scholarly journals A Case of Canine Apocrine Sweat Gland Adenoma, Clear Cell Variant

2005 ◽  
Vol 42 (2) ◽  
pp. 215-218 ◽  
Author(s):  
K. Nibe ◽  
K. Uchida ◽  
T. Itoh ◽  
S. Tateyama
Keyword(s):  
Sweat Gland ◽  
Clear Cell ◽  
Smooth Muscle Actin ◽  
Periodic Acid ◽  
Alpha Smooth Muscle Actin ◽  
Periodic Acid Schiff ◽  
Clear Cells ◽  
Apocrine Sweat Gland ◽  
Cell Variant ◽  
Clear Cell Variant

A cutaneous mass at the base of the retroauricular region of a 4-year-old, female Golden Retriever was examined pathologically. Histologically, the mass formed multiple nodules consisting of a proliferation of large clear cells with abundant cytoplasm. Mitotic figures among the neoplastic cells were very sparse. The large clear cells were intensely positive for cytokeratins (AE1/AE4, cytokeratin 8 and 18) and moderately positive for lysozyme and contained periodic acid-Schiff-positive granules in the cytoplasm. In addition, small flat cells lined the islands of neoplastic large clear cells, and these were strongly positive for alpha-smooth muscle actin and vimentin, and some were positive for cytokeratin (AE1/AE4), suggesting they were myoepithelial cells. No local recurrence or metastasis has been recognized during the 18 months since surgical excision. On the basis of these findings, the present tumor was diagnosed as apocrine sweat gland adenoma, clear cell variant. There have been few previous reports of canine apocrine adenomas showing a clear cell morphology.

scholarly journals Canine Cutaneous Clear Cell Adnexal Carcinoma: Histopathology, Immunohistochemistry, and Biologic Behavior of 26 Cases

2005 ◽  
Vol 17 (5) ◽  
pp. 403-411 ◽  
Author(s):  
F. Y. Schulman ◽  
T. P. Lipscomb ◽  
T. J. Atkin
Keyword(s):  
Clear Cell ◽  
Regional Lymph Node ◽  
Smooth Muscle Actin ◽  
Periodic Acid ◽  
Dermal Papilla ◽  
Low Grade ◽  
Periodic Acid Schiff ◽  
Regional Lymph Nodes ◽  
S 100 ◽  
Clear Cytoplasm

Thirty tumors including 27 distinctive cutaneous neoplasms and 3 metastatic tumors from 26 dogs were collected from diagnostic submissions to 3 laboratories. Characteristic histopathologic features included location in the subcutis or dermis (or both); lobular, nodular, and nest-like architecture; and a component of epithelioid cells with clear cytoplasm. Additional features present in most cases included follicular dermal papilla-like structures, low mitotic index, nuclear pleomorphism, necrosis, and mineralization. Cytoplasmic periodic acid Schiff—positivity, which was abolished by pretreatment with diastase, indicated the presence of glycogen in all cases. The oil red O stain did not demonstrate cytoplasmic lipid. Melanin granules, accentuated by the Fontana-Masson method, were observed infrequently. A sparsely cellular mucinous stroma and stromal cartilaginous differentiation were uncommon. By immunohistochemistry, neoplastic cells stained positively for cytokeratin (29 of 29), vimentin (28 of 28), S-100 protein (24 of 29), and melan A (8 of 12); results were negative for smooth muscle actin and calponin in all cases. Clinical follow-up information was obtained on all 26 dogs. One tumor recurred, 1 metastasized to a regional lymph node, and 1 metastasized to regional lymph nodes twice. In another case, possible pulmonary metastasis was noted radiographically. The findings are consistent with a poorly differentiated, low-grade, adnexal carcinoma of the skin. Similar canine cutaneous neoplasms have been reported as “clear-cell hidradenocarcinoma” and “follicular stem cell carcinoma.” The authors propose the designation “cutaneous clear cell adnexal carcinoma.”

scholarly journals Spontaneous Lung Lesions in Aging Laboratory Rabbits (Oryctolagus cuniculus)

2016 ◽  
Vol 54 (1) ◽  
pp. 178-187 ◽  
Author(s):  
T. K. Cooper ◽  
J. W. Griffith ◽  
Z. C. Chroneos ◽  
J. M. Izer ◽  
L. B. Willing ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Smooth Muscle Actin ◽  
Periodic Acid ◽  
Genetic Defect ◽  
Clinical Signs ◽  
Heterotopic Bone ◽  
Alpha Smooth Muscle Actin ◽  
Periodic Acid Schiff ◽  
Lung Lesions ◽  
Age Related

