Monitoring cardiovascular disease risk in individuals with severe mental illness in an inpatient mental health setting: a secondary data analysis

2020 ◽  
Vol 9 (3) ◽  
pp. 1-14
Author(s):  
Herbert P Mwebe ◽  
Margaret Volante ◽  
Tim Weaver

Background/Aims Life expectancy in people with lived experience of mental health conditions is reduced by up to 25 years; this is from preventable physical medical comorbidities and multi-morbidities such as cardiovascular disease, diabetes, cancers and smoking-related lung disease. Two-thirds of these deaths are avoidable if people with severe mental illness are offered prompt physical screening checks and monitoring. The aim of this article was to explore barriers to the management of cardiovascular disease risk on inpatient wards and make recommendations in relation to cardiovascular disease risk management in people with severe mental illness. Methods A structured MS Excel extraction data tool informed by best practice guidance was developed and used to extract electronic patient data on screening and monitoring of cardiovascular disease risk factors (blood pressure, smoking, alcohol, lipids, body mass index/weight, blood glucose level) across 10 inpatient psychiatric wards within one London mental health trust. A target sample of 245 electronic records of patients with severe mental illness discharged between 25 August 2018 and 13 February 2019 with length of inpatient stay >40 days was examined. Simple random sampling (MS Excel random number generator) was used to select a final sample of 120 electronic records. All the included samples had been prescribed psychotropic medication. Results Regarding patient demographics, there was an inverse correlation with age, with a greater proportion of inpatients being of a younger age: 51% aged 18–39 years compared with 14% aged 60–79 years. The study found an average of 71% compliance of the documentation of data on all individual parameters (smoking, alcohol, body mass index, blood pressure, serum glucose, serum lipids, electrocardiogram) at baseline. Results showed an average of 79% compliance for monitoring review at least once across the parameters within 3 months of admission. Conclusions It is recommended as a minimum for individuals with severe mental illness under the care of mental health services and/or taking psychotropic medication to have regular cardiometabolic risk assessment and management of risk at the point of entry into services and a review for weight, waist circumference, blood glucose checks, lipid profile, blood pressure, lifestyle choice behaviours and personal assessment of cardiovascular disease. Although progress is being made across provider services to implement the above, gaps in practice are still evident, as demonstrated in these findings.

2020 ◽  
Vol 15 (11) ◽  
pp. 1-15
Author(s):  
Herbert P Mwebe ◽  
Margaret Volante ◽  
Tim Weaver

Background/Aims Life expectancy in people with lived experience of mental health conditions is reduced by up to 25 years; this is from preventable physical medical comorbidities and multi-morbidities such as cardiovascular disease, diabetes, cancers and smoking-related lung disease. Two-thirds of these deaths are avoidable if people with severe mental illness are offered prompt physical screening checks and monitoring. The aim of this article was to explore barriers to the management of cardiovascular disease risk on inpatient wards and make recommendations in relation to cardiovascular disease risk management in people with severe mental illness. Methods A structured MS Excel extraction data tool informed by best practice guidance was developed and used to extract electronic patient data on screening and monitoring of cardiovascular disease risk factors (blood pressure, smoking, alcohol, lipids, body mass index/weight, blood glucose level) across 10 inpatient psychiatric wards within one London mental health trust. A target sample of 245 electronic records of patients with severe mental illness discharged between 25 August 2018 and 13 February 2019 with length of inpatient stay >40 days was examined. Simple random sampling (MS Excel random number generator) was used to select a final sample of 120 electronic records. All the included samples had been prescribed psychotropic medication. Results Regarding patient demographics, there was an inverse correlation with age, with a greater proportion of inpatients being of a younger age: 51% aged 18–39 years compared with 14% aged 60–79 years. The study found an average of 71% compliance of the documentation of data on all individual parameters (smoking, alcohol, body mass index, blood pressure, serum glucose, serum lipids, electrocardiogram) at baseline. Results showed an average of 79% compliance for monitoring review at least once across the parameters within 3 months of admission. Conclusions It is recommended as a minimum for individuals with severe mental illness under the care of mental health services and/or taking psychotropic medication to have regular cardiometabolic risk assessment and management of risk at the point of entry into services and a review for weight, waist circumference, blood glucose checks, lipid profile, blood pressure, lifestyle choice behaviours and personal assessment of cardiovascular disease. Although progress is being made across provider services to implement the above, gaps in practice are still evident, as demonstrated in these findings.


