scholarly journals Serum Sodium Levels Predict the Recurrence of Febrile Seizure within 24 Hours

2019 ◽  
Author(s):  
Jatuporn Duangpetsang
Keyword(s):  
Family History ◽  
Serum Sodium ◽  
Medical Records ◽  
Febrile Seizure ◽  
Serum Sodium Level ◽  
Febrile Seizures ◽  
P Value ◽  
Seizure Recurrence ◽  
History Of

Objective: Febrile seizure is a common disorder in children that occurs in 2.5% of children 6-60 months of age. The study was conducted to ascertain the role of serum sodium as a predictor of seizure recurrence within the same febrile illness.Material and Methods: A retrospective study was conducted in children with febrile seizures who were admitted to Kaengkhro Hospital between 1 January 2014 and 31 December 2017. The data collected from medical records included age, gender, serum sodium level, body temperature, duration of fever, and family history of febrile seizures.Results: Two hundred ten children were diagnosed with febrile seizures; 190 had a single febrile seizure and 20 had recurrent febrile seizures. Mean±standard deviation ages of children with a single febrile seizure and recurrent febrile seizures were 22.95 ± 0.95 and 22.34 ± 0.89 months, respectively. Serum sodium levels in children with recurrent seizures within 24 hours (130.80 mmol/L) were significantly lower than in children with a single febrile seizure (132.37 mmol/L, p-value=0.02). A family history of febrile seizures was significant for predicting recurrent seizures within 24 hours (p−value= 0.006).Conclusion: Serum sodium levels predict the recurrence of febrile seizure within 24 hours.

scholarly journals Role of serum sodium levels in recurrence and recurrent episodes of febrile seizure

2020 ◽  
Vol 7 (7) ◽  
pp. 1606
Author(s):  
Sara Benny
Keyword(s):  
Family History ◽  
Serum Sodium ◽  
Febrile Seizure ◽  
Febrile Seizures ◽  
Febrile Child ◽  
First Episode ◽  
Total Study Population ◽  
History Of ◽  
Low Serum

Background: Simple febrile seizures are the common childhood seizures, usually affecting 1 in 20 children between the age group of 6 months to 60 months. Earlier studies have shown an association between low serum sodium as a cause for febrile seizures and its recurrences. The present study was to determine the role of serum sodium in predicting febrile seizure recurrence within 24 hrs and recurrent episodes.Methods: Children aged between 6 months to 60 months with first episode of febrile seizures, admitted to the Paediatric ward of MOSC medical college Kolenchery, were recruited in the study. Inclusion criteria were demographic data, family history, clinical examinations, and laboratory investigations (serum sodium and hemoglobin).Results: Of the total study population of 100 children 33 had recurrences in 24 hours and 16 had recurrent episodes. About 57 children had a family history of febrile seizures, out which 28 children had recurrence of febrile seizure within 24 hours. 26 children had family history of epilepsy, of which only 8 had recurrences in 24 hours and 5 had recurrent episodes. Serum sodium levels of 69 children was above 130 mmol/l and 31 children had sodium level below 130mmol/l. Of 31 children, with low serum sodium levels (<130mmol/l), 29 had recurrence within 24 hours, which was not statistically significant. The sodium levels of 16 children who had recurrent episodes of seizure, was also between 130.1-135mmol/. No significant differences were seen between the serum sodium levels in simple febrile seizures and recurrent episodes.Conclusions: Study showed low serum sodium is not statistically significant to predict a recurrence within 24 hours, but a relative hyponatremia can predispose, a febrile child to occurrence of simple febrile seizure.

The Association between Serum Sodium Levels and Febrile Seizures Recurrence: Is the Degree of Hyponatremia a Risk Factor?

