Implication of Acute, Sub-chronic and Chronic Exposure to Different Pesticides via Inhalation on Male Wistar Rats

AbstractThe consequences of chronic exposure of organophosphorus compounds (OPCs) on diabetic subjects have been seldom reported. The aim of the present study was to assess the impact of non-lethal dose of terbufos sulfone (TS), an organophosphate, on the kidney of non-diabetic and streptozotocin (STZ)- induced diabetic rats. The diabetogenic effect of TS was also examined. Male Wistar rats were treated for two weeks with 130 µg/kg body weight/day of TS. This dose was 1/20 of LD

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Effects of sub-chronic exposure to palladium (as potassium hexachloro-palladate) on cytokines in male Wistar rats

Human & Experimental Toxicology ◽

10.1177/0960327108090489 ◽

2008 ◽

Vol 27 (6) ◽

pp. 493-497 ◽

Cited By ~ 12

Author(s):

I Iavicoli ◽

G Carelli ◽

A Marinaccio ◽

L Fontana ◽

EJ Calabrese

Keyword(s):

Chronic Exposure ◽

Wistar Rats ◽

Statistical Significance ◽

Response Relationship ◽

Dose Response Relationship ◽

Mean Values ◽

Male Wistar Rats ◽

The Difference

Palladium (Pd) is a heavy metal belonging to the platinum group elements. It has been shown that Pd and its compounds can cause sensitization, asthma and dermatologic disorders. In this study, Wistar rats were exposed for 3 months to 0, 1, 10, 100, and 250 ng/ml of Pd (as potassium hexachloro-palladate) in drinking water. At the end of exposure, possible changes in two type-1 cytokines [interleukin (IL)-2, interferon (INF)-γ] and one type-2 cytokine (IL-4) in the serum were measured. After the sub-chronic exposure, analysis of variance of IL-2 and INF-γ response shows that the difference between mean values in the groups of animals exposed reaches statistical significance for IL-2 ( P = 0.001), showing a J-shaped dose–response relationship. At the higher dose of 250 ng/ml Pd, it was observed a significant increase in IL-2 production when compared with the controls. Furthermore at 1 and 10 ng/ml of Pd we observed an increase of INF-γ production that was significant at 100 ng/ml of Pd, while at the higher dose of 250 ng/ml of Pd the response was indistinguishable from the control. At the doses investigated, Pd has been shown not to determine a modification of IL-4 response ( P = 0.10). These preliminary findings indicate the need to carry out further investigations regarding the effect of other Pd compounds and the measurement of other types of cytokines both in the animal model used in our study and other models.

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Hepatic and reproductive toxicity of sub-chronic exposure to dichlorvos and lead acetate on male Wistar rats

Asian Pacific Journal of Reproduction ◽

10.4103/2305-0500.298776 ◽

2020 ◽

Vol 9 (6) ◽

pp. 283

Author(s):

WahabAdekunle Oyeyemi ◽

Oore-oluwapoOlolade Daramola ◽

AdeniranOluwadamilare Akinola ◽

AdeoyeOyewole Idris ◽

Ikponmwosa Aikpitanyi

Keyword(s):

Lead Acetate ◽

Chronic Exposure ◽

Wistar Rats ◽

Reproductive Toxicity ◽

Male Wistar Rats

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Diuron exposure induces systemic and organ-specific toxicity following acute and sub-chronic exposure in male Wistar rats

Environmental Toxicology and Pharmacology ◽

10.1016/j.etap.2011.01.007 ◽

2011 ◽

Vol 31 (3) ◽

pp. 387-396 ◽

Cited By ~ 8

Author(s):

Alexandre Domingues ◽

Luis Fernando Barbisan ◽

Priscila Raquel Martins ◽

Ana Lúcia Tozzi Spinardi-Barbisan

Keyword(s):

Chronic Exposure ◽

Wistar Rats ◽

Organ Specific ◽

Male Wistar Rats

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Further analysis of behavioral and endocrine consequences of chronic exposure of male Wistar rats to subtoxic doses of endocrine disruptor chlorobenzenes

Physiology & Behavior ◽

10.1016/j.physbeh.2011.03.016 ◽

2011 ◽

Vol 103 (5) ◽

pp. 421-430 ◽

Cited By ~ 7

Author(s):

Z. Valkusz ◽

G. Nagyéri ◽

M. Radács ◽

T. Ocskó ◽

P. Hausinger ◽

...

