scholarly journals Characterization of Estrogen and Androgen Activity of Food Contact Materials by Different In Vitro Bioassays (YES, YAS, ERα and AR CALUX) and Chromatographic Analysis (GC-MS, HPLC-MS)

PLoS ONE ◽  
2014 ◽  
Vol 9 (7) ◽  
pp. e100952 ◽  
Author(s):  
Johannes Mertl ◽  
Christian Kirchnawy ◽  
Veronica Osorio ◽  
Angelika Grininger ◽  
Alexander Richter ◽  
...  
2014 ◽  
Vol 406 (17) ◽  
pp. 4251-4259 ◽  
Author(s):  
M. A. Lago ◽  
A. Rodríguez-Bernaldo de Quirós ◽  
R. Sendón ◽  
J. Bustos ◽  
M. I. Santillana ◽  
...  

2011 ◽  
Vol 304 ◽  
pp. 012038
Author(s):  
Niall Ó Claonadh ◽  
Alan Casey ◽  
Sean Lyons ◽  
Clement Higginbotham ◽  
Sanchali Gupta Mukherjee ◽  
...  

Foods ◽  
2020 ◽  
Vol 9 (2) ◽  
pp. 237
Author(s):  
Elisabeth Pinter ◽  
Bernhard Rainer ◽  
Thomas Czerny ◽  
Elisabeth Riegel ◽  
Benoît Schilter ◽  
...  

Background: Non-targeted screening of food contact materials (FCM) for non-intentionally added substances (NIAS) reveals a great number of unknown and unidentified substances present at low concentrations. In the absence of toxicological data, the application of the threshold of toxicological concern (TTC) or of EU Regulation 10/2011 requires methods able to fulfill safety threshold criteria. In this review, mammalian in vitro genotoxicity assays are analyzed for their ability to detect DNA-damaging substances at limits of biological detection (LOBD) corresponding to the appropriate safety thresholds. Results: The ability of the assays to detect genotoxic effects varies greatly between substance classes. Especially for direct-acting mutagens, the assays lacked the ability to detect most DNA reactive substances below the threshold of 10 ppb, making them unsuitable to pick up potential genotoxicants present in FCM migrates. However, suitability for the detection of chromosomal damage or investigation of other modes of action makes them a complementary tool as part of a standard test battery aimed at giving additional information to ensure safety. Conclusion: improvements are necessary to comply with regulatory thresholds to consider mammalian genotoxicity in vitro assays to assess FCM safety.


2018 ◽  
Vol 22 (12) ◽  
pp. 1249-1254 ◽  
Author(s):  
Mercedes Peltzer ◽  
Juan F. Delgado ◽  
Andres G. Salvay ◽  
Jorge R. Wagner

2021 ◽  
Vol 38 (3) ◽  
pp. 513-531
Author(s):  
Yoon S. Song ◽  
John L. Koontz ◽  
Rima O. Juskelis ◽  
Eduardo Patazca ◽  
William Limm ◽  
...  

Foods ◽  
2021 ◽  
Vol 10 (7) ◽  
pp. 1443
Author(s):  
Arabela Ramírez Carnero ◽  
Antía Lestido-Cardama ◽  
Patricia Vazquez Loureiro ◽  
Letricia Barbosa-Pereira ◽  
Ana Rodríguez Bernaldo de Quirós ◽  
...  

Perfluoroalkyl and polyfluoroalkyl substances (PFAS) are synthetic chemical compounds widely used in different industry fields including food contact materials (FCM), providing resistance to fat and humidity, and non-stick properties. PFAS enter into the food chain directly from the intake of contaminated food or indirectly from the migration of the FCM into the food. This exposure published in different research highlights a public health concern. Therefore, it is necessary to perform analysis of the content of different FCM and evaluate the migration from the FCM under normal conditions of use and storage. This bibliographical review proves that different perfluoroalkyl and polyfluoroalkyl compounds are detected in fast food packaging, microwave popcorn bags, and frying pans, among others. Furthermore, it shows the conditions or factors that favor the migration of the PFAS from the FCM into the food.


Author(s):  
Erica Selin ◽  
Kettil Svensson ◽  
Erik Gravenfors ◽  
Georgios Giovanoulis ◽  
Mitsura Iida ◽  
...  

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