scholarly journals Effects of 6-hydroxydopamine on the develop-ment of reproductive organs in male rats

1975 ◽  
Vol 21 (2) ◽  
pp. 76-82
Author(s):  
Shigeru MATSUYAMA ◽  
Yuitsu YOKOKI
Keyword(s):  
Reproductive Organs ◽  
Male Rats ◽  
6 Hydroxydopamine

REPRODUCTIVE TOXICITY OF CHLORPYRIFOS, CYPERMETHRIN AND THEIR INTERACTION IN MALE ALBINO RATS

2018 ◽  
pp. 69-86
Author(s):  
Asmaa ELnamaky ◽  
Amal Halawa ◽  
Mamdouh Abouelmaged
Keyword(s):  
Reproductive Toxicity ◽  
Prostatic Acid Phosphatase ◽  
Serum Levels ◽  
Reproductive Organs ◽  
Male Rats ◽  
Albino Rats ◽  
Glutathione S Transferase ◽  
Significant Drop ◽  
Sperm Abnormalities ◽  
Pituitary Glands

he present work was designed to investigate the reproductive toxicity induced by oral administration of chlorpyrifos (CPF), cypermethrin (CYP) and their combination in adult male albino rats. Forty mature male albino rats were separated into four groups (10 each), the first group was used as control, while second, third and fourth groups received orally 1/20 LD50 of CPF (10 mg/kg b.wt), 1/20 LD50 of CYP (17.22 mg/kg b.wt) and 1/40 LD50 of CPF plus 1/40 LD50 of CYP (5 mg/kg b.wt CPF plus 8.61 mg/kg b.wt CYP) respectively for 26 days. The results revealed that exposure to CPF and/or CYP induced a significant decrease in the reproductive organs weight. Moreover, a significant decrease in spermatic picture (sperm cell concentration and viability) was observed with high percent of sperm abnormalities. Serum levels of testosterone and pituitary gonadotropins (FSH and LH) have been declined significantly in all treated groups. Significant elevations were observed in malondialdehyde and nitric oxide concentrations, while antioxidant enzymes superoxide dismutase and glutathione-S-transferase activities were decreased significantly as a result of induced oxidative stress. A significant drop in prostatic acid phosphatase activity was observed. Additionally, the results showed some histopathological alterations in the reproductive organs as well as neurological lesions in brain and pituitary glands. In conclusion, CPF and CYP induce deleterious effects on reproductive efficiency of male rats which reflect more obvious impacts when both combined

HYPOTROPHIC REPRODUCTIVE ORGANS AND NORMAL GROWTH IN MALE RATS TREATED WITH MELATONIN

1971 ◽  
Vol 51 (1) ◽  
pp. 213-214 ◽  
Author(s):  
S. SORRENTINO ◽  
R. J. REITER ◽  
D. S. SCHALCH
Keyword(s):  
Normal Growth ◽  
Reproductive Organs ◽  
Male Rats

6-Hydroxydopamine Lesions of the Locus Coeruleus Induce a Paradoxical Increase in Growth Hormone Secretion in Male Rats

1992 ◽  
Vol 4 (1) ◽  
pp. 9-14 ◽  
Author(s):  
M. T. Bluet-Pajot ◽  
F. Mounier ◽  
D. Durand ◽  
C. Kordon ◽  
C. Llorens-Cortes ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Locus Coeruleus ◽  
Hormone Secretion ◽  
Growth Hormone Secretion ◽  
Male Rats ◽  
6 Hydroxydopamine

Ultrastructural changes in the reproductive organs of adult male rats after chronic soy diet

2013 ◽  
Vol 41 ◽  
pp. 30
Author(s):  
Paraskevi Papaioannidou ◽  
Theodora Papamitsou ◽  
Ioannis Makaronidis ◽  
Ioannis Kyriakidis ◽  
Ioannis Papaioannidis ◽  
...  
Keyword(s):  
Adult Male ◽  
Reproductive Organs ◽  
Male Rats ◽  
Ultrastructural Changes

197 DIFFERENTIAL EFFECTS OF FLUTAMIDE AND DI-(2-ETHYLHEXYL) PHTHALATE ON MALE REPRODUCTIVE ORGANS IN A RAT MODEL

2009 ◽  
Vol 21 (1) ◽  
pp. 197
Author(s):  
T. T. B. Vo ◽  
E.-M. Jung ◽  
M.-G. Back ◽  
V. H. Dang ◽  
K.-C. Choi ◽  
...  
Keyword(s):  
Sex Determination ◽  
Microarray Analysis ◽  
Expression Patterns ◽  
Reproductive Organs ◽  
Male Rats ◽  
Seminiferous Tubules ◽  
High Dose ◽  
Total N ◽  
Male Reproductive Organs ◽  
Ethylhexyl Phthalate

