scholarly journals Effect of GnRH treatment following a short-term estrous induction protocol on estrus and ovulation in Saanen goats, during the transitional period

2021 ◽  
Vol 71 (4) ◽  
pp. 2569
Author(s):  
I. DOGAN ◽  
M. B. TOKER ◽  
S. ALCAY ◽  
D. UDUM KUCUKSEN
Keyword(s):  
Transition Period ◽  
Plasma Concentrations ◽  
Physiological Saline ◽  
Transitional Period ◽  
Follicle Development ◽  
Estrus Cycle ◽  
Short Term ◽  
Pooled Data ◽  
Buserelin Acetate ◽  
Synchronization Protocol

The objective of this study was to compare the effect on the ovulation time and estrus parameters of a GnRH agonist (buserelin acetate) administered 24 or 36 h following a short-term estrus induction and synchronization treatment in non-lactating Saanen goats during the transitional period. Goats received 20 mg FGA sponges for 6 days plus 300 IU eCG and 125 μg d-cloprostenol 24 h prior to sponge removal. After removal of the sponges, goats were given either 1 ml physiological saline (0.9% NaCI) solution (Group1; n = 9) after 12 h, 0.004 mg GnRH (Group2; n = 10) after 24 h or 0.004 mg GnRH (Group3; n = 10) after 36 h. The follicle development and ovulation in the ovaries were monitored by transrectal ultrasonography starting from the sponge application until the fifth day of the estrus cycle. Blood samples were collected on the same days to determine the plasma concentrations of progesterone (P4) and estradiol (E2). No statistical differences among groups were detected in any synchronization parameters, ultrasonic evaluations and plasma P4 and E2 concentrations. The evaluation of pooled data showed that the response of Saanen goats to treatments was comparable to the results of other published trials. Results of this study indicate that administration of GnRH at 24 h or 36 h after sponge removal, at the end of a short estrus induction and synchronization protocol, does not affect plasma P4 and E2 concentrations, estrus parameters and ovulation time in goats, during the transition period.

scholarly journals The effect of a direct arterial infusion of insulin and glucose on the ovarian secretion rates of androstenedione and oestradiol in ewes with an autotransplanted ovary

1999 ◽  
Vol 163 (3) ◽  
pp. 531-541 ◽  
Author(s):  
JA Downing ◽  
J Joss ◽  
RJ Scaramuzzi
Keyword(s):  
Ovarian Function ◽  
Ovarian Follicle ◽  
Plasma Concentrations ◽  
Ovulation Rate ◽  
Follicle Development ◽  
Short Term ◽  
Arterial Infusion ◽  
Follicle Selection ◽  
Metabolic Hormone ◽  
Secretion Rates

Improving ewe nutrition even for short periods will increase ovulation rate. The increased nutrients must in some way affect the number of follicles that develop to the pre-ovulatory stage. One possible mechanism is that a nutrient or a metabolic hormone that responds to nutrition might act directly on the ovary to influence follicle development and/or follicle selection. In the study described here, insulin and glucose, alone or together, were infused directly into the ovarian artery of ewes with an autotransplanted ovary, for 13.5 h on day 11 of the oestrous cycle. The pattern of androstenedione and oestradiol secretion in response to a GnRH-stimulated LH pulse was measured 2.5 h before and 12.5 h and 24.5 h after the start of the infusion. Glucose or insulin infused alone had no effect on the secretion of androstenedione and oestradiol. However, when infused together, they decreased significantly the secretion of androstenedione and, to a lesser extent, oestradiol. We suggest that the sudden availability of additional glucose and insulin increases insulin-stimulated glucose uptake by the follicle. This leads to an inhibition of LH-stimulated steroidogenesis by the ovarian follicle which occurs in the absence of any detectable changes in circulating plasma concentrations of FSH. These results show that insulin and glucose act together to influence ovarian function directly and suggest that the effects of short-term nutrition on ovulation rate may be mediated by a direct ovarian action of insulin and glucose.

scholarly journals 38 Effects of combining nose flap weaning with short-term creep feeding of beef calves on cow and calf performance

2020 ◽  
Vol 98 (Supplement_3) ◽  
pp. 39-40
Author(s):  
Kendi Tjardes ◽  
Katy Lippolis
Keyword(s):  
Plasma Concentrations ◽  
Short Term ◽  
Beef Calves ◽  
Diarrhea Virus ◽  
Creep Feed ◽  
Calf Performance ◽  
Cow Performance ◽  
Term Creep ◽  
Viral Diarrhea Virus ◽  
Short Term Creep

