less negative emotion, and these mood changes may increase resources for self-control. Regulating positive and negative affects may reduce the negative effects of poor sleep quality on self-control.

Sleep quality mediates the relationship between frailty and cognitive dysfunction in non-demented middle aged to older adults

2019 ◽  
Vol 31 (06) ◽  
pp. 779-788 ◽  
Author(s):  
Sonya Kaur ◽  
Nikhil Banerjee ◽  
Michelle Miranda ◽  
Mitchell Slugh ◽  
Ni Sun-Suslow ◽  
...  
Keyword(s):  
Older Adults ◽  
Executive Function ◽  
Sleep Quality ◽  
Cognitive Decline ◽  
Processing Speed ◽  
Poor Sleep ◽  
Poor Sleep Quality ◽  
Subjective Sleep Quality ◽  
Delayed Recall ◽  
The Relationship

ABSTRACTObjectives:Frailty is associated with cognitive decline in older adults. However, the mechanisms explaining this relationship are poorly understood. We hypothesized that sleep quality may mediate the relationship between frailty and cognition.Participants:154 participants aged between 50-90 years (mean = 69.1 years, SD = 9.2 years) from the McKnight Brain Registry were included.Measurements:Participants underwent a full neuropsychological evaluation, frailty and subjective sleep quality assessments. Direct relationships between frailty and cognitive function were assessed using linear regression models. Statistical mediation of these relationships by sleep quality was assessed using nonparametric bootstrapping procedures.Results:Frailty severity predicted weaker executive function (B = −2.77, β = −0.30, 95% CI = −4.05 – −1.29) and processing speed (B = −1.57, β = −0.17, 95% CI = −3.10 – −0.16). Poor sleep quality predicted poorer executive function (B = −0.47, β = −0.21, 95% CI = −0.79 – −0.08), processing speed (B = −0.64, β = −0.28, 95% CI = −0.98 – −0.31), learning (B = −0.42, β = −0.19, 95% CI = −0.76 – −0.05) and delayed recall (B = −0.41, β = −0.16, 95% CI = −0.80 – −0.31). Poor sleep quality mediated the relationships between frailty severity and executive function (B = −0.66, β = −0.07, 95% CI = −1.48 – −0.39), learning (B = −0.85, β = −0.07, 95% CI = −1.85 – −0.12), delayed recall (B = −0.47, β = −0.08, 95% CI = −2.12 – −0.39) and processing speed (B = −0.90, β = −0.09, 95% CI = −1.85 – −0.20).Conclusions:Relationships between frailty severity and several cognitive outcomes were significantly mediated by poor sleep quality. Interventions to improve sleep quality may be promising avenues to prevent cognitive decline in frail older adults.

scholarly journals Sleep and Olfaction among Older Adults

2017 ◽  
Vol 48 (3-4) ◽  
pp. 147-154 ◽  
Author(s):  
V. Eloesa McSorley ◽  
Jayant Pinto ◽  
L. Philip Schumm ◽  
Kristen Wroblewski ◽  
David Kern ◽  
...  
Keyword(s):  
Older Adults ◽  
Sleep Quality ◽  
Structural Equation Models ◽  
Sleep Problems ◽  
Community Dwelling ◽  
Odor Identification ◽  
Self Report ◽  
Poor Sleep ◽  
Wrist Actigraphy ◽  
Odor Sensitivity

Background: Sleep and olfaction are both critical physiological processes that tend to worsen with age. Decline in olfaction can be an early indicator of neurodegenerative diseases, whereas poor sleep quality is associated with reduced physical and mental health. Given associations with aging-related health declines, we explored whether variations in sleep were associated with olfactory function among older adults. Methods: We assessed the relationship between sleep characteristics and olfaction among 354 community-dwelling older adults. Olfaction was measured using a validated field and survey research tool. Sleep characteristics were measured using wrist actigraphy and with self-report of sleep problems. We fit structural equation models of latent constructs of olfaction based on olfactory task items and let this be a function of each sleep characteristic. Results: Actigraph sleep quality measures were associated with odor identification, but not with odor sensitivity. Longer duration sleepers had worse odor sensitivity compared to medium (58 h) sleepers, but sleep duration was not associated with odor identification. Reported sleep problems and reported usual duration were not associated with olfaction. Conclusions: Diminished sleep quality was associated with reduced capacity to identify odors. Determining whether this is a causal association will require further study and longitudinal data.

scholarly journals Workaholism, Intensive Smartphone Use, and the Sleep-Wake Cycle: A Multiple Mediation Analysis

2019 ◽  
Vol 16 (19) ◽  
pp. 3517 ◽  
Author(s):  
Spagnoli ◽  
Balducci ◽  
Fabbri ◽  
Molinaro ◽  
Barbato
Keyword(s):  
Sleep Quality ◽  
Sleep Disorders ◽  
Daytime Sleepiness ◽  
Self Report ◽  
Poor Sleep ◽  
Multiple Mediation ◽  
Smartphone Use ◽  
The Relationship ◽  
Mediation Models

Recent contributions have reported sleep disorders as one of the health impairment outcomes of workaholism. A possible factor affecting the sleep-wake cycle might be the intensive use of smartphones. The current study aimed to explore the role of intensive smartphone use in the relationship between workaholism and the sleep-wake cycle. Two serial multiple mediation models were tested on a sample of 418 employees, who filled self-report questionnaires measuring workaholism, use of smartphones, sleep quality and daytime sleepiness, using conditional process analysis for testing direct and indirect effects. Results supported our hypotheses regarding two serial multiple mediation models—that intensive smartphone use and poor sleep quality mediated the relationship between workaholism and daytime sleepiness, and that smartphone use and daytime sleepiness mediated the relationship between workaholism and poor quality of sleep. Although the use of a cross-sectional design and the snowball technique for collecting data can be considered as possible limitations, the current study is one of the first to document the potential detrimental role of the intensive smartphone use on the workaholism-sleep disorders relationship.

