The Protective Effects of Green Tea and Curcumin against 2, 3, 7, 8-Tetrachlorodibenzo-P-Dioxin (TCDD) Induced Hepatotoxiciy in Adult Male Mice = الدور الوقائي للشاي الأخضر والكركم ضد سمية الكبد في ذكور الفئران البيضاء المستحث بواسطة 2-3-7-8 تتراكلوربينزو بدايوكسين

2017 ◽  
Vol 68 ◽  
pp. 37-54
Author(s):  
Hanem S. Abdel-Tawab ◽  
Abdallah B. Mahmoude ◽  
Mona M. Attya
Keyword(s):  
Green Tea ◽  
Adult Male ◽  
Protective Effects ◽  
Male Mice ◽  
Tetrachlorodibenzo P Dioxin

scholarly journals The Potent Humanin Analogue (HNG) Protects Germ Cells and Leucocytes While Enhancing Chemotherapy-Induced Suppression of Cancer Metastases in Male Mice

Endocrinology ◽  
2015 ◽  
Vol 156 (12) ◽  
pp. 4511-4521 ◽  
Author(s):  
YanHe Lue ◽  
Ronald Swerdloff ◽  
Junxiang Wan ◽  
Jialin Xiao ◽  
Samuel French ◽  
...  
Keyword(s):  
Stem Cells ◽  
Germ Cells ◽  
Adult Male ◽  
Lung Metastases ◽  
Sperm Count ◽  
Cell Types ◽  
Spermatogonial Stem Cells ◽  
Protective Effects ◽  
Male Mice ◽  
Cancer Metastases

Humanin is a peptide that is cytoprotective against stresses in many cell types. We investigated whether a potent humanin analogue S14G-humanin (HNG) would protect against chemotherapy-induced damage to normal cells without interfering with the chemotherapy-induced suppression of cancer cells. Young adult male mice were inoculated iv with murine melanoma cells. After 1 week, cancer-bearing mice were randomized to receive either: no treatment, daily ip injection of HNG, a single ip injection of cyclophosphamide (CP), or CP+HNG and killed at the end of 3 weeks. HNG rescued the CP-induced suppression of leucocytes and protected germ cell from CP-induced apoptosis. Lung metastases were suppressed by HNG or CP alone, and further suppressed by CP+HNG treatment. Plasma IGF-1 levels were suppressed by HNG with or without CP treatment. To investigate whether HNG maintains its protective effects on spermatogonial stem cells, sperm output, and peripheral leucocytes after repeated doses of CP, normal adult male mice received: no treatment, daily sc injection of HNG, 6 ip injections of CP at 5-day intervals, and the same regimens of CP+HNG and killed at the end of 4 weeks of treatment. Cauda epididymal sperm counts were elevated by HNG and suppressed by CP. HNG rescued the CP-induced suppression of spermatogonial stem cells, sperm count and peripheral leucocytes. We conclude that HNG 1) protects CP-induced loss of male germ cells and leucocytes, 2) enhances CP-induced suppression of cancer metastases, and 3) acts as a caloric-restriction mimetic by suppressing IGF-1 levels. Our findings suggest that humanin analogues may be promising adjuvants to chemotherapy.

scholarly journals Effect of Black and Green Tea on Experimental Sodium Oxalate-Induced Nephrotoxicity in Adult Male Mice

2019 ◽  
Vol 42 (2) ◽  
pp. 358-368
Author(s):  
Hussein Ibrahim ◽  
Abd El Ghany Moustafa ◽  
Hassan Elgebaly
Keyword(s):  
Green Tea ◽  
Adult Male ◽  
Sodium Oxalate ◽  
Male Mice

Growth hormone deficiency and excess alter the gut microbiome in adult male mice

2020 ◽  
Author(s):  
Jensen EA ◽  
Young JA ◽  
Jackson Z ◽  
Busken J ◽  
List EO ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Growth Hormone Deficiency ◽  
Adult Male ◽  
Gut Microbiome ◽  
Hormone Deficiency ◽  
Male Mice

