A longitudinal study of the effect of heparin thromboprophylaxis during pregnancy on maternal bone metabolism

The aim of this study was to determine the effect of heparin thromboprophylaxis during pregnancy on maternal biochemical markers of bone metabolism. This was a prospective longitudinal study of carboxy terminal pro-peptide of type I collagen (PICP) and cross-linked carboxyterminal telopeptide of type I collagen (ICTP) levels in 15 women, who had heparin thromboprophylaxis during pregnancy compared with those of 18 normal pregnant controls. During pregnancy, the rate of change of PICP and ICTP in women who had heparin thromboprophylaxis was similar to those of women who did not ( P = 0.184 for PICP, and P = 0.129 for ICTP), and PICP and ICTP levels at individual time points were similar in both groups. Therefore, heparin thromboprophylaxis during pregnancy does not affect maternal biochemical markers of bone metabolism.

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Biochemical markers of bone turnover during pregnancy in horses: a longitudinal study

Polish Journal of Veterinary Sciences ◽

10.2478/v10181-012-0120-5 ◽

2012 ◽

Vol 15 (4) ◽

pp. 793-795 ◽

Cited By ~ 3

Author(s):

C. Greiner ◽

E. Cavalier ◽

B. Remy ◽

A. Gabriel ◽

F. Farnir ◽

...

Keyword(s):

Bone Metabolism ◽

Biochemical Markers ◽

Type I Collagen ◽

Venous Blood ◽

Cross Linking ◽

Type I ◽

Serum Concentrations ◽

Blood Samples ◽

Markers Of Bone Turnover ◽

Carboxy Terminal

Abstract The effect of pregnancy on bone metabolism was investigated in healthy mares. Venous blood samples were collected 7 times from 19 multiparous mares starting at 20-weeks pre-parturition, continuing 6 times in 4-week intervals, including the week of parturition and one week after parturition. Serum concentrations of osteocalcin (OC) and carboxy-terminal cross-linking telopeptide of type I collagen (CTX-I) were determined. Measurement cycles and age had a significant (p < 0.01) influence on OC and CTX-I values. Pregnancy influenced bone metabolism with peak bone formation and resorption values around the time of parturition.

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Bone Metabolism in Patients Treated for Depression

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph17134756 ◽

2020 ◽

Vol 17 (13) ◽

pp. 4756

Author(s):

Elżbieta Skowrońska-Jóźwiak ◽

Piotr Gałecki ◽

Ewa Głowacka ◽

Cezary Wojtyła ◽

Przemysław Biliński ◽

...

Keyword(s):

Bone Metabolism ◽

Type I Collagen ◽

Depression Scale ◽

Type I ◽

Hamilton Depression Scale ◽

Recurrent Depression ◽

Hydroxyvitamin D ◽

Vitamin D Levels ◽

Turnover Markers ◽

Carboxy Terminal

Background: Depression and osteoporosis are severe public health problems. There are conflicting findings regarding the influence of depression on bone metabolism. The aim of the presented study was to compare bone turnover markers and vitamin D levels between patients treated for depression and healthy controls. Patients and Methods: We determined a concentration of osteocalcin, carboxy-terminal telopeptide of type I collagen (β-CTX), 25-hydroxyvitamin D (25OHD) and 1,25(OH)2D3 in 99 patients, aged 46.9 ± 11 years, treated for depression, as well as in 45 healthy subjects. Depressive status was determined with the Hamilton Depression Scale (HDRS). Results: In patients treated for depression, we demonstrated significantly lower osteocalcin concentrations (p < 0.03) and higher concentration of β-CTX (result on the border of significance; p = 0.08). Those relationship were stronger in women. The level of 25OHD and 1,25(OH)2D3 did not differ significantly between the examined groups. We observed a negative correlation between the 25OHD and HDRS score after treatment in all patients treated for depression and in subgroups of women and subjects with recurrent depression. Conclusions: Our results indicate that depression is related to disturbances in bone metabolism, especially in women and patients with recurrent depression, suggesting its role in context of osteoporosis development.

