Serum concentration of cystatin C is not affected by cellular proliferation in patients with proliferative haematological disorders

2002 ◽  
Vol 39 (3) ◽  
pp. 308-310 ◽  
Author(s):  
OA Mojiminiyi ◽  
R Marouf ◽  
N Abdella ◽  
M Kortom ◽  
R Abdul-Razzak
Keyword(s):  
Cystatin C ◽  
Blood Count ◽  
Cellular Proliferation ◽  
Normal Subjects ◽  
Full Blood Count ◽  
Serum Cystatin C ◽  
Serum Cystatin ◽  
Gault Formula ◽  
Haematological Disorders ◽  
Apparently Healthy

Background Recent reports have shown elevated concentrations of serum cystatin C (CC) in patients with solid tumours. The aim of our study was to investigate whether patients with proliferative haematological disorders have increased serum concentrations of CC compared with normal subjects. Methods Full blood count, serum CC, β2-microglobulin (β2M) and serum creatinine were determined in 27 apparently healthy subjects and 35 patients with proliferative haematological disorders. Creatinine clearance was calculated using the Cockroft-Gault formula. Results CC and β2M showed a significant correlation with each other ( r = 0·96, P < 0·0001). Serum β2M ( P = 0·001) and the serum β2M:CC ratio ( P = 0·001) were significantly higher in the patients with normal renal function than in controls, but serum CC was not significantly different ( P = 0·08). CC did not show a significant correlation with blood count parameters. Discussion Compared with β2M and the β2M:CC ratio, serum CC is not influenced by cell proliferation in haematological disorders.

scholarly journals Evaluation of Serum Cystatin C as a Marker of Early Renal Impairment in Patients with Liver Cirrhosis

2015 ◽  
Vol 2015 ◽  
pp. 1-8 ◽  
Author(s):  
Mahmoud Omar ◽  
Wael Abdel-Razek ◽  
Gamal Abo-Raia ◽  
Medhat Assem ◽  
Gasser El-Azab
Keyword(s):  
Liver Cirrhosis ◽  
Cystatin C ◽  
Living Donor ◽  
Living Donor Liver Transplantation ◽  
Donor Liver ◽  
Serum Cystatin C ◽  
Estimated Gfr ◽  
Serum Cystatin ◽  
Donor Liver Transplantation ◽  
Gault Formula

Background.Serum cystatin C (CysC) was proposed as an effective reflection of the glomerular filtration rate (GFR). However, its role in patients with liver cirrhosis has not been extensively verified especially in the detection of early RI.Patients and Methods.Seventy consecutive potential candidates for living donor liver transplantation with serum creatinine (Cr) <1.5 mg/dL were included. CysC, Cr, and estimated GFR [creatinine clearance (CCr), Cockcroft-Gault formula (C-G), MDRD equations with 4 and 6 variables, CKD-EPI-Cr, CKD-EPI-CysC, and CKD-EPI-Cr-CysC] were all correlated to isotopic GFR. Early RI was defined as GFR of 60–89 mL/min/1.73 m2.Results.Patients were 25.7% and 74.3% Child-Pugh classes B and C, respectively. GFR was ≥90, 60–89, and 30–59 mL/min/1.73 m2in 31.4%, 64.3%, and 4.3% of the patients, respectively. All markers and equations, except C-G, were significantly correlated to GFR with CKD-EPI-Cr-CysC formula having the highest correlation (r= 0.474) and the largest area under the ROC curve (0.808) for discriminating early RI. At a cutoff value of 1.2 mg/L, CysC was 89.6% sensitive and 63.6% specific in detecting early RI.Conclusion.In patients with liver cirrhosis, CysC and CysC-based equations showed the highest significant correlation to GFR and were measures that best discriminated early RI.

scholarly journals Cystatin-C as Novel Marker of Neonatal Hyperbilirubinemia, in Al-Najaf City, Iraq

2021 ◽  
Vol 2 (2) ◽  
pp. 64-70
Author(s):  
Sarah Ali Aljazaeri
Keyword(s):  
Cystatin C ◽  
Serum Levels ◽  
Neonatal Hyperbilirubinemia ◽  
Cysteine Protease Inhibitor ◽  
Serum Cystatin C ◽  
Serum Cystatin ◽  
Male And Female ◽  
Healthy Group ◽  
The Family ◽  
Apparently Healthy

Neonatal hyperbilirubinemia results from a readiness for the bilirubin production in neonates and limited their ability to excrete it. The diagnosis of hyperbilirubinemia based on yellow discoloration of the skin and whiteness of eyes, idle in the child's movement and the lack of lactation. The baby seems sick or is difficult to awaken. Serum cystatin-C, is a low molecular protein that belongs to the family of cysteine protease inhibitor, was proposed as an endogenous filtration marker. In this study sixty neonatal patients suffering from hyperbilirubinemia (35 males,25female) were collected from prematurity unit (PU) in Al-Zahra Educational Hospital/Al-Najaf Al-Ashraf during the period from August,2020 to February,2021. A group of 20 randomly (12male, 8female) selected apparently healthy group. After diagnosis of hyperbilirubinemia, the patients were divided into three groups according to age (1-3), (4-7) and (7-9) days.  The result reveals that significant increase (p<0.05) in serum cystatin-C in neonatal hyperbilirubinemia as compared with healthy group. The result of study reveals no significant increase(p<0.05) in serum levels of cystatin-C, while the study shows a significant increase (p<0.05) between male and female in serum levels of bilirubin. 