PLoS ONE ◽  
2019 ◽  
Vol 14 (9) ◽  
pp. e0221521 ◽  
Author(s):  
Ruth Cunningham ◽  
Katrina Poppe ◽  
Debbie Peterson ◽  
Susanna Every-Palmer ◽  
Ian Soosay ◽  
...  

Author(s):  
Kozeta Miliku ◽  
Theo J. Moraes ◽  
Allan B. Becker ◽  
Piushkumar J. Mandhane ◽  
Malcolm R. Sears ◽  
...  

Background Breastfeeding in infancy is associated with lower cardiovascular disease risk in adulthood; however, the amount of breastfeeding required to achieve this benefit is unknown. Methods and Results In the CHILD (Canadian Healthy Infant Longitudinal Development) Cohort Study, we analyzed 2382 children with complete data on early life feeding and blood pressure. Infant feeding was documented from hospital records in the first few days of life and reported by mothers throughout infancy. Blood pressure was measured at 3 years of age. Analyses controlled for birth weight, gestational age, socioeconomic status, maternal body mass index, and other potential confounders. We found that nearly all children (2333/2382; 97.9%) were ever breastfed, of whom 98 (4.2%) only briefly received breast milk during their birth hospitalization (“early limited breastfeeding”). At 3 years of age, blood pressure was higher in children who were never breastfed (mean systolic/diastolic 103/60 mm Hg) compared with those who were ever breastfed (99/58 mm Hg), including those who received only early limited breastfeeding (99/57 mm Hg). These differences in systolic blood pressure persisted in adjusted models (ever breastfed: −3.47 mm Hg, 95% CI, −6.14 to −0.80; early limited breastfeeding: −4.24 mm Hg, 95% CI, −7.45 to −1.04). Among breastfed children, there was no significant dose‐response association according to the duration or exclusivity of breastfeeding. Associations were not mediated by child body mass index. Conclusions Although the benefits of sustained and exclusive breastfeeding are indisputable, this study indicates any breastfeeding, regardless of duration or exclusivity, is associated with lower blood pressure at 3 years of age. Further research examining the bioactive components of early breast milk, underlying mechanisms, and long‐term associations is warranted.


Author(s):  
Maria J. Iglesias ◽  
Larissa D. Kruse ◽  
Laura Sanchez-Rivera ◽  
Linnea Enge ◽  
Philip Dusart ◽  
...  

Objective: Endothelial cell (EC) dysfunction is a well-established response to cardiovascular disease risk factors, such as smoking and obesity. Risk factor exposure can modify EC signaling and behavior, leading to arterial and venous disease development. Here, we aimed to identify biomarker panels for the assessment of EC dysfunction, which could be useful for risk stratification or to monitor treatment response. Approach and Results: We used affinity proteomics to identify EC proteins circulating in plasma that were associated with cardiovascular disease risk factor exposure. Two hundred sixteen proteins, which we previously predicted to be EC-enriched across vascular beds, were measured in plasma samples (n=1005) from the population-based SCAPIS (Swedish Cardiopulmonary Bioimage Study) pilot. Thirty-eight of these proteins were associated with body mass index, total cholesterol, low-density lipoprotein, smoking, hypertension, or diabetes. Sex-specific analysis revealed that associations predominantly observed in female- or male-only samples were most frequently with the risk factors body mass index, or total cholesterol and smoking, respectively. We show a relationship between individual cardiovascular disease risk, calculated with the Framingham risk score, and the corresponding biomarker profiles. Conclusions: EC proteins in plasma could reflect vascular health status.


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