scholarly journals Technologies and Extraction Methods of Polyphenolic Compounds Derived from Pomegranate (Punica granatum) Peels. A Mini Review

Processes ◽  
2021 ◽  
Vol 9 (2) ◽  
pp. 236
Author(s):  
Dimitrios Lampakis ◽  
Prodromos Skenderidis ◽  
Stefanos Leontopoulos
Keyword(s):  
Electric Fields ◽  
Bioactive Compounds ◽  
New Technologies ◽  
Ohmic Heating ◽  
Punica Granatum ◽  
Extraction Methods ◽  
Added Value ◽  
Green Solvents ◽  
Ultrasound Assisted Extraction ◽  
Functional Product

The interest in using plant by-product extracts as functional ingredients is continuously rising due to environmental and financial prospects. The development of new technologies has led to the achievement of aqueous extracts with high bioactivity that is preferable due to organic solvents nonuse. Recently, widely applied and emerging technologies, such as Simple Stirring, Pressure-Applied Extraction, Enzymatic Extraction, Ultrasound-Assisted Extraction, Pulsed Electric Fields, High Hydrostatic Pressure, Ohmic Heating, Microwave Assistant Extraction and the use of “green” solvents such as the deep eutectic solvents, have been investigated in order to contribute to the minimization of disadvantages on the extraction of bioactive compounds. This review is focused on bioactive compounds derived from pomegranate (Punica granatum) peels and highlighted the most attractive extraction methods. It is believed that these findings could be a useful tool for the pomegranate juices industry to apply an effective and economically viable extraction process, transforming a by-product to a high added value functional product.

scholarly journals Green and Sustainable Valorization of Bioactive Phenolic Compounds from Pinus By-Products

Molecules ◽  
2020 ◽  
Vol 25 (12) ◽  
pp. 2931 ◽  
Author(s):  
Pedro Ferreira-Santos ◽  
Elisa Zanuso ◽  
Zlatina Genisheva ◽  
Cristina M. R. Rocha ◽  
José A. Teixeira
Keyword(s):  
Phenolic Compounds ◽  
Electric Fields ◽  
Bioactive Compounds ◽  
Food Additives ◽  
Extraction Methods ◽  
Industrial Applications ◽  
Added Value ◽  
Green Technologies ◽  
By Products ◽  
Pine Species

In Europe, pine forests are one of the most extended forests formations, making pine residues and by-products an important source of compounds with high industrial interest as well as for bioenergy production. Moreover, the valorization of lumber industry residues is desirable from a circular economy perspective. Different extraction methods and solvents have been used, resulting in extracts with different constituents and consequently with different bioactivities. Recently, emerging and green technologies as ultrasounds, microwaves, supercritical fluids, pressurized liquids, and electric fields have appeared as promising tools for bioactive compounds extraction in alignment with the Green Chemistry principles. Pine extracts have attracted the researchers’ attention because of the positive bioproperties, such as anti-inflammatory, antimicrobial, anti-neurodegenerative, antitumoral, cardioprotective, etc., and potential industrial applications as functional foods, food additives as preservatives, nutraceuticals, pharmaceuticals, and cosmetics. Phenolic compounds are responsible for many of these bioactivities. However, there is not much information in the literature about the individual phenolic compounds of extracts from the pine species. The present review is about the reutilization of residues and by-products from the pine species, using ecofriendly technologies to obtain added-value bioactive compounds for industrial applications.

scholarly journals Bioactive Compounds Obtained from Polish “Marynka” Hop Variety Using Efficient Two-Step Supercritical Fluid Extraction and Comparison of Their Antibacterial, Cytotoxic, and Anti-Proliferative Activities In Vitro

