Can placebos prevent intrusive memories?

After traumatic experiences, intrusive memories can flash back and evoke significant distress. Here, we investigated whether the occurrence of intrusions can be prevented by placebo. After the exposure to an experimental psychopathology model of psychological trauma, healthy participants (N=112) were randomised to deceptive placebo (DP), open-label placebo (OLP), or a no-treatment control group. The results show that one week later, the groups did not differ in the frequency of intrusive memories. However, participants receiving OLP reported the lowest intensity of intrusions. Participants receiving DP reported the lowest burden of intrusions. Across groups, the expectation that intrusions will be intense and hardly controllable was associated with a higher frequency of intrusions, higher distress, higher burden, and more negative appraisal. The results suggest that expectations play a crucial role in the emergence of intrusive memories and that at least some of the disabling aspects of intrusive memories can be reduced by placebo.

Caregiving Appraisals and Emotional Valence: Buffering Effect of Activity Participation

Caregiving activities often lead to positive and negative appraisal for caregivers. Caregivers may limit social participation due to caregiving activities. Changes in level of activity participation could have profound consequences for caregiver’s valence. However, little is known about how activity participation could moderate the association between these caregiving appraisals and emotional valence. Data came from the National Study of Caregiving (Round 1 and 2), a nationally representative study of caregivers. Referencing Lawton’s two-factor model (1990), we examined both the level and changes in activity restriction interacting with positive and negative caregiving appraisals to predict both valence across two waves. Consistent with two factor models, findings revealed level and changes in activity restriction moderated the relationship between caregiving appraisal and outcomes for both valences. These findings highlight the role of activity restriction as a target to reduce negative valence and improve positive valence for caregivers.

Evaluation of Wadjda: A Comparative Discourse Analysis of Western and Saudi Movie Reviews

Since people are showing more interest recently in movies and as movie reviews of the same movie could vary in the degree of their objectivity, this paper seeks to answer why movie reviews may differ in their evaluation of the same work. To this end, a critical discourse analysis using Fairclough’s three-dimensional framework and Martin and White’s attitude framework is carried out to analyze two reviews of the Saudi movie Wadjda, one written in English by a western critic, and the other is Arabic written by a Saudi critic. The textual analysis of attitudinal expressions shows that the English text maintains an even distribution between the negative and positive expressions, and most of the negative expressions do not assess the aspects of the movie but rather the Saudi society. In the Arabic text, however, the negative expressions outnumber the positive ones, and they are mostly related to the movie and the director. Using Fairclough’s framework, the author explains the findings of the textual analysis of the English review and the critic’s avoidance of negative evaluation as a result of Eurocentrism and the way the western media represent Arabs and Muslims. However, the negative appraisal of several movie aspects found in the Arabic review could be seen as a result of the critic being part of the society and, thus, not distracted by the social issues.

Saying and shaking ˋNo'

In many instances, the head shake can be used instead of or in addition to verbal ˋNo'. Based on previous work on negation in dialogue, we observe head shaking as answer particles and as responding to an implicit or an exophoric (i.e., real world situation) antecedent. Exophoric head shake, however, seems to come in two flavours: with positive and with negative emotional valuation of the antecedent situation. We provide semantic analyses for all three uses (and a head nod) within an HPSG version which is implemented in Type Theory with Records and the dialogue framewok KoS. In particular, we extend on previous work by grounding ˋˋexophoric negation'' in positive or negative appraisal. Finally, we briefly speculate about differences between verbal ˋNo' and head shaking due to (the lack of) simultaneity.

Emotional Threat Perception and Its Association with Neurocognition in Social Anxiety Disorder

Background: The negative appraisal of emotional stimuli is a feature of social anxiety disorder (SAD). People with SAD demonstrate deficits in neurocognitive performance while performing tasks of attention. However, the relationship between attentional control, working memory, and threat perception in SAD has not been studied well. The present study aimed to identify patterns of threat perception in relation to performance on attention and visuospatial working memory tasks in individuals with SAD. Methods: Subjects with SAD ( n = 27) and a healthy comparative (HC) group ( n = 26) completed tasks of sustained and focused attention, visuospatial working memory, computerized emotion identification, and pictorial emotional Stroop. Results: The SAD group had decreased performance in the domains of sustained (P = 0.001) and focused attention (P = 0.04). They also had an enhanced threat perception as demonstrated by greater reaction time to anger (P = 0.03), lower emotion recognition accuracy (P = 0.05), and higher over-identification of the threat to neutral and nonthreatening faces. However, the Stroop effect was not demonstrated across the groups. No group difference was seen in the performance on the visuospatial working memory tasks. Lower focused attention was significantly correlated with higher emotional threat perception (ETP; P = 0.001) in the SAD group. Conclusion: People with SAD have greater deficits in attention processing and ETP. The attention deficits were associated with enhanced ETP in social anxiety. The link between threat perception and cognitive functions would aid in a better understanding of SAD and in planning appropriate intervention.

