Phytolaserophoresis as Integrative Approach to the Treatment of Chronic Internal Organs Diseases

10.12737/5764 ◽  
2014 ◽  
Vol 8 (1) ◽  
pp. 1-7
Author(s):  
Касаева ◽  
E. Kasaeva ◽  
Купеев ◽  
R. Kupeev ◽  
Купеев ◽  
...  
Keyword(s):  
Self Regulation ◽  
The Body ◽  
Integrative Approach ◽  
Therapeutic Effects ◽  
Primary Role ◽  
Endocrine Regulation ◽  
Material Resources ◽  
Non Invasive ◽  
Regulatory Functions

This article describes the development history and basic principles of a modern therapy method - phytolaserophoresis. It provides complex treating impact on chronic diseases, taking into account additional pathogenic disorders of nerve and endocrine regulation. Data analysis of patients with various internal chronic pathologies, revealed the primary role of osteochondrosis and other degenerative disc diseases in maintaining chronic pathological processes. Osteochondrosis doesn’t an isolated problem of the musculoskeletal system, it leads to hypoxia of the brain, the excitement of sub-cortical centers of self-regulation and, as a consequence, in violation of the nervous and endocrine regulation. Treatment by means of phytolaserophoresis method implies soft methods of therapeutic effects on central and peripheral factors to chronic disease. After normalization of the regulatory functions of the body, against the background of recovery of homeostasis and microcirculation in organs, the targeted therapeutic effect at the site of the problem becomes more efficient and can achieve a significant improvement and long-term remission. Advantages of the technique are its non-invasive, absence side effects, available technical and material resources and the possibility of applying the method in medical establishments of any capacity.

scholarly journals How stimulation frequency and intensity impact on the long-lasting effects of coordinated reset stimulation

2017 ◽  
Author(s):  
Thanos Manos ◽  
Magteld Zeitler ◽  
Peter A. Tass
Keyword(s):  
Clinical Studies ◽  
Computational Study ◽  
Stimulation Frequency ◽  
Therapeutic Effects ◽  
Neuronal Synchronization ◽  
Neuronal Synchrony ◽  
Non Invasive ◽  
Stimulation Parameters ◽  
Coordinated Reset

AbstractSeveral brain diseases are characterized by abnormally strong neuronal synchrony. Coordinated Reset (CR) stimulation was computationally designed to specifically counteract abnormal neuronal synchronization processes by desynchronization. In the presence of spike-timing-dependent plasticity (STDP) this may lead to a decrease of synaptic excitatory weights and ultimately to an anti-kindling, i.e. unlearning of abnormal synaptic connectivity and abnormal neuronal synchrony. The long-lasting desynchronizing impact of CR stimulation has been verified in pre-clinical and clinical proof of concept studies. However, as yet it is unclear how to optimally choose the CR stimulation frequency, i.e. the repetition rate at which the CR stimuli are delivered. This work presents the first computational study on the dependence of the acute and long-term outcome on the CR stimulation frequency in neuronal networks with STDP. For this purpose, CR stimulation was applied with Rapidly Varying Sequences (RVS) as well as with Slowly Varying Sequences (SVS) in a wide range of stimulation frequencies and intensities. Our findings demonstrate that acute desynchronization, achieved during stimulation, does not necessarily lead to long-term desynchronization after cessation of stimulation. By comparing the long-term effects of the two different CR protocols, the RVS CR stimulation turned out to be more robust against variations of the stimulation frequency. However, SVS CR stimulation can obtain stronger anti-kindling effects. We revealed specific parameter ranges that are favorable for long-term desynchronization. For instance, RVS CR stimulation at weak intensities and with stimulation frequencies in the range of the neuronal firing rates turned out to be effective and robust, in particular, if no closed loop adaptation of stimulation parameters is (technically) available. From a clinical standpoint, this may be relevant in the context of both invasive as well as non-invasive CR stimulation.Author SummaryAbnormally strong neuronal synchronization is found in a number of brain disorders. To specifically counteract abnormal neuronal synchrony and, hence, related symptoms, Coordinated Reset (CR) stimulation was developed. CR stimulation employs basic plasticity and dynamic self-organization principles of the nervous system. Its fundamental goal is to induce long-lasting desynchronizing effects that persist cessation of stimulation. The latter are key to reducing side effects of invasive therapies such as deep brain stimulation. Furthermore, sustained stimulation effects pave the way for non-invasive neuromodulation treatments, where a few hours of stimulation delivered regularly or occasionally may provide substantial relief. Long-lasting CR-induced desynchronizing therapeutic effects have been verified in several pre-clinical and clinical studies. However, we here present the first computational study that systematically investigates the impact of key stimulation parameters on the stimulation outcome. Our results provide experimentally testable predictions that are relevant for pre-clinical and clinical studies. Furthermore, our results may contribute to stimulation techniques that enable to probe the functional role of brain rhythms in general.