Molecules ◽  
2021 ◽  
Vol 26 (8) ◽  
pp. 2366
Author(s):  
Katarzyna Klimek ◽  
Katarzyna Tyśkiewicz ◽  
Malgorzata Miazga-Karska ◽  
Agnieszka Dębczak ◽  
Edward Rój ◽  
...  
Keyword(s):  
Supercritical Fluid Extraction ◽  
Supercritical Fluid ◽  
Bioactive Compounds ◽  
Crude Extract ◽  
Normal Skin ◽  
Extraction Methods ◽  
Biological Properties ◽  
Added Value ◽  
Fluid Extraction

Given the health-beneficial properties of compounds from hop, there is still a growing trend towards developing successful extraction methods with the highest yield and also receiving the products with high added value. The aim of this study was to develop efficient extraction method for isolation of bioactive compounds from the Polish “Marynka” hop variety. The modified two-step supercritical fluid extraction allowed to obtain two hop samples, namely crude extract (E1), composed of α-acids, β-acids, and terpene derivatives, as well as pure xanthohumol with higher yield than that of other available methods. The post-extraction residues (R1) were re-extracted in order to obtain extract E2 enriched in xanthohumol. Then, both samples were subjected to investigation of their antibacterial (anti-acne, anti-caries), cytotoxic, and anti-proliferative activities in vitro. It was demonstrated that extract (E1) possessed more beneficial biological properties than xanthohumol. It exhibited not only better antibacterial activity against Gram-positive bacteria strains (MIC, MBC) but also possessed a higher synergistic effect with commercial antibiotics when compared to xanthohumol. Moreover, cell culture experiments revealed that crude extract neither inhibited viability nor divisions of normal skin fibroblasts as strongly as xanthohumol. In turn, calculated selectivity indexes showed that the crude extract had from slightly to significantly better selective anti-proliferative activity towards cancer cells in comparison with xanthohumol.

scholarly journals Effects of Ultrasound-Assisted Extraction and Solvent on the Phenolic Profile, Bacterial Growth, and Anti-Inflammatory/Antioxidant Activities of Mediterranean Olive and Fig Leaves Extracts

Molecules ◽  
2020 ◽  
Vol 25 (7) ◽  
pp. 1718 ◽  
Author(s):  
Cristina Alcántara ◽  
Tihana Žugčić ◽  
Radhia Abdelkebir ◽  
Jose V. García-Pérez ◽  
Anet Režek Jambrak ◽  
...  
Keyword(s):  
Bioactive Compounds ◽  
Bacterial Growth ◽  
Extraction Methods ◽  
Olive Leaves ◽  
Ultrasound Assisted Extraction ◽  
Phenolic Profile ◽  
Assisted Extraction ◽  
Ultrasound Assisted ◽  
Conventional Extraction ◽  
Anti Inflammatory

Mediterranean plants, such as fig and olive leaves, are well-known to exert beneficial effects in humans because of the presence of a wide range of bioactive compounds. However, scarce information regarding the impact of extraction methods, such as ultrasound and types of solvents, on their profile of antioxidant and anti-inflammatory compounds is provided. In addition, no information is available on the effects of extraction methods and solvents on the inhibition of pathogenic bacteria or promoting probiotic growth. In this scenario, this study was aimed to study the effects of ultrasound-assisted extraction (UAE) and solvent on the phenolic profile (Triple TOF-LC-MS/MS), antioxidant and anti-inflammatory compounds of olive and fig leaves. Results showed that UAE extracted more carotenoids compared to conventional extraction, while the conventional extraction impacted on higher flavonoids (olive leaves) and total phenolics (fig leaves). The antioxidant capacity of aqueous extract of fig leaves was three times higher than the extract obtained with ethanol for conventional extraction and four times higher for UAE. In general terms, hydroethanolic extracts presented the highest bacterial growth inhibition, and showed the highest anti-inflammatory activity. In conclusion, these side streams can be used as sources of bioactive compounds for further development of high-added-value products.

scholarly journals Valorization of Mushroom By-Products as a Source of Value-Added Compounds and Potential Applications

