Silicon concentrations in maternal serum and breast milk in the postpartum period.

Background: The nutritional status of vitamin A in lactating mothers and infants is still not optimistic. Due to the dietary habits and dietary restrictions of postpartum customs in China, vitamin A supplementation has been advocated as a potential strategy to improve vitamin A status of lactating mothers with inadequate dietary vitamin A intake. Existing clinical trials are limited to single or double high-dose maternal administrations. However, in China, vitamin A supplements are readily available in the form of daily oral low-dose supplements, and the effect of these is unknown. This study aimed to evaluate the effects of daily oral low-dose vitamin A supplementation on the retinol levels in the serum and breast milk of lactating mothers and the health status of infants in China. Methods: Lactating mothers who met the inclusion criteria and planned to continue exclusive breastfeeding were randomly assigned to receive either daily oral vitamin A and D drops (one soft capsule of 1800 IU vitamin A and 600 IU vitamin D2), or a matching placebo for 2 months. Before and after the intervention, dietary intake was investigated by instant photography, and the retinol concentration in maternal serum and breast milk was determined by ultra-high performance liquid chromatography-tandem mass spectrometry. During the trial, the health status of infants was diagnosed by a paediatrician or reported by lactating mothers. A total of 245 participants completed the study, with 117 in the supplementation group and 128 in the control group. Results: After the 2-month intervention, maternal serum retinol concentrations increased in the supplementation group with no change in the control group. Although breast milk retinol concentrations decreased significantly in both groups, the decrease in the supplementation group was significantly lower than that in the control group. However, maternal vitamin A supplementation was not associated with a lower risk of infant febrile illness, respiratory tract infection, diarrhoea, and eczema. Conclusions: Daily oral low-dose vitamin A supplementation is helpful in improving maternal vitamin A status, despite having no effect on infant health status through breast milk.

Download Full-text

Eplerenone levels in maternal serum, cord blood, and breast milk during pregnancy and lactation

Hypertension Research ◽

10.1038/s41440-021-00621-5 ◽

2021 ◽

Author(s):

Jumpei Saito ◽

Asako Mito ◽

Naho Yakuwa ◽

Kayoko Kaneko ◽

Hiroyo Kawasaki ◽

...

Keyword(s):

Breast Milk ◽

Cord Blood ◽

Maternal Serum ◽

Pregnancy And Lactation

Download Full-text

Vitamin A intake of Brazilian mothers and retinol concentrations in maternal blood, human milk, and the umbilical cord

Journal of International Medical Research ◽

10.1177/0300060518757155 ◽

2018 ◽

Vol 46 (4) ◽

pp. 1555-1569 ◽

Cited By ~ 7

Author(s):

Thalia Manfrin Martins Deminice ◽

Ivan Savioli Ferraz ◽

Jacqueline Pontes Monteiro ◽

Alceu Afonso Jordão ◽

Lívia Maria Cordeiro Simões Ambrósio ◽

...

Keyword(s):

Breast Milk ◽

Vitamin A ◽

Human Milk ◽

Pregnant Women ◽

Umbilical Cord ◽

Maternal Blood ◽

Maternal Serum ◽

Serum Retinol ◽

Cross Sectional ◽

Blood Samples

Objectives To analyse intake of vitamin A (VA) and retinol concentrations in maternal blood, breast milk (BM), and the umbilical cord (UC) of newborns, and to determine the associations among these variables. Methods We performed a cross-sectional, epidemiological study of 180 mother–newborn dyads. Maternal and UC blood samples and BM were collected. VA intake by the mother over 30 days was assessed using a questionnaire. Results Mean retinol concentrations in maternal serum, the UC, and BM were 0.65 ± 0.27, 0.36 ± 0.18, and 2.95 ± 2.70 µmol/L, respectively. Retinol concentrations <0.70 µmol/L were found in 57.2% of maternal blood samples and in 94.9% of UC samples. A total of 27.9% of BM samples showed retinol concentrations <1.05 µmol/L. Mean VA intake by the mothers was 1041.33 ± 1187.86 µg retinol activity equivalents/day and was inadequate (<550 µg retinol activity equivalents/day) in 44.7%. Conclusions High proportions of insufficient retinol concentrations were observed in the UC, maternal blood, and BM. A high percentage of pregnant women had inadequate VA intake. Mothers with insufficient serum retinol concentrations had newborns with lower retinol concentrations in the UC. Higher retinol concentrations were observed in maternal blood and the UC with a higher VA intake.

