scholarly journals Influence of Serum Ferritin Combined with Blood Cadmium on Blood Pressure, and Hypertension: from the KNHNES

2021 ◽  
Vol 2021 (1) ◽  
Author(s):  
Jeoung A. Kwon ◽  
Eunjung Park ◽  
Seyoung Kim ◽  
Byungmi Kim
Keyword(s):  
Blood Pressure ◽  
Serum Ferritin ◽  
Blood Cadmium

scholarly journals Serum ferritin levels are associated with insulin resistance in Chinese men and post-menopausal women: the Shanghai Changfeng study

2018 ◽  
Vol 120 (8) ◽  
pp. 863-871 ◽  
Author(s):  
Hui Ma ◽  
Huandong Lin ◽  
Yu Hu ◽  
Xiaoming Li ◽  
Wanyuan He ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Blood Pressure ◽  
Serum Ferritin ◽  
Cell Function ◽  
Ferritin Level ◽  
Menopausal Status ◽  
Elevated Serum ◽  
Model Assessment ◽  
Menopausal Women ◽  
Post Menopausal

AbstractAssociations between ferritin and insulin sensitivity have been described in recent studies. The possible association showed conflicting results by sex and menopausal status. We aimed to investigate the cross-sectional association of ferritin levels with insulin resistance and β-cell function. A total of 2518 participants (1033 men, 235 pre-menopausal women and 1250 post-menopausal women) were enrolled from the Changfeng Study. A standard interview was conducted, as well as anthropometric measurements and laboratory analyses, for each participant. The serum ferritin level was measured using electrochemiluminescence immunoassay. Insulin resistance and β-cell function indices were derived from a homeostasis model assessment. The results showed that the serum ferritin levels were 250·4 (sd 165·2), 94·6 (sd 82·0) and 179·8 (sd 126·6) ng/ml in the men, pre-menopausal and post-menopausal women, respectively. In fully adjusted models (adjusting for age, current smoking, BMI, waist:hip ratio, systolic blood pressure, diastolic blood pressure, TAG, HDL-cholesterol, LDL-cholesterol, log urine albumin:creatinine ratio, leucocytes, alanine aminotransferase, aspartate aminotransferase and γ-glutamyl transpeptidase), serum ferritin concentrations are significantly associated with insulin resistance in men and post-menopausal females, and the null association was observed in pre-menopausal females. Interestingly, an increased β-cell function associated with higher ferritin was observed in post-menopausal participants, but not in male participants. In conclusion, these results suggested that elevated serum ferritin levels were associated with surrogate measures of insulin resistance among the middle-aged and elderly male and post-menopausal women, but not in pre-menopausal women.

scholarly journals Association between serum ferritin and the insulin resistance syndrome in a representative population

2006 ◽  
Vol 154 (2) ◽  
pp. 333-340 ◽  
Author(s):  
C E Wrede ◽  
R Buettner ◽  
L C Bollheimer ◽  
J Schölmerich ◽  
K-D Palitzsch ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Blood Pressure ◽  
Iron Overload ◽  
Serum Ferritin ◽  
Density Lipoprotein ◽  
Insulin Resistance Syndrome ◽  
German Population ◽  
Pathophysiological Mechanism ◽  
Causal Connection ◽  
Excessive Alcohol Consumption

Objective: Unexplained hepatic iron overload with increased serum ferritin (SF) values has been associated with the insulin resistance syndrome (IRS), defined by the presence of one or more of the following criteria: increased body mass index (BMI), diabetes, hyperlipidemia or hypertension. However, as yet the association between IRS and SF in a representative population has not been investigated. Methods: The study subjects participated in a nationwide epidemiological survey on metabolic disorders in the adult German population. The 1200 probands included in this study are representative of the German population. To eliminate major causes of secondary iron overload, 114 (9.5%) subjects with excessive alcohol consumption and 16 (1.5%) subjects with serological evidence for hepatitis B or C were excluded. For all remaining 1070 probands, complete clinical data of SF, HbA1c, known diabetes, BMI, cholesterol, high-density lipoprotein-cholesterol and blood pressure were available. Results: SF values were significantly increased in men and women with high BMI (> 25 kg/m2), increased cholesterol (> 200 mg/dl), and increased systolic (> 160 mmHg) blood pressure, in women with diabetes, and in men with increased diastolic (> 95 mmHg) blood pressure. Furthermore, there was a significant correlation between the number of IRS criteria and SF. Conclusions: This study shows a significant correlation between SF and the presence of IRS criteria in a large representative population. Interestingly, the severity of the IRS seems to be associated with increased SF levels suggesting a causal connection. Further studies are required to investigate the pathophysiological mechanism and consequences of increased SF levels in patients with IRS.

