Effect Of Incomplete Recovery On Vo2-on Kinetic During Moderate-intensity Exercise Transitions In Healthy Males.

2014 ◽  
Vol 46 ◽  
pp. 524-525
Author(s):  
Silvia Pogliaghi ◽  
Enrico Tam ◽  
Carlo Capelli
2011 ◽  
Vol 301 (1) ◽  
pp. R218-R224 ◽  
Author(s):  
Juan M. Murias ◽  
Matthew D. Spencer ◽  
John M. Kowalchuk ◽  
Donald H. Paterson

Older adults (O) may have a longer phase I pulmonary O2 uptake kinetics (V̇o2p) than young adults (Y); this may affect parameter estimates of phase II V̇o2p. Therefore, we sought to: 1) experimentally estimate the duration of phase I V̇o2p (EE phase I) in O and Y subjects during moderate-intensity exercise transitions; 2) examine the effects of selected phase I durations (i.e., different start times for modeling phase II) on parameter estimates of the phase II V̇o2p response; and 3) thereby determine whether slower phase II kinetics in O subjects represent a physiological difference or a by-product of fitting strategy. V̇o2p was measured breath-by-breath in 19 O (68 ± 6 yr; mean ± SD) and 19 Y (24 ± 5 yr) using a volume turbine and mass spectrometer. Phase I V̇o2p was longer in O (31 ± 4 s) than Y (20 ± 7 s) ( P < 0.05). In O, phase II τV̇o2p was larger ( P < 0.05) when fitting started at 15 s (49 ± 12 s) compared with fits starting at the individual EE phase I (43 ± 12 s), 25 s (42 ± 10 s), 35 s (42 ± 12 s), and 45 s (45 ± 15 s). In Y, τV̇o2p was not affected by the time at which phase II V̇o2p fitting started (τV̇o2p = 31 ± 7 s, 29 ± 9 s, 30 ± 10 s, 32 ± 11 s, and 30 ± 8 s for fittings starting at 15 s, 25 s, 35 s, 45 s, and EE phase I, respectively). Fitting from EE phase I, 25 s, or 35 s resulted in the smallest CI τV̇o2p in both O and Y. Thus, fitting phase II V̇o2p from (but not constrained to) 25 s or 35 s provides consistent estimates of V̇o2p kinetics parameters in Y and O, despite the longer phase I V̇o2p in O.


2008 ◽  
Vol 105 (2) ◽  
pp. 446-456 ◽  
Author(s):  
Alan R. Barker ◽  
Joanne R. Welsman ◽  
Jonathan Fulford ◽  
Deborah Welford ◽  
Neil Armstrong

The splitting of muscle phosphocreatine (PCr) plays an integral role in the regulation of muscle O2 utilization during a “step” change in metabolic rate. This study tested the hypothesis that the kinetics of muscle PCr would be faster in children compared with adults both at the onset and offset of moderate-intensity exercise, in concert with the previous demonstration of faster phase II pulmonary O2 uptake kinetics in children. Eighteen peri-pubertal children (8 boys, 10 girls) and 16 adults (8 men, 8 women) completed repeated constant work-rate exercise transitions corresponding to 80% of the Pi/PCr intracellular threshold. The changes in quadriceps [PCr], [Pi], [ADP], and pH were determined every 6 s using 31P-magnetic resonance spectroscopy. No significant ( P > 0.05) age- or sex-related differences were found in the PCr kinetic time constant at the onset (boys, 21 ± 4 s; girls, 24 ± 5 s; men, 26 ± 9 s; women, 24 ± 7 s) or offset (boys, 26 ± 5 s; girls, 29 ± 7 s; men, 23 ± 9 s; women 29 ± 7 s) of exercise. Likewise, the estimated theoretical maximal rate of oxidative phosphorylation (Qmax) was independent of age and sex (boys, 1.39 ± 0.20 mM/s; girls, 1.32 ± 0.32 mM/s; men, 2.36 ± 1.18 mM/s; women, 1.51 ± 0.53 mM/s). These results are consistent with the notion that the putative phosphate-linked regulation of muscle O2 utilization is fully mature in peri-pubertal children, which may be attributable to a comparable capacity for mitochondrial oxidative phosphorylation in child and adult muscle.


2019 ◽  
Vol 20 (1) ◽  
pp. 80-89 ◽  
Author(s):  
D. J. Miller ◽  
C. Sargent ◽  
G. D. Roach ◽  
A. T. Scanlan ◽  
G. E. Vincent ◽  
...  

2009 ◽  
Vol 34 (6) ◽  
pp. 1065-1072 ◽  
Author(s):  
Liza Stathokostas ◽  
John M. Kowalchuk ◽  
Robert J. Petrella ◽  
Donald H. Paterson

The lack of estrogen in postmenopausal women not using hormone replacement therapy (HRT), compared with those using HRT, may reduce submaximal blood flow during exercise and result in an oxygen delivery limitation constraining oxygen uptake (VO2) kinetics. The adaptation of pulmonary VO2 (VO2p) during the transition to exercise in older women was examined in this study. Thirty-one healthy postmenopausal women (mean age, 61 ± 6 years), 15 not using HRT and 16 using HRT, performed repeated exercise transitions (6 min) on a cycle, to work rates corresponding to 80% of estimated ventilatory threshold (moderate-intensity exercise) and to Δ50 (heavy-intensity exercise). There was no difference in moderate-intensity τVO2p between non-HRT (40 ± 9 s) and HRT (41 ± 9 s) women. Similarly, there was no difference in heavy-intensity τVO2p between non-HRT (44 ± 8 s) and HRT (45 ± 8 s) women. Thus, HRT did not affect the slowing of VO2 kinetics of older women.


Author(s):  
Bradley S. Lander ◽  
Dermot M. Phelan ◽  
Matthew W. Martinez ◽  
Elizabeth H. Dineen

Abstract Purpose of review This review will summarize the distinction between hypertrophic cardiomyopathy (HCM) and exercise-induced cardiac remodeling (EICR), describe treatments of particular relevance to athletes with HCM, and highlight the evolution of recommendations for exercise and competitive sport participation relevant to individuals with HCM. Recent findings Whereas prior guidelines have excluded individuals with HCM from more than mild-intensity exercise, recent data show that moderate-intensity exercise improves functional capacity and indices of cardiac function and continuation of competitive sports may not be associated with worse outcomes. Moreover, recent studies of athletes with implantable cardioverter defibrillators (ICDs) demonstrated a safer profile than previously understood. In this context, the updated American Heart Association/American College of Cardiology (AHA/ACC) and European Society of Cardiology (ESC) HCM guidelines have increased focus on shared decision-making and liberalized restrictions on exercise and sport participation among individuals with HCM. Summary New data demonstrating the safety of exercise in individuals with HCM and in athletes with ICDs, in addition to a focus on shared decision-making, have led to the most updated guidelines easing restrictions on exercise and competitive athletics in this population. Further athlete-specific studies of HCM, especially in the context of emerging therapies such as mavacamten, are important to inform accurate risk stratification and eligibility recommendations.


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