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Serum markers of bone metabolism in multiple myeloma: prognostic value of the carboxy‐terminal telopeptide of type I collagen (ICTP)

British Journal of Haematology ◽

10.1046/j.1365-2141.1997.8672495.x ◽

1997 ◽

Vol 96 (1) ◽

pp. 103-110 ◽

Cited By ~ 42

Author(s):

N. Abildgaard ◽

S. M. Bentzen ◽

J. L. Nielsen ◽

L. Heickendorff

Keyword(s):

Multiple Myeloma ◽

Bone Metabolism ◽

Prognostic Value ◽

Type I Collagen ◽

Serum Markers ◽

Type I ◽

Carboxy Terminal

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Weight loss on stimulant medication: how does it affect body composition and bone metabolism? – A prospective longitudinal study

International Journal of Pediatric Endocrinology ◽

10.1186/1687-9856-2012-30 ◽

2012 ◽

Vol 2012 (1) ◽

Cited By ~ 18

Author(s):

Alison Poulton ◽

Julie Briody ◽

Thomas McCorquodale ◽

Elaine Melzer ◽

Markus Herrmann ◽

...

Keyword(s):

Weight Loss ◽

Body Composition ◽

Longitudinal Study ◽

Bone Metabolism ◽

Stimulant Medication ◽

Prospective Longitudinal Study ◽

Prospective Longitudinal

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Serum concentrations of carboxyterminal telopeptide of type I collagen (ICTP) and aminoterminal propeptide of type I collagen (PICP) as biochemical markers for bone metastasis of primary lung cancer

Lung Cancer ◽

10.1016/s0169-5002(00)80880-6 ◽

2000 ◽

Vol 29 (1) ◽

pp. 256

Author(s):

H Oda ◽

T Kashii ◽

T Miwa ◽

K Sassa ◽

N Arai ◽

...

Keyword(s):

Lung Cancer ◽

Bone Metastasis ◽

Biochemical Markers ◽

Type I Collagen ◽

Primary Lung Cancer ◽

Type I ◽

Serum Concentrations ◽

Carboxyterminal Telopeptide

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Elevated carboxy terminal cross linked telopeptide of type I collagen in alcoholic cirrhosis: relation to liver and kidney function and bone metabolism

Gut ◽

10.1136/gut.44.3.417 ◽

1999 ◽

Vol 44 (3) ◽

pp. 417-423 ◽

Cited By ~ 6

Author(s):

S Møller ◽

M Hansen ◽

J Hillingsø ◽

J-E B Jensen ◽

J H Henriksen

Keyword(s):

Bone Mass ◽

Bone Metabolism ◽

Liver Dysfunction ◽

Type I Collagen ◽

Alcoholic Cirrhosis ◽

Type I ◽

Mild Degree ◽

Liver And Kidney ◽

Cirrhotic Patients ◽

Carboxy Terminal

BACKGROUNDThe carboxy terminal cross linked telopeptide of type I collagen (ICTP) has been put forward as a marker of bone resorption. Patients with alcoholic liver disease may have osteodystrophy.AIMSTo assess circulating and regional concentrations of ICTP in relation to liver dysfunction, bone metabolism, and fibrosis.METHODSIn 15 patients with alcoholic cirrhosis and 20 controls, hepatic venous, renal venous, and femoral arterial concentrations of ICTP, and bone mass and metabolism were measured.RESULTSCirculating ICTP was higher in patients with cirrhosis than in controls. No overall significant hepatic disposal or production was found in the patient or control groups but slightly increased production was found in a subset of patients with advanced disease. Significant renal extraction was observed in the controls, whereas only a borderline significant extraction was observed in the patients. Measurements of bone mass and metabolism indicated only a mild degree of osteodystrophy in the patients with cirrhosis. ICTP correlated significantly in the cirrhotic patients with hepatic and renal dysfunction and fibrosis, but not with measurements of bone mass or metabolism.CONCLUSIONSICTP is highly elevated in patients with cirrhosis, with no detectable hepatic net production or disposal. No relation between ICTP and markers of bone metabolism was identified, but there was a relation to indicators of liver dysfunction and fibrosis. As the cirrhotic patients conceivably only had mild osteopenia, the elevated ICTP in cirrhosis may therefore primarily reflect liver failure and hepatic fibrosis.

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