scholarly journals VAKSIN FLU BURUNG DI MANUSIA SEBAGAI UPAYA ALTERNATIF PENCEGAHAN TERHADAP RE-EMERGING VIRUS H5N1

2021 ◽  
Vol 13 (1) ◽  
pp. 35-44
Author(s):  
Ratih Dian Saraswati ◽  
Risqa Novita
Keyword(s):  
Avian Influenza ◽  
Influenza Vaccine ◽  
Case Fatality Rate ◽  
Case Fatality ◽  
Preventive Measure ◽  
Influenza Vaccines ◽  
Fatality Rate ◽  
Human Relationships ◽  
H5n1 Avian Influenza ◽  
Influenza Transmission

A total of 182 human cases of avian influenza have been reported in Indonesia in the period 2004-2011, with a case fatality rate (CFR) among them of 86%. Various risk factors for avian influenza transmission have also been identified, including a high population, having many types of poultry (broiler, layer, village chickens, etc), traditional poultry systems that promote close human relationships, and the presence of several areas in Indonesia which are strategic locations as a place to rest and meet various wild birds. Vaccination is one of the efforts to prevent the re-emergence of H5N1 avian influenza transmission. However, the avian influenza vaccine for the public is not yet available in Indonesia. The purpose of this review article is to examine the avian influenza vaccine in humans as a preventive measure against the re-emergence of avian influenza in Indonesia, and to determine the progress of developing avian influenza vaccines. The results of the review show that several avian influenza vaccine candidates have been approved by WHO, one of which is a vaccine candidate using an isolated virus from Indonesia. This information on the development of avian influenza vaccines for humans is useful and can be used as an avian influenza pre-pandemic preparedness in Indonesia. Abstrak Sebanyak 182 kasus flu burung pada manusia telah dilaporkan di Indonesia pada periode tahun 2004-2011, dengan case fatality rate (CFR) sebesar 86%. Berbagai faktor risiko penularan flu burung juga telah diidentifikasi, antara lain jumlah penduduk yang tinggi, memiliki banyak jenis unggas (ayam broiler, layer, kampong, dsb), sistem perunggasan tradisional yang membuat kedekatan hubungan antara manusia, dan adanya beberpa wilayah di Indonesia yang menjadi lokasi strategis sebagai tempat istirahat dan bertemunya berbagai unggas liar. Vaksinasi merupakan salah satu upaya untuk mencegah munculnya kembali penularan flu burung H5N1. Namun demikian, vaksin flu burung untuk masyarakat belum tersedia hingga saat ini. Tujuan dari review artikel ini adalah untuk mengkaji  vaksin flu burung pada manusia sebagai tindakan pencegahan terhadap kemunculan kembali flu burung di Indonesia, dan untuk mengetahui kemajuan pengembangan vaksin flu burung. Hasil review menunjukkan beberapa kandidat vaksin flu burung telah disetujui oleh WHO, salah satunya adalah kandidat vaksin menggunakan isolat virus asal Indonesia. Informasi perkembangan vaksin flu burung bagi manusia ini bermanfaat dan dapat digunakan sebagai kesiapsiagaan prepandemi flu burung di Indonesia.

Finding the real case-fatality rate of H5N1 avian influenza

2008 ◽  
Vol 62 (6) ◽  
pp. 555-559 ◽  
Author(s):  
F C K Li ◽  
B C K Choi ◽  
T Sly ◽  
A W P Pak
Keyword(s):  
Avian Influenza ◽  
Case Fatality Rate ◽  
Case Fatality ◽  
Real Case ◽  
Fatality Rate ◽  
The Real ◽  
H5n1 Avian Influenza

scholarly journals Pengetahuan Dan Sikap Masyarakat Dalam Mencegah Leptospirosis di Desa Pabelan Kabupaten Sukoharjo

2018 ◽  
Vol 1 (1) ◽  
pp. 13-17
Author(s):  
Agus Sudaryanto ◽  
Fatkhurrohman Ilham Fuadi ◽  
Endang Zulaicha Susilaningsih
Keyword(s):  
Quantitative Research ◽  
Case Fatality Rate ◽  
Case Fatality ◽  
Preventive Measure ◽  
Fatality Rate ◽  
Cross Sectional ◽  
Positive Attitudes ◽  
Cross Sectional Design ◽  
Severe Leptospirosis ◽  
The Relationship

