scholarly journals Interview with 2021 Hooke medal winner Stephen Royle

2021 ◽  
Vol 134 (17) ◽  
Keyword(s):  
Biological Sciences ◽  
Membrane Trafficking ◽  
Cell Biology ◽  
Molecular Mechanisms ◽  
P2x Receptor ◽  
Advisory Groups ◽  
University Of Cambridge ◽  
The Board Of Directors ◽  
Set Up ◽  
The University

ABSTRACT Stephen Royle studied Biological Sciences at the University of Sheffield. He then pursued a PhD in the lab of Ruth Murrell-Lagnado at the University of Cambridge, UK, where he investigated the molecular mechanisms of P2X receptor trafficking. In 2002, he joined Leon Lagnado's group at the MRC Laboratory of Molecular Biology in Cambridge for his postdoc to work on synaptic vesicle endocytosis in neurons, and here he also discovered a novel mitotic function of clathrin. Steve set up his lab at the University of Liverpool in 2006, and in 2013 moved to the Centre for Mechanochemical Cell Biology, Warwick Medical School as a Senior Cancer Research UK Fellow; there he has been a Professor since 2019. The Royle lab is interested in understanding molecular mechanisms of membrane trafficking and mitosis. Steve is also on the Board of Directors of The Company of Biologists and the Advisory Groups of Journal of Cell Science and preLights. He is the recipient of the 2021 Hooke medal, established to recognize an emerging leader in cell biology.

scholarly journals Graphitization of Small Carbonate Samples for Paleoceanographic Research at the Godwin Radiocarbon Laboratory, University of Cambridge

Radiocarbon ◽  
2016 ◽  
Vol 58 (1) ◽  
pp. 89-97 ◽  
Author(s):  
E Freeman ◽  
L C Skinner ◽  
R Reimer ◽  
A Scrivner ◽  
S Fallon
Keyword(s):  
Iron Powder ◽  
Hydrogen Reduction ◽  
Ion Beam ◽  
Small Sample ◽  
Small Samples ◽  
University Of Cambridge ◽  
National University ◽  
Set Up ◽  
The University ◽  
Selection Of

AbstractA new radiocarbon preparation facility was set up in 2010 at the Godwin Laboratory for Palaeoclimate Research, at the University of Cambridge. Samples are graphitized via hydrogen reduction on an iron powder catalyst before being sent to the Chrono Centre, Belfast, or the Australian National University for accelerator mass spectrometry (AMS) analysis. The experimental setup and procedure have recently been developed to investigate the potential for running small samples of foraminiferal carbonate. By analyzing background values of samples ranging from 0.04 to 0.6 mg C along with similar sized secondary standards, the setup and experimental procedures were optimized for small samples. “Background” modern 14C contamination has been minimized through careful selection of iron powder, and graphitization has been optimized through the use of “small volume” reactors, allowing samples containing as little as 0.08 mg C to be graphitized and accurately dated. Graphitization efficiency/fractionation is found not to be the main limitation on the analysis of samples smaller than 0.07 mg C, which rather depends primarily on AMS ion beam optics, suggesting further improvements in small sample analysis might yet be achieved with our methodology.

scholarly journals Cell scientist to watch – Prachee Avasthi

2021 ◽  
Vol 134 (18) ◽  
Keyword(s):  
San Francisco ◽  
Protein Trafficking ◽  
Cell Biology ◽  
Medical Center ◽  
Associate Professor ◽  
Integrative Physiology ◽  
University Of Utah ◽  
School Of Medicine ◽  
Set Up ◽  
The University

ABSTRACT Prachee Avasthi studied Molecular and Integrative Physiology at the University of Illinois at Urbana-Champaign. She received her PhD in neuroscience in 2009 from the lab of Wolfgang Baehr at the University of Utah for her work on the control of membrane protein trafficking in photoreceptors. Prachee then moved to Wallace Marshall's group at the University of California, San Francisco, for her postdoc, where she studied ciliary assembly and the regulation of ciliary length. She set up her lab at the University of Kansas Medical Center in 2015, and relocated to the Geisel School of Medicine at Dartmouth in 2020, where she is an Associate Professor of Biochemistry and Cell Biology. Her group investigates the biogenesis of cilia and the coordination of actin- and microtubule-based trafficking.