It takes two: An antenatal to postnatal RDoC framework for investigating the origins of maternal attachment and mother–infant social communication

Transformation of the maternal–fetal relationship into the mother–infant relationship remains an enigmatic process. This progression is considered using a Research Domain Criteria (RDoC) informed approach centered on domains of Arousal/Regulation, Positive/Negative Valence, and Social Processes. One hundred and fifty-eight maternal–fetal dyads began participation during pregnancy, maternal–infant dyads were followed at 6 months postpartum. Women exhibited stability in feelings of attachment to the fetus and infant, and in positive/negative appraisal of pregnancy and motherhood. Elicited maternal physiological arousal to emotionally evocative videos generated fetal heart rate variability and motor activity responses. Parasympathetic (i.e., heart rate variability) suppression in the fetus was associated with more positive and regulated infant social communication in the Face-to-Face Still Face protocol; suppression of maternal respiratory sinus arrhythmia was related to infant affect but in the opposite direction. Maternal ratings of infant temperament aligned with maternal antenatal affective valence. Attachment trajectories characterized by stability from antenatal to postnatal periods were most associated with maternal affective appraisal of pregnancy; shifts were influenced by infant characteristics and maternal sympathetic responsivity. Results illustrate how variation in arousal and regulatory systems of the pregnant woman and fetus operate within the context of maternal positive and negative valence systems to separately and jointly shape affiliation and temperament in early infancy.

An Experimental Medicine Investigation of the Effects of Subacute Pramipexole Treatment on Emotional Information Processing in Healthy Volunteers

Treatment with the dopamine D2/D3 receptor agonist pramipexole has demonstrated promising clinical effects in patients with depression. However, the mechanisms through which pramipexole might alleviate depressive symptoms are currently not well understood. Conventional antidepressant drugs are thought to work by biasing the processing of emotional information in favour of positive relative to negative appraisal. In this study, we used an established experimental medicine assay to explore whether pramipexole treatment might have a similar effect. Employing a double-blind, parallel-group design, 40 healthy volunteers (aged 18 to 43 years, 50% female) were randomly allocated to 12 to 15 days of treatment with either pramipexole (at a peak daily dose of 1.0 mg pramipexole salt) or placebo. After treatment was established, emotional information processing was assessed on the neural level by measuring amygdala activity in response to positive and negative facial emotional expressions, using functional magnetic resonance imaging (MRI). In addition, behavioural measures of emotional information processing were collected at baseline and on drug, using an established computerized task battery, tapping into different cognitive domains. As predicted, pramipexole-treated participants, compared to those receiving placebo, showed decreased neural activity in response to negative (fearful) vs. positive (happy) facial expressions in bilateral amygdala. Contrary to our predictions, however, pramipexole treatment had no significant antidepressant-like effect on behavioural measures of emotional processing. This study provides the first experimental evidence that subacute pramipexole treatment in healthy volunteers modifies neural responses to emotional information in a manner that resembles the effects of conventional antidepressant drugs.

Web-scraping the Expression of Loneliness during COVID-19

We investigated the subjective experience of loneliness during COVID-19 by analyzing social media postings from March 2020 to January 2021. We collected text data from loneliness-related subgroups of Reddit and sampled 12787 posts that were written in ten consecutive days from each month. The results suggest that when individuals express their loneliness, they show an internal focus of attention on their emotions, desires, and cognitive appraisals rather than an external focus of attention on situations or other people. Linguistic markers of emotions expressed by lonely individuals included depression, anxiety, anger, hate, helplessness, and sadness. Also, loneliness-related topics were generally about their internal states pertinent to various social relationships, interpersonal interaction deficits, and their own lives in broad time perspectives. COVID-19 related loneliness was associated with negative appraisal of one’s situation and reaching out for new relationships online.

N-effects are not-P-effects

This paper analyzes pronominal competition and its pragmatic consequences in Scottish Gaelic (Celtic). In cases of competition cross-linguistically, use of a particular pronoun can trigger pragmatic effects like negative appraisal (N-effects). Although Scottish Gaelic exhibits a superficially similar pattern of competition and negative appraisal, I show that existing accounts based on referential potential (Sichel and Wiltschko 2020) and structure (Patel-Grosz and Grosz 2017) are unable to capture the Scottish Gaelic pattern. Instead, I argue that negative appraisal in Scottish Gaelic stems from the absence of positive appraisal, signaled via use of exempt anaphors. Following Charnavel (2020), I propose that exempt anaphors are anteceded by a null prolog introduced by a logophoric operator, which requires its complement to be evaluated from the perspective of prolog’s antecedent. By using an exempt anaphor, a speaker adopts the perspective of the pronoun’s referent, indicating positive appraisal since they are willing to take the referent’s point of view. Yet when a speaker chooses not to use an exempt anaphor, they refuse to make this perspective shift, which translates as negative appraisal. Apparent N-effects in Scottish Gaelic are, then, better characterized as not-P-effects.