A New Approach to the Classification of Filamemts of Rejuvenascence of Skin of Face and Neck

10.12737/5011 ◽  
2014 ◽  
Vol 21 (2) ◽  
pp. 104-109 ◽  
Author(s):  
Кодяков ◽  
A. Kodyakov ◽  
Груздев ◽  
D. Gruzdev ◽  
Федоров ◽  
...  
Keyword(s):  
Side Effects ◽  
Evaluation Criteria ◽  
Aging Effects ◽  
Actual Problem ◽  
New Approach ◽  
Negative Appraisal ◽  
Minimum Number ◽  
Definition Of

This paper is devoted to the actual problem of cosmetology - the procedures of filament rejuvenation of face and neck, which become popular every year. Literature data on the efficacy of these methods are controversial. The authors of most works indicate the minimum number of complications in the practical absence of negative appraisal methodology. The issues of development of the indication for use of some types of filaments and optimal criteria of evaluation of the expected effect in clinical practice are relevant and are discussed in this paper. Taking into account the absence of objective information about long-term consequences, other practical aspects of filament rejuvenation, the authors on the basis of many years of research and experience has specified evaluation criteria and suggested own classification of cosmetic filaments used in the method of filament rejuvenation of face and neck. Installation of filaments with different cosmetic features allows to reaching three different anti-aging effects: lifting, reinforcing and bio-stimulation. The degree of manifestation of these effects depends on the installation method of the thread, but first of all - on the design of conductive filament and needle or cannula. Based on the above data, the authors propose to divide all known cosmetic filaments on the basis of their purpose, proceeding from the achieved effect for three species - lifting, reinforcing and bio-stimulating. The new classification can be used in practice to optimize the selection of filaments for rejuvenation of face and neck and to reduce unintended side effects. The proposed classification of filaments has the purpose of definition of a fundamental criterion for their beauty opportunities. The practical application of this classification contributes to ensure adequate choice of filaments to perform the procedure, reduce side effects and create realistic expectations of doctors and patients from the procedures of the rejuvenation of face and neck.

Issues Involved in the Definition and Classification of Chronic Health Conditions

PEDIATRICS ◽  
1993 ◽  
Vol 91 (4) ◽  
pp. 787-793 ◽  
Author(s):  
Ellen C. Perrin ◽  
Paul Newacheck ◽  
I. Barry Pless ◽  
Dennis Drotar ◽  
Steven L. Gortmaker ◽  
...  
Keyword(s):  
Chronic Conditions ◽  
Research Policy ◽  
Age Groups ◽  
Health Condition ◽  
Children And Families ◽  
New Approach ◽  
Time Period ◽  
Definition Of ◽  
Use Of Medical Services

The need for a widely applicable definition of chronic conditions for research, policy, and program development has led to an extensive review of the development of such definitions, the considerations involved in their use, and some recommendations for a new approach. This paper examines some of the methodologic and conceptual issues related to defining and classifying chronic conditions and describes some consequences resulting from decisions made about these issues. While most examples are taken from child health applications, the basic concepts apply to all age groups. The dominant method for identifying and classifying children as having a chronic condition has relied on the presence of an individual health condition of lengthy duration. This condition-specific or "categorical" approach has increasingly seemed neither pragmatically nor conceptually sound. Thus, the development of a "generic" approach, which focuses on elements that are shared by many conditions, children, and families, is recommended. Such a definition might reflect the child's functional status or ongoing use of medical services over a specified time period. In addition, it is suggested that conditions be classified based on the experience of individual children, thus emphasizing the tremendous variability in expression of seemingly similar conditions.

Use of Plerixafor in Predicted and Proven Poor Mobilizer (according to GITMO criteria). Experience of Policlinico Universitario Tor Vergata

Blood ◽  
2012 ◽  
Vol 120 (21) ◽  
pp. 4415-4415
Author(s):  
Massimiliano Postorino ◽  
Alessandro Lanti ◽  
Eleonora Fiorelli ◽  
Angelo Salvatore Ferraro ◽  
Oana Marilena Chiru ◽  
...  
Keyword(s):  
Side Effects ◽  
Conflicts Of Interest ◽  
Minimum Requirement ◽  
Correct Definition ◽  
Cd34 Cells ◽  
Minimum Number ◽  
Poor Mobilizer ◽  
Operational Criteria ◽  
Definition Of ◽  
To Receive