Non-occupational Lead and Cadmium Exposure and Blood Pressure in Thai Men

2004 ◽  
Vol 16 (2) ◽  
pp. 133-137 ◽  
Author(s):  
J. Sirivarasai ◽  
S. Kaojarern ◽  
W. Wananukul ◽  
W. Deechakwan ◽  
P. Srisomerarn
Keyword(s):  
Blood Pressure ◽  
Diastolic Blood Pressure ◽  
Stepwise Regression ◽  
Lead Concentration ◽  
Geometric Mean ◽  
Blood Lead ◽  
Lead And Cadmium ◽  
Blood Cadmium ◽  
The Mean ◽  
Blood Cadmium Levels

In this study, the effects of low level exposure to lead and cadmium on blood pressure among 212 men have been examined. The mean age was 41 years (range 34-53). The means of systolic and diastolic blood pressure were 126 (range 94-159) and 78 (range 58-117) mmHg, respectively. Blood lead concentration ranged from 144.31 to 779.34 ηmol/L with a geometric mean (GM) of 363.11 ηmol/L. Blood cadmium levels ranged from 1.33-37.81ηmol/L with GM of 8.09 ηmol/L. For stepwise regression analysis, an increase in systolic blood pressure was significantly predictive by an increasing blood lead ( p<0.001) whereas blood cadmium showed no significant correlation with blood pressure. Body mass index and alcohol consumption also contributed to both systolic and diastolic blood pressure. These findings also supported our proposal concerning the association between blood lead and blood pressure. Asia Pac J Public Health 2004; 16(2): 133-137.

scholarly journals Serum ferritin levels among schoolchildren and its correlation with lipid profile and adiposity

2021 ◽  
Vol 70 (3) ◽  
pp. 155-163
Author(s):  
Mariana Orta-Duarte ◽  
Rosa del Carmen Vázquez-Zapien ◽  
Hugo Ventura-Cisneros ◽  
Mario del Toro-Equihua ◽  
Benjamin Trujillo-Hernández ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Waist Circumference ◽  
Lipid Profile ◽  
Body Fat ◽  
Serum Ferritin ◽  
Overweight And Obesity ◽  
School Age Children ◽  
Body Fat Percentage ◽  
Fat Percentage ◽  
Grasa Corporal