Spontaneous age-related lesions of laboratory rabbits are not well documented in the contemporary scientific literature. A retrospective study of diagnostic necropsies of 36 rabbits >2 years of age found a number of common lung lesions. Fibromuscular intimal hyperplasia affected medium and to a lesser extent large pulmonary arteries and was present to a variable extent in all 36 rabbits >2 years of age. The lesions were characterized by fragmentation and/or reduplication of the internal elastic lamina (IEL), proliferation of smoothelin+/alpha-smooth muscle actin (α-SMA)+/vimentin− smooth muscle cells and fewer smoothelin−/α-SMA+/vimentin+ myofibroblasts, and intimal deposition of collagen without thrombosis, embolism, or evidence of pulmonary hypertension. Pulmonary emphysema, present in 30/36 rabbits, was characterized by the loss of alveolar septa; most affected rabbits did not have clinical signs of respiratory disease. In 8/13 rabbits of the inbred EIII/JC audiogenic strain, we identified a unique syndrome of granulomatous pneumonia containing hyaline brown to gray, globular to ring-like acellular material that was Alcian blue and periodic acid-Schiff positive. The material was immunoreactive for surfactant protein-A and had the ultrastructural appearance of multilamellar vesicles, suggesting a genetic defect in surfactant metabolism. Additionally, we found small benign primary lung tumors (fibropapillomas, 5 rabbits) not previously described. Other findings included heterotopic bone (5 rabbits), subacute to chronic suppurative bronchopneumonia, pyogranulomatous pneumonia with plant material, and pulmonary artifacts from barbiturate euthanasia solution.

Mast cell infiltration associated with tubulointerstitial fibrosis in chronic Aristolochic Acid Nephropathy

2005 ◽  
Vol 24 (2) ◽  
pp. 41-47 ◽  
Author(s):  
Yichao Wu ◽  
Zhihong Liu ◽  
Weixin Hu ◽  
Leishi Li
Keyword(s):  
Mast Cell ◽  
Aristolochic Acid ◽  
Interstitial Fibrosis ◽  
Smooth Muscle Actin ◽  
Periodic Acid ◽  
Basement Membranes ◽  
Cell Infiltration ◽  
Alpha Smooth Muscle Actin ◽  
Periodic Acid Schiff ◽  
Aristolochic Acid Nephropathy

Aristolochic Acid Nephropathy (AAN) is regarded as a kind of toxic nephropathy caused by the formation of DNA- aristolochic acid adducts in renal parenchymal cells. However, the underlying mechanisms driving the progression of renal interstitial fibrosis in AAN still remains unclear. This study aims to elucidate the role of some immunological factors, especially mast cells (MCs), in the pathogenesis of AAN. Sixteen patients with AAN were enrolled in this study, including five acute and 11 chronic AAN. Monoclonal antibodies against human tryptase, alpha smooth muscle actin (α-SMA), and CD68 were applied on serial sections, which were further counterstained with Periodic Acid-Schiff. It was found that massive tryptase-positive MCs were observed in the fibrotic areas in chronic AAN, especially around thickened tubular basement membranes where myofibroblasts accumulated too. In contrast, MCs infiltrated to a less extent in acute AAN, and were barely found in normal control kidneys. In chronic AAN, the number of MCs in the tubulointerstitium was positively correlated with the degree of renal fibrosis ( r=0.64, P<0.05), but not with serum creatinine levels. Meanwhile, the recruitment of MCs into the renal interstitium is accompanied with local proliferation of myofibroblasts. Macrophages were not abundant, neither in acute nor in chronic AAN. Our findings show for the first time that mast cell infiltration seems to be associated with the progression of fibrosis in the renal tubulointerstitium in chronic AAN.

scholarly journals Epithelial-myoepithelial carcinoma of floor of mouth: A case report of double clear cell variant with immunohistochemical correlation

2020 ◽  
pp. 181
Author(s):  
Keyword(s):  
Salivary Gland ◽  
Case Report ◽  
Clear Cell ◽  
Cell Types ◽  
Myoepithelial Carcinoma ◽  
Clear Cells ◽  
Floor Of Mouth ◽  
Cell Variant ◽  
Epithelial Myoepithelial Carcinoma ◽  
Clear Cell Variant

