scholarly journals Anti-Diabetic Activity of Polypeptide-K Isolated from Momordica Charantia: A Retrospective Study of 142 Cases

2021 ◽  
Vol 14 (4) ◽  
pp. 2007-2015
Author(s):  
Yong Yean Sirn ◽  
Lee Cheng Lok ◽  
Pak Hoe Weng ◽  
Zuraini Ahmad ◽  
Muhammad Nazrul Hakim
Keyword(s):  
Retrospective Study ◽  
Blood Glucose ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Momordica Charantia ◽  
T Test ◽  
Post Treatment ◽  
Diabetic Patients ◽  
Paired Sample ◽  
Significant Difference

Diabetes Mellitus occurs when the pancreas fails to produce sufficient insulin, or the body is unable to use the insulin produced effectively. In order to regulate the blood glucose of diabetic patients, Diabegard®, a herbal antidiabetic medicine and daily supplement, contains polypeptide-k which exists in the seed of Momordica Charantia (bitter gourd) was prescribed. Purpose: A retrospective study is therefore done with the aim to examine the effectiveness of Diabegard®, polypeptide-k in regulating the blood glucose and cholesterol level of diabetic patients who took Diabegard® for four weeks with a dose of 60 mg per day. Methods: A database record of 105 male and 37 female (ages 25-81) treated with Diabegard®, polypeptide-k was assessed. The effectiveness of Diabegard®, polypeptide-k in blood glucose regulation was determined based on four aspects: gender, three different age categories, four different categories of duration of the disease and five different categories of severity of the disease. The Pearson's correlation was used to find the correlation among variables. Paired sample t-test was used to compare the means of pre- and post-treatment of blood glucose level. One-way ANOVA was used to compare the means of different groups for each aspect. Results: Result showed that age and duration of disease (r2=0.469), pre-treatment of blood glucose and post-treatment of blood glucose (r2=0.606) showed positive relationship. Both paired sample T-test of pre-and post-treatment of blood glucose showed significant difference (p<0.05). Categories with very mild (7 mmol/L), severe (13.9-19.4mmol/L) and very severe (>19.4mmol/L) diabetes showed significant difference (p<0.05). Other tests showed no significant difference. Conclusion: In conclusion, this present retrospective study showed that Diabegard®, polypeptide-k was effective in controlling blood glucose level of all diabetic patients especially in patients with mild (26.87% reduction), severe (40.43% reduction) and very severe diabetes (49.27% reduction).

scholarly journals Achievement of Awareness in a Diabetic Population

1970 ◽  
pp. 7-10
Author(s):  
Mirza Azizul Hoque ◽  
Md Sirajul Islam ◽  
Md Abdul Maleque Khan ◽  
Rehana Aziz ◽  
HAM Nazmul Ahasan
Keyword(s):  
Blood Glucose ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Educational Status ◽  
Diabetic Patients ◽  
Cross Sectional Survey ◽  
Cross Sectional ◽  
Educational Group ◽  
Diabetic Clinic ◽  
Significant Difference

This cross-sectional survey was carried out during the period, October 2005 to December 2005, among 184 randomly chosen diabetic patients in Khulna Diabetic Centre, Khulna, Bangladesh, to evaluate the knowledge of the patients for their control of diabetes mellitus and also to explore the association(s) of their attitude and knowledge regarding diabetic awareness towards educational status and socio-demographic profile. In this study, we found a significant difference, in diabetic awareness to keep correct blood glucose level, in different educational group. But, it did not influence the subjects of different educational group to visit the diabetic clinic. There was no significant difference in the knowledge of correct blood glucose level and in regularity of visit to the diabetic clinic, in rural and urban people. Knowledge of correct blood glucose level varied significantly among male and female patients, although, no significant variation was found among them in visiting to the diabetic clinic. We can conclude that, diabetic education programs can improve self-regulatory behavior and in the long run, can reduce morbidity and mortality.   doi:10.3329/jom.v10i3.2008 J Medicine 2009; 10 (Supplement 1): 7-10  

scholarly journals A Comparison Between the Effect of Three Types of Low-Calorie Diets on Controlling Blood Glucose and Lipids in People with Type 2 Diabetes

