This chapter examines global megatrends such as demographic shifts, technological progress, globalization, and climate change and emphasizes the important role of gender equality in mitigating their adverse consequences. The chapter first discusses demographic change, globalization, technological progress, and climate change before explaining how the main challenges posed by these megatrends could be offset by increasing gender equality, providing more equal access to economic opportunities for women, and boosting female economic participation. In particular, it considers ways of mitigating the impact of population ageing, harnessing urbanization for growth and gender equity, catalysing change to reduce income inequality, accelerating economic diversification, and mitigating vulnerability to climate change. The chapter concludes with an evaluation of policy options for mitigating the risks posed by megatrends through gender equality, such as unleashing fiscal policy, easing the burden of non-market work, and removing legal discrimination against women.