Abstract Abstract 4415 BACKGROUND. Autologous stem cell transplantation (ASCT) of PBSCs has become a widely applied treatment for Multiple Mieloma (MM), non- Hodgking's lymphoma (NHL) and Hodgking's lymphoma (HL). Successful engraftment correlates with the number of CD34 hemopoietic progenitors cells infused. However, a part of MM or lymphoma patients (5% to 40%) fail to mobilize adequate numbers of PBSCs and thus cannot undergo to ASCT. The success of PBSCs mobilization is usually assessed by the total number of CD34+ stem cells collected, with a cutoff of 2.0–2.5 ×106 CD34+ cells/kg recipient body weight being considered as a minimum requirement for transplant. Poor mobilization of PBSCs is a major limitation to ASCT. Recently GITMO Working Group worked to define operational criteria for the identification/prediction of the poor mobilizer (PM) patients (Olivieri et al. 2011). Plerixafor, a CXCR4 chemochine antagonist, has been showed to improve significantly PBSC mobilization in PM patients. We present our experience using Plerixafor in PM patients classified according to GITMO criteria. METHODS. Between September 2009 and June 2012, a total of 17 patients (9F-8M) were enrolled. The diagnosis were: 10 MM (5F-5M), 1HL (1M), 6 NHL (4F-2M). The median age was 57 (range 15–66). 7 patients (3MM, 4NHL) were defined “Proven PM” and 10 patients (7MM, 2NHL, 1HL) “Predicted PM” according to GITMO criteria. The mobilization protocol included G-CSF, administered at a dose of 10μg/kg daily on 4 consecutive days. In the evening of the fourth day, patients received subcutaneous plerixafor at a dose of 0,24 mg/kg. Apheresis was initiated on the fifth day, 10–12 h after plerixafor and 1 h after G-CSF administration. Apheresis and daily administration of G-CSF and plerixafor continued until the patient collected enough CD34+ cells for auto- HSCT (> 2 ×106/kg; max 7 plerixafor injections if required). PBSC collection was initiated if peripheral CD34+ cells count was >10μl. A successful mobilization was defined as a total yeld of > 2×106/kg. RESULTS. 13 patients (76,5%) collected the minimum number of CD34 cells > 2×106/kg. The diagnosis were: 8MM, 1HL,1 NHL. 7 patients (2NHL; 4 MM; 1 LH; 7 predicted) were able to collect > 5×106/Kg. Only 4 patients (3 MM; 1 LNH; 4 proven) failed the mobilization because the numbers of cells CD34 were < 10μL and these patients did not undergo to apheresis procedures. The collection target of 2×106/Kg was reached in a median of 2 apheresis session (range 1–3). The technical characteristics of the procedures were (median value): blood volume processed 12 L (range 9–14), total CD34+/Kg collected 3,06 × 106(range 2,21-8,62), procedure efficiency 47,5% (range 35,3–79), duration of the procedure 261 minutes (range 210–309). Plerixafor was well tolerated and mild side effects were: reactions in the injection site, gastrointestinal disturbs, muscle pain. During administration of plerixafor we did not observe any significant laboratory abnormalities of liver or renal function. CONCLUSION. Unsuccessful mobilization represents an important limitation to ASCT in lymphoma and MM. In our experience plerixafor allowed to collect an appropriate amount of CD34 also in patients defined “proven PM” significantly reducing the percentage of patients that could not undergo ASCT (target value obtained in 43% of “proven PM”). Confirming the recent literature plerixafor is well tolerated with minimal side effects. We retrospectively applied GITMO criteria for PM patients and our experience, although limited, confirm that the use of a correct definition of PM allows the appropriate use of new mobilizing agents like plerixafor increasing significantly the therapeutic options also in patients who had no possibilities to receive an ASCT with the traditional mobilizing therapy. Disclosures: No relevant conflicts of interest to declare.

scholarly journals Primary biliary cholangitis – a new nosological unit in the classification of liver diseases (literature review and own clinical observation)

2019 ◽  
pp. 76-82
Author(s):  
T. V. Penkina ◽  
E. A. Shikina ◽  
D. T. Dicheva ◽  
O. E. Berezutskaya ◽  
N. L. Golovkina ◽  
...  
Keyword(s):  
Biochemical Parameters ◽  
Clinical Observation ◽  
Primary Biliary Cholangitis ◽  
Routine Practice ◽  
Biliary Cirrhosis ◽  
Long Term Monitoring ◽  
Definition Of ◽  
Term Monitoring