2018 ◽  
Vol 8 (1) ◽  
pp. 18
Author(s):  
Zoleika Moazezi ◽  
Seyed Reza Hosseini ◽  
Parvin Sajadi Kaboudi ◽  
Bahareh Esbakian ◽  
Sahar Rahmani ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Blood Glucose ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Serum Lipids ◽  
Fasting Blood Glucose ◽  
Diabetic Patients ◽  
Low Calorie ◽  
Significant Difference

The blood glucose level of people with diabetes can be normalized through an appropriate diet, physical activity, the use of chemical drugs and medicinal plants. This study aims to investigate the effects of low-calorie diets (1200, 1500, and 1800 kcal) on glucose and serum lipids in poorly controlled type 2 diabetic patients. This clinical trial was conducted among 60 patients with type 2 diabetes mellitus. The criteria for entering the study were fasting blood glucose higher than 130 mg/dl, hemoglobin A1C higher than 7% and BMI higher than 25. Blood glucose, fasting blood glucose and lipid levels were measured before and after intervention two hours after each meal. Patients were trained by an expert. Then, the questionnaires were completed and analyzed. In this study, the mean fasting blood glucose level in patients who used 1500 and 1200 kcal diet decreased significantly after intervention (p&lt;0.05). Glucose decreased significantly after two hours using a 1500  kcal diet (p&lt;0.009). In addition, triglyceride and cholesterol levels were significantly reduced in patients who used the 1500 kcal diet (p&lt;0.05). Although, there was no significant difference in blood glucose levels between 1200, 1500 and 1800 kcal diets based on gender, residencency and BMI. Regarding the fact that there was no significant difference in reducing blood glucose and serum lipids between 1200 and 1500 kcal diets. It is recommended to use a 1500 kcal diet instead of 1200 kcal diet, which imposes fewer limitations and is easier to tolerate.

scholarly journals Effect of Local Anesthesia with 1:100,000 Epinephrine on Glycemic Level of Type II Diabetic Patients Undergoing Oral Surgery

1969 ◽  
Vol 11 (4) ◽  
pp. 181-184
Author(s):  
Muhammad Tariq Khan ◽  
Muhammad Ilyas ◽  
Salman Khan ◽  
Jawad Ahmad Kundi ◽  
Fariha Kifayat
Keyword(s):  
Diabetes Mellitus ◽  
Blood Glucose ◽  
Blood Glucose Level ◽  
Local Anesthesia ◽  
Glucose Level ◽  
Oral Surgery ◽  
Diabetic Patients ◽  
Type Ii ◽  
Glycemic Level ◽  
Significant Difference

Background: The rate of type II diabetic patients is increasing and results in oral manifestations. The oral surgery needsextraordinary measures in these patients.Objective: To assess the effect of anesthetic agent with 1:100,000 epinephrine and without epinephrine in the blood glucose levelof diabetic patients.Material and Methods: This was a randomized study of 60 patients having type 2 diabetes mellitus who were undergoing toothextraction. The study was double blind. 30-70years aged patients were selected. Blood glucose level was monitored 15 minutesbefore giving local anesthesia and after 20 minutes of the injection. ANOVA was used for comparison between groups.Results: No significant difference was seen in glycemic level using local anesthesia with 1:100,000 epinephrine (p=0.345). Therewas slight decrease noted in the blood glucose level of both groups.Conclusion: The use of 2% local anesthesia with 1:100,000epinephrine didn't cause hyperglycemia in diabetic patients.Keywords: Diabetes Mellitus, Local Anesthesia, Epinephrine, Tooth Extraction, Lidocaine.

scholarly journals TO STUDY THE EFFECT OF YOGA ON BLOOD SUGAR PROFILE IN DIABETICS TYPE-2 PATIENTS

2019 ◽  
Vol 3 (7) ◽  
Author(s):  
Dr. B S Gupta ◽  
Dr. Yogesh Singh
Keyword(s):  
Diabetes Mellitus ◽  
Blood Glucose ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Mean Value ◽  
T Test ◽  
Diabetic Patients ◽  
The Mean ◽  
The Difference