scholarly journals Cystatin C: A Better Predictor of Kidney Function in Diabetic Patients

2013 ◽  
Vol 4 (1) ◽  
pp. 16-20 ◽  
Author(s):  
TS Shima ◽  
A Khatun ◽  
F Yeasmin ◽  
S Ferdousi ◽  
K Kirtania ◽  
...  
Keyword(s):  
Renal Function ◽  
Serum Creatinine ◽  
Cystatin C ◽  
Diabetic Patients ◽  
Serum Cystatin C ◽  
Creatinine Concentration ◽  
Serum Cystatin ◽  
Gault Formula ◽  
Function Impairment ◽  
Sensitivity Specificity

Serum cystatin C is a new promising marker of renal function. The aim of this study was to analyze serum cystatin C as a better predictor of renal function in diabetic nephropathy. In 60 diagnosed diabetic patients, serum cystatin C and serum creatinine were assessed. Glomerular filtration rate was estimated based on the cystatin C concentration according to Cockcroft- Gault formula and based on serum creatinine concentration according to Larsson formula. DTPA-GFR (Diethylenetriamene pentaacetate Renogram) was done as reference standard. The cross tabulation of DTPA-GFR was done with eGFR- creatinine and eGFRcystatin C. The calculated sensitivity, specificity and accuracy of eGFR- creatinine were 85%, 87.2% and 85% respectively. The eGFR- cystatin C showed higher sensitivity, specificity and accuracy than eGFR- creatinine in studied diabetic subjects. The cystatin C showed more significant correlation, r=0.78, p<0.001 than serum creatinine, r=0.59, p<0.001 with DTPA-GFR in diabetic patients. This study demonstrates that serum cystatin C may be used for early prediction for renal function impairment in diabetic kidney disease. DOI: http://dx.doi.org/10.3329/bjmb.v4i1.13777 Bangladesh J Med Biochem 2011; 4(1): 16-20

509-P: Utility of Serum Cystatin C in Early Kidney Dysfunction in Prediabetics

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 509-P
Author(s):  
JULIA I.F. BRANDA ◽  
BIANCA ALMEIDA ◽  
SANDRA R.G. VIVOLO
Keyword(s):  
Cystatin C ◽  
Kidney Dysfunction ◽  
Serum Cystatin C ◽  
Serum Cystatin

scholarly journals Reference intervals for serum cystatin C and serum creatinine in an adult sub-Saharan African population

2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Bertille Elodie Edinga-Melenge ◽  
Adrienne Tchapmi Yakam ◽  
Jobert Richie Nansseu ◽  
Catherine Bilong ◽  
Suzanne Belinga ◽  
...  
Keyword(s):  
Serum Creatinine ◽  
Cystatin C ◽  
Reference Intervals ◽  
African Population ◽  
Serum Cystatin C ◽  
Serum Cystatin ◽  
Sub Saharan

scholarly journals Assessment of Subclinical Renal Glomerular and Tubular Dysfunction in Children with Beta Thalassemia Major

Children ◽  
2021 ◽  
Vol 8 (2) ◽  
pp. 100
Author(s):  
Asmaa A. Mahmoud ◽  
Doaa M. Elian ◽  
Nahla MS. Abd El Hady ◽  
Heba M. Abdallah ◽  
Shimaa Abdelsattar ◽  
...  
Keyword(s):  
Cystatin C ◽  
Kidney Injury ◽  
Thalassemia Major ◽  
Beta Thalassemia ◽  
Good Survival ◽  
Control Group ◽  
Healthy Children ◽  
Serum Cystatin C ◽  
Serum Cystatin ◽  
Beta Thalassemia Major

Background: A good survival rate among patients with beta thalassemia major (beta-TM) has led to the appearance of an unrecognized renal disease. Therefore, we aimed to assess the role of serum cystatin-C as a promising marker for the detection of renal glomerular dysfunction and N-acetyl beta-D-glucosaminidase (NAG) and kidney injury molecule 1 (KIM-1) as potential markers for the detection of renal tubular injury in beta-TM children. Methods: This case-control study was implemented on 100 beta-TM children receiving regular blood transfusions and undergoing iron chelation therapy and 100 healthy children as a control group. Detailed histories of complete physical and clinical examinations were recorded. All subjected children underwent blood and urinary investigations. Results: There was a significant increase in serum cystatin-C (p < 0.001) and a significant decrease in eGFR in patients with beta-TM compared with controls (p = 0.01). There was a significant increase in urinary NAG, KIM-1, UNAG/Cr, and UKIM-1/Cr (p < 0.001) among thalassemic children, with a significant positive correlation between serum cystatin-C, NAG and KIM-1 as regards serum ferritin, creatinine, and urea among thalassemic patients. A negative correlation between serum cystatin-C and urinary markers with eGFR was noted. Conclusion: Serum cystatin-C is a good marker for detection of glomerular dysfunction. NAG and KIM-1 may have a predictive role in the detection of kidney injury in beta-TM children.

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