2021 ◽  
Author(s):  
Esma Keleş Alp ◽  
Ahmet Midhat Elmacı
Keyword(s):  
Serum Sodium ◽  
Medical Records ◽  
Febrile Seizure ◽  
Serum Sodium Level ◽  
Febrile Seizures ◽  
Lower Sensitivity ◽  
Operating Characteristics ◽  
Serum Electrolyte ◽  
Optimal Cutoff ◽  
Characteristics Analysis

AbstractFebrile seizures are common disorders in childhood. We evaluated the serum electrolyte levels and the associated factors in children with single and recurrent febrile seizures in 24 hours period of hospitalization. The medical records of children who were clinically diagnosed with febrile seizures and hospitalized were retrospectively revealed and analyzed. Data were collected for children aged 1 to 6 years including demographic parameters and serum electrolyte levels. A total of 244 children were enrolled in the study in which 209 were diagnosed with single febrile seizures and 35 of them with recurrent febrile seizures. Serum sodium levels were significantly lower in children with recurrent febrile seizure (138.5 ± 2.38 and 134.2 ± 3.55, p < 0.001). Correlation analysis revealed that mild hyponatremia is associated with recurrence of febrile seizure within 24 hours. However, receiver-operating characteristics analysis for hyponatremia showed lower sensitivity (50.3%) and specificity (43.1%) values for optimal cutoff value of 133.5 mmol/L of serum sodium level. Our study suggested that serum sodium levels were significantly lower in children with recurrent febrile seizures. However, because of its lower sensitivity and specificity values, mild hyponatremia cannot be used as an indicator for febrile seizure recurrence.

scholarly journals Major clinical risk factors for seizures in febrile children aged 6 to 60 months.

2020 ◽  
Vol 27 (05) ◽  
pp. 891-894
Author(s):  
Shahid Ishaq ◽  
Ejaz Mazari ◽  
Fazal ur Rehman
Keyword(s):  
Risk Factors ◽  
Family History ◽  
Febrile Seizures ◽  
Study Groups ◽  
Clinical Risk Factors ◽  
P Value ◽  
Chi Square ◽  
Clinical Risk ◽  
Significant Difference ◽  
History Of

Objectives: Febrile seizures (FS) are the most common type of seizures and typically transpire in children with ages from 6 to 60 months. This study was planned to find out major clinical risk factors for seizures in febrile children who were aged 6 to 60 months. A total of 100 febrile children aged 6 to 60. Study Design: Analytical Study. Setting: Department of Neurology, Children’s Hospital and the Institute of Child Health, Multan. Period: From 1st April 2018 to 31st December 2018. Material & Methods: Group A had 40 children with febrile seizures while group B had 60 febrile children but without seizures. Demographic features along with family history of (H/O) epilepsy as well as family history of febrile seizure, types of seizure and infection diseases were noted and analyzed using SPSS version 20. Odds ratio was calculated for various risk factors. Chi square test was applied and P value < 0.05 was considered as significant. Results: Out of a total of 100 children, there were 54 (54.0%) male and 46 (46.0%) female. There was no statistical difference in terms of gender between the two groups (p value = 0.566). Overall, mean age of the children was 26.02 months with standard deviation of 13.4 months. There were 28 (70.0%) children who reported with simple seizures while complex seizures were found in 12 (30.0%) cases. Statistically significant difference (p value = 0.001) was seen in terms of types of infections between the two study groups. When risk of seizures for various risk factors was calculated, family H/O FS, family H/O epilepsy, and upper RTI were as 14, 7 and 3 times respectively and turned out to be the major risk factors for seizures in febrile children. Conclusions: Family H/O FS, family H/O epilepsy and upper RTIs are the major risk factors related with seizures in febrile children. Measures to prevent these risk factors can decrease the burden of FS in our population.

scholarly journals Serum Sodium Level on the Recurrence of Febrile Seizure within the Same Febrile Illness-Experience in a District Level Hospital

2019 ◽  
Vol 32 (1) ◽  
pp. 39-45
Author(s):  
M Luthfor Rahman ◽  
Belal Hossain ◽  
Belal Uddin ◽  
Sanaul Haq Mia
Keyword(s):  
Serum Sodium ◽  
Febrile Seizure ◽  
Sodium Level ◽  
Serum Sodium Level ◽  
Central Nervous System Infection ◽  
Febrile Illness ◽  
Febrile Seizures ◽  
Febrile Episode ◽  
Cross Sectional ◽  
Recurrent Seizure