Background: Diabetes mellitus is a syndrome complex characterized by impaired carbohydrate, protein and fat metabolism. Methods: Prospective study was conducted on 100 type 2 diabetes mellitus patients and 100 normal healthy persons. Cases were recruited from a yoga centre. Control subjects were selected from diabetic patients attending hospital. Alcoholic or smoker subjects were excluded. Results: The mean value of blood glucose level of subjects was 136.4±9.42 mg/dl and that of controls was 183.2±9.16 mg/dl.  The difference between the mean value of fasting blood glucose level determined by unpaired  ‘t’ test was statistically highly significant (p=<0001). The mean value of blood glucose level of subjects was 6.32±1.35 % and that of controls was 7.46±1.41%.  The difference between the mean value of HB1Ac level determined by unpaired  ‘t’ test was statistically highly significant (p=<0001). Conclusion: Yoga can be used as an alternate therapy to reduce the blood glucose level along with the drug therapy. Keywords: Yoga, Diabetics, Drugs.

Glucose Intolerance in Intensive Care Patients: Incidence and Outcome

QJM ◽  
2021 ◽  
Vol 114 (Supplement_1) ◽  
Author(s):  
Ahmed A El Shebiny ◽  
Gamal M Elewa ◽  
Ez alregal G Gouda ◽  
Reham M Hashim
Keyword(s):  
Mechanical Ventilation ◽  
Intensive Care ◽  
Blood Glucose ◽  
Critical Illness ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Glucose Intolerance ◽  
Diabetic Patients ◽  
Intensive Care Patients ◽  
Significant Difference

Abstract Introduction Critical illness is associated with modification in metabolic status. Insulin resistance and elevated blood glucose levels occur during stressful conditions. Objective to evaluate the incidence and outcome of glucose intolerance in intensive care. Patients and method This prospective clinical study included 290 patients, admitted to intensive care unit (ICU), from December 2018 to January 2020. They were divided into three groups according to maximum blood glucose level during the initial 48 hours of admission: Normoglycemic, hyperglycemic and hypoglycemic. Each group was subdivided into: known diabetic and not known diabetic. Patients’ age, sex, APACHI II, admission diagnosis were recorded. Blood glucose level was followed every six hours; high blood glucose during first 48 hours of admission was defined as acute hyperglycemia. Use of vasopressor and corticosteroid therapy, type of feeding, days on mechanical ventilation, total days of stay in ICU, and fate of patients were recorded. Results Hyperglycemia was common with critical illness. Its incidence was 45.5 % and 67.2% on ICU admission and during 48 hours. after admission respectively;. Of them, 51% were diabetics, while 16.2% were non diabetics. Hyperglycemia was associated with increased morbidity in the form of difficult weaning from mechanical ventilation and long ICU stay. Of hyperglycemic patients, 66.4 % were orally fed.Mortality among normoglycemic patients was 37.5 %; slightly lower than mortality among hyperglycemic patients (39.2%), but without statistical significant difference. Glucose intolerance in critically ill patients was not related to severity of the disease or cause of admission and vasopressors and steroids were not risk factors for glucose intolerance during the initial 48 hrs. of admission Conclusion Glucose intolerance is high in intensive care patients and is associated with high morbidity and mortality.

scholarly journals Comparison of the Effectiveness of Compassion-Focused Therapy and Attachment-Based Compassion Therapy on Blood Glucose Level and Medication Adherence in Diabetics

2020 ◽  
Keyword(s):  
Blood Glucose ◽  
Medication Adherence ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Blood Glucose Control ◽  
Analysis Of Covariance ◽  
Diabetic Patients ◽  
Training Course ◽  
Compassion Focused Therapy ◽  
Experimental Group