scholarly journals Fatigue in primary biliary cirrhosis

Gut ◽  
1998 ◽  
Vol 43 (5) ◽  
pp. 705-710 ◽  
Author(s):  
K Cauch-Dudek ◽  
S Abbey ◽  
D E Stewart ◽  
E J Heathcote
Keyword(s):  
Liver Disease ◽  
Primary Biliary Cirrhosis ◽  
Sleep Quality ◽  
Sleep Problems ◽  
Self Report ◽  
Poor Sleep ◽  
Biliary Cirrhosis ◽  
Duration Of Disease ◽  
Fatigue Severity

Background—Fatigue is a frequent and debilitating symptom in patients with primary biliary cirrhosis (PBC).Aims—To study fatigue in relation to sleep, depression, and liver disease severity.Methods—Patients with PBC completed validated self report questionnaires measuring fatigue, sleep quality, depression, and functional capacity. Verbally reported fatigue and observer rated measure of depression and ursodeoxycholic acid (UDCA) use were recorded. Liver biochemistry and tests to rule out metabolic causes of fatigue were performed.Results—Mean age of the 88 patients enrolled was 57 years; 86% were female and mean duration of disease was 6.6 years. Median bilirubin was 13 μmol/l (mean 18.6). Verbally reported fatigue (for more than six months) was present in 60 patients (68%). The self rated Fatigue Severity Score (FSS) correlated well with verbally reported fatigue (p=0.0001). The FSS did not correlate with age, duration of disease, serum bilirubin, Mayo Risk Score, or UDCA use, but correlation was seen with sleep quality. Fatigued patients had more sleep problems and higher depression scores than non-fatigued patients. Self rated depression was present in 28% (17/60) of fatigued compared with 4% (1/28) of non-fatigued patients.Conclusions—Long term fatigue affected 68% of the patients with PBC but it was not related to the severity of their liver disease. Poor sleep quality and depression were commonly associated with fatigue.

scholarly journals The relationship between fatigability and sleep quality in people with multiple sclerosis

2016 ◽  
Vol 2 ◽  
pp. 205521731668277 ◽  
Author(s):  
Mayis Aldughmi ◽  
Jessie Huisinga ◽  
Sharon G Lynch ◽  
Catherine F Siengsukon
Keyword(s):  
Multiple Sclerosis ◽  
Sleep Quality ◽  
Quality Index ◽  
Sleep Disturbances ◽  
Performance Test ◽  
Pittsburgh Sleep Quality Index ◽  
Self Report ◽  
Poor Sleep ◽  
Poor Sleep Quality ◽  
The Relationship

Background Perceived fatigue and fatigability are constructs of multiple sclerosis (MS)-related fatigue. Sleep disturbances lead to poor sleep quality, which has been found to be associated with perceived fatigue in people with MS (PwMS). However, the relationship between fatigability and sleep quality is unknown. Objective To explore the relationship between physical and cognitive fatigability with self-reported and objective measures of sleep quality in PwMS. Methods Fifty-one ambulatory PwMS participated in the study. Physical fatigability was measured by percent-change in meters walked on the six-minute walk test (6MWT) and in force exerted on a repeated maximal hand grip test. Cognitive fatigability was measured using response speed variability on the continuous performance test. Self-report sleep quality was measured using the Pittsburgh Sleep Quality Index, and objective sleep quality was measured using 1 week of actigraphy. Results Components of the Pittsburgh Sleep Quality Index and several actigraph parameters were significantly associated with physical fatigability and cognitive fatigability. However, controlling for depression eliminated the association between the sleep outcomes and cognitive fatigability and attenuated the association between the sleep outcomes and physical fatigability. Conclusion Poor sleep quality is related to fatigability in MS but depression appears to mediate these relationships.

scholarly journals Good Sleep Quality Improves the Relationship Between Pain and Depression Among Individuals With Chronic Pain

2021 ◽  
Vol 12 ◽  
Author(s):  
Zoe Zambelli ◽  
Elizabeth J. Halstead ◽  
Antonio R. Fidalgo ◽  
Dagmara Dimitriou
Keyword(s):  
Chronic Pain ◽  
Sleep Quality ◽  
Sleep Problems ◽  
Pain Severity ◽  
Pain Interference ◽  
Poor Sleep ◽  
Regression Analyses ◽  
Cross Sectional Survey ◽  
The Relationship ◽  
Good Sleep

Individuals with chronic pain often experience co-existing sleep problems and depression-related states. Chronic pain, sleep problems, and depression interrelate, and have been shown to exacerbate one another, which negatively impacts quality of life. This study explored the relationships between pain severity, pain interference, sleep quality, and depression among individuals with chronic pain. Secondly, we tested whether sleep quality may moderate the relationship between pain and depression. A cross-sectional survey was completed by 1,059 adults with non-malignant chronic pain conditions (Mage 43 years, 88% identified as women) and collected measures related to pain severity, pain interference, sleep quality, and depression. Multiple regression analyses found that pain severity, pain interference, and sleep quality are all significantly associated with depression. Secondly, moderated regression analyses revealed that sleep quality moderates the relationship between pain interference and depression among individuals with chronic pain such that good sleep quality attenuates the effect of pain interference on depression, and poor sleep quality amplifies the effect of pain interference on depression. These findings suggest that sleep quality may be a relevant therapeutic target for individuals with chronic pain and co-existing depression.

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