Introduction: Febrile convulsion is the most common seizure disorder in the pediatric age group. It occurs in 2-5% of children. A febrile seizure is a seizure accompanied by fever (temperature 100.4°F or 38°C by any method), without central nervous system infection, that occurs in infants and children 6 through 60 months of age. Aim: The study was conducted to see the effect of serum sodium level on the recurrence of febrile seizure during the same febrile illness. Materials and Method: A cross-sectional descriptive study which enrolled 65 children admitted with febrile seizures at 100 bed district hospital, Naogaon. They were divided in to two groups, those with a single seizure and the rest were children with more than one seizures. Serum sodium levels were estimated after stabilization of patients. The probability of recurrent febrile seizures and serum sodium level was analyzed. Results: Hyponatremia (serum sodium <135 mmol/l) was seen in 12(18.5%) of 65 children and the remaining 81.5% children had normal serum sodium level (serum sodium 135-145 mmol/l). Among the hyponatremia group all children developed more than one seizure during the same febrile episode. The mean serum sodium level in patients with single and recurrent seizure was 138.48±2.17mmol/l and 135.27±3.11mmol/(P<0.001). The relationship between the probability of a recurrent seizure and serum sodium level is statistically highly significant. Conclusion: Estimation of the seum sodium in children with febrile seizures help in deciding for admission in hospital as well as to predict seizure recurrence within the same febrile episode. TAJ 2019; 32(1): 39-45

Retrospective Study of Febrile Seizures: Subsequent Electroencephalogram Findings, Unprovoked Seizures and Epilepsy in Adolescents

2002 ◽  
Vol 30 (6) ◽  
pp. 560-565 ◽  
Author(s):  
HN Piperidou ◽  
IN Heliopoulos ◽  
ES Maltezos ◽  
GA Stathopoulos ◽  
IA Milonas
Keyword(s):  
Retrospective Study ◽  
Family History ◽  
Secondary School ◽  
Febrile Seizure ◽  
Age At Onset ◽  
Febrile Seizures ◽  
Unprovoked Seizure ◽  
History Of ◽  
The Mean ◽  
Retrospective Questionnaire

A retrospective questionnaire to determine the prevalence of febrile seizures was given to adolescents (16- and 17-year-olds) in the final 2 years of secondary school at the five schools in Alexandroupolis, Greece. Parents were interviewed, and clinical and electroencephalographic examinations were performed in all adolescents with a history of febrile seizures. Of 1708 adolescents, 56 (3.3%) had experienced at least one febrile seizure. Of these, 44 (78.6%) were simple and 12 (21.4%) were complex febrile seizures. Recurrent seizures occurred in 22 cases (39.3%), and the mean age at onset was 25.1 months. There was a positive first-degree family history in eight cases (14.3%) and this increased to 27.3% in cases with recurrent seizures. Two of the adolescents (3.6%) had had one unprovoked seizure before the age of 3 years, and another two children developed epilepsy. Epileptiform electroencephalogram discharges were observed in only one case (1.8%) with generalized tonic-clonic epilepsy.

scholarly journals Clinical, epidemiological and laboratory characteristics of children with febrile seizures

2020 ◽  
Vol 7 (7) ◽  
pp. 1598
Author(s):  
Poornima Shankar ◽  
Shajna Mahamud
Keyword(s):  
Family History ◽  
Febrile Seizure ◽  
Monsoon Season ◽  
Febrile Seizures ◽  
First Episode ◽  
Upper Respiratory Tract ◽  
History Of ◽  
Upper Respiratory ◽  
One Year ◽  
Tract Infections

