Hyaluronan in skin wound healing: therapeutic applications

2020 ◽  
Vol 29 (12) ◽  
pp. 782-787
Author(s):  
Ian CC King ◽  
Parviz Sorooshian
Keyword(s):  
Wound Healing ◽  
Cell Migration ◽  
Clinical Practice ◽  
Inflammatory Response ◽  
Tissue Repair ◽  
Therapeutic Potential ◽  
Skin Wound ◽  
Clinical Applications ◽  
Skin Wound Healing ◽  
Proliferative Phase

Hyaluronan is a vital constituent in effective skin wound healing. This polysaccharide is ubiquitous throughout the human body and has functional significance for tissue repair and remodelling. The importance of hyaluronan in the proliferative phase of healing is diverse, impacting on cell migration, proliferation, modification of the inflammatory response and on angiogenesis. As such, it holds therapeutic potential for a variety of clinical applications that range from facilitating effective wound healing to burns management and scarring. This overview of the multifaceted roles of hyaluronan considers its current applications to clinical practice in plastic surgery as well as the latest advances in research.

Juglone ameliorates skin wound healing by promoting skin cell migration through Rac1/Cdc42/PAK pathway

2016 ◽  
Vol 24 (5) ◽  
pp. 786-794 ◽  
Author(s):  
Hussain M. Wahedi ◽  
Yong U. Park ◽  
Eun-Yi Moon ◽  
Sun Y. Kim
Keyword(s):  
Wound Healing ◽  
Cell Migration ◽  
Skin Wound ◽  
Skin Wound Healing ◽  
Skin Cell

Rapid epithelialisation of fetal wounds is associated with the early deposition of tenascin

1991 ◽  
Vol 99 (3) ◽  
pp. 583-586 ◽  
Author(s):  
D.J. Whitby ◽  
M.T. Longaker ◽  
M.R. Harrison ◽  
N.S. Adzick ◽  
M.W. Ferguson
Keyword(s):  
Wound Healing ◽  
Cell Migration ◽  
Temporal Distribution ◽  
Cell Types ◽  
Skin Wound ◽  
Skin Wound Healing ◽  
Early Appearance ◽  
Complex Process ◽  
Healing Wounds ◽  
Fetal Wound

Wound healing is a complex process involving the interaction of many cell types with the extracellular matrix (ECM). Fetal skin wound healing differs from that in the adult in that it occurs rapidly and without scar formation. The mechanisms underlying these differing processes may be related to the fetal environment, the stage of differentiation of the fetal cells or the ECM deposited in the wound. The spatial and temporal distribution of two components of the ECM, fibronectin and tenascin, were studied by immunostaining of cryosections from trunk wounds of fetal and adult sheep. Epithelialisation was complete earlier in the fetal wound than in the adult. The distribution of fibronectin was similar in fetal and adult wounds but tenascin was present earlier in the fetal wound. Fibronectin has several roles in wound healing including acting as a substratum for cell migration and as a mediator of cell adhesion through cell surface integrins. The attachment of fibroblasts to fibronectin is inhibited by tenascin and during development the appearance of tenascin in the ECM of migratory pathways correlates with the initiation of cell migration. Similarly, the appearance of tenascin in healing wounds may initiate cell migration. Tenascin was present in these wounds prior to cell migration and the rapid epithelialisation of fetal wounds may be due to the early appearance of tenascin in the wound.

scholarly journals Adaptive immunity and skin wound healing in amphibian adults

2019 ◽  
Vol 14 (1) ◽  
pp. 420-426 ◽  
Author(s):  
Antonella Franchini
Keyword(s):  
Wound Healing ◽  
Tissue Repair ◽  
Tissue Injury ◽  
Skin Wound ◽  
Tissue Response ◽  
Cellular Mechanisms ◽  
Skin Wound Healing ◽  
Whole Process ◽  
Tissue Repair And Regeneration ◽  
Adaptive Immune Cells

AbstractRegeneration and repair with scarring of the skin are two different responses to tissue injury that proceed depending on the animal species. Several studies in multiple organisms have shown that the effectiveness of tissue repair gradually decreases with age in most vertebrates, while the molecular and cellular mechanisms underlying the diverse potentials remain incompletely understood. It is clear, however, that immune system actively participates in the whole process and immune-related activities can mediate both negative and positive roles to influence the quality and diversity of tissue response to damage. Compared with innate immunity, our understanding of the significance of adaptive immune cells in normal repair outcome is limited and deserves further investigation. Here, experimental evidence supporting the contribution of lymphocytes and the involvement of lymphoid organs in skin wound healing are discussed, focusing on the findings emerged in adult amphibians, key animal models for tissue repair and regeneration research.

scholarly journals Tissue repair genes: the TiRe database and its implication for skin wound healing

Oncotarget ◽  
2016 ◽  
Vol 7 (16) ◽  
pp. 21145-21155 ◽  
Author(s):  
Hagai Yanai ◽  
Arie Budovsky ◽  
Robi Tacutu ◽  
Thomer Barzilay ◽  
Amir Abramovich ◽  
...  
Keyword(s):  
Wound Healing ◽  
Tissue Repair ◽  
Skin Wound ◽  
Skin Wound Healing ◽  
Repair Genes

