Regulation of interferon-γ, interleukin-4 and interleukin-2 by Schizonepeta tenuifolia through differential effects on nuclear factor-κB, NFATc2 and STAT4/6

2010 ◽  
Vol 235 (2) ◽  
pp. 230-236 ◽  
Author(s):  
Hee Kang ◽  
Ja-Young Moon ◽  
Nak-Won Sohn
Keyword(s):  
Interleukin 2 ◽  
Nuclear Factor Κb ◽  
Interferon Γ ◽  
Interleukin 4 ◽  
Nuclear Factor ◽  
Differential Effects ◽  
Schizonepeta Tenuifolia

scholarly journals Age-related aspects of cytokine profile of immune response in children with pertussis

2020 ◽  
Vol 65 (3) ◽  
pp. 84-90
Author(s):  
O. P. Popova ◽  
M. S. Blyakher ◽  
I. M. Fedorova ◽  
S. I. Koteleva ◽  
I. V. Kapustin
Keyword(s):  
Interleukin 2 ◽  
Humoral Response ◽  
Interleukin 10 ◽  
Interferon Γ ◽  
Interleukin 4 ◽  
Cytokine Network ◽  
Immunological Markers ◽  
Age Related ◽  
Immunoregulatory Cytokines ◽  
The Relationship

The article presents a comparative analysis of the cytokine network in 161 patients with pertussis under the age of 1 year and in 180 patients over the age of 1 year. The studies revealed lower production of immunoregulatory cytokines (interferon-γ and interleukin-2) in patients under the age of 1 year at all stages of the disease and with all variants of pertussis (both mono- and mixed infections). The researchers revealed the relationship between the level of interferon-γ production and the severity of pertussis. They revealed age differences in the interferon-8 production in patients with mixed infection, which can determine clinical features and cause bronchopulmonary complications. The authors demonstrated the features of the dynamics of spontaneous and induced production of interleukin-6 and anti-inflammatory cytokines (interleukin-4, interleukin-10) in children under the age of 1 year; these features can be considered as immunological markers determining the imperfection of the humoral response in patients with pertussis in this age group.

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