scholarly journals Διερεύνηση του πιθανού διαμεσολαβητικού ρόλου των πρωτεϊνών θερμικού shock ανάμεσα στο ψυχοφυσιολογικό στρες και τις οργανικές παθήσεις

2013 ◽  
Author(s):  
Ηλίας Βλάχος

Objective – To investigate the hypothesis that depression and anxiety levelscould beassociatedwith theinduction of theantiapoptoticHeatShock Protein70 (HSP70) inthe colon of patients with Inflammatory Bowel Diseases (IBD),namelyulcerativecolitis(UC)andCrohn‟sdisease(CD).Methods- 54 consecutive, hospitalized IBD patients in relapse gave theirinformed consent, filled out psychometric questionnaires [Zung DepressionRatingScale(ZDRS),SpielbergerState-TraitAnxietyInventory(STAIFormXI,IIas a state andas a trait), Hospital Anxiety and Depression Scale (HADS)].Simultaneously, intestinal biopsies were taken to be diagnosed in a blindedmanner by two pathologists. The type and severity of inflammation wereassessedoneachsection withhematoxylin/eosinstaining.Thelocalizationandintensity of expression ofHSP70 expression were studiedimmunohistochemically.Results:31/54patientssufferedfromactiveUC,14fromCDand9wereinremission.InducibleHSP70(HSP70i)wasscarcelydetectableintheintestinalmucosa of UC and CD patients. There was statistically significant correlationbetween depression and anxiety levels and inducible HSP70 in thepolymorphonuclearcells(PMN)ofpatientswithactiveUC.Conclusion: Inducible HSP70 is clearly expressed in PMN cells of IBD patientsand in patients with active UC this finding positively correlates with thedepression and anxiety levels. Given the antiapoptotic, cytoprotective effect ofHSP70onPMNcells and thedestructiverole thatPMNcellsexertonintestinalmucosa of IBD patients, light could be shed on the psychosomatic aspect ofautoimmunityinthesediseases.

2021 ◽  
Vol 36 (6) ◽  
pp. 1171-1171
Author(s):  
Winter Olmos ◽  
Daniel W Lopez-Hernandez ◽  
Isabel Munoz ◽  
Laura Schierholz ◽  
Rachel A Rugh-Fraser ◽  
...  

Abstract Introduction We examined the relationship between depression and anxiety, language, and functional outcomes in persons with traumatic brain injury (TBI). Methods The sample consisted of 48 acute TBI (ATBI: 23 Spanish-English Bilinguals; 25 English monolinguals), 30 chronic TBI (CTBI: 17 Spanish English Bilinguals; 12 English monolinguals), and 47 healthy comparison (HC: 29 Spanish-English Bilinguals; 18 English monolinguals) participants. The Hospital Anxiety and Depression Scale was used to measure depression (HADS-D) and anxiety (HADS-A). The Mayo Portland Adaptability Inventory-4 (MPAI-4) was used to measure functional outcomes (ability, adjustment, participation). Results An ANCOVA, controlling for age, revealed the ATBI group reported lower anxiety levels compared to the CTBI group, p = 0.034 np2 = 0.06. HC participants demonstrated significantly higher functional ability compared to both TBI groups, p < 0.05, np2 = 0.08–0.19. The ATBI group demonstrated worse participation scores compared to the CTBI and HC groups, p = 0.001, np2 = 0.11. Pearson correlations revealed mood was related to functional status in ATBI monolinguals (HADS-A: r = 0.29–0.64; HADS-D, r = 0.49–0.62). Monolingual participants with ATBI demonstrated correlations between depressive symptoms and functional adjustment (r = 0.57, p = 0.005) and ability (r = 0.44, p = 0.034). For monolinguals with CTBI, HADS-A correlated with functional outcomes, r = 0.60–0.66, p < 0.05. For bilinguals with CTBI, functional outcomes correlated with HADS-A, r = 0.53–0.66, p < 0.05, and HADS-D, r = 0.54–0.66, p < 0.05. For HC monolinguals, functional outcomes correlated with HADS-A, r = 0.53–0.70, p < 0.05, and HADS-D, r = 0.50–0.72, p < 0.05. Finally, for HC bilinguals, functional outcomes correlated with HADS-A, r = 0.59–0.68, p < 0.05. Conclusion Our results suggest that a relationship between anxiety and depressive symptoms is related more to functional outcomes in monolingual TBI survivors compared to bilingual TBI survivors.


