Role of Polymorphism IL-1β Gene in Development of Febrile Seizures in Children (Review)

This review provides information on the definition of febrile seizures in children, presents modern data on the dependence of the genetic predisposition to IL-Ιβ gene mutations and development of febrile seizures in children. Purpose of the review is analysis of available publications devoted to the study of the role of IL-Ιβ polymorphism in the development of febrile seizures in children. The literature search included available full-text publications in Russian and English databases. It was found that febrile seizures are characteristic for children from 6 months to 3 years. The causes of seizures still serve as a subject of debate. Family history of febrile seizures in the development is most important risk factor. Positive family history can be detected in 25-40% of patients. Components of the immune response may play a role in the pathogenesis of febrile seizures. One factor is a pro-inflammatory cytokine gene polymorphism of interleukin-ΐβ (IL-Ιβ). The analysis of the literature demonstrates the need for a detailed study of the genetic causes of febrile seizures in children, especially in patients with a positive family history.

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ABDOMINAL EPILEPSY IN CHILDHOOD

PEDIATRICS ◽

10.1542/peds.25.1.151 ◽

1960 ◽

Vol 25 (1) ◽

pp. 151-154

Author(s):

George H. Schade ◽

Helen Gofman

Keyword(s):

Family History ◽

Clinical Diagnosis ◽

Past History ◽

Febrile Seizures ◽

Detailed Consideration ◽

Complete Family ◽

The Past ◽

Seizure State ◽

History Of ◽

Definition Of

A complete family history as to the past seizures experienced by the patient or by members of his family may be revealing and helpful in establishing a diagnosis of abdominal epilepsy. In our study 19 of the 46 children revealed a past history of seizure state and 25 had experienced febrile seizures in infancy. Detailed consideration of the type of pain, its site, and allied symptoms should be evaluated carefully. Disorientation during an episode of pain followed by exhaustion and sleep is suggestive of abdominal epilepsy. Electroencephalography is usually helpful in supporting the clinical diagnosis of abdominal epilepsy. Discussion with the child and his parents, when practical and possible, in regard to the diagnosis and therapy, is recommended. Clarification and definition of the regimen and of the condition are essential, as the term "epilepsy" still carries a stigma to the lay person. Consideration of the patient and parental feelings and attitudes leads to understanding, co-operation, and ultimate success in the control of symptoms.

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Age at Onset of Bilateral Breast Cancer, the Presence of Hereditary BRCA1, BRCA2, CHEK2 Gene Mutations and Positive Family History of Cancer

Oncology Research and Treatment ◽

10.1159/000200930 ◽

2009 ◽

Vol 32 (4) ◽

pp. 182-188 ◽

Cited By ~ 2

Author(s):

Elżbieta Skasko ◽

Anna Kluska ◽

Anna Niwińska ◽

Ewa Kwiatkowska ◽

Aneta Bałabas ◽

...

Keyword(s):

Breast Cancer ◽

Family History ◽

Age At Onset ◽

Positive Family History ◽

Bilateral Breast Cancer ◽

Gene Mutations ◽

History Of ◽

Brca1 Brca2 ◽

I Gene ◽

History Of Cancer

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Serum Sodium Levels Predict the Recurrence of Febrile Seizure within 24 Hours

Journal of Health Science and Medical Research ◽

10.31584/jhsmr.201961 ◽

2019 ◽

Author(s):

Jatuporn Duangpetsang

Keyword(s):

Family History ◽

Serum Sodium ◽

Medical Records ◽

Febrile Seizure ◽

Serum Sodium Level ◽

Febrile Seizures ◽

P Value ◽

Seizure Recurrence ◽

History Of

Objective: Febrile seizure is a common disorder in children that occurs in 2.5% of children 6-60 months of age. The study was conducted to ascertain the role of serum sodium as a predictor of seizure recurrence within the same febrile illness.Material and Methods: A retrospective study was conducted in children with febrile seizures who were admitted to Kaengkhro Hospital between 1 January 2014 and 31 December 2017. The data collected from medical records included age, gender, serum sodium level, body temperature, duration of fever, and family history of febrile seizures.Results: Two hundred ten children were diagnosed with febrile seizures; 190 had a single febrile seizure and 20 had recurrent febrile seizures. Mean±standard deviation ages of children with a single febrile seizure and recurrent febrile seizures were 22.95 ± 0.95 and 22.34 ± 0.89 months, respectively. Serum sodium levels in children with recurrent seizures within 24 hours (130.80 mmol/L) were significantly lower than in children with a single febrile seizure (132.37 mmol/L, p-value=0.02). A family history of febrile seizures was significant for predicting recurrent seizures within 24 hours (p−value= 0.006).Conclusion: Serum sodium levels predict the recurrence of febrile seizure within 24 hours.