Protective Effects of Green Tea Seed Extract against UVB-irradiated Human Skin Fibroblasts

2014 ◽  
Vol 43 (1) ◽  
pp. 1-8 ◽  
Author(s):  
Ok Kyung Kim ◽  
Da-Eun Nam ◽  
Min-Jae Lee ◽  
Namgil Kang ◽  
Jae-Youn Lim ◽  
...  
Keyword(s):  
Human Skin ◽  
Green Tea ◽  
Seed Extract ◽  
Skin Fibroblasts ◽  
Protective Effects ◽  
Human Skin Fibroblasts

Effect of Hematopoietic Stem Cells and Platelet-Rich Plasma on the Healing of Experimental Skin Burned Tissues: A Comparative Study in Adult Male Mice

2019 ◽  
Vol 42 (3) ◽  
pp. 740-754
Author(s):  
Heba Saad Eldien ◽  
Nashwa Mostafa ◽  
Ola Abd ElTawab ◽  
Hussein Hassan ◽  
Tarek Abd Elhamid ◽  
...  
Keyword(s):  
Stem Cells ◽  
Comparative Study ◽  
Hematopoietic Stem Cells ◽  
Adult Male ◽  
Platelet Rich Plasma ◽  
Male Mice ◽  
Hematopoietic Stem

The Protective Effects of Green Tea Catechins in the Management of Neurodegenerative Diseases: A Review

2019 ◽  
Vol 16 (1) ◽  
pp. 57-65 ◽  
Author(s):  
Tahereh Farkhondeh ◽  
Hanieh Shaterzadeh Yazdi ◽  
Saeed Samarghandian
Keyword(s):  
Neurodegenerative Diseases ◽  
Signaling Pathways ◽  
Green Tea ◽  
Molecular Mechanisms ◽  
Main Role ◽  
Related Factor ◽  
Protective Effects ◽  
Tea Catechins ◽  
Green Tea Catechins ◽  
And Control

Background: The therapeutic strategies to manage neurodegenerative diseases remain limited and it is necessary to discover new agents for their prevention and control. Oxidative stress and inflammation play a main role in the pathogenesis of neurodegenerative diseases. The aim of this study is to review the effects of green tea catechins against the Neurodegenerative Diseases. Methods: In this study, we extensively reviewed all articles on the terms of Green tea, catechins, CNS disorders, and different diseases in PubMed, Science Direct, Scopus, and Google Scholar databases between the years 1990 and 2017. Results: The present study found that catechins, the major flavonoids in green tea, are powerful antioxidants and radical scavengers which possess the potential roles in the management of neurodegenerative diseases. Catechins modulate the cellular and molecular mechanisms through the inflammation-related NF-&amp;#954;B and the nuclear factor erythroid 2-related factor 2 (Nrf2) signaling pathways. Conclusion: The findings of the present review shows catechins could be effective against neurodegenerative diseases due to their antioxidation and anti-inflammation effects and the involved biochemical pathways including Nrf2 and NF-kB signaling pathways.<P&gt;

The possible protective role of curcumin on the toxic effect of nicotine in the lung of adult male mice

2012 ◽  
Vol 35 (4) ◽  
pp. 805-811
Author(s):  
Dorria A.M. Zaghloul ◽  
Esam Salah Kamel ◽  
Hekmat O. Abd el-Aziz ◽  
Mohammed A. Mahmoud
Keyword(s):  
Toxic Effect ◽  
Adult Male ◽  
Protective Role ◽  
Male Mice

scholarly journals Diisopropylfluorophosphate-induced status epilepticus drives complex glial cell phenotypes in adult male mice

2021 ◽  
Vol 152 ◽  
pp. 105276
Author(s):  
Clémence Maupu ◽  
Julie Enderlin ◽  
Alexandre Igert ◽  
Myriam Oger ◽  
Stéphane Auvin ◽  
...  
Keyword(s):  
Status Epilepticus ◽  
Glial Cell ◽  
Adult Male ◽  
Male Mice ◽  
Cell Phenotypes
Sign in / Sign up

Export Citation Format

Share Document