Background and Objectives: Diabetes is one of the most rampant chronic diseases that is accompanied by numerous psychological problems. The present study aimed to compare the effectiveness of compassion-focused therapy (CFT) and attachment-based compassion therapy (ABCT) on blood glucose level and medication adherence in diabetic patients. Materials and Methods: This quasi-experimental study was conducted based on a pretest and posttest design. At first, using the available voluntary sampling method, a number of 45 individuals were selected from 300 diabetic patients referred to Alborz Diabetes Association, Alborz, Iran. They were randomly divided into two experimental and one control groups. At the outset, in addition to the hemoglobin (Hb) A1c blood test, they completed a medication adherence questionnaire. Afterward, the first experimental group participated in eight two-h sessions of the compassionate therapy training course, and the second experimental group participated in 10 90-min sessions of the ABCT training course. All three groups received standard treatment for diabetic patients. At the end of the treatment, the HbA1c levels of blood in all three groups were re-evaluated, and again all patients completed the medication adherence questionnaire at the post-test stage. It should be mentioned that the collected data were analyzed using the analysis of covariance. Results: Based on the results, CFT and ABCT could reduce blood glucose level (HbA1c) (F=5.13, P<0.008, Eta= 0.20) and increase medication adherence (F=2.82, P<0.035, Eta= 0.12) in both of the experimental groups. Conclusion: The CFT and ABCT can be effective in improving medication adherence and blood glucose control (HbA1c) in diabetic patients. Therefore, it is suggested to provide such training together with other medical interventions as part of comprehensive therapy of diabetes.

scholarly journals Comparison between the QRMA Measurement with the Anamnesis and the Capillary Blood Glucose Test

Jurnal NERS ◽  
2020 ◽  
Vol 14 (2) ◽  
pp. 224
Author(s):  
Muflih Muflih ◽  
Suwarsi Suwarsi ◽  
Fajarina Lathu Asmarani
Keyword(s):  
Blood Glucose ◽  
Blood Glucose Level ◽  
Blood Sugar ◽  
Glucose Level ◽  
Blood Sugar Level ◽  
Capillary Blood ◽  
Capillary Blood Glucose ◽  
Blood Glucose Test ◽  
Significant Difference ◽  
Glucose Test

ABSTRACTIntroduction: The examination of patients with diabetes mellitus (DM) can be done by reviewing their complaints and through a capillary blood glucose level test to determine the value of their Random Blood Glucose Level. QRMA (Quantum Resonance Magnetic Analyzer) is claimed to be able to check the patient’s bodily condition (including blood glucose) with an accuracy of 85%. The purpose of this study was to verify the validity of the QRMA tool and its accuracy by comparing the results of the anamnesis and the examination conducted using the capillary blood glucose test method.Methods: The research method used was a cross-sectional design. The total sample consisted of 44 respondents in the working area of the Community Health Centers in Yogyakarta with the risk factor being blood sugar level instability. The sampling technique used was purposive sampling. The main variable in this study was the value of the blood sugar level measured based on the coefficient value of the QRMA tool and the value of Random Blood Glucose obtained through the capillary blood glucose test.Results: The blood glucose value was not correlated significantly with the coefficient value of QRMA. The value of blood glucose when examined alongside the result of the respondent's anamnesis showed there to be a significant difference. The value of the QRMA coefficient when examined against the results from the history of the respondents showed no significant difference. Linear regression showed that the variables of height, body weight, and IMT had a correlation with the QRMA coefficient value.Conclusion: The QRMA tool was not able to provide a picture of the actual condition of the blood glucose level of the respondents when compared with the results of the anamnesis and the blood glucose value from the capillary blood glucose test. Non-invasive health measurement devices such as QRMA are not used by nurses as a standard for determining the health status of DM patients.

scholarly journals Diabetes in COVID-19 patients: challenges and possible management strategies

2021 ◽  
Vol 15 (1) ◽  
Author(s):  
Riyan Al Islam Reshad ◽  
Sumaiya Hafiz Riana ◽  
Mohammad Al-baruni Chowdhury ◽  
Abu Tayab Moin ◽  
Faruque Miah ◽  
...  
Keyword(s):  
Blood Glucose ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Healthy Lifestyle ◽  
Management Strategies ◽  
Diabetic Patients ◽  
Main Body ◽  
High Blood Glucose ◽  
High Blood Glucose Level ◽  
Global Population