Background: Febrile seizure is the most common type of seizure disorder that occurs in children aged 6-60 months. Recurrences are common. This study was conducted to evaluate the epidemiology, clinical profile and laboratory parameters of children presenting with febrile seizure in a teaching hospital.Methods: This was a descriptive retrospective study among children presenting with febrile seizure admitted to KIMS, Bengaluru from March (2018-2019). Children between six months to five years were included in the study while patients with prior episodes of afebrile seizures, abnormal neurodevelopment and not meeting the age criteria were excluded. Patient’s demographic and clinical data were collected from the in-patient records and analysed.Results: Among 60 children with febrile seizures were enrolled in our study with highest prevalence in males (58%) and amongst 13-24 months age group (37%). Majority (20%) presented in the monsoon season (June) and in the morning hours (43%). Simple febrile seizures and complex febrile seizures were observed in 60% and 40% respectively. Majority (73%) who developed first episode of seizure were below 24 months ago with mean age of 18.71±11.50 months. 42% had recurrence and was significantly associated with first episode of febrile seizures at age ≤1 year and family history of seizures. Upper respiratory tract infections were the commonest cause of fever. Anaemia and leucocytosis were seen in 72% and 70% cases respectively.Conclusions: Febrile seizure was observed predominantly in children below two years, simple febrile seizure being the commonest. Recurrence was common and significantly associated with the first episode of febrile seizure at the age one year or below and family history. Majority had anaemia which showed that iron deficiency anaemia could be a risk factor. Leucocytosis was present in most which could be either due to underlying infection or due to the stress of seizure itself.

Letters to the Editor

PEDIATRICS ◽  
1980 ◽  
Vol 65 (3) ◽  
pp. 680-680
Author(s):  
Karin B. Nelson ◽  
Jonas H. Ellenberg
Keyword(s):  
Medical Records ◽  
Febrile Seizure ◽  
Febrile Seizures ◽  
Sources Of Information ◽  
Letters To The Editor ◽  
Drug Usage ◽  
Medical Experience ◽  
History Of

The sources of information concerning treatment of febrile seizures in our recent study were medical records written at the time of treatment of an initial or later febrile seizure, the nine scheduled interval histories, and a full history of the child's medical experience recorded when registrants reached the age of 7 years. However, information on drug usage, unlike the remainder of the information utilized in these studies, was not based upon structured portions of the questionnaires and was not systematically available for all registrants.

scholarly journals Risk Factors of First Febrile Seizures Admitted in a Tertiary Care Hospital

2018 ◽  
Vol 6 (1-2) ◽  
pp. 56-61
Author(s):  
Fauzia Nahid ◽  
Farhana Rahman ◽  
Md Mahbubul Hoque ◽  
Md Ruhul Amin ◽  
Tahmina Yasmin ◽  
...  
Keyword(s):  
Risk Factors ◽  
Family History ◽  
Breast Feeding ◽  
Febrile Seizure ◽  
Perinatal Asphyxia ◽  
Febrile Convulsion ◽  
Febrile Seizures ◽  
Control Group ◽  
Care Hospital ◽  
History Of

Background & objective: Febrile seizure (FS) is the most common convulsive event in children. It is the most common type of seizure that every pediatrician has to deal with. However, the etiology of febrile seizure is still unclear. The present study was intended to identify the risk factors of first febrile convulsion among 6 months to 5 years old children. Materials & Methods: A case-control study was carried out on a total of 200 children-100 cases (children with febrile convulsion) & 100 controls (without febrile convulsion) selected from the In-patient Department of Dhaka Shishu Hospital over a period of six months between May 2012 to October 2012. Data were collected on variables of interest using a semi-structured research instrument. The Chi-square test and Odd Ratio were employed to compare the risk factors between case and control groups. Result: There was no association of febrile seizure with age of the children, but males were more often associated with FS than the females with risk of developing febrile seizures in boys was 3.5-fold (95% CI=1.8 -6.8) higher than that in girls (p<0.001). The risk of having FS in children with prematurity and caesarean delivery was 2.8 times (95% CI=1.5-5.0) and 2-times (95% CI=1.4-2.6) greater than those in children without having these conditions (p=0.001 and p<0.001 respectively). The children with family history of febrile seizure tends to be associated with first febrile seizures and the odds of having the condition is 36.4 (95% CI=15.4-85.7). There was no significant relationship between family history of epilepsy and first febrile seizure (p=0.061). The children with shorter duration of breast feeding (6-12 months) carry 2.9(95% CI=2.0-4.0) times higher risk of having first febrile seizure than those with longer duration of breast-feeding (p<0.001). Exclusively breast-fed children were less susceptible to develop febrile seizures (OR=0.149, 95% CI: 0.08-0.23). Twelve cases developed perinatal asphyxia as opposed to only 2 of the control group and the risk of having FS in children with perinatal asphyxia was 1.8(95% CI=1.4-2.3) times higher than those without having the history ofperinatal asphyxia (p<0.001). Three-quarters of the children presented with FS had viral fever whereas only 4% of the controls had viral fever indicating that viral fever triggers the development of FS much more frequently than any other childhood illness (p<0.001). Conclusion: The study concluded that male sex, preterm baby, positive family history of febrile seizures, less than 6 months of exclusive breast feeding, not continuing the breast-feeding beyond 12 months, perinatal asphyxia and viral infections are the predictors of first febrile seizure. Preventive measures in removing these risk factors can go a long way to a decrease the incidence of febrile seizures. Ibrahim Card Med J 2016; 6 (1&2): 56-61