To determine the association between serum ferritin levels, lipid profile and adiposity in school-age children. Methods: A cross-sectional study was conducted on obese and non-obese children. Weight, height, waist circumference and blood pressure were measured for all participants. Lipid profile, serum ferritin and glucose were determined and analysed through absorbance. The Spearman correlation was performed for the quantitative variables and a regression analysis was used to determine the interaction between variables. Eighty-nine children were included, with a median age of 9.0 years. Results: When comparing serum ferritin levels in normal weight group, vs. the overweight and obesity group, values were significantly higher in the latter. Serum ferritin correlated positively with BMI (Rho .282, p <0.01), waist circumference (Rho .372, p < 0.01), diastolic blood pressure (Rho .244, p < 0.05), body fat percentage (Rho .375, p < 0.001), insulin (Rho .254, p <.05) and sex (Rho .224, p <.05); and negatively with high-density lipoprotein cholesterol (Rho. -221, p< 0.05). When analysing the significant variables in a multivariate regression model, sex, body mass index, waist circumference, and body fat percentage remained statistically significant (p <0.01). Conclusion: We observed associations between serum ferritin and obesity in Mexican school aged children. Determinar la asociación entre los niveles de ferritina sérica, el perfil de lípidos y la adiposidad en niños en edad escolar. Metodología: Se realizó un estudio transversal en niños obesos y no obesos. Se midieron el peso, la altura, la circunferencia de cintura y la presión arterial en todos los participantes. El perfil lipídico, la ferritina sérica y la glucosa se determinaron y analizaron mediante absorbancia. Se realizó correlación de Spearman para las variables cuantitativas y se utilizó un análisis de regresión para determinar la interacción entre las variables. Se incluyeron ochenta y nueve niños, con una edad media de 9,0 años. Resultados: Al comparar los niveles de ferritina sérica en el grupo de peso normal, frente al grupo de sobrepeso y obesidad, los valores fueron significativamente más altos en este último. La ferritina sérica se correlacionó positivamente con el IMC (Rho 0,282, p <0,01), la circunferencia de cintura (Rho 0,372, p <0,01), la presión arterial diastólica (Rho 0,244, p <0,05), el porcentaje de grasa corporal (Rho 0,375, p < 0,001), insulina (Rho 0,254, p <0,05) y sexo (Rho 0,224, p < 0,05); y negativamente con colesterol de lipoproteínas de alta densidad (Rho -0,221, p <0,05). Al analizar las variables significativas en un modelo de regresión multivariante, el sexo, el índice de masa corporal, la circunferencia de cintura y el porcentaje de grasa corporal se mantuvieron estadísticamente significativos (p <0,01). Conclusión: Observamos asociaciones entre la ferritina sérica y la obesidad en niños mexicanos en edad escolar.

scholarly journals Sympathetic Overactivation in Patients With Essential Hypertension and Hepatic Iron Overload

Hypertension ◽  
2020 ◽  
Vol 76 (5) ◽  
pp. 1444-1450
Author(s):  
Gino Seravalle ◽  
Raffaella Dell’Oro ◽  
Fosca Quarti-Trevano ◽  
Domenico Spaziani ◽  
Silvio Bertoli ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Essential Hypertension ◽  
Iron Overload ◽  
Serum Ferritin ◽  
Sympathetic Nerve ◽  
Blood Pressure Variability ◽  
Elevated Serum ◽  
Hepatic Iron ◽  
Sympathetic Activation

Iron overload has been recently shown to be associated with a hyperadrenergic state in genetic hemochromatosis. Whether this is also the case in essential hypertension, characterized by sympathetic activation and frequently by body iron overload, is unknown. In 17 healthy normotensive controls (age 52.3±3.2 years, mean±SE), in 21 age-matched patients with hypertension with iron overload (HT+), defined by serum ferritin levels, and in 28 hypertensives without this condition, we measured efferent postganglionic muscle sympathetic nerve traffic (microneurography), heart rate and blood pressure variability (power spectral analysis), serum ferritin, and metabolic variables. Muscle sympathetic nerve traffic was significantly ( P <0.02 at least) greater in HT+ than in patients with hypertension without iron overload and normotensive subjects both when expressed as bursts incidence over time (41.8±1.4 versus 31.5±1.4 and 23.6±0.9 bursts/min) and as bursts corrected for heart rate (55.3±1.8 versus 42.3±1.2 and 31.7±1.2 bursts/100 heartbeats). In HT+, low-frequency systolic blood pressure variability was significantly reduced. In HT+, but not in the other 2 groups, muscle sympathetic nerve traffic was significantly related to serum ferritin ( r =0.51, P <0.03), transferrin saturation ( r =0.47, P <0.03), and hepatic iron load ( r =0.76, P <0.0001, magnetic resonance imaging), as well as to homeostatic model assessment index values ( r =0.46, P <0.05). These data provide the first evidence that in HT+ elevated serum ferritin is associated with a hyperadrenergic state of greater magnitude than the one seen in patients with hypertension without iron overload. They also show that the potentiation of the sympathetic activation detected in HT+ is related to elevated serum ferritin and to the associated metabolic alterations, possibly participating in the increased cardiovascular risk characterizing iron overload.

scholarly journals Relationship of heart rate variability with iron status in metabolic syndrome