scholarly journals Urinary nucleic acids can be concentrated, dried on membranes and stored at room temperature in vacuum bags

2014 ◽  
Author(s):  
Fanshuang Zhang ◽  
Yuan Yuan ◽  
Jianqiang Wu ◽  
Youhe Gao
Keyword(s):  
Nucleic Acids ◽  
Large Scale ◽  
Room Temperature ◽  
Invasive Disease ◽  
The Body ◽  
Clinical Samples ◽  
Good Source ◽  
Disease Biomarkers ◽  
Non Invasive

Urine accumulates traces of changes that occur in the body and can potentially serve as a better biomarker source. Urinary nucleic acids are a promising class of non-invasive disease biomarkers. However, long-term frozen human urine samples are not a good source for the extraction of nucleic acids. In this paper, we demonstrate that urinary nucleic acids can be concentrated, dried on membranes and stored in vacuum bags at room temperature for several months. The amount of total RNA on the membranes after storage at room temperature for three months was unchanged. The levels of miR-16 and miR-21 exhibited no significant differences (P = 0.564, 0.386). This simple and economical method makes the large-scale storage of clinical samples of urinary nucleic acids possible.

scholarly journals Long term EIT based compliance monitoring in COVID-19 patients

2021 ◽  
Vol 7 (2) ◽  
pp. 323-326
Author(s):  
Imanol Isasa Reinoso ◽  
Rongqing Chen ◽  
András Lovas ◽  
Knut Moeller
Keyword(s):  
Electrical Impedance ◽  
Disease Diagnosis ◽  
The Body ◽  
Respiratory Complications ◽  
Impedance Tomography ◽  
Non Invasive ◽  
Phenotype Classification ◽  
Continuous Technology

Abstract The COVID-19 is a viral infection that causes respiratory complications. Infected lungs often present ground glass opacities, thus suggesting that medical imaging technologies could provide useful information for the disease diagnosis, treatment, and posterior recovery. The Electrical Impedance Tomography (EIT) is a non-invasive, radiationfree, and continuous technology that generates images by using a sequence of current injections and voltage measurements around the body, making it very appropriate for the study to monitor the regional behaviour of the lung. Moreover, this tool could also be used for a preliminary COVID-19 phenotype classification of the patients. This study is based on the monitoring of lung compliances of two COVID-19-infected patients: the results indicate that one of them could belong to the H-type, while the other is speculated belongs to L-type. It has been concluded that the EIT is a useful tool to obtain information regarding COVID-19 patients and could also be used to classify different phenotypes.

New possibilities in the treatment of uterine body myomas – HIFU-technology

2017 ◽  
pp. 47-51
Author(s):  
T.M. Kozarenko ◽  
◽  
I.Yu. Karacharova ◽  
V.N. Goncharenko ◽  
A.N. Klyusov ◽  
...  
Keyword(s):  
Clinical Symptoms ◽  
The Body ◽  
Uterine Myoma ◽  
Long Term Results ◽  
Clinical Material ◽  
General Effect ◽  
Non Invasive ◽  
Ultrasound Ablation ◽  
Clinically Significant