Abstract One hundred four Angus calves were ranked by gender, BW, age, and dam parity, and assigned to 1 of 4 pre-weaning treatments: 1) nose flaps for 7-d prior to weaning (NF), 2) traditional weaning (TRAD), 3) traditional weaning and creep feed for 3-wk prior to weaning (TRADC), or 4) nose flaps for 7-d prior to weaning and creep feed for 3-wk prior to weaning (NFC). Cow-calf pairs were housed in dry lot pens on d -28. From d -21 to 0, calves in creep treatments were provided free choice access to creep feed. Nose flaps were placed on d -7, and calves were weaned on d 0. Calves were vaccinated and dewormed on d -21 and 0. There was no difference (P ≥ 0.97) in calf BW on d -28 or -21. During the 7-d period that nose flaps were placed, NFC calves had greater (P ≤ 0.0001) ADG than NF and TRAD calves, and tended to have greater (P ≤ 0.10) ADG than TRADC calves. At weaning on d 0, TRADC and NFC calves tended to have greater BW (P = 0.07) and had greater overall change in BW (P < 0.0001) during the pre-weaning period than TRAD and NF calves. Additionally, there was a greater (P ≤ 0.001) increase in BW of NFC and TRADC cows during the pre-weaning period compared to NF and TRAD cows. From d -21 to 0 there was no differences (P > 0.41) in plasma concentrations for Bovine Viral Diarrhea Virus (BVD). By d 14, the TRADC calves had the greatest plasma concentrations for BVD (P < 0.04). Therefore, providing short-term creep feed prior to placing nose flaps can improve pre-weaning calf and cow performance compared to traditional and nose flap weaning without creep feed supplementation, however, did not improve response to vaccination.

scholarly journals Short-Term Treadmill Running as a Model for Studying Cell-Free DNA Kinetics In Vivo

2011 ◽  
Vol 57 (4) ◽  
pp. 633-636 ◽  
Author(s):  
Thomas Beiter ◽  
Annunziata Fragasso ◽  
Jens Hudemann ◽  
Andreas M Nieß ◽  
Perikles Simon
Keyword(s):  
Time Course ◽  
Treadmill Exercise ◽  
Plasma Concentrations ◽  
High Mobility ◽  
Treadmill Running ◽  
Short Term ◽  
Cell Free Dna ◽  
Free Dna ◽  
Cross Country

BACKGROUND Increased plasma concentrations of cell-free DNA (cf-DNA) are considered a hallmark of various clinical conditions. Despite intensive research in this field, limited data are available concerning the time course of release and clearance of cf-DNA in vivo. METHODS We extracted cf-DNA from plasma samples taken before and immediately after a 10-km cross-country run, and from samples taken before, immediately after, and 30 min after exhaustive short-term treadmill exercise. The contribution of nuclear (nDNA) and mitochondrial DNA (mtDNA) was measured by quantitative real-time PCR. The incremental treadmill exercise setup was exploited to delineate the precise sequencing and timing of cf-nDNA, lactate, and high-mobility group box 1 protein (HMGB1) release during the exercise and recovery phases. RESULTS Postexercise plasma cf-nDNA concentrations in cross-country and treadmill runners were significantly increased, by 7.6-fold and 9.9-fold, respectively (P < 0.001). cf-nDNA concentrations were not correlated with age, sex, or body mass index. Plasma concentrations of cf-nDNA and HMGB1 in postexercise samples of treadmill runners were significantly correlated (r = 0.84; P = 0.004). cf-mtDNA concentrations were not affected by treadmill exercise. Time-course analyses demonstrated that cf-nDNA is released within minutes after the onset of exercise and is rapidly cleared from the circulation after the cessation of exercise. Nearly congruent kinetics for cf-nDNA, lactate, and HMGB1 were observed during the exercise phase. CONCLUSIONS A single bout of exhaustive short-term treadmill exercise constitutes a versatile model system suitable for addressing basic questions about cf-DNA biology.

