scholarly journals Protective effect of coenzyme Q10 against hypoxic cellular damage.

1985 ◽  
Vol 33 (7) ◽  
pp. 2896-2903 ◽  
Author(s):  
NOBORU SUZUKI ◽  
TETSUYA NAKAMURA ◽  
HIDEYUKI ISHIDA ◽  
KIYOSHI HOSONO
Keyword(s):  
Protective Effect ◽  
Coenzyme Q10 ◽  
Cellular Damage

scholarly journals Protective Action of Antioxidants on Hepatic Damage Induced by Griseofulvin

2014 ◽  
Vol 2014 ◽  
pp. 1-8 ◽  
Author(s):  
M. del C. Martinez ◽  
S. G. Afonso ◽  
A. M. Buzaleh ◽  
A. Batlle
Keyword(s):  
Oxidative Stress ◽  
Protective Effect ◽  
Liver Damage ◽  
Protective Action ◽  
Protoporphyrin Ix ◽  
Antioxidant Defense System ◽  
Cellular Damage ◽  
Antioxidant Compounds ◽  
Stress Markers ◽  
Heme Regulation

Erythropoietic protoporphyria (EPP) is a disease associated with ferrochelatase deficiency and characterized by the accumulation of protoporphyrin IX (PROTO IX) in erythrocytes, liver, and skin. In some cases, a severe hepatic failure and cholestasis were observed. Griseofulvin (Gris) develops an experimental EPP with hepatic manifestations in mice such as PROTO IX accumulation followed by cellular damage as wells as necrotic and inflammatory processes. The antioxidant defense system was also altered. The aim was to evaluate the possible protective effect of different antioxidant compounds: trolox (Tx), ascorbic acid (Asc), the combination Tx and Asc, melatonin (Mel), and the polyphenols: ellagic acid, quercetin, chlorogenic acid, caffeic acid, gallic acid, and ferulic acid on liver damage and oxidative stress markers in a mouse model of EPP. Coadministration of Gris with Tx, Asc, and its combination, or Mel mainly affected heme biosynthetic pathway, resulting in a decrease in ALA-S activity which was increased by Gris, while the tested polyphenols exerted a protective effect on oxidative stress, decreasing lipid peroxidation and the activity of some antioxidant enzymes. In conclusion, antioxidant compounds can only protect partially against the liver damage induced by Gris, reducing oxidative stress or acting on heme regulation.

scholarly journals Protective Effect and Mechanism of Total Flavones fromRhododendron simsiiPlanch Flower on Cultured Rat Cardiomyocytes with Anoxia and Reoxygenation

2015 ◽  
Vol 2015 ◽  
pp. 1-10 ◽  
Author(s):  
Yi Jiao ◽  
Yi-Fei Fan ◽  
Yu-Ling Wang ◽  
Jun-Yan Zhang ◽  
Shuo Chen ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Protective Effect ◽  
Cell Viability ◽  
Ischemia Reperfusion ◽  
Cellular Damage ◽  
Protective Mechanism ◽  
Patch Clamp Technique ◽  
Rat Cardiomyocytes ◽  
Whole Cell Patch Clamp ◽  
Myocardial Ischemia Reperfusion

Many flavonoids have cardioprotection against myocardial ischemia/reperfusion (I/R) injury. Total flavones fromRhododendron simsiiPlanch flower (TFR) can protect myocardial ischemic injuries. However, its protective mechanism is still unknown. The present study was designed to investigate the mechanism of TFR on myocardial I/R and anoxia/reoxygenation (A/R) injuries. Rat model of myocardial I/R injury was made, and myocardial infarction was determined. A/R injury was induced in cultured rat cardiomyocytes; cellular damage was evaluated by measuring cell viability, LDH and cTnT releases, and MDA content. Expressions of ROCK1and ROCK2protein were examined by Western blot analysis, and K+currents were recorded by using whole-cell patch clamp technique. TFR 20~80 mg/kg markedly reduced I/R-induced myocardial infarction. TFR 3.7~300 mg/L significantly inhibited A/R-induced reduction of cell viability, LDH and cTnT releases, and MDA production. Exposure to A/R significantly increased ROCK1and ROCK2expressions in rat cardiomyocytes, but TFR 33.3~300 mg/L obviously inhibited this increase. 300 mg/L TFR significantly augmented inward rectifier K+current and other K+currents in rat cardiomyocytes. These results indicate that TFR has a protective effect on rat cardiomyocytes A/R damage, and the protective mechanism may be engaged with the inhibition of ROCK1and ROCK2and activation of K+channels.

scholarly journals Protective effect of Coenzyme Q10 against gentamicin induced acute renal failure in mice.

2016 ◽  
Vol 2 (6) ◽  
pp. 401-406
Author(s):  
Abdel Razik H. Farrag ◽  
Rania A. Ibrahim ◽  
Shimaa N. El-Sayed
Keyword(s):  
Renal Failure ◽  
Acute Renal Failure ◽  
Protective Effect ◽  
Coenzyme Q10

scholarly journals Histomorphometrical and Stereological Study of the Lungs in Neonatal Rats Born to Paraquat-poisoned Pregnant Rats: Protective Effect of Coenzyme Q10

2020 ◽  
Vol 14 (2) ◽  
pp. 71-80
Author(s):  
Fatemeh Balazadeh ◽  
◽  
Rasoul Shahrooz ◽  
Ali Shalizar Jalali ◽  
Hamid Karimi ◽  
...  
Keyword(s):  
Protective Effect ◽  
Olive Oil ◽  
Coenzyme Q10 ◽  
Complete Recovery ◽  
Control Group ◽  
Interstitial Tissue ◽  
Newborn Rats ◽  
Paraffin Sections ◽  
Pregnant Rats ◽  
Hematoxylin And Eosin

Background: Paraquat (PQ), an herbicide, is a very poisonous compound for both humans and animals. This study was conducted to examine the protective effect of the Coenzyme Q10 (CoQ10) in newborn rats from pregnant rats pre-treated with PQ. Methods: The experiments were conducted on 25 rats, divided in five groups randomly and equally: 1. Control Group received normal saline (0.1 ml/day); 2. PQ Group received PQ only (5 mg/kg/day); 3. PQ+CoQ10 Group received PQ (5 mg/kg) and CoQ10 (10 mg/kg) daily; 4. PQ+olive oil Group received PQ (5 mg/kg) and olive oil (10 mg/kg) daily; 5. Olive oil Group received olive oil (10 mg/kg/day). All of the injections were made intraperitoneally and started on the 16th day of pregnancy through to parturition. Sixteen days after parturition, the lungs were removed from the newborn rats, paraffin sections were made and stained with hematoxylin and eosin, and analyzed histomorphometrically and stereologically. Results: The results revealed that interstitial tissue and lung alveoli had normal structures in the control and olive oil groups. In PQ and PQ-olive oil groups alveolar hemorrhage, inflammation, extensive fibrosis, decreased alveolar numbers, increased mast cells, and changes in the epithelia were observed. In PQ-CoQ10 Group there was a significant recovery in all of the histological alterations. Conclusion: Generally, Coenzyme Q10 had a protective effect against lung damages caused by PQ, but a complete recovery of the damaged lung tissue would probably take longer than 16 days after birth.

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