Molecules ◽  
2020 ◽  
Vol 25 (11) ◽  
pp. 2672 ◽  
Author(s):  
Filipa Antunes ◽  
Sara Marçal ◽  
Oludemi Taofiq ◽  
Alcina M. M. B. Morais ◽  
Ana Cristina Freitas ◽  
...  
Keyword(s):  
Bioactive Compounds ◽  
Food System ◽  
Animal Feed ◽  
Value Added ◽  
Pharmaceutical Formulations ◽  
Extraction Methods ◽  
Industrial Wastes ◽  
Added Value ◽  
Future Research ◽  
By Products

Nowadays, the food sector is highly concerned with environmental issues and foreseen to develop strategies to reduce waste and losses resulting from activities developed in the food system. An approach is to increment added value to the agro-industrial wastes, which might provide economic growth and environmental protection, contributing to a circular economy. Mushroom by-products represent a disposal problem, but they are also promising sources of important compounds, which may be used due to their functional and nutritional properties. Research has been developed in different fields to obtain value added solutions for the by-products generated during mushroom production and processing. Bioactive compounds have been obtained and applied in the development of nutraceutical and pharmaceutical formulations. Additionally, other applications have been explored and include animal feed, fertilizer, bioremediation, energy production, bio-based materials, cosmetics and cosmeceuticals. The main purpose of this review is to highlight the relevant composition of mushroom by-products and discuss their potential as a source of functional compounds and other applications. Future research needs to explore pilot and industrial scale extraction methods to understand the technological feasibility and the economic sustainability of the bioactive compounds extraction and valorization towards different applications.

scholarly journals Green solvents and Ultrasound-Assisted Extraction of bioactive orange (Citrus sinensis) peel compounds

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Abigail Montero-Calderon ◽  
Clara Cortes ◽  
Ana Zulueta ◽  
Ana Frigola ◽  
Maria J. Esteve
Keyword(s):  
Antioxidant Capacity ◽  
Bioactive Compounds ◽  
Orange Peel ◽  
Green Solvents ◽  
Ultrasound Assisted Extraction ◽  
Total Carotenoids ◽  
Carotenoid Concentration ◽  
Assisted Extraction ◽  
Physicochemical Evaluation ◽  
Ultrasound Assisted

Abstract Byproducts such as orange peel have potential uses because of their bioactive compounds, which are important for their potential to reduce the risk factors of diseases caused by aging. The lack of effective techniques and the high levels of pollution produced by the conventional extraction of bioactive compounds using organic solvents have highlighted the need to enhance the ‘green chemistry’ trend. This study evaluates the use of ultrasound to extract bioactive compounds from orange peel. The antioxidant capacity, phenolic content, ascorbic acid, total carotenoids, and HPLC profile of phenolic compounds from orange peel extracts were obtained by a physicochemical evaluation. The results demonstrate that the optimal conditions for the ultrasound-assisted extraction of bioactive orange peel compounds were a power of 400 W, a time of 30 min, and 50% ethanol in water. These conditions were used to obtain a total carotenoid concentration of 0.63 mg ß-carotene/100 g, vitamin C concentration of 53.78 mg AA/100 g, phenolic concentration of 105.96 mg GAE/100 g, and antioxidant capacity of ORAC = 27.08 mM TE and TEAC = 3.97 mM TE. The major phenolic compound identified in all orange peel extracts was hesperidin, with a maximum concentration of 113.03 ± 0.08 mg/100 g.

scholarly journals APPLICATION OF GREEN EXTRACTION METHODS TO RESVERATROL EXTRACTION FROM PEANUT (ARACHIS HYPOGAEA L.) SKIN

2020 ◽  
pp. 38-42
Author(s):  
REZI RIADI SYAHDI ◽  
RATNA NADYANA ◽  
RIZQI HERU PUTRI ◽  
ROSEDIANA SANTI ◽  
ABDUL MUN’IM
Keyword(s):  
Choline Chloride ◽  
Dry Weight ◽  
Extraction Methods ◽  
Green Solvents ◽  
Liquid Ratio ◽  
Ultrasound Assisted Extraction ◽  
Peanut Skin ◽  
Assisted Extraction ◽  
Arachis Hypogaea L ◽  
Solid Liquid