2021 ◽  
pp. 42-46
Author(s):  
V. E. Bandel ◽  
E. I. Mikhailova

Objective. To study the quality of life (QoL) and psycho-emotional state in patients with different degrees of ulcerative colitis (UC) activity.Materials and methods. The study involved 52 patients with UC and 52 healthy volunteers (HVs). The survey was performed using the questionnaire IBDQ, assessing the quality of life in patients with inflammatory bowel diseases, the Hospital Anxiety and Depression Scale (HADS), and the questionnaire by A.M. Vein.Results. The patients with UC in comparison with the HVs have a lower QoL in the overall score (p < 0.05), a greater severity of psychological problems both according to the anxiety scale (p < 0.05) and to the depression scale (p < 0.05).), and they tend to develop the autonomic dysfunction syndrome more often (p < 0.05).Conclusion. The method of the QoL assessment and psycho-emotional state in patients with UC provides accurate scientifc information about the physical, psychological, emotional and social status of the patients.


2021 ◽  
Vol 10 (15) ◽  
pp. 3270
Author(s):  
Lorenzo Bertani ◽  
Brigida Barberio ◽  
Domenico Tricò ◽  
Federico Zanzi ◽  
Daria Maniero ◽  
...  

During the coronavirus disease 2019 (COVID-19) pandemic, immunomodulatory therapies and hospital admission were suspected to increase the risk of infection. Nevertheless, patients with inflammatory bowel diseases (IBD) treated with intravenous (i.v.) biologics had to move to hospitals for drug infusion. We investigated the impact of hospitalisation in patients with IBD. We conducted a survey including consecutive IBD patients initially in clinical and biochemical remission treated with biologics at the end of the first lockdown period. Patients underwent the normally scheduled clinical visits, performed at hospital for i.v.-treated patients or at home for patients treated with s.c. drugs. We administered to all patients the Hospital Anxiety and Depression Scale (HADS) questionnaire and other 12 questions, specifically related to COVID-19 and its implications. A total of 189 IBD patients were recruited, 112 (59.3%) treated with i.v. drugs and 77 (40.7%) with s.c. ones. No relapses were recorded in either group (hospitalized vs. non-hospitalized, p = ns), as well as which, COVID-19 infections were not demonstrated in patients in contact with people with suspected symptoms or directly experiencing them. The total HADS score obtained by the sum of all items was also almost identical between groups (37.1 ± 2.8 vs. 37.2 ± 2.8; p = 0.98). In patients treated with i.v. drugs receiving a televisit (n = 17), the rate of satisfaction with telemedicine (58.8%) was significantly lower compared with those treated with s.c. drugs (94.8%; p < 0.0005). Our results suggest that hospitalisation during the COVID-19 outbreak does not increase the risk of COVID-19 infection as well as the risk of IBD relapse; moreover, the similar levels of anxiety in both groups could confirm that there is no need to convert patients from i.v. to s.c. therapy.


1993 ◽  
Vol 15 (2) ◽  
pp. 69-74 ◽  
Author(s):  
Brendan T. Carroll ◽  
Roger G. Kathol ◽  
Russell Noyes ◽  
Tina G. Wald ◽  
Gerald H. Clamon

2017 ◽  
Vol 20 ◽  
Author(s):  
Alejandro Magallares ◽  
Patricia Bolaños-Rios ◽  
Inmaculada Ruiz-Prieto ◽  
Pilar Benito de Valle ◽  
Jose Antonio Irles ◽  
...  

AbstractObesity may be considered a social stigma. In addition, people with obesity are frequently aware of stigma directed at others who have a similar weight and come to think stigmatized thoughts about themselves. Our study focused specifically on how blatant and subtle discrimination and weight self-stigma are related to depression and anxiety in people with obesity. The sample comprised 170 participants from the Clinical Nutrition Unit of the “Hospital de Valme” (Seville, Spain). The Weight Self-Stigma Questionnaire, the Multidimensional Perceived Discrimination Scale, and the Hospital Anxiety and Depression Scale were used. It was found that blatant and subtle discrimination and weight self-stigma were positively related to depression (.31, .38, and .45 respectively) and anxiety (.30, .36, and .49 respectively; all ps < .01). The path analysis conducted showed that there was a mediational effect of weight self-stigma between blatant (β = .36) and subtle discrimination (β = .40) and depression (β = .24) and anxiety (β = .49; all ps < .01). According to these results, it can be said that weight self-stigma was a full mediator in the model found because the relationships between the independent and the dependent variables were non-significant. Finally, results are discussed in the frame of the obesity stigma literature, and some clinical implications of the results of the study are suggested.


