Higher quality maternal diet attenuates negative associations of maternal paraben concentrations with newborn weight and length

Aim: Nutritional vitamin B12 deficiency in infants may occur because the maternal diet contains inadequate animal products. Clinical presentations of the infants who had nutritional vitamin B12 deficiency were analyzed in this study. Subjects and Methods: Patients with nutritional vitamin B12 deficiency were enrolled in the study between 2003 and 2010. The diagnosis was based on a nutritional history of mothers and infants, clinical findings, hematological evaluation, and low level of serum vitamin B12. Results: Thirty children aged 1 - 21 months constituted the study group. Poverty was the main cause of inadequate consumption of animal products of the mothers. All infants had predominantly breastfed. The most common symptoms were developmental delay, paleness, apathy, lethargy, anorexia, and failure to thrive. Hematological findings were megaloblastic anemia (83.3 %), thrombocytopenia (30 %), and severe anemia (13.3 %). All of the mothers had low serum B12 levels; eight of them had megaloblastic anemia. Conclusion: The unusual clinical manifestations of vitamin B12 deficiency may also be seen apart from neurological and hematological findings. Nutritional vitamin B12 deficiency due to maternal deficiency might be a serious health problem in infants. Therefore, screening and supplementation of pregnant and lactating women to prevent infantile vitamin B12 deficiency should be considered.

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Maternal Diet in Rural Costa Rica: Identifying Cultural Norms and Changing Trends With Implications for the Developmental Origins of Obesity-Related Disorders

PsycEXTRA Dataset ◽

10.1037/e639972011-001 ◽

2010 ◽

Author(s):

Allison Cantor

Keyword(s):

Costa Rica ◽

Maternal Diet ◽

Cultural Norms ◽

Developmental Origins ◽

Changing Trends

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Effect of maternal diet on the amino acid composition of human uterine fluid

Reproduction Abstracts ◽

10.1530/repabs.1.p299 ◽

2014 ◽

Author(s):

Alexandra Jayne Kermack ◽

Ying Cheong ◽

Nick Brook ◽

Nick Macklon ◽

Franchesca D Houghton

Keyword(s):

Amino Acid ◽

Amino Acid Composition ◽

Acid Composition ◽

Maternal Diet ◽

Uterine Fluid

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Obstetrical and neonatal factors associated with optimal public banking of umbilical cord blood in the context of delayed cord clamping

Clinical & Investigative Medicine ◽

10.25011/cim.v42i3.33093 ◽

2019 ◽

Vol 42 (3) ◽

pp. E56-E63 ◽

Cited By ~ 1

Author(s):

Anna Munro ◽

Daniel J. Corsi ◽

Lisa Martin ◽

Michael Halpenny ◽

Nicholas Dibdin ◽

...

Keyword(s):

Cord Blood ◽

Umbilical Cord ◽

Umbilical Cord Blood ◽

Delayed Cord Clamping ◽

Factors Associated ◽

Cell Counts ◽

Cord Clamping ◽

Newborn Weight ◽

Cord Blood Banks

Purpose: To assess the association of specific newborn and maternal factors with indicators of increased blood-forming capacity in umbilical cord blood to inform strategic collection strategies that could augment the quality of units in public cord blood banks. Methods: Data regarding 268 consecutive cord blood units (CBUs) banked by Canadian Blood Services were analyzed. Multivariate analysis was performed to identify factors associated with markers of hematopoietic potency and likelihood of utilization. Results: Delayed clamping of the cord beyond 60 s was associated with reduced volume collected. Any delay in clamping of the cord was associated with reduced total nucleated cell counts. Newborn weight >4,000 g was also associated with greater blood volume in the collection but not with other measures of hematopoietic potency. Cord blood acidosis at birth (pH

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Faculty Opinions recommendation of Maternal diet and aging alter the epigenetic control of a promoter-enhancer interaction at the Hnf4a gene in rat pancreatic islets.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.9070956.9647054 ◽

2011 ◽

Author(s):

Michael Symonds

Keyword(s):

Pancreatic Islets ◽

Maternal Diet ◽

Epigenetic Control ◽

Rat Pancreatic Islets

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Diet and Contaminants: Driving the Rise to Obesity Epidemics?

