Hepatoprotective Effect of Ethanolic Extract of Fresh Leaves of Cassia alata on Carbon Tetrachloride-induced Toxicity in Albino Rats

2013 ◽  
Vol 10 (1) ◽  
pp. 95-97
Author(s):  
J.C. Mordi ◽  
U.E. Uzuegbu
Keyword(s):  
Carbon Tetrachloride ◽  
Ethanolic Extract ◽  
Hepatoprotective Effect ◽  
Albino Rats ◽  
Cassia Alata

Hepatoprotective Effect of Cornus mas Fruits Extract Against Carbon Tetrachloride-Induced Hepatic Damage in Male Albino Rats

Thrita ◽  
2014 ◽  
Vol 3 (2) ◽  
Author(s):  
Mohammad Hossein Somi ◽  
Nafiseh Banihabib ◽  
Gholamreza Dehghan ◽  
Masoud Es. Haghi ◽  
Farid Panahi
Keyword(s):  
Carbon Tetrachloride ◽  
Hepatic Damage ◽  
Hepatoprotective Effect ◽  
Albino Rats ◽  
Cornus Mas

scholarly journals Hepatoprotective effect of aqueous extract of Melothria perpusilla against carbon tetrachloride induced liver injury in albino rats

2017 ◽  
Vol 5 (3) ◽  
pp. 806 ◽  
Author(s):  
Nokul S. Yengkhom ◽  
Ngangom Gunindro ◽  
Sania M. Kholi ◽  
Rakesh S. Moirangthem ◽  
Bharati D. Rajkumari
Keyword(s):  
Carbon Tetrachloride ◽  
Liver Injury ◽  
Aqueous Extract ◽  
Liquid Paraffin ◽  
Herbal Medicines ◽  
Modern Medicine ◽  
Hepatoprotective Effect ◽  
Albino Rats ◽  
Group Iii ◽  
Group I

Background: In absence of reliable hepatoprotective drug in modern medicine, the traditional herbal medicines have been emphasized. Present study was designed to assess hepatoprotective effect of aqueous extract of Melothria perpusilla (AEMP) against carbon tetrachloride (CCl4) induced liver injury.Methods: Five groups of animals with 6 rats in each were treated for 7 days.  Group I received 1% gum acacia in distilled water (1 ml/200 g p.o.) daily.  Group II, III, IV and V received CCl4 in liquid paraffin (1 ml/kg s.c.) on day 2, 4 and 6. Group III, IV and V were treated respectively with silymarin (100 mg/kg p.o.), AEMP- 200 and 400 mg/kg p.o. daily. On day 8, liver injury was assessed by measuring serum ALT, AST, ALP and bilirubin.Results: ALT, AST, ALP and bilirubin were significantly reduced in groups receiving both CCl4 and AEMP when compared with CCl4 treated group.Conclusions: AEMP produced hepatoprotective effect against CCl4 induced liver injury.

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