The technology of HIFU-ablation has a number of advantages in comparison with other methods of treatment of patients with uterine myoma, since it is non-invasive, organ-preserving, has no clinically significant general effect on the body, is not accompanied by a long period of rehabilitation and temporary disability. The objective: was to increase the effectiveness of treatment of women with uterine myoma by optimizing the protocols of ultrasound ablation. Patients and methods. The clinical material consisted of 90 remote ultrasound ablations for women diagnosed with «symptomatic myoma of the uterus body», which were performed at KMECC, the Center for Nuclear Medicine. The procedure was carried out on a JC apparatus (manufactured by: Chongqing Haifu (HIFU) Technology Co., Ltd., China). Results. The power during treatment was 350±70 W, the total energy was 282 487±47 650 J, the average time of insonation was 765±137 s. With dynamic observation, the regression of the volume of myoma nodes on average averaged 25±14.6% after 1 month, 33±12.9% after 3 months, and 61±17.8% after 6 months. But 4 (9,7%) patients had an unsatisfactory effect after the procedure, and the treatment was continued. All patients recorded a decrease in clinical symptoms already in the first month after the procedure. When the procedure was performed, 5 (12.2%) patients had a first-degree skin burn, 14 (34.1%) women had a short-term increase in body temperature to 37.6°C on the day of the procedure, which stabilized independently in for 3 days, in 1 (2.4%) – cystitis. The conclusion. The method is selective, does not damage surrounding tissues, thereby being safe for the endometrium, which is important for maintaining fertility. The area of fibrosis, which is formed after treatment and the regression process of the myoma node, is safe for further gestation. For the clinical evaluation of this method, its impact on the quality of life, immediate and long-term results, further accumulation and analysis of the clinical material is necessary. Key words: uterine myoma, local adenomyosis, ultrasonic ablation, HIFU-technology, treatment.

ASSESSMENT OF STRESS LEVELS DURING PROLONGED EXPOSURE TO AN IRRITANT ON THE BODY

2020 ◽  
pp. 114-121
Author(s):  
Виктория Эдуардовна Безносова ◽  
Ирина Анатольевна Аполлонова ◽  
Александр Петрович Николаев
Keyword(s):  
Heart Rate ◽  
Emotional Disorders ◽  
Prolonged Exposure ◽  
Analysis Data ◽  
The Body ◽  
Large Cities ◽  
Non Invasive ◽  
Medical Centers ◽  
Prolonged Stress

В современном мире большинство жителей крупных городов подвергается постоянному стрессу. При длительном воздействии стрессора на организм адаптационная энергия исчерпывается, вследствие чего возникает риск развития тяжелых заболеваний. Перманентный стресс может спровоцировать ряд нарушений со стороны кровеносной, иммунной, репродуктивной систем, ЖКТ, метаболических процессов, привести к психоэмоциональным нарушениям. На сегодняшний день не существует системы регистрации длительного стресса, которая была бы полезна для психологических и медицинских центров для более качественного отслеживания состояния здоровья пациента и для более точного подбора вида реабилитации. В статье представлено описание стадий развития стресса, приведены возможные последствия длительного стресса на организм, инвазивные и неинвазивные методы регистрации уровня стресса, обоснован выбор устройства для системы регистрации длительного стресса, представлена система регистрации уровня стресса при длительном воздействии стрессора на организм. Система состоит из следующих блоков: пульсометр (устройство, регистрирующее ЧСС), сервер (хранение, обработка, анализ данных), мобильное устройство, компьютеры, пользователь, врачи и психологи (медицинские и психологические центры). Создание безопасной, защищенной, доступной системы, которая включает в себя точный сбор данных, грамотную программу анализа, обработки данных, качественное соединение и обратную связь, позволит людям своевременно выявлять истощение организма и предотвращать различные заболевания Nowadays most people are constantly stressed, especially those who live in large cities. With prolonged exposure to the stressor on the body adaptive energy is exhausted, and there is a risk of developing of serious diseases as a result. Permanent stress can provoke a number of disorders from the circulatory, immune and reproductive systems, gastrointestinal tract, metabolic processes, and lead to psycho-emotional disorders. Now there is no system for recording long-term stress that would be useful for psychological and medical centers for better monitoring of the patient’s health and for more accurate selection of the type of rehabilitation. This article describes the stages of stress development, provides the possible consequences of prolonged stress on the body, invasive and non-invasive methods for recording the level of stress, it also justifies the choice of a device for the registration of long-term stress and provides a system for recording the level of stress with prolonged exposure to the stressor on the body. The system consists of the following blocks: a heart rate monitor (a device that records heart rate), a server (storage, processing, data analysis), a mobile device, computers, a user, doctors and psychologists (medical and psychological centers). The creation of a safe, secure, affordable system, which includes accurate data collection, a competent program of analysis, data processing, high-quality connection and feedback, will allow people to detect exhaustion and prevent various diseases in time