Download Full-text

Trazodone Levels in Maternal Serum, Cord Blood, Breast Milk, and Neonatal Serum

Breastfeeding Medicine ◽

10.1089/bfm.2021.0191 ◽

2021 ◽

Author(s):

Jumpei Saito ◽

Mariko Ishii ◽

Asako Mito ◽

Naho Yakuwa ◽

Hiroyo Kawasaki ◽

...

Keyword(s):

Breast Milk ◽

Cord Blood ◽

Maternal Serum

Download Full-text

Abatacept concentrations in maternal serum and breast milk during breastfeeding and an infant safety assessment: a case study

Rheumatology ◽

10.1093/rheumatology/kez135 ◽

2019 ◽

Vol 58 (9) ◽

pp. 1692-1694 ◽

Cited By ~ 1

Author(s):

Jumpei Saito ◽

Naho Yakuwa ◽

Chinatsu Takai ◽

Kayoko Kaneko ◽

Mikako Goto ◽

...

Keyword(s):

Breast Milk ◽

Safety Assessment ◽

Maternal Serum ◽

Infant Safety

Download Full-text

Belimumab Concentrations in Maternal Serum and Breast Milk During Breastfeeding and the Safety Assessment of the Infant: A Case Study

Breastfeeding Medicine ◽

10.1089/bfm.2020.0068 ◽

2020 ◽

Vol 15 (7) ◽

pp. 475-477

Author(s):

Jumpei Saito ◽

Naho Yakuwa ◽

Tatsuo Ishizuka ◽

Mikako Goto ◽

Akimasa Yamatani ◽

...

Keyword(s):

Breast Milk ◽

Safety Assessment ◽

Maternal Serum

Download Full-text

Women's Plasma Phospholipid DHA Concentration Directly Relates to Breast Milk and Infant DHA Status in the Alberta Pregnancy Outcomes and Nutrition Study

Current Developments in Nutrition ◽

10.1093/cdn/nzaa054_053 ◽

2020 ◽

Vol 4 (Supplement_2) ◽

pp. 981-981

Author(s):

Catherine Field ◽

Susan Goruk ◽

Nour Wattar ◽

Mohammadreza Pakseresht

Keyword(s):

Fatty Acid ◽

Breast Milk ◽

Pregnancy Outcomes ◽

Plasma Phospholipid ◽

Maternal Serum ◽

Chain Polyunsaturated Fatty Acid ◽

Gas Liquid Chromatography ◽

Funding Sources ◽

Nutrition Study ◽

Education Status

Abstract Objectives The fatty acids docosahexaenoic (DHA) and arachidonic (AA) acids are in breast milk are important for the infant's development. Our objective was to use data collected in the Alberta Pregnancy Outcomes and Nutrition (APrON) cohort, to identify the relationship between maternal serum status of DHA and the concentration of DHA in breast milk and infants’ plasma phospholipids (PL) at three months postpartum. Methods The study used data from the APrON cohort. The cohort participants were 31.1 ± 4.5 years and the majority had a healthy BMI (24.2 ± 4.8 kg/m,2) and high education status (88% trade, university or higher). Maternal and infant blood samples and breast milk spot samples were collected and the fatty acid composition/concentration of DHA and AA determined by gas liquid chromatography. Results The median DHA concentrations (µg/mL) in maternal serum phospholipids (PL) significantly changed through gestation (P < 0.05) and was 43 (IQR 28–59, n = 287), 58 (IQR 38–80, n = 1115), 83 (IQR 65–103, n = 794) and 10 (IQR 7–14, n = 891) for each trimester and 3 months postpartum, respectively. Compared to trimester 1, DHA concentration was the higher in the third trimester and lowest during breastfeeding (P < 0.001). The %DHA in breast milk (median: 0.19%, IQR: 0.13–0.29%, n = 1483) was lower than the reported global average, while AA (median: 0.47%, IQR: 0.36–0.55%, n = 1483) was similar. Postpartum breast milk DHA directly correlated with maternal (r = 0.38, P < 0.001) and infant serum PL DHA concentrations (P < 0.05). Conclusions In summary, maternal PL DHA concentration changed significantly through gestation and DHA concentration in breast milk at three months postpartum was below the proportion considered optimal (0.30–0.64%). Targeting maternal DHA status will help optimize the concentration of this essential long chain polyunsaturated fatty acid in breast milk and ultimately improve infant status. Funding Sources CIHR and Alberta Innovates.

Download Full-text