Keyword(s):

Chronic Exposure ◽

Endocrine Disruptor ◽

Wistar Rats ◽

Male Wistar Rats

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Effects of chronic exposure to lead, cadmium, and manganese mixtures on oxidative stress in rat liver and heart / Utjecaj kronične istodobne izloženosti olovu, kadmiju i manganu na oksidativni stres u jetri i srcu štakora

Archives of Industrial Hygiene and Toxicology ◽

10.1515/aiht-2015-66-2515 ◽

2015 ◽

Vol 66 (1) ◽

pp. 51-62 ◽

Cited By ~ 18

Author(s):

Iwona Markiewicz-Górka ◽

Lidia Januszewska ◽

Aleksandra Michalak ◽

Adam Prokopowicz ◽

Ewa Januszewska ◽

...

Keyword(s):

Oxidative Stress ◽

Drinking Water ◽

Liver Function ◽

Chronic Exposure ◽

Wistar Rats ◽

Combined Exposure ◽

Bilirubin Concentration ◽

Animal Group ◽

Male Wistar Rats ◽

Alt Activity

Abstract The aim of this study was to assess the effects of chronic combined exposure to low, environmental doses of Cd, Pb, and Mn on oxidative stress in the liver and heart of rats and on their liver function parameters. Male Wistar rats were divided randomly into eight groups. For nine months controls were receiving drinking water alone, whereas the exposed groups were receiving drinking water with Pb (0.2 mg L-1), Cd (1 mg L-1), and Mn (2 mg L-1) alone or in combinations. Malondialdehyde (MDA) significantly increased in both heart and liver of the animals after combined exposure to metals. Heart MDA correlated with blood Cd, Pb, and Mn and liver MDA with blood Cd. Aspartate aminotransferase (AST) activity and bilirubin concentration also increased significantly in the animal group exposed to all three metals and correlated positively with blood Cd, Pb, and Mn. Our study has confirmed the synergistic effect of the Cd, Mn, and Pb combination on the increase in heart MDA. A similar synergy was observed for Pb+Mn in the increase of serum alanine aminotransferase (ALT) activity as an indicator of liver function.

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Antioxidant Effects of Red Fruit Oil on MMP-1 Gene Expression and Malondialdehyde Levels on Skin Exposed to UVB Rays

Molecular and Cellular Biomedical Sciences ◽

10.21705/mcbs.v3i2.68 ◽

2019 ◽

Vol 3 (2) ◽

pp. 100

Author(s):

Monita Sugianto ◽

Achadiyani Achadiyani ◽

Gaga Irawan Nugraha

Keyword(s):

Chronic Exposure ◽

Wistar Rats ◽

Beta Carotene ◽

Oxygen Species ◽

Not Given ◽

Male Wistar Rats ◽

Ros Formation ◽

Fruit Oil ◽

Antioxidant Effects ◽

Β Carotene

Background: Chronic exposure ultraviolet (UV)-B radiation causes reactive oxygen species (ROS) formation. Furthermore, ROS will induce the formation of malondialdehyde and increase matrix metalloproteinase (MMP)-1 expression. One strategy against the free radicals effects is by consuming antioxidants. This study aims to analyze the antioxidants effect of red fruit oil (RFO) on MMP-1 expression and malondialdehyde levels due to exposure to UVB rays.Materials and Methods: Thirty male Wistar rats were divided into 5 groups. The P0 group was not given treatment, the P1 group was only exposed to UVB light, the P2 group was exposed to UVB light and given 0.5 mL/200 g body weight (BW) of RFO, the P3 group was exposed to UVB light and given 1 mL/200 g BW of RFO, and group P4 exposed to UVB rays and given 2 mL/200 g BW of RFO. Experimental animals would be examined for MMP-1 expression and malondialdehyde level. RFO would be identified with β-carotene and tocopherol content.Results: Beta-carotene and tocopherol were detected in RFO. RFO reduced significantly MMP-1 expression (p<0.05) in P2 group (0.73±1.27), P3 group (0.63±0.95), P4 group (9.56±20.97) compared group P1 (48.07±65.58). However, RFO did not reduce malondialdehyde levels (p>0.05).Conclusion: Our research demonstrates RFO containing tocopherol and β-carotene can reduce the MMP-1 expression, but does not affect malondialdehyde levels due to exposure to UVB rays. An effective dose that can reduce malondialdehyde levels and MMP-1 expression is 1 mL/200 g BW.Keywords: red fruit oil, antioxidant, skin, MMP-1 expression, malondialdehyde, UVB rays, photoaging