Leptospirosis merupakan penyakit zoonosis yang mempunyai dampak signifikan terhadap kesehatan di banyak belahan dunia beriklim sub tropis dan tropis. Bakteri Leptospira merupakan penyebab leptospirosis yang dapat menyerang hewan dan manusia. Infeksi pada manusia merupakan kejadian yang bersifat insidental, karena reservoir atau penyebar utama Leptospira adalah tikus. Air kencing tikus yang terinfeksi Leptospira terbawa banjir dan dapat masuk ke tubuh manusia melalui kulit yang terluka dan selaput mukosa. Semua kasus leptospirosis ringan (anikterik) dapat sembuh sempurna, berbeda dengan leptospirosis berat (ikterik) yang mempunyai angka Case Fatality Rate tinggi, antara 5%-40%. Upaya pencegahan merupakan salah satu cara untuk menekan angka kejadian leptospirosis, diantaranya ialah dengan menumbuhkan sikap dan pengetahuan yang baik tentang leptospirosis. Tujuan penelitian ini adalah untuk mengetahui hubungan antara pengetahuan dengan sikap masyarakat dalam mencegah leptospirosis di Desa Pabelan, Kecamatan Kartasura, Kabupaten Sukoharjo. Jenis penelitian ini adalah kuantitatif dengan menggunakan rancangan cross sectional. Sampel dalam penelitian ini adalah masyarakat Desa Pabelan sejumlah 212 responden dengan menggunakan accidental sampling. Mayoritas responden mempunyai pengetahuan yang kurang (53,3%). Sebaliknya, 80,7% dari responden mempunyai skor sikap yang baik. Leptospirosis is a zoonotic disease which has a significant effect on human health most commonly found in tropical or sub-tropical countries. Leptospira bacteria is the cause of leptospirosis which can attack animals and humans. Infection in humans is accidental, because the main reservoir or spreader of leptospira is rodents. The urine of infected rodents carried away by floodwaters can enter the human body through broken skin and mucous membranes. All patients with mild leptospirosis (anicteric) can recover completely. It is very different from patients with severe leptospirosis (jaundice) who have a high case fatality rate from 5% to 40%. Preventive measure is one way to reduce the incidence of leptospirosis by developing positive attitudes and improving good knowledge about leptospirosis. The objective of this study was to determine the relationship between knowledge and attitudes of the community concerning on the prevention of leptospirosis in Pabelan village, Sukoharjo Regency. This study employed quantitative research with a cross sectional design in a sample of 212 respondents from Pabelan village selected by using accidental sampling. Majority of respondents demonstrated moderate knowledge (53.3%). However, 80.7% of the them demonstrated good attitude scores.

scholarly journals Age-specific infection and death rates for human A(H5N1) avian influenza in Egypt

2009 ◽  
Vol 14 (18) ◽  
Author(s):  
J P Dudley
Keyword(s):  
Influenza A ◽  
Case Fatality Rate ◽  
Case Fatality ◽  
Age Group ◽  
Fatality Rate ◽  
Death Rates ◽  
H5n1 Avian Influenza ◽  
Human H5n1 ◽  
Sex Biases ◽  
Age And Sex

The age-specific infection and death profiles among confirmed human cases of influenza A(H5N1) infection in Egypt differ markedly from those recorded in other countries. The case fatality rate among human H5N1 cases in Egypt is 34%, versus an average of 66% in other countries. In Egypt, children younger than 10 years comprise 48% of reported cases, nearly twice the global average of approximately 25%, and no H5N1 fatalities have been confirmed among individuals in this age group as of 23 April 2009. Females outnumber males among confirmed H5N1 cases by a factor of nearly 2:1, and 90% of reported fatalities in Egypt have been females. The evident age and sex biases in morbidity and mortality among H5N1 cases in Egypt are phenomena that warrant further investigation and analysis.

scholarly journals Antibody-Dependent Cell-Mediated Cytotoxicity to Hemagglutinin of Influenza A Viruses After Influenza Vaccination in Humans

2016 ◽  
Vol 3 (2) ◽  
Author(s):  
Weimin Zhong ◽  
Feng Liu ◽  
Jason R. Wilson ◽  
Crystal Holiday ◽  
Zhu-Nan Li ◽  
...  
Keyword(s):  
Avian Influenza ◽  
Influenza Vaccine ◽  
Influenza A ◽  
Influenza Vaccines ◽  
Virus Neutralization ◽  
Antigenic Specificity ◽  
Specific Antibodies ◽  
H5n1 Avian Influenza ◽  
Activation Assay ◽  
Dependent Cell