Role of Polymorphism IL-1β Gene in Development of Febrile Seizures in Children (Review)

2015 ◽  
Vol 22 (3) ◽  
pp. 183-188
Author(s):  
Мартынова ◽  
G. Martynova ◽  
Шнайдер ◽  
N. Shnayder ◽  
Строганова ◽  
...  
Keyword(s):  
Family History ◽  
Literature Search ◽  
Positive Family History ◽  
Gene Mutations ◽  
Febrile Seizures ◽  
Cytokine Gene ◽  
Cytokine Gene Polymorphism ◽  
History Of ◽  
Definition Of

This review provides information on the definition of febrile seizures in children, presents modern data on the dependence of the genetic predisposition to IL-Ιβ gene mutations and development of febrile seizures in children. Purpose of the review is analysis of available publications devoted to the study of the role of IL-Ιβ polymorphism in the development of febrile seizures in children. The literature search included available full-text publications in Russian and English databases. It was found that febrile seizures are characteristic for children from 6 months to 3 years. The causes of seizures still serve as a subject of debate. Family history of febrile seizures in the development is most important risk factor. Positive family history can be detected in 25-40% of patients. Components of the immune response may play a role in the pathogenesis of febrile seizures. One factor is a pro-inflammatory cytokine gene polymorphism of interleukin-ΐβ (IL-Ιβ). The analysis of the literature demonstrates the need for a detailed study of the genetic causes of febrile seizures in children, especially in patients with a positive family history.

scholarly journals Intermittent clobazam prophylaxis in simple febrile convulsions: a randomised controlled trial

2019 ◽  
Vol 6 (2) ◽  
pp. 732
Author(s):  
Vinod Kumar ◽  
Ashish Gupta
Keyword(s):  
Side Effects ◽  
Febrile Seizure ◽  
Controlled Trial ◽  
Central Nervous System Infection ◽  
Febrile Seizures ◽  
P Value ◽  
Seizure Recurrence ◽  
Normal Children ◽  
Double Blind ◽  
Effective Measure

Background: Febrile seizure (FS) is the most common type of childhood seizure disorder with a prevalence of 2-5% in children less than 5 years. Although the prognosis of febrile seizure is usually good, however, the possibility of recurrence keeps many parents and families in a state of anxiety and concerned, for years after the first seizure. Thus, intermittent prophylactic treatment might be advised in children with high risk of recurrence.Methods: The study was a prospective randomized, double blind, placebo-controlled trial conducted at Department of Pediatrics, Umaid Hospital, Dr S N Medical College, Jodhpur on neurologically normal children aged from 6 months to 5 years with a history of simple febrile seizures and normal electroencephalogram without any evidence of acute central nervous system infection. Subjects were randomly prescribed oral clobazam according to weight of child and placebo when they developed a febrile disease during the first 48 h of the onset of fever.  Temperature reduction measures with paracetamol and tepid sponging were also advised. Patients were followed up for the frequency and time of febrile seizure recurrence, febrile episodes and side effects of drugs for 12 months.Results: Ten (3.8%) of 257 episodes in clobazam group and 38 (14.07%) episodes in placebo group had seizure recurrence (p value <0.001). The two groups were not significantly different in terms of side effects. (p >0.05).Conclusions: Intermittent oral clobazam therapy is a very effective measure in preventing recurrence of febrile seizures.

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