Lack of Analgesic Activity of Morphine-6-glucuronide after Short-term Intravenous Administration in Healthy Volunteers 

1997 ◽  
Vol 87 (6) ◽  
pp. 1348-1358 ◽  
Author(s):  
Jorn Lotsch ◽  
Gerd Kobal ◽  
Anne Stockmann ◽  
Kay Brune ◽  
Gerd Geisslinger ◽  
...  
Keyword(s):  
Healthy Volunteers ◽  
Analgesic Activity ◽  
Intravenous Administration ◽  
Opioid Analgesic ◽  
Plasma Concentrations ◽  
Experimental Pain ◽  
Controlled Study ◽  
Short Term ◽  
Analgesic Effects ◽  
Relative Contribution

Background The analgesic activity of morphine-6-glucuronide (M-6-G) is well recognized for its contribution to the effects of morphine and its possible use as an opioid analgesic with a wider therapeutic range than morphine. The present study attempted to quantify the relative contribution of M-6-G to analgesia observed after systemic administration of morphine. Methods In a placebo-controlled, sixfold crossover study in 20 healthy men, the effects of M-6-G were assessed at steady-state plasma concentrations of M-6-G identical to and two and three times higher than those measured after administration of morphine. Morphine and M-6-G were administered as an intravenous bolus followed by infusion over 4 h. Dosage A was M-6-G-bolus of 0.015 mg/kg plus infusion of 0.0072 mg x kg(-1) x h(-1). Dosage B was M-6-G-bolus of 0.029 mg/kg plus infusion of 0.014 mg x kg(-1) x h(-1). Dosage C was M-6-G-bolus of 0.044 mg/kg plus infusion of 0.022 mg x kg(-1) x h(-1). Dosage D was a morphine bolus of 0.14 mg/kg plus infusion of 0.05 mg x kg(-1) x h(-1) for 4 h. Dosage E was M-6-G combined with morphine (doses A + D). Dosage F was a placebo. The analgesic effects of M-6-G and morphine were measured before administration of the bolus and after 3.5 h using an experimental pain model based on pain-related cortical potentials and pain ratings after specific stimulation of the nasal nociceptor with short pulses of gaseous carbon dioxide. Results Morphine significantly reduced subjective and objective pain correlates compared with placebo. In contrast, M-6-G produced no statistically significant effects. The addition of M-6-G to morphine did not increase the effects of morphine. Morphine produced significantly more side effects than M-6-G. Conclusion After short-term intravenous administration at doses that produce plasma concentrations of M-6-G similar to those seen after administration of morphine, M-6-G had no analgesic effects in the present placebo-controlled study in healthy volunteers.

Recovery ability of common carp (Cyprinus carpio) after a short-term exposure to terbuthylazine

2013 ◽  
Vol 16 (1) ◽  
pp. 17-23 ◽  
Author(s):  
I. Mikulikova ◽  
H. Modra ◽  
J. Blahova ◽  
K. Kruzikova´ ◽  
P. Marsalek ◽  
...  
Keyword(s):  
Cyprinus Carpio ◽  
Histopathological Examination ◽  
Recovery Period ◽  
Plasma Concentrations ◽  
Hepatosomatic Index ◽  
Short Term ◽  
Plasma Albumin ◽  
Short Term Exposure ◽  
High Regeneration ◽  
Biomarkers Of Oxidative Stress

Abstract Effects of a high terbuthylazine concentration (3.3 mg/l) on Cyprinus carpio were studied using a commercial herbicide formulation Click 500 SC (terbuthylazine 500 g/l). The fish were exposed to the pesticide for 24 h and allowed to recover for 6 days. Biometric parameters, plasma biochemical parameters and biomarkers of oxidative stress as well as histopathological changes in selected tissues were assessed on day 1 and 7. After a 24-h exposure, there were significant alterations found in the activities of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) as well as in the plasma concentrations of glucose, natrium, chlorides, calcium and phosphorus. Hepatosomatic index, plasma albumin and lactate reflected the treatment with a delay. Ion levels and ALT were found to be restored after a 6-day recovery period, which was too short for AST activity and glucose to diminish to the control levels. The histopathological examination revealed disorders in the gills of the exposed fish, however, the changes were not detected after a 6-day recovery period. The study shows high regeneration potential of the fish.