Objective: This study compared the maceration extraction method with non-conventional extraction methods such as ultrasound-assisted extraction(UAE) and microwave-assisted extraction (MAE).Methods: To obtain resveratrol, various conditions were optimized: Solvent types (organic solvent [i.e. 70% ethanol] and green solvents [i.e. naturaldeep eutectic solvent (NADES) and ionic liquid (IL)]) and extraction methods. The resveratrol content in the extracts was analyzed by high-performanceliquid chromatography.Results: It was determined that resveratrol extracted by UAE with NADES was composed of choline chloride–oxalic acid when the followingconditions were used: The solid/liquid ratio of 1:20 (g/mL) and the extraction time of 15 min. These conditions produced higher resveratrol content(0.049 mg/g dry weight) than that using MAE with 70% ethanol (0.011 mg/g dry weight). However, the maceration method yielded the highestamount of resveratrol (0.221 mg/g dry weight), and MAE with IL produced the smallest amount of resveratrol (0.157 × 10−3 mg/g dry weight).Conclusion: Peanut skin extracted using the maceration method produced the highest amount of resveratrol compared to that using other methods.

scholarly journals Critical Variables Influencing the Ultrasound-Assisted Extraction of Bioactive Compounds—A Review

2021 ◽  
Vol 5 (1) ◽  
pp. 50
Author(s):  
Anxo Carreira-Casais ◽  
Maria Carpena ◽  
Antia G. Pereira ◽  
Franklin Chamorro ◽  
Anton Soria-Lopez ◽  
...  
Keyword(s):  
Green Chemistry ◽  
Bioactive Compounds ◽  
Extraction Methods ◽  
Extraction Time ◽  
Solvent Ratio ◽  
Ultrasound Assisted Extraction ◽  
Assisted Extraction ◽  
Ultrasound Assisted ◽  
Extraction Performance ◽  
Ultrasound Power

Ultrasound-assisted extraction (UAE) is a novel methodology, belonging to the so-called “Green Chemistry”, which has gained interest in recent years due to the potential to recover bioactive compounds, especially those from plant matrices. It is widely recognized that the extraction of molecules by UAE gives rise to higher or similar yields than those obtained by traditional extraction methods. UAE has certain advantages inherent to Green Chemistry extraction methods, such as short extraction time and low solvent consumption. The aim of this review is to critically present the different variables and parameters that can be modified in UAE, such as ultrasound power, time, temperature, solvent, and solid to solvent ratio that influence yield and extraction performance.

scholarly journals Improved Extraction Efficiency of Antioxidant Bioactive Compounds from Tetraselmis chuii and Phaedoactylum tricornutum Using Pulsed Electric Fields

Molecules ◽  
2020 ◽  
Vol 25 (17) ◽  
pp. 3921
Author(s):  
Marialena Kokkali ◽  
Francisco J. Martí-Quijal ◽  
Mercedes Taroncher ◽  
María-José Ruiz ◽  
Katerina Kousoulaki ◽  
...  
Keyword(s):  
Electric Fields ◽  
Bioactive Compounds ◽  
Extraction Efficiency ◽  
Pulsed Electric Fields ◽  
Selective Extraction ◽  
Extraction Time ◽  
Added Value ◽  
Promising Alternative ◽  
Tetraselmis Chuii ◽  
Pigment Extraction

