The impact of smoking on wound healing: the role of the nurse

2018 ◽  
Vol 27 (6) ◽  
pp. S10-S14
Author(s):  
Peter Ellis
Keyword(s):  
Wound Healing ◽  
The Impact

scholarly journals Role of infection in wound healing

2020 ◽  
Vol 19 (4) ◽  
pp. 598-602
Author(s):  
Malik Asif Hussain ◽  
Flavia Huygens
Keyword(s):  
Wound Healing ◽  
Pathogenic Bacteria ◽  
Chronic Wounds ◽  
Medical Science ◽  
Vascular Diseases ◽  
Research Papers ◽  
Patients With Diabetes ◽  
Research Findings ◽  
The Impact

Chronic wounds, particularly infected wounds are clinically very important due to their significant impact on health budgets as well as patients` health worldwide. Patients with diabetes mellitus, vascular diseases especially peripheral vascular disease and pressure ulcers are major categories of patients presenting with chronic wounds. It is known that there are multiple factors determining chronic wound prognosis. The presence of multiple types of pathogenic bacteria, with specific virulence and adherent (biofilm) properties, contribute a significant role to the development of chronic wounds. This review article is based on the research project entitled” An investigation of the impact of bacterial diversity, pathogenic determinants and biofilms on chronic wounds”. The research findings have been published in form of research papers as well as conference posters. The aim of this article is to highlight various important aspects of bacterial impact on wound healing. Bangladesh Journal of Medical Science Vol.19(4) 2020 p.598-602

An audit to assess the impact of prescribing a monofilament fibre debridement pad for patients with unhealed wounds after six months

2021 ◽  
Vol 30 (5) ◽  
pp. 381-388
Author(s):  
Joanna Burnett ◽  
Andrew Kerr ◽  
Margaret Morrison ◽  
Abbe Ruston
Keyword(s):  
Wound Healing ◽  
Chronic Wounds ◽  
Wound Care ◽  
Mechanical Method ◽  
Dry Skin ◽  
Business Services ◽  
Clinical Role ◽  
Show Evidence ◽  
The Impact

A monofilament fibre debridement pad has been found to be a rapid and effective mechanical method of removing dry skin, biofilm and debris from acute and chronic wounds with minimal patient discomfort. Evidence of its impact on prescribing and wound healing, however, has been more limited. The aim of this audit was to show evidence of the monofilament fibre debridement pad's impact on wound treatment costs through an analysis of NHS wound-care prescribing data in England. A dataset for 486 uniquely identified patients who had been newly prescribed the monofilament fibre debridement pad was obtained from the NHS Business Services Authority. All data were anonymised. Costs were identified for the six months before and six months after the month of first prescription of the monofilament fibre debridement pad. The total cost of wound-care prescribing fell by 14% or £101,723 in the six months after the intervention compared with the six months before. The average monthly expenditure per patient fell from £244 before the intervention to £209 (n=486) after. These results indicate that use of the monofilament fibre debridement pad could reduce prescribing costs and the use of antimicrobial and negative pressure therapies. Further research is warranted to investigate the clinical role of the monofilament fibre debridement pad in wound healing

scholarly journals Role of Apoptosis in Wound Healing and Apoptosis Alterations in Microgravity

2021 ◽  
Vol 9 ◽  
Author(s):  
Stefan Riwaldt ◽  
Thomas J. Corydon ◽  
Desiré Pantalone ◽  
Jayashree Sahana ◽  
Petra Wise ◽  
...  
Keyword(s):  
Wound Healing ◽  
Current Knowledge ◽  
Protective Layer ◽  
Health Concern ◽  
Human Organism ◽  
Impaired Wound Healing ◽  
Cell Lineages ◽  
Space Tourism ◽  
The Impact

Functioning as the outermost self-renewing protective layer of the human organism, skin protects against a multitude of harmful biological and physical stimuli. Consisting of ectodermal, mesenchymal, and neural crest-derived cell lineages, tissue homeostasis, and signal transduction are finely tuned through the interplay of various pathways. A health problem of astronauts in space is skin deterioration. Until today, wound healing has not been considered as a severe health concern for crew members. This can change with deep space exploration missions and commercial spaceflights together with space tourism. Albeit the molecular process of wound healing is not fully elucidated yet, there have been established significant conceptual gains and new scientific methods. Apoptosis, e.g., programmed cell death, enables orchestrated development and cell removal in wounded or infected tissue. Experimental designs utilizing microgravity allow new insights into the role of apoptosis in wound healing. Furthermore, impaired wound healing in unloading conditions would depict a significant challenge in human-crewed exploration space missions. In this review, we provide an overview of alterations in the behavior of cutaneous cell lineages under microgravity in regard to the impact of apoptosis in wound healing. We discuss the current knowledge about wound healing in space and simulated microgravity with respect to apoptosis and available therapeutic strategies.

scholarly journals Angiosome Concept in the Endovascular Management of Chronic Atherosclerotic Ischaemia of Lower Extremities in Diabetics

2020 ◽  
Vol 1 (2) ◽  
pp. 36-40
Author(s):  
Ahmed Sayed ◽  
Hussein Elwan ◽  
Mostafa Elshal ◽  
Ahmed Taha
Keyword(s):  
Wound Healing ◽  
Limb Salvage ◽  
Tissue Loss ◽  
Chi Square ◽  
Sex Risk ◽  
Run Off ◽  
Foot Arch ◽  
Chi Square Test ◽  
The Impact