Current Medicinal Chemistry ◽

10.2174/0929867324666170518095736 ◽

2019 ◽

Vol 26 (19) ◽

pp. 3471-3482 ◽

Cited By ~ 13

Author(s):

Agostino Di Ciaula ◽

Piero Portincasa

Keyword(s):

Dietary Habits ◽

Maternal Diet ◽

Critical Role ◽

Food Contaminants ◽

Obesity Epidemic ◽

Gene Environment ◽

Generational Transmission ◽

Modifiable Factors ◽

Toxic Food ◽

Diet And Lifestyle

The obesity epidemic is spreading worldwide without reversal trend and despite specific policies oriented to dietary habits and lifestyle, which seem to have modest effects. Genetic factors only partly explain the rise, whereas environmental factors seem to play a key role, mainly by gene-environment interactions through epigenetic mechanisms. A number of animal and human studies point to maternal diet, intestinal microbiota and chemicals introduced as contaminants with food, all factors able to increase the risk of obesity. Widely diffused toxics (mainly BPA, phthalates, pesticides) are able to promote obesity in children and adults, mainly by acting on the differentiation pathway linking multipotent stromal stem cell to mature adipocyte, modulating epigenetic factors and influencing a series of mechanisms finally leading to altered dietary habits, increased adipocyte formation and fat storage. Furthermore, the adipose tissue is an important target for several chemicals (mainly POPs) which represent a threat to metabolic health. In conclusion, besides excessive individual energy intake and inadequate lifestyle, other broadly diffused and modifiable factors (mainly ingestion of toxic chemicals with food) seem to have a critical role in the rapid epidemiological growing of obesity, also considering trans-generational transmission of risk and later development of obesity due to exposure during early life. Further studies are needed, to better assess interactions between cumulative effects of toxic food contaminants and modification of diet and lifestyle, and to verify the efficacy of primary prevention strategies acting on all these factors and potentially able to reverse the continuous rising of the obesity epidemic.

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Lifestyle, Maternal Nutrition and Healthy Pregnancy

Current Vascular Pharmacology ◽

10.2174/1570161118666200401112955 ◽

2020 ◽

Vol 19 (2) ◽

pp. 132-140

Author(s):

Alfonso Mate ◽

Claudia Reyes-Goya ◽

Álvaro Santana-Garrido ◽

Carmen M. Vázquez

Keyword(s):

Physical Activity ◽

Maternal Nutrition ◽

Muscle Tone ◽

Maternal Diet ◽

Perinatal Outcomes ◽

Psychosocial Health ◽

World Health ◽

Large For Gestational Age ◽

Moderate Physical Activity ◽

Healthy Pregnancy

: Healthy lifestyle habits spanning from preconception to postpartum are considered as a major safeguard for achieving successful pregnancies and for the prevention of gestational diseases. Among preconception priorities established by the World Health Organization (WHO) are healthy diet and nutrition, weight management, physical activity, planned pregnancy and physical, mental and psychosocial health. Most studies covering the topic of healthy pregnancies focus on maternal diet because obesity increases the risks for adverse perinatal outcomes, including gestational diabetes mellitus, large for gestational age newborns, or preeclampsia. Thus, foods rich in vegetables, essential and polyunsaturated fats and fibre-rich carbohydrates should be promoted especially in overweight, obese or diabetic women. An adequate intake of micronutrients (e.g. iron, calcium, folate, vitamin D and carotenoids) is also crucial to support pregnancy and breastfeeding. Moderate physical activity throughout pregnancy improves muscle tone and function, besides decreasing the risk of preeclampsia, gestational diabesity (i.e. diabetes associated with obesity) and postpartum overweight. Intervention studies claim that an average of 30 min of exercise/day contributes to long-term benefits for maternal overall health and wellbeing. Other factors such as microbiome modulation, behavioural strategies (e.g. smoking cessation, anxiety/stress reduction and sleep quality), maternal genetics and age, social class and education might also influence the maternal quality of life. These factors contribute to ensure a healthy pregnancy, or at least to reduce the risk of adverse maternal and foetal outcomes during pregnancy and later in life.

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Placental Transfer of Calcium and Strontium in the Rat and Rabbit

American Journal of Physiology-Legacy Content ◽

10.1152/ajplegacy.1957.189.1.91 ◽

1957 ◽

Vol 189 (1) ◽

pp. 91-97 ◽

Cited By ~ 53

Author(s):

R. H. Wasserman ◽

C. L. Comar ◽

M. M. Nold ◽

F. W. Lengemann

Keyword(s):

Steady State ◽

Urinary Excretion ◽

Fetal Development ◽

Placental Transfer ◽

Maternal Diet ◽

Late Pregnancy ◽

Placental Barrier ◽

Tracer Techniques ◽

Comparative Metabolism ◽

Differential Movement

The comparative metabolism of calcium and strontium during fetal development was investigated in rats and rabbits using double tracer techniques. In general, the placental transfer from dam to fetus of strontium was about one-half that of calcium; the site of discrimination was the placental barrier. The major discrimination occurred in movement of Ca* and Sr* from dam to fetus, with little or no differential movement from fetus to dam. Under steady state conditions in the rat the relative Sr*/Ca* ratios in the fetus, maternal skeleton and diet were 0.17, 0.28 and 1, respectively. The over-all discrimination of 0.17 between fetus and diet resulted from absorption (0.42), urinary excretion (0.63) and placental transfer (0.65). In the rat it was estimated that 92% of the fetal calcium had originated from the maternal diet. In the rabbit during late pregnancy, it was determined that about 24 mg of calcium/fetus/day moved across the placenta as compared with a need of about 13 mg for fetal development.

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