Reproductive Behavior during the Pre-Transitional Period: Evidence from Rural Bologna

2012 ◽  
Vol 42 (4) ◽  
pp. 615-643 ◽  
Author(s):  
Rosella Rettaroli ◽  
Francesco Scalone
Keyword(s):  
Reproductive Behavior ◽  
Multivariate Analyses ◽  
Premature Death ◽  
Transitional Period ◽  
Price Effect ◽  
Short Term ◽  
Born Child ◽  
Micro Level ◽  
Daily Wage ◽  
Wage Earners

A longitudinal, micro-level study of the effect of socioeconomic transformations on fertility mechanisms in the rural hinterland of Bologna between 1818 and 1900 (the beginning of the demographic transition) demonstrates that the premature death of a last-born child reduces the interval between two consecutive childbirths. Thus does it confirm the importance of breast-feeding in determining birth spacing. Women living in complex sharecropping households experienced a significantly higher risk of childbirth than did women in families headed by daily wage earners. In addition, the reproductive behavior of sharecroppers seemed to be substantially invariant to short-term fluctuations in prices, whereas the laborers' group experienced a negative price effect. Both descriptive and multivariate analyses indicate a slight and gradual decrease in fertility levels during the period in question.

Truncal vagotomy does not affect postabsorptive glucose metabolism in humans

1995 ◽  
Vol 79 (1) ◽  
pp. 97-101 ◽  
Author(s):  
E. P. Corssmit ◽  
J. J. Van Lanschot ◽  
J. A. Romijn ◽  
E. Endert ◽  
H. P. Sauerwein
Keyword(s):  
Glucose Metabolism ◽  
Glucose Oxidation ◽  
Plasma Concentrations ◽  
Glucose Production ◽  
Radical Resection ◽  
Truncal Vagotomy ◽  
Glucose Turnover ◽  
Short Term ◽  
Serum Free Fatty Acid ◽  
Glucoregulatory Hormones

To evaluate the effects of hepatic vagal denervation on the adaptation of glucose metabolism to short-term starvation (i.e., < 24 h), glucose metabolism was studied after 16 and again after 22 h of fasting in postsurgical patients with truncal vagotomy (n = 9; radical resection of esophageal carcinoma) and without truncal vagotomy (n = 5; partial resection of the large bowel for carcinoma). Glucose metabolism was studied 3–7.5 mo postoperatively by [3–3H]glucose turnover and by indirect calorimetry. Basal glucose production, plasma glucose concentration, glucose oxidation, serum free fatty acid concentration, and fat oxidation were not different between groups; neither were plasma concentrations of glucoregulatory hormones. The adaptation to prolongation of the fast by 6 h was not different for any of these parameters between both groups. In conclusion, truncal vagotomy does not affect the adaptation of glucose metabolism to the postabsorptive state (16–22 h of fasting).

A Review of Metabolic Parameters in Quetiapine Studies Across Diagnoses

2009 ◽  
Vol 24 (S1) ◽  
pp. 1-1
Author(s):  
J. Newcomer ◽  
R. Ratner ◽  
M. Åström ◽  
H. Eriksson
Keyword(s):  
Atypical Antipsychotics ◽  
Extended Release ◽  
Term Treatment ◽  
Metabolic Parameters ◽  
Short Term ◽  
Pooled Data ◽  
Long Term Treatment ◽  
Potential Risks ◽  
The Difference

Background:Data pertaining to changes in weight during long-term treatment with quetiapine (QTP) have been published previously (1).Methods:Pooled data are presented from 26 short-term clinical studies (up to 12 weeks) of QTP or quetiapine extended-release (QTP XR)-as monotherapy or adjunct therapy-conducted by AstraZeneca up to November 2007. Studies were conducted in adult patients (18-65 years) across a number of psychiatric diagnoses. Variables were analyzed irrespective of fasting status with similar analyses planned in the fasting subset. LSM changes from baseline for the difference between QTP and placebo are presented.Results:Approximately 10000 patients were included in the analyses, 70% of whom were treated with QTP or QTP XR. Across the entire short-term dataset, the difference in LSM change in weight for QTP vs. placebo was 1.07 kg. Corresponding differences in glucose regulation parameters were 1.39 mg/dL for glucose and 0.04% units for HbA1C. the overall difference in total cholesterol was 5.48 mg/dL, with differences in HDL and LDL cholesterol of -0.62 mg/dL and 1.69 mg/dL. the difference in LSM change in triglycerides was 22.62 mg/dL.Discussion:Within the context of balancing potential risks against the acknowledged benefits of atypical antipsychotics, the degree and significance of variations in metabolic parameters is an area of continued interest. This analysis helps clinicians to better understand changes in important metabolic parameters across trials with QTP and QTP XR, and the size and uniqueness of the dataset permits further analyses within this important area.Supported by funding from AstraZeneca Pharmaceuticals LP.

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