Introduction: The role of the angiosome theory in infrapopliteal disease is controversial. We aimed to study the impact of direct angiosomal revascularization on the outcome in the presence and absence of a complete foot arch. Method: We studied consecutive patients presenting with infrapopliteal disease from February 2013 to January 2014, Rutherford categories 5&6, where only one infrapopliteal vessel was successfully revascularized. Patients were classified into the following groups: (i)DF: direct angiosome revascularization with patent foot arch, (ii)DN: direct angiosome revascularization with no foot arch, (iii)IF: indirect angiosome revascularization with patent foot arch, and (iv)IN: indirect angiosome revascularization with no foot arch. The outcome of the four groups was compared using Chi square test and ANOVA tests. Results: 75 patients presented during the study period; 20 DF, 22 DN, 17 IF, & 16 IN. There were no statistical differences in age, sex, risk factors, run off vessel, or site of tissue loss. Limb salvage rates after 12 months were 95% in DF, 91% in DN, 76.5% in IF, and 44% in IN (p=0.0046). Mean number of days till wound healing was 72.2±16.7 in DF, 122.9±20.6 in DN, 229.4±30.3 in IF, and 308.1±29.6 in IN (p<0.001). Conclusion: Group DF showed significantly better results in limb salvage and wound healing, followed by DN, IF, and lastly IN. A complete foot arch had a significant impact on clinical outcome, in addition to direct angiosomal revascularization. Future studies on the angiosome concept should include the completeness of foot arch as an important factor contributing to healing and limb salvage. Keywords: angiosome, infrapopliteal angioplasty, foot arch

P8 KERATIN 17 PROMOTES CELLS PROLIFERATION AND METASTASIS IN ESOPHAGEAL SQUAMOUS CELL CARCINOMA

2019 ◽  
Vol 32 (Supplement_2) ◽  
Author(s):  
Liu Zhun ◽  
Shen Zhimin ◽  
Zhang Peipei ◽  
Yu Shaobin ◽  
Gao Lei ◽  
...  
Keyword(s):  
Wound Healing ◽  
Colony Formation ◽  
Prognostic Significance ◽  
Migration And Invasion ◽  
Migration Ability ◽  
Chamber Experiment ◽  
Proliferation And Metastasis ◽  
The Impact

Abstract Background Keratin17(KRT17), as a multifunction cytoskeletal protein, associated with a multitudinous of biological processes, including cell proliferation, migration, and invasion. Previously, we have found up-expression of KRT17 genes in ESCC tissues. Currently, published kinds of researches claimed KRT17 is engaged in the tumorigenesis and progression of multiple cancers. However, the prognostic significance of KRT17 in ESCC patients and its effects in ESCC progression remains indistinct. Methods We verified the expression level of KRT17 in ESCC tissues by Western blotting and q-PCR and constructed KRT17 upregulated and knockdown EC9706 and Eca109 cells by Lentivirus overexpression and CAS9. The function of KRT17 in ESCC proliferation and metastasis were studied in vitro. We performed CCK-8 assays and plate colony formation assays and the plate colony formation assays to explore the effect of KRT17 on the proliferation, Moreover, the trans-well migration chamber experiment and wound healing test was taken to reveal the impact of KRT17 on migration capabilities. Results We verified that KRT17 is overexpressed in ESCC tissues and the role of KRT17 in the malignant behavior of ESCC in vitro and vivo . In CCK-8 assays and plate colony formation assays. We conformed proliferation capacity was notably enhanced by overexpression of KRT17 but compromised when KRT17 was knocked out. On the other hand, we used the plate colony formation assays to explore the effect of KRT17 on the proliferation of ESCC cells. KRT17 up-regulated significantly strengthened the proliferation while the KRT17 knockdown was weakened. To reveal the impact of KRT17 on migration, the trans-well migration chamber experiment was used to compare the role of down-regulation and up-regulation of KRT17 in migration; the results demonstrated that reducing expression of KRT17 significantly blocked the movement of ESCC cells as compared with the empty vector control. Otherwise, it has been confirmed that the cell migration ability employs a wound healing/scratch test because wound closure is generally a measure of cell motility. The results showed KRT17 overexpression notably reinforced the mobility of ESCC cells compared with the empty groups, whereas KRT17 knockdown cells prolonged the time to close the injury compared to blank groups. Collectively, these discoveries support that the increased expression of KRT17 in ESCC cells promoted a more proliferation and migratory phenotype in vitro. Conclusion The breakthrough indicated that the up-regulation of KRT17 in ESCC is closely related to malignant progression. Our data confirmed that KRT17 plays an essential role in reinforcing proliferation and metastasis in ESCC. Thence, KRT17 may serve as a significant molecular target for the diagnosis and therapy of ESCC.

Intergroup Threat and Outgroup Attitudes

2013 ◽  
Vol 44 (5) ◽  
pp. 311-319 ◽  
Author(s):  
Marco Brambilla ◽  
David A. Butz
Keyword(s):  
Gay Men ◽  
Social Group ◽  
Welfare Recipients ◽  
Intergroup Attitudes ◽  
Social Policies ◽  
Intergroup Threat ◽  
Economic Threat ◽  
The Impact ◽  
General Climate

Two studies examined the impact of macrolevel symbolic threat on intergroup attitudes. In Study 1 (N = 71), participants exposed to a macrosymbolic threat (vs. nonsymbolic threat and neutral topic) reported less support toward social policies concerning gay men, an outgroup whose stereotypes implies a threat to values, but not toward welfare recipients, a social group whose stereotypes do not imply a threat to values. Study 2 (N = 78) showed that, whereas macrolevel symbolic threat led to less favorable attitudes toward gay men, macroeconomic threat led to less favorable attitudes toward Asians, an outgroup whose stereotypes imply an economic threat. These findings are discussed in terms of their implications for understanding the role of a general climate of threat in shaping intergroup attitudes.

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