scholarly journals Antibody Persistence and Booster Responses to Split-Virion H5N1 Avian Influenza Vaccine in Young and Elderly Adults

PLoS ONE ◽  
2016 ◽  
Vol 11 (11) ◽  
pp. e0165384
Author(s):  
Rajeka Lazarus ◽  
Sarah Kelly ◽  
Matthew D. Snape ◽  
Corinne Vandermeulen ◽  
Merryn Voysey ◽  
...  
Keyword(s):  
Avian Influenza ◽  
Influenza Vaccine ◽  
Elderly Adults ◽  
Antibody Persistence ◽  
H5n1 Avian Influenza

scholarly journals Nasal delivery of H5N1 avian influenza vaccine formulated with GenJet™ or in vivo-jetPEI® induces enhanced serological, cellular and protective immune responses

Drug Delivery ◽  
2018 ◽  
Vol 25 (1) ◽  
pp. 773-779 ◽  
Author(s):  
Weiping Cao ◽  
Margarita Mishina ◽  
Samuel Amoah ◽  
Wadzanai P. Mboko ◽  
Caitlin Bohannon ◽  
...  
Keyword(s):  
Avian Influenza ◽  
Immune Responses ◽  
Influenza Vaccine ◽  
Nasal Delivery ◽  
H5n1 Avian Influenza

scholarly journals Individual and flock immunity responses of naïve ducks on smallholder farms after vaccination with H5N1 Avian Influenza vaccine: a study in a province of the Mekong Delta, Vietnam

PeerJ ◽  
2019 ◽  
Vol 7 ◽  
pp. e6268
Author(s):  
Hoa Thi Thanh Huynh ◽  
Liem Tan Truong ◽  
Tongkorn Meeyam ◽  
Hien Thanh Le ◽  
Veerasak Punyapornwithaya
Keyword(s):  
Avian Influenza ◽  
Influenza Vaccine ◽  
Prevention And Control ◽  
Booster Vaccination ◽  
Primary Vaccination ◽  
Vaccination Program ◽  
Smallholder Farms ◽  
H5n1 Avian Influenza ◽  
Antibody Titers ◽  
And Control

In Vietnam, vaccination has played a crucial role in the national strategy for the prevention and control of H5 highly pathogenic avian influenza (HPAI). This study aimed to evaluate antibody responses of immunologically naïve domestic ducks to H5N1 avian influenza vaccine currently used in the national mass vaccination program of Vietnam. Blood samples of 166 ducks reared on smallholder farms were individually collected at three sampling time points, namely, right before vaccination, 21 days after primary vaccination, and 21 days after booster vaccination. Vaccine-induced antibody titers of duck sera were measured by the hemagglutination inhibition assay. Temporal differences in mean antibody titers were analyzed using the generalized least-squares method. No sampled ducks showed anti-H5 seropositivity pre-vaccination. The geometric mean titer (GMT) of the vaccinated ducks was 5.30 after primary vaccination, with 80% of the vaccinated ducks showing seropositivity. This result indicates that the immunity of duck flocks met the targets of the national poultry H5N1 HPAI mass vaccination program. GMT and seropositive rates of the ducks were 6.48 and 96.3%, respectively, after booster vaccination, which were significantly higher than those after primary vaccination. Flock-level seroprotection rate significantly increased from 68% to 84.7%, whereas variability in GMT titers decreased from 34.87% to 26.3%. This study provided important information on humoral immune responses of ducks to the currently used H5N1 vaccine under field conditions. Our findings may help guide veterinary authorities in planning effective vaccine protocols for the prevention and control of H5N1 in the target poultry population.

scholarly journals Safety Test and Field Study of an Inactivated Oil-Adjuvanted H5N1 Avian Influenza Vaccine

2010 ◽  
Vol 72 (11) ◽  
pp. 1455-1463
Author(s):  
Takashi IMAMURA ◽  
Ryuichi SAKAMOTO ◽  
Takashi SASAKI ◽  
Norihide KOKUMAI ◽  
Toshiaki OHGITANI ◽  
...  
Keyword(s):  
Avian Influenza ◽  
Influenza Vaccine ◽  
Field Study ◽  
Safety Test ◽  
H5n1 Avian Influenza

scholarly journals Cell-Based Systems Biology Analysis of Human AS03-Adjuvanted H5N1 Avian Influenza Vaccine Responses: A Phase I Randomized Controlled Trial