Malcolm MacNaughtan Bowie 1943–2007

2009 ◽  
Author(s):  
Marian Hobson
Keyword(s):  
Sigmund Freud ◽  
Stephane Mallarme ◽  
Research Centre ◽  
East Anglia ◽  
Henri Michaux ◽  
University Of Oxford ◽  
University Of Cambridge ◽  
International Profile ◽  
Set Up ◽  
The University

Malcolm MacNaughtan Bowie (1943–2007), a Fellow of the British Academy, was appointed from an assistant lectureship at the University of East Anglia to one in the University of Cambridge in 1969. At Cambridge, he worked as a specialist in difficult poets in French beginning with ‘M’, particularly Henri Michaux and Stephane Mallarmé. These are writers of involuted complexity, to read whom both a sensitivity to how word play plays and to how French prosody in poetry or prose works were essential. These studies by Bowie were followed by work on mind-altering psychoanalysis: on Sigmund Freud and Jacques Lacan. He was the first director of the Romance Languages Institute, ran its vigorous seminar programme, and gave this a strong international profile by his invitations. At the University of Oxford, Bowie set up the European Humanities Research Centre, followed by an associated publishing venture, Legenda.

Projects: Millennium Mathematics Project: Enriching Maths for All

2004 ◽  
Vol 97 (3) ◽  
pp. 223
Author(s):  
Gina Foletta
Keyword(s):  
School Curriculum ◽  
Mathematical Skills ◽  
Joint Project ◽  
University Of Cambridge ◽  
Set Up ◽  
The University

The Millennium Mathematics Project (MMP) was set up within the University of Cambridge in 1999 as a joint project between the faculties of mathematics and education. It brings together a number of existing outreach activities, which have since been developed and extended and which now have a national and international user base. The MMP aims to support maths education and promote the development of mathematical skills and understanding, particularly through enrichment and extension activities beyond the school curriculum.

scholarly journals Industrial cryo-EM facility setup and management

2020 ◽  
Vol 76 (4) ◽  
pp. 313-325
Author(s):  
Kasim Sader ◽  
Rishi Matadeen ◽  
Pablo Castro Hartmann ◽  
Tor Halsan ◽  
Chris Schlichten
Keyword(s):  
Image Processing ◽  
Materials Science ◽  
Early Stage ◽  
Lessons Learned ◽  
Process Scheduling ◽  
Structure Based Drug Design ◽  
University Of Cambridge ◽  
Thermo Fisher Scientific ◽  
Set Up ◽  
The University

Cryo-electron microscopy (cryo-EM) has rapidly expanded with the introduction of direct electron detectors, improved image-processing software and automated image acquisition. Its recent adoption by industry, particularly in structure-based drug design, creates new requirements in terms of reliability, reproducibility and throughput. In 2016, Thermo Fisher Scientific (then FEI) partnered with the Medical Research Council Laboratory of Molecular Biology, the University of Cambridge Nanoscience Centre and five pharmaceutical companies [Astex Pharmaceuticals, AstraZeneca, GSK, Sosei Heptares and Union Chimique Belge (UCB)] to form the Cambridge Pharmaceutical Cryo-EM Consortium to share the risks of exploring cryo-EM for early-stage drug discovery. The Consortium expanded with a second Themo Scientific Krios Cryo-EM at the University of Cambridge Department of Materials Science and Metallurgy. Several Consortium members have set up in-house facilities, and a full service cryo-EM facility with Krios and Glacios has been created with the Electron Bio-Imaging Centre for Industry (eBIC for Industry) at Diamond Light Source (DLS), UK. This paper will cover the lessons learned during the setting up of these facilities, including two Consortium Krios microscopes and preparation laboratories, several Glacios microscopes at Consortium member sites, and a Krios and Glacios at eBIC for Industry, regarding site evaluation and selection for high-resolution cryo-EM microscopes, the installation process, scheduling, the operation and maintenance of the microscopes and preparation laboratories, and image processing.

scholarly journals Cell scientist to watch – Vivian Li

2021 ◽  
Vol 134 (16) ◽  
Keyword(s):  
Cancer Research ◽  
Mouse Models ◽  
Cell Biology ◽  
Molecular Mechanisms ◽  
Wnt Signalling ◽  
Early Career ◽  
British Society ◽  
Francis Crick ◽  
Primary Focus ◽  
The University

ABSTRACT Vivian Li obtained her PhD from the University of Hong Kong in 2008, where she investigated the molecular mechanisms of human colonic development and tumorigenesis. Funded by a Croucher Foundation Fellowship, she joined the lab of Hans Clevers at the Hubrecht Institute in the Netherlands for her postdoctoral work. There, she identified novel Wnt signalling mechanisms at different subcellular levels and characterised intestinal stem cell genes using newly created transgenic mouse models. Vivian established her group at the MRC National Institute for Medical Research, which is now part of the Francis Crick Institute, London, in February 2013. In her lab she uses genetic mouse models and organoids to investigate the regulation of intestinal homeostasis and cancer with a primary focus on the Wnt signalling pathway. Vivian was awarded a Future Leaders in Cancer Research Prize in 2018 by Cancer Research UK and is the winner of the 2021 Women in Cell Biology Early Career Medal awarded by the British Society for Cell Biology.