scholarly journals Transdermal delivery of Non-Steroidal Anti-Inflammatory Drugs (NSAIDs): a mini review

2020 ◽  
Vol 4 (2) ◽  
Author(s):  
Raditya Weka Nugraheni
Keyword(s):  
Drug Administration ◽  
Oral Route ◽  
The Body ◽  
Promising Alternative ◽  
Non Invasive ◽  
Gastrointestinal Side Effects ◽  
Inflammatory Drugs ◽  
Foreign Materials ◽  
Transdermal Route

The transdermal route has several advantages over the oral route, especially for the drugs which significantly experience the first-pass effect in the liver. Another advantage of drug administration via the transdermal route is its non-invasive way and can be used by patients themselves. Also, it allows long-term use, thereby increasing patient compliance and is generally inexpensive. The development of transdermal preparation itself is not easy because of the permeability factor of drug ingredients through the skin is relatively low compared to the gastrointestinal route or mucous membrane because the skin is part of the body's defense system and prevents foreign materials to entering the body. The biggest challenge for drug administration via the transdermal route is that the limitations of drugs can be administrated through this route. NSAIDs are drugs that are widely used in chronic conditions and can cause serious gastrointestinal side effects. Therefore the transdermal route is expected to be a promising alternative in the future. The drug-loaded nanoparticle delivered using the iontophoresis method can improve the bioavailability of NSAIDs via the transdermal route.

scholarly journals Urinary nucleic acids can be concentrated, dried on membranes and stored at room temperature in vacuum bags

2014 ◽  
Author(s):  
Fanshuang Zhang ◽  
Yuan Yuan ◽  
Jianqiang Wu ◽  
Youhe Gao
Keyword(s):  
Nucleic Acids ◽  
Large Scale ◽  
Room Temperature ◽  
Invasive Disease ◽  
The Body ◽  
Clinical Samples ◽  
Good Source ◽  
Disease Biomarkers ◽  
Non Invasive

Urine accumulates traces of changes that occur in the body and can potentially serve as a better biomarker source. Urinary nucleic acids are a promising class of non-invasive disease biomarkers. However, long-term frozen human urine samples are not a good source for the extraction of nucleic acids. In this paper, we demonstrate that urinary nucleic acids can be concentrated, dried on membranes and stored in vacuum bags at room temperature for several months. The amount of total RNA on the membranes after storage at room temperature for three months was unchanged. The levels of miR-16 and miR-21 exhibited no significant differences (P = 0.564, 0.386). This simple and economical method makes the large-scale storage of clinical samples of urinary nucleic acids possible.

scholarly journals Catheter Ablation in Persistent AF, the Evolution towards a More Pragmatic Strategy

2021 ◽  
Vol 10 (18) ◽  
pp. 4060
Author(s):  
Louisa O’Neill ◽  
Jean-Yves Wielandts ◽  
Kris Gillis ◽  
Gabriela Hilfiker ◽  
Jean-Benoit Le Polain De Waroux ◽  
...  
Keyword(s):  
Catheter Ablation ◽  
Large Scale ◽  
The Body ◽  
Success Rates ◽  
Meaningful Improvement ◽  
Non Invasive ◽  
Technological Advances ◽  
Mapping Techniques ◽  
Catheter Technology