2018 ◽  
Vol 10 (Especial 5) ◽  
pp. 89-94
Author(s):  
Silas de Oliveira Damasceno ◽  
José Henrique Piedade Cardoso ◽  
Raíssa Puzzi Ladvig ◽  
Luana Martins de Paula ◽  
Renilton José Pizzol ◽  
...  

Pain, anxiety, and depression are symptoms that need attention in physiotherapeutic practice, once they influence the functionality of patients, so understanding them becomes an important tool. The aim of the study was to verify the levels of pain, depression, and anxiety in patients attended at a physiotherapy center. A cross-sectional clinical study in which a sociodemographic questionnaire was applied, the Visual Analogue Scale (VAS), the Hospital Anxiety and Depression Scale (HADS) and the Roland Morris Disability Questionnaire (MRQ). Seven patients participated and presented a MRI score of 18.57 ± 2.63 points, HADS in the topic anxiety 12.71 ± 5.43 points, HADS depression 9.57 ± 5.22 points and the resting VAS presented an average of 4 , 42 ± 3.9 pain points and in motion showed 8.71 ± 0.95. It is concluded that the population with low back pain has high intensity of pain, probable anxiety and possible level of depression.


2021 ◽  
Vol 79 (8) ◽  
pp. 682-685
Author(s):  
Eduardo Almeida Guimarães Nogueira ◽  
Flavia Rodrigues de Oliveira ◽  
Vitor Martinez de Carvalho ◽  
Carina Telarolli ◽  
Yara Dadalti Fragoso

ABSTRACT Background: Catastrophization is a psychological aspect of pain that alters its perception and expression. Objective: To investigate the feature of catastrophization in migraine. Methods: An online survey of individuals suffering from migraine attacks at least twice a month, for at least one year was carried out. Confidentiality was assured and participants gave details of their headache (including a visual analogue pain scale) and answered the Hospital Anxiety and Depression Scale and the Catastrophization Scale questionnaires. Results: The survey included 242 individuals with migraine attacks at least twice a month. The median scores observed in this group of individuals were 7 for pain, 11 for anxiety, 7 for depression, and 2 for catastrophization. Catastrophization had no correlation with the duration (p=0.78) or intensity (p=0.79) of the migraine. There was no correlation between catastrophization and headache frequency (p=0.91) or the monthly amount of headache medication taken (p=0.85). High scores for catastrophization (≥3.0) were identified in one third of the participants. These high scores were not associated with age, headache duration, pain severity, frequency of attacks, or traits of depression or anxiety. There was a moderate association between both depression and anxiety traits with catastrophization. Conclusions: Catastrophization seems to be a trait of the individual and appears to be unrelated to the characteristics of the migraine.


2020 ◽  
Vol 5 (3) ◽  
pp. 273-285
Author(s):  
Pınar Ünal-Aydın ◽  
Yasin Arslan ◽  
Orkun Aydın

The goal of this study was to examine the effects of mindfulness (MF) and spiritual intelligence (SI) as predictors of depression and anxiety, the most frequent manifestations of mental disorders – among 184 Turkish participants of diverse ages, predominantly students, living in Istanbul and Sarajevo. Four instruments were administered either directly or via web-based services: Scale for Spiritual Intelligence (SSI), Hospital anxiety and depression scale (HADS), Five Facet Mindfulness Questionnaire – Short Form (FFMQ-S) and Sociodemographic Information Form. Through the use of linear regression analysis, Actaware (b=-.19, p≤.001), Nonjudge (b=-.22, p≤.001), Nonreact (b=-.19, p≤.001) subscales of FFMQ-S were found to be negative predictors for depression and anxiety, whereas, Self-understanding subscale of SSI was not significant. Although our findings suggest that spiritual intelligence is not significant in prediction of depression and anxiety, our research provides empirical evidence for the link between MF, SI, depression and anxiety, as well as revealing MF as predictor for anxiety and depression which may be useful for further improvements in the scope of current interventions.


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