A Novel Isoquinoline Derivative Anticancer Agent and Its Targeted Delivery to Tumor Cells Using Transferrin-Conjugated Liposomes

Cancer is one of the reason for mortality and its individual and collective impact is substantial. Conventional chemotherapy utilizes drugs that can destroy Tumor cells effectively. But these agents destroy healthy cells along with the tumor cells, leading to many adverse effects which include hypersensitivity reactions, nephrotoxicity, and neurotoxicity. To minimize the adverse effects, various drug delivery systems (DDSs) has been developed. Among them, nanoparticles are attractive platforms for it. So this review paper explores the recent work done on targeted delivery, enhancing tumor accumulation and longer blood circulation using more effective biomaterial that will enhance the properties of nanoparticles. Moreover, various target-specific delivery of drugs like antibody-targeted, targeting delivery through angiogenesis, mitochondria, CD44 receptor are also explained.

Download Full-text

Bone tumor-targeted delivery of theranostic 195mPt-bisphosphonate complexes promotes killing of metastatic tumor cells

Materials Today Bio ◽

10.1016/j.mtbio.2020.100088 ◽

2020 ◽

pp. 100088

Author(s):

Robin A. Nadar ◽

Gerben M. Franssen ◽

Natasja W.M. Van Dijk ◽

Karlijn Codee-van der Schilden ◽

Mirjam de Weijert ◽

...

Keyword(s):

Tumor Cells ◽

Bone Tumor ◽

Targeted Delivery ◽

Metastatic Tumor

Download Full-text

Enhanced transfection efficiency and targeted delivery of self-assembling h-R3-dendriplexes in EGFR-overexpressing tumor cells

Oncotarget ◽

10.18632/oncotarget.4614 ◽

2015 ◽

Vol 6 (28) ◽

pp. 26177-26191 ◽

Cited By ~ 10

Author(s):

Jun Li ◽

Shengnan Li ◽

Songyun Xia ◽

Jinfeng Feng ◽

Xuedi Zhang ◽

...

Keyword(s):

Tumor Cells ◽

Targeted Delivery ◽

Transfection Efficiency ◽

Self Assembling

Download Full-text

Docetaxel immunonanocarriers as targeted delivery systems for HER2-positive tumor cells: preparation, characterization, and cytotoxicity studies

International Journal of Nanomedicine ◽

10.2147/ijn.s23211 ◽

2011 ◽

pp. 1903 ◽

Cited By ~ 4

Author(s):

Rassoul Dinarvand ◽

Mona Noori Koopaei ◽

Amini ◽

Rabbani ◽

Ostad ◽

...

Keyword(s):

Tumor Cells ◽

Targeted Delivery ◽

Delivery Systems ◽

Her2 Positive ◽

Cytotoxicity Studies ◽

Targeted Delivery Systems

Download Full-text

Photosensitizer Chlorin e6 Internalization into Tumor Cells in Phospholipid Nanoparticles Conjugated with Peptide Containing the NGR Sequence

Biomedical Chemistry Research and Methods ◽

10.18097/bmcrm00063 ◽

2018 ◽

Vol 1 (4) ◽

pp. e00063 ◽

Cited By ~ 3

Author(s):

V.N. Prozorovskiy ◽

L.V. Kostryukova ◽

E.I. Korotkevich ◽

T.I. Torkhovskaya ◽

G.E. Morozevich ◽

...

Keyword(s):

Photodynamic Therapy ◽

Amino Acid ◽

Tumor Cells ◽

Targeted Delivery ◽

Aminopeptidase N ◽

Chlorin E6 ◽

Phospholipid Nanoparticles ◽

Chlorine E6 ◽

Targeting Peptide ◽

Mcf 7

The possibility of increased internalization of the photosensitizer chlorin e6 in tumor cells was investigatedusing soy phosphatidylcholine nanoparticles 20-30 nm with or without attached peptide containing Asn-Gly-Arg (NGR) motif was studied. This amino acid sequence exhibits affinity to aminopeptidase N (CD13), wich is overexpressed in a number of tumor cells and vessels. Nanoparticles with chlorin e6 were prepared with added of distearoylphosphatidylcholine (DSPE) conjugated through PEG with a hexapeptide containing the NGR sequence, and then were incubated with tumor cells НерG2 and MCF-7. Chlorin e6 accumulation in СD13-negative cells (MCF-7) did not depend on the presence of peptide NGR in nanoparticles. However, for НерG2 cells a twofold increase of chlorine e6 internalization was observed as compared with the same particles without NGR. Differences in the response of these two cell lines, differed in expression of aminopeptidase N (APN), suggest the possibility of this protein using for targeted delivery. The prospectivity of usage of phospholipids nanoparticles conjugated with targeting peptide for photodynamic therapy is discussed, taking into account possible variation of APN expression, inherent for many solid tumors.

Download Full-text

Electrospray preparation of biocompatible lactide–glycolide copolymer capsules with incorporation of interferon

Доклады Академии наук ◽

10.31857/s0869-56524846703-708 ◽

2019 ◽

Vol 484 (6) ◽

pp. 703-708

Author(s):

I. A. Khlusov ◽

E. V. Kibler ◽

V. L. Kudryavtseva ◽

S. I. Tverdokhlebov ◽

E. N. Bolbasov ◽

...

Keyword(s):

Cytotoxic Activity ◽

Tumor Cells ◽

Targeted Delivery ◽

Structural Integrity ◽

Environmental Safety ◽

Biological Molecules ◽

Confocal Laser ◽

Human Interferon ◽

First Time ◽

Scanning Electron

The electrospray method was used for the first time to prepare polymeric capsules from bioresorbable dl-lactide and glycolide copolymer loaded with biological molecules from the cell secretome and, in particular, human interferon a-2b (IFN a-2b). The obtained nearly spherical submicron capsules were studied by scanning electron and confocal laser microscopy. The capsules retain the structural integrity and the cytotoxic activity of IFN a-2b towards tumor cells. The electrospray method is distinguished by high adaptability and environmental safety and is suitable for manufacture of a broad range of materials with different composition and morphology promising for the targeted delivery of drugs and biological molecules.

Download Full-text