Atrial fibrillation (AF) is the most common cardiac arrhythmia worldwide and represents a heterogeneous disorder with a complex pathological basis. While significant technological advances have taken place over the last decade in the field of catheter ablation of AF, response to ablation varies and long-term success rates in those with persistent AF remain modest. Mechanistic studies have highlighted potentially different sustaining factors for AF in the persistent AF population with substrate-driven focal and re-entrant sources in the body of the atria identified on invasive and non-invasive mapping studies. Translation to clinical practice, however, remains challenging and the application of such mapping techniques to clinical ablation has yet to demonstrate a significant benefit beyond pulmonary vein isolation (PVI) alone in the persistent AF cohort. Recent advances in catheter and ablation technology have centered on improving the durability of ablation lesions at index procedure and although encouraging results have been demonstrated with early studies, large-scale trials are awaited. Further meaningful improvement in clinical outcomes in the persistent AF population requires ongoing advancement in the understanding of AF mechanisms, coupled with continuing progress in catheter technology capable of delivering durable transmural lesions.

scholarly journals CONTROL OF FINE MOTOR SKILLS IN WOMEN ENGAGED IN RECREATIONAL PHYSICAL CULTURE: BILATERAL INDICATORS

2021 ◽  
pp. 129-138
Author(s):  
Ashot Chatinyan ◽  
Elena Hakobyan
Keyword(s):  
Negative Impact ◽  
Self Regulation ◽  
Movement Control ◽  
The Elderly ◽  
The Body ◽  
Fine Motor ◽  
Physical Culture ◽  
Reduced Mobility ◽  
Health Care Safety

The issue of studying the features of movement control among elderly people and the disclosureof ways to reduce the negative impact of involutional processes on the body functions areup-to-dateand relevant in terms of ensuring long-term health care safety and wellbeingfor the population in that age group. The reduced mobility of central nervous system forces older people to spend more time preparing, organizing and managing their own actions. First of all, self-regulation processes of the finest movements weaken: the elderly become unable to effectively control the movements of hands and especially fingers. In this regard, the issue of studying the influenceof recreational physical cultureon the indicators of fine movements control among the elderly is of scientific interest.

scholarly journals Using invasive and non-invasive methods to evaluate the therapeutic effect of dielectric barrier discharge (DBD) Plasma in skin graft surgery

2021 ◽  
Vol 3 (SI3) ◽  
pp. first
Author(s):  
Ngo Thi Minh Hien ◽  
Do Tuyet Nhi ◽  
Nguyen Quoc Duy Nam ◽  
Vo Duong Van Anh ◽  
Nguyen Duy Phuong ◽  
...  
Keyword(s):  
Wound Healing ◽  
Human Skin ◽  
Skin Graft ◽  
Evaluation Methods ◽  
Healing Time ◽  
The Body ◽  
Therapeutic Effects ◽  
Dbd Plasma ◽  
Dielectric Barrier ◽  
Non Invasive

Skin graft is effective method to reconstruct large lesions on the skin. Long-term injuries such as burns, skin ulcers, skin flaps, skin grafts... can affect the health of the patient. Skin plays a very important role because it protects the body from dehydration, helps regulate temperature, helps prevent pathogenic bacteria or viruses from entering the body and minimizes skin deformation. In recent years the cold plasma has been used to aid the treatment of chronic skin wounds, burns, ulcers,... To assess the effectiveness of the wound healing process of Plasma, this study uses non – invasive (assess the shrinkage of the wound, the temperature change of the wound) and invasive methods (regeneration of skin tissue structure) to evaluate the therapeutic effects of Dielectric Barrier Dissections Plasma (DBD Plasma) in skin graft surgery. Experimenting with the entire skin graft model on mice, this use of DBD Plasma treatment along with clinical evaluation methods, this is to compare wound healing time between wounds treated with plasma DBD and untreated wound. After 21 days of experimentation, evaluation methods and results processing tools, it was shown that wound healing of skin lesions on mice of the wound area treated with DBD Plasma faster than nontreatment about: (1) The surface shrinkage rate is about 25%; (2) The average wound temperature is less than 0.5-1oC; (3) Healing time is faster from 5 to 6 days. Therefore, DBD Plasma is able to be a potential treatment for wound healing combined with skin graft surgery in the future. The initial study of DBD model is the premise from which could be broader in other animals such as rabbits and pigs with skin structure closer to the human skin. And further, the DBD Plasma shows the potential for preclinical application to human skin graft.

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