Effect of Atorvastatin on Wound Healing in Rats

2014 ◽  
Vol 17 (2) ◽  
pp. 159-168 ◽  
Author(s):  
Vanessa Ferraz Suzuki-Banhesse ◽  
Flávia Figueiredo Azevedo ◽  
Eliana Pereira Araujo ◽  
Maria Esméria Corezola do Amaral ◽  
Andrea Moro Caricilli ◽  
...  
Keyword(s):  
Wound Healing ◽  
Tissue Repair ◽  
Glycogen Synthase ◽  
Skin Wound ◽  
Acute Injury ◽  
Lipid Lowering ◽  
Post Injury ◽  
Skin Wound Healing ◽  
Extracellular Signal ◽  
Tnf Α

Skin-wound healing is a complex and dynamic biological process involving inflammation, proliferation, and remodeling. Recent studies have shown that statins are new therapeutical options because of their actions, such as anti-inflammatory and antioxidant activity, on vasodilation, endothelial dysfunction and neoangiogenesis, which are independent of their lipid-lowering action. Our aim was to investigate the effect of atorvastatin on tissue repair after acute injury in healthy animals. Rats were divided into four groups: placebo-treated (P), topical atorvastatin-treated (AT), oral atorvastatin-treated (AO), topical and oral atorvastatin-treated (ATO). Under anesthesia, rats were wounded with an 8-mm punch in the dorsal region. Lesions were photographed on Days 0, 1, 3, 7, 10, 12, and 14 post-injury and samples taken on Days 1, 3, 7, and 14 for protein-expression analysis of insulin receptor substrate (IRS)-1, phosphatidylinositol 3-kinase (PI3K), protein kinase B (Akt), glycogen synthase kinase (GSK)-3, endothelial nitric oxide synthase (eNOS), vascular endothelial growth factor (VEGF), extracellular signal-regulated kinase (ERK), interleukin (IL)-10, IL-1β, IL-6, and tumor necrosis factor (TNF)-α. Upon macroscopic examination, we observed significant reductions of lesion areas in groups AT, AO, and ATO compared to the P group. Additionally, AT and AO groups showed increased expression of IRS-1, PI3K, Akt, GSK-3, and IL-10 on Days 1 and 3 when compared with the P group. All atorvastatin-treated groups showed higher expression of IRS-1, PI3K, Akt, GSK-3, IL-10, eNOS, VEGF, and ERK on Day 7. On Days 1, 3, and 7, all atorvastatin-treated groups showed lower expression of IL-6 and TNF-α when compared with the P group. We conclude that atorvastatin accelerated tissue repair of acute lesions in rats and modulated expressions of proteins and cytokines associated with cell-growth pathways.

Invariant NKT cells promote skin wound healing by preventing a prolonged neutrophilic inflammatory response

2017 ◽  
Vol 25 (5) ◽  
pp. 805-815 ◽  
Author(s):  
Hiromasa Tanno ◽  
Kazuyoshi Kawakami ◽  
Emi Kanno ◽  
Aiko Suzuki ◽  
Naoyuki Takagi ◽  
...  
Keyword(s):  
Wound Healing ◽  
Inflammatory Response ◽  
Nkt Cells ◽  
Skin Wound ◽  
Skin Wound Healing ◽  
Invariant Nkt Cells

scholarly journals The Role of MSC in Wound Healing, Scarring and Regeneration

Cells ◽  
2021 ◽  
Vol 10 (7) ◽  
pp. 1729
Author(s):  
Raquel Guillamat-Prats
Keyword(s):  
Wound Healing ◽  
Wound Repair ◽  
Therapeutic Potential ◽  
Healing Process ◽  
Repair Process ◽  
Skin Wound ◽  
Wound Healing Process ◽  
Matrix Remodeling ◽  
Skin Wound Healing ◽  
Tissue Repair And Regeneration

Tissue repair and regeneration after damage is not completely understood, and current therapies to support this process are limited. The wound healing process is associated with cell migration and proliferation, extracellular matrix remodeling, angiogenesis and re-epithelialization. In normal conditions, a wound will lead to healing, resulting in reparation of the tissue. Several risk factors, chronic inflammation, and some diseases lead to a deficient wound closure, producing a scar that can finish with a pathological fibrosis. Mesenchymal stem/stromal cells (MSCs) are widely used for their regenerative capacity and their possible therapeutically potential. Derived products of MSCs, such as exosomes or extravesicles, have shown a therapeutic potential similar to MSCs, and these cell-free products may be interesting in clinics. MSCs or their derivative products have shown paracrine beneficial effects, regulating inflammation, modifying the fibroblast activation and production of collagen and promoting neovascularization and re-epithelialization. This review describes the effects of MSCs and their derived products in each step of the wound repair process. As well, it reviews the pre-clinical and clinical use of MSCs to benefit in skin wound healing in diabetic associated wounds and in pathophysiological fibrosis.

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