Enhanced wound healing by topical application of ointment containing a low concentration of povidone-iodine

2016 ◽  
Vol 25 (9) ◽  
pp. 521-529 ◽  
Author(s):  
O. Mitani ◽  
A. Nishikawa ◽  
I. Kurokawa ◽  
E.C. Gabazza ◽  
M. Ikeda ◽  
...  
Keyword(s):  
Wound Healing ◽  
Topical Application ◽  
Povidone Iodine ◽  
Low Concentration

scholarly journals Use of extracts of sunflower-seed oil (Helianthus annus L.) for the treatment of cutaneous injuries in equine metatarsus: a case report

2012 ◽  
Vol 14 (1) ◽  
pp. 125-129 ◽  
Author(s):  
C.S. Coelho ◽  
J.A.N. Gama ◽  
L.A.T. Oliveira Júnior ◽  
B.S.F. Silva ◽  
V.R.C. Souza ◽  
...  
Keyword(s):  
Wound Healing ◽  
Case Report ◽  
Stearic Acid ◽  
Topical Application ◽  
Sunflower Seed ◽  
Seed Oil ◽  
Povidone Iodine ◽  
Sunflower Seed Oil ◽  
Helianthus Annus ◽  
Main Component

This study describes an eighteen-year-old filly after an injury in the region of the dorsal left metatarsus, admitted to veterinary assistance. In addition to the normal treatment, which was characterized by cleaning and topical application of povidone-iodine, sunflower-seed oil was applied locally in order to improve and fasten wound healing. Macroscopic and clinical improvements of the wound healing were observed. The preliminary chemical and physical analyses have shown the stearic acid as the main component. The results suggest that the sunflower-seed oil enable a faster wound healing in horses.

scholarly journals Topical Application of Ozonated Oils for the Treatment of MRSA Skin Infection in an Animal Model of Infected Ulcer

Biology ◽  
2021 ◽  
Vol 10 (5) ◽  
pp. 372
Author(s):  
Vanessa Silva ◽  
Cecília Peirone ◽  
Rosa Capita ◽  
Carlos Alonso-Calleja ◽  
José A Marques-Magallanes ◽  
...  
Keyword(s):  
Wound Healing ◽  
Animal Model ◽  
Topical Application ◽  
Early Stage ◽  
Bacterial Load ◽  
Ozone Treatment ◽  
Diabetic Patients ◽  
Colony Forming Units ◽  
Group 2 ◽  
Epidermal Regeneration

Diabetic foot ulcers are a common cause of morbidity in diabetic patients. One of the main pathogens found in these ulcers is methicillin-resistant Staphylococcus aureus (MRSA). MRSA often carries resistance to several classes of antibiotics and their infections are becoming harder to treat. Therefore, new alternatives are urgently needed. Thus, this study aimed to investigate the capacity of topical ozonated oil application on the treatment of early-stage skin infected with MRSA in an animal model. Ozonated oil was prepared from a mixture of oils subjected to a gas stream of O2/O3 mixture. Sixteen Wistar rats were inoculated by an intradermic injection of MRSA suspension, producing an abscess lesion. After 3 days, the skin epidermis was removed to open the wound. Group 1 received an application of oil mixture without ozone treatment and Group 2 received an application of ozonated oil. After the treatment period, skin was collected, colony-forming units (CFU) of bacteria were quantified and the histological analysis of the skin was carried out. Skin samples from the control 1 and 2 had a bacterial load was of 1.1 × 105 and 5.7 × 103 CFU/mL, respectively. Group 2 showed better wound healing from mild to moderate epidermal regeneration. Topical application of ozonated vegetable oil in MRSA-infected skin in rats showed a small reduction of the bacterial load and better wound healing.

Acceleration of wound healing by topical application of honey

1983 ◽  
Vol 145 (3) ◽  
pp. 374-376 ◽  
Author(s):  
Arieh Bergman ◽  
Joseph Yanai ◽  
Jerry Weiss ◽  
David Bell ◽  
Menachem P. David
Keyword(s):  
Wound Healing ◽  
Topical Application

Comparison of topical honey and povidone iodine-based dressings for wound healing: a systematic review and meta-analysis

2021 ◽  
Vol 30 (Sup4) ◽  
pp. S28-S36
Author(s):  
Fujie Zhang ◽  
Zongnan Chen ◽  
Feng Su ◽  
Taijuan Zhang
Keyword(s):  
Wound Healing ◽  
Hospital Stay ◽  
Analogue Scale ◽  
Povidone Iodine ◽  
Meta Analysis ◽  
Length Of Hospital Stay ◽  
Beneficial Effects ◽  
Vas Score ◽  
Wound Recovery ◽  
Hospital Stay Duration

Objectives: In this review and meta-analysis, we analyse the evidence to compare the efficacy of honey and povidone iodine-based dressings on the outcome of wound healing. Method: A systematic literature search was performed using PRISMA guidelines in academic databases including MEDLINE, Scopus, Embase and CENTRAL. A meta-analysis was carried out to assess the effect of honey and povidone iodine-based dressings on mean healing duration, mean hospital stay duration and visual analogue scale (VAS) score of pain. Results: From the search, 12 manuscripts with a total of 1236 participants (mean age: 40.7±11.7 years) were included. The honey-based dressings demonstrated a medium-to-large effect in reduction of mean healing duration (Hedge's g: –0.81), length of hospital stay (–3.1) and VAS score (–1.2) as compared with the povidone iodine-based dressings. We present evidence (level 1b) in favour of using honey for improvement of wound recovery as compared with povidone iodine. Conclusion: This review and meta-analysis demonstrate beneficial effects of honey-based dressings over povidone iodine-based dressings for wound recovery.