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Genetic and Environmental Influences on Achievement Outcomes Based on Family History of Learning Disabilities Status

Journal of Learning Disabilities ◽

10.1177/0022219418775116 ◽

2018 ◽

Vol 52 (2) ◽

pp. 135-145 ◽

Cited By ~ 5

Author(s):

Florina Erbeli ◽

Sara A. Hart ◽

Jeanette Taylor

Keyword(s):

Learning Disabilities ◽

Family History ◽

Learning Disability ◽

Positive Family History ◽

Reading Behavior ◽

Achievement Outcomes ◽

History Of ◽

Mean Differences ◽

Achievement Outcome

A risk to develop a learning disability has been shown to run in families. Having a positive family history of learning disability seems to account for mean differences in achievement outcomes (reading, math) in that children with a positive family history score significantly lower compared to their peers with no such family history. However, the role of family history status in explaining etiological (genetic and environmental) differences among these subgroups of children has yet to be established. The present study of 872 twins ( Mage = 13.30, SDage = 1.40) from the Florida Twin Project on Reading, Behavior, and Environment utilized a multigroup approach to examine etiological differences on reading, spelling, and math among two subgroups defined by family history status. Results showed significant mean differences on all achievement outcomes, aside from math; however, no significant etiological differences on any achievement outcome were found among the two subgroups. Results support previous literature that the risk for developing a learning disability is transmitted through a family, but this is seemingly not manifested by differential etiology.

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Intellectual Differences in Relation to Personal and Family Handedness

Quarterly Journal of Experimental Psychology ◽

10.1080/14640747608400586 ◽

1976 ◽

Vol 28 (4) ◽

pp. 591-601 ◽

Cited By ~ 70

Author(s):

Gary G. Briggs ◽

Robert D. Nebes ◽

Marcel Kinsbourne

Keyword(s):

College Students ◽

Family History ◽

Hemispheric Specialization ◽

Positive Family History ◽

Full Scale ◽

The Other ◽

Cognitive Tests ◽

Left Handed ◽

History Of

Right, mixed and left-handed college students were given the complete WAIS, and a series of cognitive factor tests. Results showed left- and mixed-handed individuals to have a significantly lower full scale I.Q. than right-handers. There was no difference between the mixed and left-handers. In all three handedness groups, subjects with a positive family history of sinistrality had a lower full scale I.Q. than did subjects without left-handed relatives. Neither handedness nor family history differentially affected the Verbal or Performance subscales, nor did they have a significant effect on scores in the other cognitive tests. These results are discussed with respect to Levy's theory of hemispheric specialization, and to the role of inheritance and brain damage in the causation of left- and mixed-handedness.

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Review of seizure disorders in children in the age group of six months to five years

International Journal of Contemporary Pediatrics ◽

10.18203/2349-3291.ijcp20182028 ◽

2018 ◽

Vol 5 (4) ◽

pp. 1236

Author(s):

Chandrashekhar Koli ◽

Sachin Darne

Keyword(s):

Family History ◽

Positive Family History ◽

Previous History ◽

Febrile Seizures ◽

Seizure Disorder ◽

Diagnostic Tools ◽

Age Group ◽

Etiological Factors ◽

Seizure Disorders ◽

History Of

Background: Seizure disorder a term used to include epilepsy, febrile seizures and other types. The international classification and Diagnostic tools including EEG monitoring and MRI are helpful to categorize seizure and treat them with various antiepileptic medications.Methods: Data from patients in the age group of 6 months to 5 years, over 2 months period, presenting with seizure disorders was collected in prescribed proforma and evaluated for type of seizure disorder, age of onset, family history of seizures, previous history of febrile convulsions, presence of neurological abnormality, EEG changes and response to drugs. They were followed up over a period of 2 years.Results: In this study 200 children’s with seizure disorders from a period of 2 months, were screened, reviewed and followed up for a period of two years. Incidence of seizure disorder is 4.37% with male predominance. Of which febrile seizures (52.5%), Generalized Seizures (25.5%), partial seizures (12%), besides unclassified (10%) and status epilepticus (10%). 12% of the children had positive family history of epilepsy and 14.56% had history of previous febrile convulsion. Birth injuries (19.4%) and CNS infection (38.6%) and space occupying lesions (9.7%) constitute the major etiological factors. 10% patient with seizure disorder had abnormal neurological signs. EEG Examination showed 56.8% normal and 33.2% Generalized abnormality. On follow up 51% where found regular, out of which 30% went into remission.Conclusions: Seizure disorder is quite significant condition in children. Though benign, the febrile seizures are the most common type of seizure in children. The major preventable etiological factors for seizures are Birth trauma and CNS infections. Clinical and EEG work up is necessary for proper management of seizures. Health education is needed to stress the importance of regular treatment and to educate for removal of stigmata.