Epithelial-myoepithelial carcinoma (EMC) is a rare biphasic low-grade malignancy accounting for only 0.5% of all salivary gland tumors. Commonly, EMC affects parotid gland (70%) and rarely affecting other salivary glands. Clearing of both, epithelial and myoepithelial cell types, is rare and gives an impression of a monocellular neoplasm. Case report: A 42-year-old male reported to Oral and Maxillofacial Surgery Department in Faculty of Oral and Dental Medicine, Misr International University with a painless growth in the floor of mouth since 5 years. The soft tissue window of computerized tomography (CT) revealed a well-circumscribed swelling in the sublingual space. The provisional diagnosis was pleomorphic adenoma. Results: The histopathological examination showed solid sheets of rounded to polyhedral clear cells forming lobes and lobules separated by connective tissue mucoid septa. A thin fibrous capsule, invaded with some tumor cells was also present. The presented pattern of clear cells together with the encapsulation of the tumor provides an impression of clear cell variant of monocellular neoplasm. Conclusion: The presented case relates to an epithelial-myoepithelial carcinoma originating from the sublingual salivary gland, which is a rare site for this lesion. Based on immunohistochemical staining, differentiation between the double clear cell types was confirmed using S-100 protein and SMA for the myoepithelial nature of the outer cells while the epithelial nature of the inner cells was confirmed by CK-19 and EMA. Thus, the diagnosis of double clear cell variant of EMC was given.

Mucoepidermoid carcinoma of the palate composed exclusively of clear cells (clear cell variant)

2004 ◽  
Vol 445 (5) ◽  
pp. 541-543 ◽  
Author(s):  
Tadashi Terada ◽  
Shinobu Ikeuchi ◽  
Chie Inomoto ◽  
Kazuo Shimamura
Keyword(s):  
Mucoepidermoid Carcinoma ◽  
Clear Cell ◽  
Clear Cells ◽  
Cell Variant ◽  
Clear Cell Variant

scholarly journals Is Conservative Surgery the Best Approach for Peripheral Calcifying Epithelial Odontogenic Tumors?

2018 ◽  
Vol 12 (1) ◽  
pp. 856-863
Author(s):  
Isadora Luana Flores ◽  
Tissiana Rachel Rossi Schneider ◽  
Ana Carolina Uchoa Vasconcelos ◽  
Sandra Beatriz Chaves Tarquinio ◽  
Ricardo Alves de Mesquita ◽  
...  
Keyword(s):  
Clear Cell ◽  
Treatment Approach ◽  
Case Reports ◽  
English Literature ◽  
Conservative Surgery ◽  
Odontogenic Tumors ◽  
Clear Cells ◽  
Recommended Treatment ◽  
Cell Variant ◽  
Clear Cell Variant

Background: Peripheral Calcifying Epithelial Odontogenic Tumors (CEOT) rich in clear cells are a rare entity in the oral cavity, with only 14 previous case reports in the English literature. None have discussed recommended treatment approaches for extraosseous CEOT. Objective: This brief descriptive review describes a treatment approach for peripheral CEOT including the clear cell variant. Study design: A complete review of all well-documented extraosseous case reports with an emphasis on the treatment was performed. Additionally, the present article reports a case of a 21-year-old woman with an asymptomatic swelling in the gingiva finally diagnosed as peripheral CEOT abundant in clear cells. Results: Twenty-four cases of peripheral CEOT were described; conservative surgery was the first treatment approach in approximately 80% of cases, with only one recurrence. Discussion: Clear cell finding was not associated with more aggressive behavior. Conclusion: Conservative surgery may be an advantageous approach for this group of peripheral lesions with or without clear cells, with a recurrence rate of approximately 4%.

Clear Cell Melanoma: A Cutaneous Clear Cell Malignancy

2014 ◽  
Vol 138 (10) ◽  
pp. 1328-1336 ◽  
Author(s):  
Maria A. Pletneva ◽  
Aleodor Andea ◽  
Nallasivam Palanisamy ◽  
Bryan L. Betz ◽  
Shannon Carskadon ◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
Clear Cell ◽  
Smooth Muscle Actin ◽  
Periodic Acid ◽  
Clear Cell Sarcoma ◽  
Braf V600e ◽  
Periodic Acid Schiff ◽  
Cell Sarcoma ◽  
Molecular Studies ◽  
Cell Malignancy