Treating a collagen scaffold with a low concentration of nicotine promoted angiogenesis and wound healing

2013 ◽  
Vol 182 (2) ◽  
pp. 353-361 ◽  
Author(s):  
Pham Hieu Liem ◽  
Naoki Morimoto ◽  
Ran Ito ◽  
Katsuya Kawai ◽  
Shigehiko Suzuki
Keyword(s):  
Wound Healing ◽  
Collagen Scaffold ◽  
Low Concentration

scholarly journals Topical Application of Sadat-Habdan Mesenchymal Stimulating Peptide (SHMSP) Accelerates Wound Healing in Diabetic Rabbits

2012 ◽  
Vol 2012 ◽  
pp. 1-6
Author(s):  
Abdulmohsen H. Al-Elq ◽  
Mir Sadat-Ali ◽  
Mohamed Elsharawy ◽  
Ibrahim Al-Habdan ◽  
Fatin Othman Al-Aqeel ◽  
...  
Keyword(s):  
Wound Healing ◽  
Blood Vessel ◽  
Topical Application ◽  
Inflammatory Cell ◽  
Inflammatory Cell Infiltration ◽  
Cell Infiltration ◽  
Control Group ◽  
Collagen Deposition ◽  
Peptide Group ◽  
Diabetic Rabbits

Objective. Diminished wound healing is a common problem in diabetic patients due to diminished angiogenesis. SHMSP was found to promote angiogenesis. The present study was carried out to examine the effect of this peptide in healing of wounds in diabetic rabbits.Materials and Methods. Twenty male New Zealand rabbits were used in this study. Diabetes mellitus was induced and the rabbits were randomly divided into two equal groups: control group and peptide group. A-full thickness punch biopsy was made to create a wound of about 10 mm on the right ears of all rabbits. Every day, the wound was cleaned with saline in control groups. In the peptide group, 15 mg of SHMSP was applied after cleaning. On day 15th, all animals were sacrificed, and the wounds were excised with a rim of 5 mm of normal surrounding tissue. Histo-pathological assessment of wound healing, inflammatory cell infiltration, blood vessel proliferation, and collagen deposition was performed.Results. There were no deaths among the groups. There was significant increase in wound healing, blood vessel proliferation and collagen deposition, and significant decrease in inflammatory cell infiltration in the peptide group compared to the control group.Conclusion. Topical application of SHMSP improves wound healing in diabetic rabbits.

scholarly journals Pharmacological Evaluation of Chrozophora tinctoria as Wound Healing Potential in Diabetic Rat’s Model

2016 ◽  
Vol 2016 ◽  
pp. 1-7 ◽  
Author(s):  
Harikesh Maurya ◽  
Monika Semwal ◽  
Susheel Kumar Dubey
Keyword(s):  
Wound Healing ◽  
Disease Control ◽  
Povidone Iodine ◽  
Diabetic Rats ◽  
Control Group ◽  
Standard Drug ◽  
Group Iii ◽  
Group I ◽  
Elevated Blood Glucose Level ◽  
Pharmacological Potential

Objective. The study was designed to evaluate pharmacological potential of hydroalcoholic leaves extract of Chrozophora tinctoria intended for wound healing in diabetic rats’ model. Methods. The method used to evaluate the pharmacological potential of hydroalcoholic leave extract was physical incision rat model. In this model, cutting of the skin and/or other tissues with a sharp blade has been made and the rapid disruption of tissue integrity with minimal collateral damage was observed shortly. Animals used in the study were divided into four groups that consist of six animals in each group. Group I serves as normal control, Group II serves as disease control, Group III was used as standard treatment (Povidone iodine 50 mg/kg b.w.), and Group IV was used for test drug (C. tinctoria 50 mg/kg b.w.). Result. The hydroalcoholic leave extract of Chrozophora tinctoria has been significantly observed to heal the wound (98%) in diabetic rats within 21 days, while standard drug (Povidone iodine) healed the wound about 95% in the same condition. The oral dose (50 mg/kg b.w.) of Chrozophora tinctoria was also found to improve the elevated blood glucose level in comparison to disease control group, which increased after the oral administration of Streptozotocin. Conclusion. The Chrozophora tinctoria has significant wound healing potential in the animal having physically damaged tissue in diabetic condition.

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