PLoS ONE ◽  
2017 ◽  
Vol 12 (1) ◽  
pp. e0167488 ◽  
Author(s):  
Leigh M. Howard ◽  
Kristen L. Hoek ◽  
Johannes B. Goll ◽  
Parimal Samir ◽  
Allison Galassie ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Systems Biology ◽  
Avian Influenza ◽  
Influenza Vaccine ◽  
Phase I ◽  
Controlled Trial ◽  
Vaccine Responses ◽  
Randomized Controlled ◽  
H5n1 Avian Influenza

scholarly journals Protein Fraction Profiles on Dry Holstein Cows Vaccinated Using H5N1 Avian Influenza Vaccine

2020 ◽  
Vol 478 ◽  
pp. 012021
Author(s):  
A Esfandiari ◽  
Andriyanto ◽  
S H Sulaiman ◽  
S Murtini ◽  
S D Widhyari ◽  
...  
Keyword(s):  
Avian Influenza ◽  
Influenza Vaccine ◽  
Protein Fraction ◽  
Holstein Cows ◽  
H5n1 Avian Influenza

scholarly journals VAKSIN FLU BURUNG DI MANUSIA SEBAGAI UPAYA ALTERNATIF PENCEGAHAN TERHADAP RE-EMERGING VIRUS H5N1

2021 ◽  
Vol 13 (1) ◽  
pp. 35-44
Author(s):  
Ratih Dian Saraswati ◽  
Risqa Novita
Keyword(s):  
Avian Influenza ◽  
Influenza Vaccine ◽  
Case Fatality Rate ◽  
Case Fatality ◽  
Preventive Measure ◽  
Influenza Vaccines ◽  
Fatality Rate ◽  
Human Relationships ◽  
H5n1 Avian Influenza ◽  
Influenza Transmission

A total of 182 human cases of avian influenza have been reported in Indonesia in the period 2004-2011, with a case fatality rate (CFR) among them of 86%. Various risk factors for avian influenza transmission have also been identified, including a high population, having many types of poultry (broiler, layer, village chickens, etc), traditional poultry systems that promote close human relationships, and the presence of several areas in Indonesia which are strategic locations as a place to rest and meet various wild birds. Vaccination is one of the efforts to prevent the re-emergence of H5N1 avian influenza transmission. However, the avian influenza vaccine for the public is not yet available in Indonesia. The purpose of this review article is to examine the avian influenza vaccine in humans as a preventive measure against the re-emergence of avian influenza in Indonesia, and to determine the progress of developing avian influenza vaccines. The results of the review show that several avian influenza vaccine candidates have been approved by WHO, one of which is a vaccine candidate using an isolated virus from Indonesia. This information on the development of avian influenza vaccines for humans is useful and can be used as an avian influenza pre-pandemic preparedness in Indonesia. Abstrak Sebanyak 182 kasus flu burung pada manusia telah dilaporkan di Indonesia pada periode tahun 2004-2011, dengan case fatality rate (CFR) sebesar 86%. Berbagai faktor risiko penularan flu burung juga telah diidentifikasi, antara lain jumlah penduduk yang tinggi, memiliki banyak jenis unggas (ayam broiler, layer, kampong, dsb), sistem perunggasan tradisional yang membuat kedekatan hubungan antara manusia, dan adanya beberpa wilayah di Indonesia yang menjadi lokasi strategis sebagai tempat istirahat dan bertemunya berbagai unggas liar. Vaksinasi merupakan salah satu upaya untuk mencegah munculnya kembali penularan flu burung H5N1. Namun demikian, vaksin flu burung untuk masyarakat belum tersedia hingga saat ini. Tujuan dari review artikel ini adalah untuk mengkaji  vaksin flu burung pada manusia sebagai tindakan pencegahan terhadap kemunculan kembali flu burung di Indonesia, dan untuk mengetahui kemajuan pengembangan vaksin flu burung. Hasil review menunjukkan beberapa kandidat vaksin flu burung telah disetujui oleh WHO, salah satunya adalah kandidat vaksin menggunakan isolat virus asal Indonesia. Informasi perkembangan vaksin flu burung bagi manusia ini bermanfaat dan dapat digunakan sebagai kesiapsiagaan prepandemi flu burung di Indonesia.

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