Comparison of Near-Infrared and Laser-Induced Breakdown Spectroscopy for Determination of Magnesium Stearate in Pharmaceutical Powders and Solid Dosage Forms

2005 ◽  
Vol 59 (3) ◽  
pp. 340-347 ◽  
Author(s):  
Robert L. Green ◽  
Mark D. Mowery ◽  
Julie A. Good ◽  
John P. Higgins ◽  
Steven M. Arrivo ◽  
...  
Keyword(s):  
Quantitative Analysis ◽  
Near Infrared ◽  
Matrix Effects ◽  
Nir Spectroscopy ◽  
Magnesium Stearate ◽  
Laser Induced Breakdown Spectroscopy ◽  
Breakdown Spectroscopy ◽  
Laser Induced Breakdown ◽  
Pharmaceutical Processing

Near-infrared (NIR) spectroscopy has become well established in both the pharmaceutical arena and other areas as a useful technique for rapid quantitative analysis of solid materials. Though laser-induced breakdown spectroscopy (LIBS) has not been widely applied in the pharmaceutical industry, the technique has been used for rapid quantitative analysis of solids in many other applications. One analysis amenable to each technique is the determination of magnesium stearate in solids during the lubrication blending unit operation of pharmaceutical processing. A comparative study of the utility of these two techniques for this application will be presented. Necessary sample preparations and the extent and type of matrix effects will be discussed. Additionally, it will be shown that NIR provides better accuracy and precision than LIBS with the experimental parameters used; however, LIBS showed superior selectivity as it was demonstrated to be more robust to sample matrix perturbations. Examples of blending applications will also be presented.

A NOVEL STRATEGY FOR DIRECT ELEMENTAL DETERMINATION USING LASER-INDUCED BREAKDOWN SPECTROSCOPY: FLUENCE CALIBRATION

2021 ◽  
Author(s):  
Raquel C Machado ◽  
Diego Victor Babos ◽  
Daniel Fernandes Andrade ◽  
Edenir Rodrigues Pereira-Filho
Keyword(s):  
Quantitative Analysis ◽  
Matrix Effects ◽  
Calibration Method ◽  
Laser Induced Breakdown Spectroscopy ◽  
Breakdown Spectroscopy ◽  
Elemental Determination ◽  
Laser Induced Breakdown ◽  
Direct Solid Analysis ◽  
Novel Strategy ◽  
Direct Solid

Quantitative analysis requires several efforts to obtain an adequate calibration method to overcome matrix effects employing direct solid analysis by laser-induced breakdown spectroscopy (LIBS). To this end, in this study,...

Determination of Carbon Content in Steel Using Laser-Induced Breakdown Spectroscopy

1992 ◽  
Vol 46 (9) ◽  
pp. 1382-1387 ◽  
Author(s):  
J. A. Aguilera ◽  
C. Aragón ◽  
J. Campos
Keyword(s):  
Carbon Content ◽  
Matrix Effects ◽  
Sample Surface ◽  
Nitrogen Atmosphere ◽  
Laser Induced Breakdown Spectroscopy ◽  
Time Resolved ◽  
Breakdown Spectroscopy ◽  
Use Of Time ◽  
Laser Induced Breakdown

Laser-induced breakdown spectroscopy has been used to determine carbon content in steel. The plasma was formed by focusing a Nd:YAG laser on the sample surface. With the use of time-resolved spectroscopy and generation of the plasma in nitrogen atmosphere, a precision of 1.6% and a detection limit of 65 ppm have been obtained. These values are similar to those of other accurate conventional techniques. Matrix effects for the studied steels are reduced to a small slope difference between the calibration curves for stainless and nonstainless steels.

Matrix Effects in Quantitative Analysis of Laser-Induced Breakdown Spectroscopy (LIBS) of Rock Powders Doped with Cr, Mn, Ni, Zn, and Co

2017 ◽  
Vol 71 (4) ◽  
pp. 600-626 ◽  
Author(s):  
Kate H. Lepore ◽  
Caleb I. Fassett ◽  
Elly A. Breves ◽  
Sarah Byrne ◽  
Stephen Giguere ◽  
...  
Keyword(s):  
Quantitative Analysis ◽  
Matrix Effects ◽  
Laser Induced Breakdown Spectroscopy ◽  
Breakdown Spectroscopy ◽  
Laser Induced Breakdown

scholarly journals Detection of Rare Earth Elements in Minerals and Soils by Laser-Induced Breakdown Spectroscopy (LIBS) Using Interval PLS

Minerals ◽  
2021 ◽  
Vol 11 (12) ◽  
pp. 1379
Author(s):  
Nina Rethfeldt ◽  
Pia Brinkmann ◽  
Daniel Riebe ◽  
Toralf Beitz ◽  
Nicole Köllner ◽  
...  
Keyword(s):  
Rare Earth ◽  
Rare Earth Elements ◽  
Matrix Effects ◽  
Principal Component ◽  
Laser Induced Breakdown Spectroscopy ◽  
Regression Methods ◽  
Breakdown Spectroscopy ◽  
Field Samples ◽  
Laser Induced Breakdown