Abstract Background.  Detection of neutralizing antibodies (nAbs) to influenza A virus hemagglutinin (HA) antigens by conventional serological assays is currently the main immune correlate of protection for influenza vaccines However, current prepandemic avian influenza vaccines are poorly immunogenic in inducing nAbs despite considerable protection conferred. Recent studies show that Ab-dependent cell-mediated cytotoxicity (ADCC) to HA antigens are readily detectable in the sera of healthy individuals and patients with influenza infection. Methods.  Virus neutralization and ADCC activities of serum samples from individuals who received either seasonal or a stock-piled H5N1 avian influenza vaccine were evaluated by hemagglutination inhibition assay, microneutralization assay, and an improved ADCC natural killer (NK) cell activation assay. Results.  Immunization with inactivated seasonal influenza vaccine led to strong expansion of both nAbs and ADCC-mediating antibodies (adccAbs) to H3 antigen of the vaccine virus in 24 postvaccination human sera. In sharp contrast, 18 individuals vaccinated with the adjuvanted H5N1 avian influenza vaccine mounted H5-specific antibodies with strong ADCC activities despite moderate virus neutralization capacity. Strength of HA-specific ADCC activities is largely associated with the titers of HA-binding antibodies and not with the fine antigenic specificity of anti-HA nAbs. Conclusions.  Detection of both nAbs and adccAbs may better reflect protective capacity of HA-specific antibodies induced by avian influenza vaccines.

scholarly journals Association of Bacille Calmette-Guérin (BCG), Adult Pneumococcal and Adult Seasonal Influenza Vaccines with Covid-19 Adjusted Mortality Rates in Level 4 European countries

2020 ◽  
Author(s):  
Joe Gallagher ◽  
Chris Watson ◽  
Mark Ledwidge
Keyword(s):  
Influenza Vaccination ◽  
Population Size ◽  
Case Fatality Rate ◽  
Seasonal Influenza ◽  
Case Fatality ◽  
Mortality Rates ◽  
Influenza Vaccines ◽  
Dependency Ratio ◽  
Fatality Rate ◽  
Confounding Variables

AbstractIntroductionNon-specific effects of vaccines have gained increasing interest during the Covid-19 pandemic. In particular, population use of BCG vaccine has been associated with improved outcomes. This study sought to determine the association of population use of BCG, adult pneumococcal and adult seasonal influenza vaccination with Covid-19 mortality when adjusted for a number of confounding variables.MethodsUsing publicly available data, mortality adjusted for the timeframe of crisis, population size and population characteristics was calculated. The primary analysis was the relationship between each of the day 15 and day 30 standardised mortality rates and BCG, adult pneumococcal and influenza vaccination scores using unadjusted measures and with adjustment for population structure and case fatality rates. Secondary analyses were measures of case increases and mortality increases from day 15 to day 30 for each of the relative vaccination scores. Finally, we also analysed the peak Z score reflecting increases in total mortality from historical averages reported by EuroMOMO (Euromomo.eu),ResultsFollowing adjustment for the effects of population size, median age, population density, the proportion of population living in an urban setting, life-expectancy, the elderly dependency ratio (or proportion over 65 years), net migration, days from day 1 to lockdown and case-fatality rate, only BCG vaccination score remained significantly associated with Covid-19 mortality at day 30. In the best fit model, BCG vaccination score was associated with a 64% reduction in log(10) mortality per 10 million population (OR 0.362 reduction [95% CI 0.188 to 0.698]), following adjustment for population size, median age, density, urbanization, elderly dependency ratio, days to lockdown, yearly migration and case fatality rate.ConclusionBCG vaccine was associated with reduced mortality rates in level 4 countries while adult pneumococcal and adult seasonal influenza vaccines were not when adjusted for a number of confounding variables. A number of trials are ongoing to determine if BCG is protective against severe Covid-19 infection.

Impact of hydroxychloroquin/azithromycin protocol on COVID-19 case-fatality rate reduction in Algeria. (Preprint)

2020 ◽  
Author(s):  
Ahmed Youssef Kada
Keyword(s):  
Case Fatality Rate ◽  
Doubling Time ◽  
Case Fatality ◽  
World Health ◽  
Fatality Rate ◽  
Therapeutic Protocol ◽  
First Case ◽  
The World ◽  
The Impact ◽  
At Home