Identification of changes in biochemical parameters of liver functional activity during screening studies requires additional examination of the patient in order to determine the genesis of the disease. In recent years, in routine practice, the most frequently used is an isolated definition of the level of transaminases (ALT, AST), which does not allow timely detection of latent cholestasis syndrome. Primary biliary cholangitis (PBC), previously referred to as primary biliary cirrhosis, is a relatively rare chronic autoimmune cholesthetic liver disease, predominantly affecting middle-aged women and prone to progressing liver cirrhosis. The recommendations of AASLD and EASL note the need for long-term monitoring of patients with ongoing UDCA therapy and regular diagnostic studies to identify signs of disease progression. A clinical example of successful treatment of a patient with PBC with the Russian drug Exhol® is described.

scholarly journals Managerial innovations: Approach to definition and classification

2020 ◽  
Vol 19 (4) ◽  
pp. 493-519
Author(s):  
Yaroslav D. Sovetkin ◽  
Keyword(s):  
General Concept ◽  
Business Community ◽  
Scientific Publications ◽  
Bibliographic Analysis ◽  
New Approach ◽  
Citation Indexes ◽  
Definition Of ◽  
The Relationship ◽  
Managerial Innovation

Managerial innovations have become the topic of interest for many scholars, but this concept remains underdeveloped and poorly managed among the academy and business community in Russia. This paper offers the composition of approach to definition and classifi cation of managerial innovations, formed on the basis of exploration of the concept “managerial innovation” evolution, and estimation of the relationship with a more general concept “innovation”. The suggested composition of approach is based on the three-stage bibliographic analysis of scientific literature. In course of the bibliographic research, scientific articles were selected according to the key words, period of publication and citation index. 140 scientific publications were identified and collected for the period from 1975 to 2019 covering citation indexes from 0 to 12 476 by Web of Science citation database and from 4 to 2 185 by Scopus database. On the basis of the conducted bibliographic research, the author introduces his definition of innovation and managerial innovation and explains the connection between them. Within the conducted research different approaches to classification of managerial innovations were studied and on their basis a new approach to classification of managerial innovations was proposed. The findings can be useful for different avenues of further research regarding managerial innovations.

Percival S. Bailey: eminent scholar of neurosciences who revealed the workings of the hypothalamus through clinicopathological research on craniopharyngiomas

2020 ◽  
Vol 133 (1) ◽  
pp. 197-209 ◽  
Author(s):  
Ruth Prieto ◽  
José M. Pascual
Keyword(s):  
Surgical Planning ◽  
Close Contact ◽  
Third Ventricle ◽  
Experimental Demonstration ◽  
Hypothalamic Nuclei ◽  
Eminent Scholar ◽  
Peter Bent Brigham Hospital ◽  
Definition Of

Percival S. Bailey (1892–1973) was a scholar, neuroscientist, neuropathologist, and neurosurgeon who made decisive contributions in the field of neuro-oncology. Far less known are his groundbreaking insights into understanding hypothalamic physiology through the study of craniopharyngiomas. As one of Harvey W. Cushing’s most talented trainees, Bailey was instrumental in developing Cushing’s project of a histologically based prognostic classification of brain tumors. He worked at Peter Bent Brigham Hospital on and off between 1919 and 1928, owing to frequent clashes with his mentor. A major cause of this long-term conflict was Bailey’s 1921 experimental demonstration of the hypothalamic origin of diabetes insipidus and Fröhlich’s syndrome. This finding challenged Cushing’s view that both alterations were due to pituitary gland insufficiency. In a seminal monograph written with John F. Fulton in 1929, both authors provided the first comprehensive account of the specific hypothalamic disturbances caused by tumors that originated within the infundibulum and third ventricle. The methodical study of Cushing’s craniopharyngioma specimens allowed Bailey to recognize the close contact between these lesions and hypothalamic nuclei, a key concept that Bailey originally advanced for proper surgical planning. This article aims to credit Bailey for his pioneering definition of craniopharyngiomas as tumors with a true intrahypothalamic position.