The numerous applications of rare earth elements (REE) has lead to a growing global demand and to the search for new REE deposits. One promising technique for exploration of these deposits is laser-induced breakdown spectroscopy (LIBS). Among a number of advantages of the technique is the possibility to perform on-site measurements without sample preparation. Since the exploration of a deposit is based on the analysis of various geological compartments of the surrounding area, REE-bearing rock and soil samples were analyzed in this work. The field samples are from three European REE deposits in Sweden and Norway. The focus is on the REE cerium, lanthanum, neodymium and yttrium. Two different approaches of data analysis were used for the evaluation. The first approach is univariate regression (UVR). While this approach was successful for the analysis of synthetic REE samples, the quantitative analysis of field samples from different sites was influenced by matrix effects. Principal component analysis (PCA) can be used to determine the origin of the samples from the three deposits. The second approach is based on multivariate regression methods, in particular interval PLS (iPLS) regression. In comparison to UVR, this method is better suited for the determination of REE contents in heterogeneous field samples.

scholarly journals Application of Laser Induced Breakdown Spectroscopy in Soil Element Analysis of Watershed

2018 ◽  
Vol 246 ◽  
pp. 01114
Author(s):  
C. P. Chen ◽  
L. Hei ◽  
S. C. Yu ◽  
W. L. Chen ◽  
M. X. Cai
Keyword(s):  
Quantitative Analysis ◽  
Elemental Analysis ◽  
Matrix Effects ◽  
Rapid Development ◽  
Internal Standard ◽  
Laser Induced Breakdown Spectroscopy ◽  
Element Analysis ◽  
Breakdown Spectroscopy ◽  
Analysis Methods ◽  
Laser Induced Breakdown

With the rapid development of spectroscopy technology, laser induced breakdown spectroscopy (LIBS) has become the focus of elemental analysis technology in recent years. With its advantages of non-destructive testing, rapid and multi-element detection, LIBS has been successfully applied to the analysis of geochemical characteristics of soil elements in river basins. The application of LIBS technology in soil elemental analysis of watershed is reviewed in detail. The accuracy of LIBS technology in soil element analysis is studied with the Masha River Basin as the research area. On this basis, the key problems in the process of soil element analysis, such as spectral enhancement methods and quantitative analysis methods, were analyzed. The analysis results show that the accuracy of elemental analysis between LIBS and traditional chemical methods is not much different, but the analysis time of LIBS method is shorter. Methods such as MLR, PLSR, and internal standard methods can improve the fit of the calibration curve and reduce the quantitative analysis error. By changing parameters such as laser energy and delay time, the spectral intensity can be enhanced to reduce the effects of matrix effects. In the process of elemental analysis, the effects of soil physical and chemical parameters should be considered comprehensively, and appropriate quantitative analysis methods should be adopted to improve the accuracy of the analysis results.

Determination of boron in aqueous solution using a method combining laser ablation molecular isotopic spectrometry with molecular laser-induced fluorescence and isotopic dilution

2021 ◽  
Author(s):  
Kun Liu ◽  
Ran Zhou ◽  
Wen Zhang ◽  
Zhiyang Tang ◽  
Qingzhou Li ◽  
...  
Keyword(s):  
Aqueous Solution ◽  
Quantitative Analysis ◽  
Laser Induced Fluorescence ◽  
Isotopic Dilution ◽  
Laser Induced Breakdown Spectroscopy ◽  
Inhomogeneous Distribution ◽  
Molecular Laser ◽  
Breakdown Spectroscopy ◽  
Laser Induced Breakdown

Laser-induced breakdown spectroscopy(LIBS) has been applied in quantitative and isotopic detection of boron. However, the inhomogeneous distribution and possible loss of substance affect the accuracy of quantitative analysis in aqueous...

Optimizing the binder percentage to reduce matrix effects for the LIBS analysis of carbon in coal

2017 ◽  
Vol 32 (4) ◽  
pp. 766-772 ◽  
Author(s):  
Shunchun Yao ◽  
Jingbo Zhao ◽  
Jialong Xu ◽  
Zhimin Lu ◽  
Jidong Lu
Keyword(s):  
Quantitative Analysis ◽  
Matrix Effects ◽  
Laser Induced Breakdown Spectroscopy ◽  
Breakdown Spectroscopy ◽  
Laser Induced Breakdown

Quantitative analysis of elements by laser-induced breakdown spectroscopy (LIBS) is significantly affected by matrix effects in coal.

Effective Normalization Technique for Correction of Matrix Effects in Laser-Induced Breakdown Spectroscopy Detection of Magnesium in Powdered Samples

2002 ◽  
Vol 56 (4) ◽  
pp. 433-436 ◽  
Author(s):  
S. I. Gornushkin ◽  
I. B. Gornushkin ◽  
J. M. Anzano ◽  
B. W. Smith ◽  
J. D. Winefordner
Keyword(s):  
Matrix Effects ◽  
Certified Reference Materials ◽  
Sample Surface ◽  
Laser Induced Breakdown Spectroscopy ◽  
Adhesive Tape ◽  
Breakdown Spectroscopy ◽  
Wide Range ◽  
Laser Induced Breakdown ◽  
The Matrix

The goal of this research was to investigate the influence of the matrix on the laser-induced spectroscopy of magnesium. Powdered samples were used and were presented to the measurement as thin distributions on adhesive tape. A wide range of NIST certified reference materials were used as samples. With careful sample preparation and correction for sample surface density on the tape (determined by weighing), reasonable consistency in the Mg signal intensity was obtained regardless of sample matrix. Relative error of ∼10% and a precision of 10–20% were obtained for the determination of Mg in several certified samples.

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