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Role of serum sodium levels in recurrence and recurrent episodes of febrile seizure

International Journal of Contemporary Pediatrics ◽

10.18203/2349-3291.ijcp20202625 ◽

2020 ◽

Vol 7 (7) ◽

pp. 1606

Author(s):

Sara Benny

Keyword(s):

Family History ◽

Serum Sodium ◽

Febrile Seizure ◽

Febrile Seizures ◽

Febrile Child ◽

First Episode ◽

Total Study Population ◽

History Of ◽

Low Serum

Background: Simple febrile seizures are the common childhood seizures, usually affecting 1 in 20 children between the age group of 6 months to 60 months. Earlier studies have shown an association between low serum sodium as a cause for febrile seizures and its recurrences. The present study was to determine the role of serum sodium in predicting febrile seizure recurrence within 24 hrs and recurrent episodes.Methods: Children aged between 6 months to 60 months with first episode of febrile seizures, admitted to the Paediatric ward of MOSC medical college Kolenchery, were recruited in the study. Inclusion criteria were demographic data, family history, clinical examinations, and laboratory investigations (serum sodium and hemoglobin).Results: Of the total study population of 100 children 33 had recurrences in 24 hours and 16 had recurrent episodes. About 57 children had a family history of febrile seizures, out which 28 children had recurrence of febrile seizure within 24 hours. 26 children had family history of epilepsy, of which only 8 had recurrences in 24 hours and 5 had recurrent episodes. Serum sodium levels of 69 children was above 130 mmol/l and 31 children had sodium level below 130mmol/l. Of 31 children, with low serum sodium levels (<130mmol/l), 29 had recurrence within 24 hours, which was not statistically significant. The sodium levels of 16 children who had recurrent episodes of seizure, was also between 130.1-135mmol/. No significant differences were seen between the serum sodium levels in simple febrile seizures and recurrent episodes.Conclusions: Study showed low serum sodium is not statistically significant to predict a recurrence within 24 hours, but a relative hyponatremia can predispose, a febrile child to occurrence of simple febrile seizure.

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Family history as an important factor for stratifying participants in genetic studies of major depression

Balkan Journal of Medical Genetics ◽

10.2478/bjmg-2018-0010 ◽

2018 ◽

Vol 21 (1) ◽

pp. 5-12 ◽

Cited By ~ 1

Author(s):

B Zalar ◽

A Blatnik ◽

A Maver ◽

Z Klemenc-Ketiš ◽

B Peterlin

Keyword(s):

Family History ◽

Genetic Risk ◽

Positive Family History ◽

Risk Variants ◽

Common Genetic Variants ◽

World Mental Health Survey ◽

History Of ◽

Sporadic Cases ◽

Family History Of Depression

Abstract Depression is estimated to affect 350 million people worldwide. The World Mental Health Survey conducted in 17 countries found that, on average, about one in 20 people reported having an episode of depression in the previous year. Although depression has been shown to be moderately heritable by studies conducted in the past, the search for its so-called missing heritability has so far been unsuccessful. The difficulty in identifying common genetic variants predisposing to depression could be due to large sample sizes needed to detect small effects on genetic risk and the heterogeneous nature of major depressive disorder (MDD). The aim of our study was to determine whether there was a connection between a family history of depression in MDD patients and the presence of putative risk variants in the well-studied SLC6A4, COMT and PCLO genes. We analyzed 133 patients with MDD (30.0% with a positive family history for MDD and 70.0% sporadic cases) and compared them to 279 healthy controls. When comparing all the depressed patients to controls, no significant differences in genotype and allele distributions were detected. After stratifying patients according to their family history, the PCLO rs2522833 C allele was shown to be significantly less common in patients with a positive family history (p = 0.001), indicating a possible difference in the genetic structure of MDD between familial and sporadic cases and a less important role of the common genetic risk variants for the development of MDD in familial cases.

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