Clear cell melanoma is a rare clear cell malignancy. Accurate diagnosis of clear cell melanoma requires integration of immunohistochemical and morphologic findings, with molecular studies to rule out clear cell sarcoma. The differential diagnosis includes melanoma, carcinoma, perivascular epithelioid cell tumor, and epidermotropic clear cell sarcoma. We use a case of a lesion on the helix of an 86-year-old man as an example. Histologic examination revealed an ulcerated clear cell malignant tumor. Tumor cell cytoplasm contained periodic acid-Schiff–positive, diastase-sensitive glycogen. Tumor cells showed positive labeling for S100, HMB-45, and Melan-A, and negative labeling for cytokeratins, p63, and smooth muscle actin. Molecular studies demonstrated BRAF V600E mutation, copy gains at the 6p25 (RREB1) and 11q13 (CCND1) loci, and absence of EWSR1-ATF1 fusion. These findings supported a diagnosis of clear cell melanoma. The rare pure clear cell morphology occurs due to accumulation of intracytoplasmic glycogen. We review the differential diagnosis of clear cell melanoma and describe the utility of immunohistochemical and molecular studies in confirming this diagnosis.

scholarly journals Clear Cell variant of Calcifying Epithelial Odontogenic Tumor without Calcification: A Rarity

2014 ◽  
Vol 15 (1) ◽  
pp. 119-121 ◽  
Author(s):  
Vimi Sunil Mutalik ◽  
Monica Solomon ◽  
Prasanna Nichat ◽  
Sunitha Carnelio ◽  
Raghu Radhakrishnan
Keyword(s):  
Clear Cell ◽  
Odontogenic Tumor ◽  
Epithelial Tumor ◽  
Calcifying Epithelial Odontogenic Tumor ◽  
Clear Cells ◽  
Unusual Variant ◽  
Pas Staining ◽  
Cell Variant ◽  
Clear Cell Variant ◽  
Epithelial Odontogenic Tumor

ABSTRACT Calcifying epithelial odontogenic tumor (CEOT) is a rare, benign, locally aggressive odontogenic epithelial tumor that affects the jaws. Although there are numerous reports on the variants of CEOT, occurrence of clear cells with complete absence of calcification has been a rarity. Histochemical analysis of tumor cells revealed glycogen granules with PAS staining, with absence of CD 1a staining in clear cells, while the amyloid-like deposit associated with clear cells showed green birefringence with Congo red. We report an unusual variant of CEOT occurring in a 27 years old male patient. How to cite this article Mutalik VS, Nichat P, Carnelio S, Solomon M, Radhakrishnan R. Clear Cell variant of Calcifying Epithelial Odontogenic Tumor without Calcification: A Rarity. J Contemp Dent Pract 2014;15(1):119-121.

Clear Cell Carcinoma of the Larynx

1980 ◽  
Vol 89 (2) ◽  
pp. 168-172 ◽  
Author(s):  
In Sook Seo ◽  
Charles E. Tomich ◽  
Kathleen A. Warfel ◽  
Meredith T. Hull
Keyword(s):  
Electron Microscopy ◽  
Light Microscopy ◽  
Cell Carcinoma ◽  
Mucoepidermoid Carcinoma ◽  
Clear Cell ◽  
Clear Cell Carcinoma ◽  
Clear Cells ◽  
Carcinoma Of The Larynx ◽  
Cell Variant ◽  
Clear Cell Variant

A case of clear cell carcinoma of the larynx is presented. By light microscopy the lesion was composed mainly of sheets of clear cells, containing intracytoplasmic mucin and glycogen. Glandular lumina, tonofilaments, and desmosome-tonofilament complexes were observed on electron microscopy. The presence of these features established that this unusual neoplasm was a clear cell variant of mucoepidermoid carcinoma.

Hyalinizing clear cell carcinoma of the hard palate

2004 ◽  
Vol 118 (5) ◽  
pp. 382-384 ◽  
Author(s):  
Ting-Kuang Chao ◽  
Chien-Chen Tsai ◽  
Shiou-Yu Yeh ◽  
Jonathan Eng-Kiat Teh
Keyword(s):  
Cell Carcinoma ◽  
Standard Treatment ◽  
Clear Cell ◽  
Clear Cell Carcinoma ◽  
Periodic Acid ◽  
Pathological Examination ◽  
Periodic Acid Schiff ◽  
Clear Cells ◽  
Hyalinizing Clear Cell Carcinoma

Hyalinizing clear cell carcinoma (HCCC) of the salivary gland is new disease only recognized in recent years. It is rare and the standard treatment is still under investigation. This is a report of a 42-year-old female with HCCC who presented with a painless submucosal hard palatal mass of three years duration. Wide excision of the tumour and the underlying palatal and maxillary bones was performed. Pathological examination revealed typical clear cells arranged in anastomosing trabeculae, cords, nests, or solid sheets with a hyalinizing stroma. These clear cells were positive for the periodic acid-Schiff (PAS) reaction but were negative for the mucin stain. Immunohistochemically, these neoplastic cells were positive for cytokeratin, but negative for actin. No recurrence nor distant metastasis was found during the eight-month follow-up period.

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