Pulsed electric fields (PEF) is a promising technology that allows the selective extraction of high-added value compounds by electroporation. Thus, PEF provides numerous opportunities for the energy efficient isolation of valuable microalgal bioactive substances (i.e., pigments and polyphenols). The efficiency of PEF-assisted extraction combined with aqueous or dimethyl sulfoxide (DMSO) solvents in recovering pigments and polyphenols from microalgae Tetraselmis chuii (T. chuii) and Phaeodactylum tricornutum (P. tricornutum) was evaluated. Two PEF treatments were applied: (1 kV/cm/400 pulses, 3 kV/cm/45 pulses), with a specific energy input of 100 kJ/kg. The total antioxidant capacity (TAC) was positively influenced by the use of DMSO. The highest TAC in the T. chuii culture was achieved at a lower extraction time and electric field than for P. tricornutum. The use of DMSO only improved the polyphenols′ extraction for P. tricornutum, whereas the PEF and extraction time were more important for T. chuii. Carotenoids and chlorophyll a were more efficiently extracted using DMSO, while chlorophyll b levels were higher following aqueous extraction for both microalgae. In P. tricornutum, the TAC and pigment extraction efficiency were in general higher at lower extraction times. It can be concluded that PEF may be a promising alternative for the enhancement of the selective extraction of antioxidant bioactive compounds from microalgae.

Ohmic Heating and Moderate Electric Field Processing

2008 ◽  
Vol 14 (5) ◽  
pp. 419-422 ◽  
Author(s):  
S. Sastry
Keyword(s):  
Electric Field ◽  
Electric Fields ◽  
New Technologies ◽  
Ohmic Heating ◽  
Basic Research ◽  
Federal Research Funding ◽  
Research Areas ◽  
Federal Research ◽  
Significant Research ◽  
Moderate Electric Field

Ohmic heating has been revived in the 1980s and after a brief pause in the 1990s, has reemerged in a number of food processing applications. An offshoot, Moderate Electric Field (MEF) processing has emerged from the recognition that even relatively mild electric fields themselves have significant effects on food and other biological materials. A number of significant research areas have been identified in this connection. In addition, a discussion is provided on priorities for federal research funding, including the need for basic research balanced with industry relevance, availability of pilot facilities for development of new technologies, and potentially, a mechanism for helping inventions survive through the initial ``Valley of Death'' phase.

scholarly journals Optimization of Extraction of Bioactive Compounds from Baphicacanthus cusia Leaves by Hydrophobic Deep Eutectic Solvents

Molecules ◽  
2021 ◽  
Vol 26 (6) ◽  
pp. 1729
Author(s):  
Zhiqin Xu ◽  
Yini Cai ◽  
Qing Ma ◽  
Zhimin Zhao ◽  
Depo Yang ◽  
...  
Keyword(s):  
Lactic Acid ◽  
Medicinal Plants ◽  
Bioactive Compounds ◽  
Radical Scavenging Activity ◽  
Radical Scavenging ◽  
Deep Eutectic Solvents ◽  
Green Solvents ◽  
Ultrasound Assisted Extraction ◽  
Assisted Extraction ◽  
Ultrasound Assisted

Deep eutectic solvents (DESs) are considered as efficient and green solvents for the extraction of bioactive compounds from medicinal plants. In this work, a novel method of DES-based ultrasound-assisted extraction of bioactive compounds from Baphicacanthus cusia leaves (BCL) was established. Systematic screening and the morphology of the original and treated BCL were observed with scanning electron microscopy to determine the extraction efficiency of different solvents. The extraction conditions were optimized by Box–Behnken design (BBD) tests and the optimal extraction conditions were as follows: lactic acid/L-menthol ratio of 5: 2 (mol/mol), solid–liquid ratio of 80.0 mL/g and temperature of 60.5 °C. The extraction yields of tryptanthrin, indigo and indirubin reached 0.356, 1.744 and 0.562 mg/g, respectively. The results of a 2,2-diphenyl-1-picrylhydrazy (DPPH) radical scavenging activity test indicated the feasibility of DESs in the extraction of bioactive compounds. This study indicated that L-menthol/lactic acid was a green and efficient solvent for the extraction of bioactive compounds from BCL, and DES-based ultrasound-assisted extraction could be used as an effective application strategy for the extraction of bioactive compounds from medicinal plants.

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