2020 ◽  
Vol 15 (1) ◽  
pp. 46-53
Author(s):  
Halima Akter Munni ◽  
Shelina Begum
Keyword(s):  
Blood Pressure ◽  
Metabolic Syndrome ◽  
Heart Rate ◽  
Standard Deviation ◽  
Serum Ferritin ◽  
Iron Status ◽  
Rr Intervals ◽  
Rr Interval ◽  
Increased Risk ◽  
Relationship Of

Background: Clustering of some most dreadful cardiovascular risk factors gives rise to metabolic syndrome (MetS). Higher iron status and impaired cardiac autonomic status may important play role in increased risk of cardiovascular morbidity in this group of patients. Objective: To observe the relationship of HRV with iron status in patients with MetS. Methods: This cross-sectional study was conducted in the Department of Physiology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Shahbag, Dhaka from March, 2019 to February, 2020. For this study, 35 MetS female patients aged 25 to 45 years were enrolled in MetS group and equal number of age and sex matched apparently healthy subjects constituted control group. For evaluation of iron status, serum iron, serum ferritin, total iron binding capacity (TIBC) and transferrin saturation (Tsat) were measured by autoanalyzer. HRV was assessed by Powerlab 8/35, AD instruments, Australia. Data were expressed as mean±SD. Statistical analysis was done by Independent sample ‘t’ test and Pearson’s correlation coefficient test as applicable. Results: In this study, resting pulse rate, systolic blood pressure (SBP), diastolic blood pressure (DBP) were significantly (p<0.001) higher and mean heart rate, standard deviation of the RR intervals (SDRR),mean R-R interval, standard deviation of the difference betweensuccessive RR intervals (SDSD), square root of mean squared differences of successive RR intervals (RMSSD), proportion of difference of successive RR interval greater than 50 ms (pRR50) were significantly (p<0.001) lower in MetS patients compared to control. Among the parameters of iron status, serum ferritin was significantly (p£<0.05) higher and TIBCwas significantly(p<0.05) lower in MetS patients in comparison to control. On correlation analysis, only the TIBC showed significant positive correlation with mean RR interval, SDRR, CVRR, SDSD, RMSSD, pRR50 (p<0.05) in MetS patients. Conclusion: This study reveals that poor parasympathetic activity is related to higher iron status in metabolic syndrome patients. J Bangladesh Soc Physiol. 2020, June; 15(1): 46-53

scholarly journals Serum ferritin and blood pressure modulation in first-time and regular blood donors

2019 ◽  
pp. 1-10
Author(s):  
OV Osinkalu ◽  
AS Akanmu ◽  
AS Lawal-Folorunso
Keyword(s):  
Blood Pressure ◽  
Serum Ferritin ◽  
Blood Donors ◽  
Blood Donation ◽  
Enzyme Linked Immunosorbent Assay ◽  
Iron Store ◽  
Body Iron ◽  
Body Iron Store ◽  
First Time

Background: The health benefits of blood donation are well known. However, the overall effect of long term regular blood donation on body iron store and blood pressure need to be evaluated among voluntary blood donors. Objective: To determine the effect of long term, regular blood donation on body iron store and blood pressure among regular voluntary non-remunerated blood donors in Lagos, Nigeria. Methods: Consenting adult blood donors (n = 320), ranging from the first time to regular blood donors were studied over six months. Supine blood pressure (BP) readings were taken twice at 30 minutes interval with a mercury sphygmomanometer. Venous whole blood was drawn into EDTA anti-coagulated and plain tubes for haematological parameters and serum ferritin estimation using Enzyme-linked Immunosorbent Assay (ELISA) method. Results: The mean serum ferritin levels declined significantly from 95.5ng/mL among first time donors to 68.9ng/mL among Category III donors (p = 0.035). Male voluntary blood donors had increased risk of low serum ferritin level (OR = 5.02; 95%CI= 1.12-22.51; p = 0.035). Lower values of serum ferritin were recorded more frequently among donors within the 21-30 year age category (OR = 1.54; 95%CI = 1.0-2.71; p= 0.042). Long term regular voluntary blood donation was associated with significant reduction in mean systolic blood pressure (p = 0.01). Conclusion: Long term blood donation resulted in the reduction of blood pressure. Progressive increase in the duration of donation resulted in reduced iron stores even as haemoglobin concentration levels remained acceptable for blood donation.

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