Land Economy: An Education and Philosophy for the Surveyor’s Profession

1977 ◽  
Vol 31 (2) ◽  
pp. 119-131 ◽  
Author(s):  
Donald Denman
Keyword(s):  
Land Management ◽  
Resource Development ◽  
Environmental Policies ◽  
Professional Services ◽  
Land Law ◽  
University Of Cambridge ◽  
Land Economics ◽  
Set Up ◽  
The University

The role of the professional land surveyor has been decreasing in importance because he has not pursued his legitimate role as an adviser in land management. The University of Cambridge has, over the last 16 years, developed a land economy course that includes land law, land economics, economics, agricultural and resource development, environmental policies, etc. Similar courses have been set up in many Commonwealth countries. Such courses can equip surveyors to provide the professional services that should be his preserve.

The Peculiars of the University of Cambridge

2012 ◽  
Vol 15 (1) ◽  
pp. 59-68 ◽  
Author(s):  
Burkhard Steinberg
Keyword(s):  
Legal Definition ◽  
University Of Cambridge ◽  
The Reformation ◽  
Set Up ◽  
The University ◽  
Episcopal Authority

Are the University of Cambridge and its colleges peculiars? The university has always claimed independence from episcopal authority for itself and its colleges. A struggle was resolved in 1434 by a tribunal set up by the Pope, in which the Prior of the monastery of Barnwell heard both sides and decided that the University and its colleges were to be exempt from the supervision of the Archbishop of Canterbury and of the Bishop of Ely, in whose diocese the University was situated. This became known as the Barnwell Process. It established the University and it colleges as peculiars defined as having an Ordinary other than the diocesan bishop. Colleges founded later but before the Reformation claimed the same privileges. At the Reformation, the authority of the Pope was replaced by that of the King and the Archbishop of Canterbury, but the privileges that the University and its colleges enjoyed continued to apply. Post-Reformation foundations of colleges tended to claim the same exemptions from episcopal jurisdiction, but without documented evidence. This article argues that the continued acceptance by the Bishop of Ely of the University and its colleges as extra-diocesan confirms them to be peculiars within the legal definition.

scholarly journals Ubiquitination-Dependent Regulation of Small GTPases in Membrane Trafficking: From Cell Biology to Human Diseases

2021 ◽  
Vol 9 ◽  
Author(s):  
Zehui Lei ◽  
Jing Wang ◽  
Lingqiang Zhang ◽  
Cui Hua Liu
Keyword(s):  
Membrane Trafficking ◽  
Cell Biology ◽  
Molecular Mechanisms ◽  
Neurological Diseases ◽  
Small Gtpases ◽  
Small Gtpase ◽  
Human Diseases ◽  
Nucleotide Exchange ◽  
Temporal Regulation ◽  
Spatio Temporal

Membrane trafficking is critical for cellular homeostasis, which is mainly carried out by small GTPases, a class of proteins functioning in vesicle budding, transport, tethering and fusion processes. The accurate and organized membrane trafficking relies on the proper regulation of small GTPases, which involves the conversion between GTP- and GDP-bound small GTPases mediated by guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs). Emerging evidence indicates that post-translational modifications (PTMs) of small GTPases, especially ubiquitination, play an important role in the spatio-temporal regulation of small GTPases, and the dysregulation of small GTPase ubiquitination can result in multiple human diseases. In this review, we introduce small GTPases-mediated membrane trafficking pathways and the biological processes of ubiquitination-dependent regulation of small GTPases, including the regulation of small GTPase stability, activity and localization. We then discuss the dysregulation of small GTPase ubiquitination and the associated human membrane trafficking-related diseases, focusing on the neurological diseases and infections. An in-depth understanding of the molecular mechanisms by which ubiquitination regulates small GTPases can provide novel insights into the membrane trafficking process, which knowledge is valuable for the development of more effective and specific therapeutics for membrane trafficking-related human diseases.

scholarly journals Cell scientist to watch – Liang Ge

2021 ◽  
Vol 134 (9) ◽  
Keyword(s):  
Cell Biology ◽  
Molecular Mechanisms ◽  
Life Sciences ◽  
Cholesterol Absorption ◽  
University Of California ◽  
Tsinghua University ◽  
Chinese Academy Of Sciences ◽  
Intermediate Compartment ◽  
The University ◽  
Academy Of Sciences

ABSTRACT Liang Ge pursued his PhD in the lab of Dr Bao-Liang Song at the Institutes of Biochemistry and Cell Biology, Chinese Academy of Sciences, where he studied the molecular mechanisms of cholesterol absorption. In 2011 he moved to California for a postdoc and later a research specialist position with Randy Schekman at the University of California, Berkeley. There, he discovered key roles for LC3 lipidation and the ER–Golgi intermediate compartment in autophagosome biogenesis. Liang established his group in the School of Life Sciences at Tsinghua University at the end of 2017, where he combines cell biology and biochemistry techniques, mouse models and computational biology to study the mechanisms of autophagy and unconventional protein secretion.

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