ELEMENTS OF THE EDUCATIONAL SYSTEM IN THE ECOLOGICAL FIELD PRINCIPLES OF ENVIRONMENTAL LEGISLATION

2021 ◽  
Author(s):  
Adrian Ioana ◽  
Daniela Tufeanu ◽  
Dragos Florin Marcu ◽  
Bogdan Florea ◽  
Daniela Luta
Keyword(s):  
Environmental Protection ◽  
National Policy ◽  
Essential Element ◽  
Ecological Principles ◽  
Starting Point ◽  
Protected Territory ◽  
Ecological Principle ◽  
Definition Of

This article has as a starting point the definition of the concept of ecological principles. Then, after classification of the principles of ecology (domestic principles and international principles), we present and critically analyze and compare the main principles in the field of ecology. Among the ecological principles on the domestic chain, we present and analyze 11 principles, namely: pollution must be combated at the source; the interests of environmental protection must be taken into account in all design or execution decisions; any exploitation or use of natural resources must be avoided if it is accompanied by damage; it is necessary to raise the level of scientific and technological knowledge, inter alia by supporting scientific research; the costs of preventing and combating pollution to be borne by the polluter; the activity of one state not to harm the environment of another state; during the elaboration of the community policy in the field of environmental protection to take into account the interests of the developing states; community environmental protection policy must be developed in the long term and protection must be comprehensive and international, which is achieved, inter alia, through cooperation within international bodies; the cause of environmental protection is everyone's responsibility and for this reason education is irreplaceable; depending on the source of pollution, the most appropriate level of action must be established taking into account the nature of the pollution, the necessary measures, the characteristics of the protected territory. This principle is defined as a "subsidiary principle"; it is necessary to harmonize and coordinate national policy in the field of environmental protection in accordance with the long-term commonly accepted directives. We also present and analyze the principle according to which environmental protection must be an essential element of the economic and social policy of the state. Finally, another ecological principle, the principle of prevention of ecological risks and damage

Inner Knowledge: A New Approach Building Upon Innovation

2021 ◽  
pp. 2140006
Author(s):  
Irina de la Flor ◽  
Maria Sarabia ◽  
Fernando Crecente ◽  
Maria Teresa Del Val
Keyword(s):  
Job Satisfaction ◽  
Knowledge Management ◽  
Theoretical Model ◽  
Traditional Knowledge ◽  
Model Building ◽  
New Approach ◽  
Innovative Model ◽  
Theoretical Paper

This paper proposes an innovative theoretical model building upon traditional Knowledge Management (KM) that could help increase both job satisfaction and efficiency of workers. The model introduces two new dimensions to KM: the classification of knowledge according to its origin; and the degree of impact the knowledge has on an individual’s efficiency and long-term satisfaction. This allows us to categorize knowledge as inner or outer according to its objective/subjective nature and the nature of the object aimed to be known. This theoretical paper proposes an innovative model called the Inner KM Model introducing a new variable defined as Inner Knowledge.

scholarly journals Learning and memory

1989 ◽  
Vol 8 (1) ◽  
pp. 12-24
Author(s):  
P. A. J. Ryke
Keyword(s):  
Short Term Memory ◽  
Cultural Learning ◽  
Long Term Memory ◽  
Latent Learning ◽  
Short Term ◽  
Term Memory ◽  
The One ◽  
Definition Of

Under various circumstances and in different species the outward expression of learning varies considerably, and this has led to the classification of different categories of learning. Just as there is no generally agreed on definition of learning, there is no one system of classification. Types of learning commonly recognized are: Habituation, sensitization, classical conditioning, operant conditioning, trial and error, taste aversion, latent learning, cultural learning, imprinting, insight learning, learning-set learning and instinct. The term memory must include at least two separate processes. It must involve, on the one hand, that of learning something and on the other, at some later date, recalling that thing. What lies between the learning and (he remembering must be some permanent record — a memory trace — within the brain. Memory exists in at least two forms: memory for very recent events (short-term) which is relatively labile and easily disruptable; and long-term memory, which is much more stable. Not everything that gets into short-term memory becomes fixed in the long-term store; a filtering mechanism selects things that might be important and discards the rest.

The development of geophysical maps’new classification

2017 ◽  
Vol 923 (5) ◽  
pp. 26-33
Author(s):  
D.S. Loginov ◽  
S.A. Krylov
Keyword(s):  
Geological Mapping ◽  
Natural Phenomena ◽  
New Classification ◽  
New Approaches ◽  
Current State ◽  
The Common ◽  
Definition Of ◽  
Geophysical Mapping

At the present time, the common classification of geophysical maps is missing, which is a consequence of their long-term development of the geological mapping. The features of existing approaches to the definition of geophysical maps’ place among maps of natural phenomena and the limitations of existing lists of mapping themes were determined and identified in this article. New approaches to the classification of geophysical maps that take into account the completeness of their contents and the current state of geophysical mapping were offered. A new classification of geophysical maps was elaborated based on four criteria

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