Abstract Background The recent pandemic of coronavirus disease 19 (COVID-19) has been causing intense stress among the global population. In the case of hospitalized and ICU-admitted COVID-19 patients with comorbidities, it has been observed that a major portion of them are diabetic. Therefore, researchers had indicated a link between diabetes mellitus (DM) and COVID-19. Furthermore, DM is a potential risk factor for the severity of COVID-19 cases. Thus, in this study, the correlation existing between diabetic patients and COVID-19 was summarized. Main body of the abstract Diabetic patients have a weaker immune system, less viral clearance rate, malfunctions of metabolic activity due to their high blood glucose level, and other associated problems. This does not increase the susceptibility for the patients to be infected with COVID-19. However, the severity of COVID-19 can worsen due to the comorbidity of DM. Short conclusion Proper management, appropriate use of drugs that do not increase the ACE2 expression, lowering blood glucose level, decreasing the susceptibility of SARS-CoV-2, and maintaining a healthy lifestyle could be effective.

scholarly journals Treatment of Diabetic Condition in Streptozotocin Induced Diabetic Wister Rats Using Food Blends Such as Unripe Plantain, Soybean and Ginger

2019 ◽  
pp. 1-12
Author(s):  
I. Iwanegbe ◽  
M. Suleiman ◽  
A. Jimah
Keyword(s):  
Body Weight ◽  
Blood Glucose ◽  
Blood Glucose Level ◽  
Lipid Profile ◽  
Cell Volume ◽  
Glucose Level ◽  
Normal Control ◽  
Packed Cell Volume ◽  
Diabetic Rats ◽  
Diabetic Patients

Aims: To investigate the effect of food blends (plantain, soybean and ginger) on the blood glucose, lipid profile and haematological indices on streptozotocin induced diabetic rats. Methodology: A total of 35 rats of mean body weight 219.07 g separated into7 groups (5 per group) where induced by a single intraperitoneal (I.P) injection of streptozotocin (0.1 g dissolved in 5 ml of freshly prepared sodium citrate buffer 0.1 M, pH 4.5) at a dose of 40 mg/kg body weight after fasting for 12 hours and fed with flours/blends. The flours were produced from plant materials for different treatments/blends (blend A=100% unripe plantain, B=80% unripe plantain, 14% soybean, 6% ginger, C=70% unripe plantain, 26% soybean, 4% ginger, D= 60% unripe plantain, 38% soybean, 2% ginger, E= 50% unripe plantain, 50% soybean) and the phytochemicals and minerals content were determined. Blood glucose was determined at 5 days interval for 25 days. Diabetes was confirmed in rats with blood glucose concentrations >200 mg/dl. After 25 days rats were anaesthetized with chloroform vapour and blood samples collected by cardiac puncture for haematology and lipid profile determination. Results: The results showed that unripe plantain, soya beans and ginger in adequate proportion(C=70% unripe plantain, 26% soybean, 4% ginger or D= 60% unripe plantain, 38% soybean, 2% ginger) could help to reduce blood glucose, improve haematological parameters and lipid profile. Significant reduction was observed in the blood glucose level of rats fed blends C and D from 286 to 85 mg/dl and 307 to 90 mg/dl respectively at the end of experiment. These results also demonstrated that the inclusion of ginger at 6% causes rise in blood glucose level. Total cholesterol (TC) increased in all the blends. However, the lowest concentration of TC was observed in blends C and D. The highest packed cell volume (60%) and Haemoglobin (20 g/dl) level observed in rats fed blend C was significantly higher than the normal control fed conventional feeds. The increase in packed cell volume (PCV) (50%) and Hb (17 g/dl) in diabetic rats demonstrated that the formulated blend C was able to raise PCV and Hb above 50% and 17 g/dl (Normal control NC) respectively. Significant increase (P<0.05) in low density lipoprotein cholesterol (LDLc) was also observed in all the blends with blend C having the least (4.0 mg/dl) close to NC (2.0 mg/dl). Conclusion: From the results it is evident that blend C will manage and improve the health status of diabetic patients.

Sign in / Sign up

Export Citation Format

Share Document