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Chronic exposure of adult male Wistar rats to bisphenol A causes testicular oxidative stress: Role of gallic acid

Endocrine Regulations ◽

10.2478/enr-2020-0003 ◽

2020 ◽

Vol 54 (1) ◽

pp. 14-21 ◽

Cited By ~ 2

Author(s):

Samuel Gbadebo Olukole ◽

Eunice Olufunke Ola-Davies ◽

Damilare Olaniyi Lanipekun ◽

Bankole Olusiji Oke

Keyword(s):

Oxidative Stress ◽

Bisphenol A ◽

Gallic Acid ◽

Adult Male ◽

Chronic Exposure ◽

Wistar Rats ◽

The Body ◽

Male Rats ◽

Male Wistar Rats

AbstractObjectives. Bisphenol A (BPA) has been reported that among other male reproductive dys-functions, it can cause marked estrogenic effects including alteration in serum hormones as well as testicular lesions in exposed animals. This work sought to study the role of gallic acid (GA), a known antioxidant, on the BPA-induced testicular oxidative stress in adult male Wistar rats using serum hormone analysis, histopathology, and biochemical assays.Methods. Adult male rats were divided into four groups (n=10) including control (0.2 ml of corn oil), GA (20 mg/kg/day), BPA (10 mg/kg/day), BPA+GA (BPA, 10 mg/kg/day + GA, 20 mg/kg/day). All medications were given by oral gavage for 45 consecutive days. The body and testicular weights were measured. Blood and organ samples were collected for the serum hormonal assay: testosterone (T), luteinizing hormone (LH), follicle stimulating hormone (FSH) and prolactin (PRL), and tissue biochemistry analysis: superoxide dismutase (SOD), reduced glutathione (GSH), glutathione-S-transferase (GST), malondialdehyde (MDA), hydrogen peroxide (H2O2), respectively.Results. The BPA-treated rats showed significant reduction in the gonadosomatic index. BPA also caused significant decrease in the levels of the serum testosterone and prolactin. Furthermore, BPA induced testicular oxidative stress by decreasing the activities of antioxidant enzymes and increasing reactive oxygen species. However, co-treatment with GA protected against these alterations.Conclusion. Findings from the present study confirmed the previously reported data and show that the ability of GA, as a potent antioxidant, may protect against BPA-induced alterations in the male reproductive function. Hence, GA protects against testicular oxidative stress in adult male Wistar rats following chronic exposure to BPA.

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Structural and functional renal alterations in five-sixth nephrectomized rats on unrestricted diet

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s042482010014333x ◽

1986 ◽

Vol 44 ◽

pp. 342-343

Author(s):

I. Stachura ◽

M. Pardo ◽

J. Costello ◽

D.M. Landwehr

Keyword(s):

Wistar Rats ◽

Renal Damage ◽

Standard Diet ◽

Experimental Conditions ◽

Phosphate Intake ◽

Dietary Restrictions ◽

Severe Reduction ◽

Male Wistar Rats ◽

Unrestricted Diet ◽

Progressive Renal Insufficiency

Under experimental conditions severe reduction of renal mass results in the hyperfiltration of the remaining nephrons leading to a progressive renal insufficiency. Similar changes are observed in patients with various renal disorders associated with a loss of the functioning nephrons. The progression of renal damage is accelerated by high protein and phosphate intake, and may be modified by the dietary restrictions.We studied 50 five-sixth nephrectarrized male Wistar rats on a standard diet (Rodent Laboratory Chow 5001 Ralston Purina Co., Richmond, Indiana; containing 23.4% protein) over a 20 week period.

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