Endocrine disruptors (EDs) with androgenic and anti-androgenic effects may alter reproductive function by binding to androgenic receptors (AR) and inducing or modulating AR-dependent responses in the male reproductive system. However, the molecular mechanism(s) underlying these events remains unclear. Thus, in the present study, we elucidated the prenatal effects of maternal testosterone propionate (TP), flutamide (Flu), and di-(2-ethylhexyl) phthalate (DEHP) on male reproductive organs of newborn rats. Pregnant Sprague-Dawley (n = 32 in total, n = 8/each group) rats were treated with these compounds at gestation days 11 to 21, and newborn males (n = 154 in total) were euthanized at post-neonatal day (PND) 63. Interestingly, maternal exposure to Flu or DEHP caused fluctuations in the neonatal levels of serum testosterone (T) and luteinizing hormone (LH). Serum T and LH were up-regulated by Flu, but these hormones were down-regulated by DEHP. The anogenital distances (AGD) of male newborns were detected at PND 1, 21, and 63. Male rats treated prenatally with DEHP (100 mg kg–1 mother’s body weight) or Flu showed an AGD shorter than that of control rats. At PND 63, the sperm concentration, viability, and mobility were reduced in the maternal DEHP and Flu-treated groups. The numbers of seminiferous tubules were reduced in the Flu- and DEHP-treated offspring when compared with vehicle- and TP-treated groups, and the tubules of the testes at PND 63 were disrupted by a high dose of Flu. In addition, we examined differential gene expression patterns in the testes by microarray analysis following ED exposure, particularly in sex determination-related genes. Significantly distinct expressions of sex determination-related genes were observed in the testes by microarray analysis following treatments with different types of EDs in this study. Although Flu and DEHP are considered to be identical with regard to their anti-androgenic effects, their effects on developing male reproductive organs were distinct, suggesting that Flu competes with endogenous T, while DEHP influences a different step in androgenesis.

Expression of Nerve Growth Factor (NGF), and Its Receptors TrkA and p75 in the Reproductive Organs of the Adult Male Rats

2005 ◽  
Vol 22 (8) ◽  
pp. 933-937 ◽  
Author(s):  
ChunMei Li ◽  
Gen Watanabe ◽  
Qiang Weng ◽  
WanZhu Jin ◽  
Chie Furuta ◽  
...  
Keyword(s):  
Nerve Growth Factor ◽  
Growth Factor ◽  
Adult Male ◽  
Reproductive Organs ◽  
Male Rats ◽  
Nerve Growth

scholarly journals Synthesis, Characterization, and Evaluation of Antimicrobial and Antifertility Efficacy of Heterobimetallic Complexes of Copper (II)

2017 ◽  
Vol 2017 ◽  
pp. 1-9 ◽  
Author(s):  
Ashu Chaudhary ◽  
Anshul Singh
Keyword(s):  
Reproductive Organs ◽  
Male Rats ◽  
Spectral Studies ◽  
Molecular Weight Determination ◽  
Mass Spectral ◽  
Heterobimetallic Complexes ◽  
Group 4 ◽  
Electronic Spin ◽  
Substantial Decline

Heterobimetallic complexes of the copper with remarkable antimicrobial and antifertility action have been synthesized by the conventional method by reacting CuCl2 and o-phenylenediamine in the methanolic medium forming the mononuclear complex of the type CuC6H8N22Cl2 which was further treated with group 4 or 14 organometallic dichlorides (Ph2M′Cl2, Me2M′Cl2, and Cp2M′′Cl2) [M′ = Sn, Si, and M′′ = Ti, Zr] leading to formation of heterobimetallic complexes. All the synthesized complexes were characterized in the light of various physicochemical techniques like elemental analyses, conductivity measurements, molecular weight determination, electronic and infrared spectra, electronic spin resonance, X-ray, and mass spectral studies. The in vitro antibacterial activity of synthesized complexes against Escherichia coli and Staphylococcus aureus was tested to evaluate their inhibiting activities. The antifungal activities of mono- and heterobimetallic complexes were studied by screening the compounds against Fusarium oxysporum and Alternaria alternata. These complexes were then investigated to reveal their effect on the reproductive organs of male rats. The treatment has shown substantial decline in the sperm motility and density signifying the imperious antifertility activity.

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