BACKGROUND Covid-19 is an emerging infectious disease like viral zoonosis caused by new coronavirus SARS CoV 2. On December 31, 2019, Wuhan Municipal Health Commission in Hubei province (China) reported cases of pneumonia, the origin of which is a new coronavirus. Rapidly extendable around the world, the World Health Organization (WHO) declares it pandemic on March 11, 2020. This pandemic reaches Algeria on February 25, 2020, date on which the Algerian minister of health, announced the first case of Covid-19, a foreign citizen. From March 1, a cluster is formed in Blida and becomes the epicentre of the coronavirus epidemic in Algeria, its total quarantine is established on March 24, 2020, it will be smoothly alleviated on April 24. A therapeutic protocol based on hydroxychloroquine and azithromycin was put in place on March 23, for complicated cases, it was extended to all the cases confirmed on April 06. OBJECTIVE This study aimed to demonstrate the effectiveness of hydroxychloroquin/azithromycin protocol in Algeria, in particular after its extension to all patients diagnosed COVID-19 positive on RT-PCR test. We were able to illustrate this fact graphically, but not to prove it statistically because the design of our study, indeed in the 7 days which followed generalization of therapeutic protocol, case fatality rate decrease and doubling time increase, thus confirming the impact of wide and early prescription of hydroxychloroquin/azithromycin protocol. METHODS We have analyzed the data collected from press releases and follow-ups published daily by the Ministry of Health, we have studied the possible correlations of these data with certain events or decisions having a possible impact on their development, such as confinement at home and its reduction, the prescription of hydroxychloroquine/azithromycin combination for serious patients and its extension to all positive COVID subjects. Results are presented in graphics, the data collection was closed on 31/05/2020. RESULTS Covid-19 pandemic spreads from February 25, 2020, when a foreign citizen is tested positive, on March 1 a cluster is formed in the city of Blida where sixteen members of the same family are infected during a wedding party. Wilaya of Blida becomes the epicentre of coronavirus epidemic in Algeria and lockdown measures taken, while the number of national cases diagnosed begins to increases In any event, the association of early containment measures combined with a generalized initial treatment for all positive cases, whatever their degree of severity, will have contributed to a reduction in the fatality rate of COVID 19 and a slowing down of its doubling time. CONCLUSIONS In Algeria, the rapid combination of rigorous containment measure at home and early generalized treatment with hydroxychloroquin have demonstrated their effectiveness in terms of morbidity and mortality, the classic measures of social distancing and hygiene will make it possible to perpetuate these results by reducing viral transmission, the only unknown, the reopening procedure which can only be started after being surrounded by precautions aimed at ensuring the understanding of the population. CLINICALTRIAL Algeria, Covid-19, pandemic, hydroxychloroquin, azithromycin, case fatality rate

scholarly journals Author Correction: Calcium channel blocker amlodipine besylate therapy is associated with reduced case fatality rate of COVID-19 patients with hypertension

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Lei-Ke Zhang ◽  
Yuan Sun ◽  
Haolong Zeng ◽  
Qingxing Wang ◽  
Xiaming Jiang ◽  
...  
Keyword(s):  
Calcium Channel ◽  
Calcium Channel Blocker ◽  
Case Fatality Rate ◽  
Channel Blocker ◽  
Case Fatality ◽  
Fatality Rate ◽  
Amlodipine Besylate

A Correction to this paper has been published: https://doi.org/10.1038/s41421-021-00267-0

scholarly journals Early determination of case fatality rate of COVID-19 pandemic during the ongoing Yemeni armed conflict

2021 ◽  
pp. 1-15
Author(s):  
Abdulla Salem Bin Ghouth ◽  
Ali Ahmed Al-Waleedi ◽  
Marhami Fahriani ◽  
Firzan Nainu ◽  
Harapan Harapan
Keyword(s):  
Young Adults ◽  
Intensive Care ◽  
Armed Conflict ◽  
Case Fatality Rate ◽  
Preventive Measures ◽  
Case Fatality ◽  
Fatality Rate ◽  
Mechanical Ventilators ◽  
Poor Outcomes

Abstract Objectives: To determine the case-fatality rate (CFR) of coronavirus disease 2019 (COVID-19) and its associated determinants in order to understand the true magnitude of the problem during ongoing conflict in Yemen. Methods: The CFR among confirmed COVID-19 cases in Yemen was calculated. The data was retrieved from national COVID-19 surveillance between April 10, when the first COVID-19 case reported, and May 31, 2020. Results: A total of 419 confirmed COVID-19 cases were reported. There were 14.1% and 5.7% of cases who required intensive care and mechanical ventilators, respectively. Out of total cases, 95 deaths were reported, giving CFR of 22.6% which is much higher compared to other countries. CFR was significantly higher among elderly compared to young adults and varied between governorates. Mortality was associated with preexisting hypertension (OR: 2.30; 95%CI: 1.58, 3.54) and diabetes (OR: 1.68; 95%CI: 1.08, 2.61). Conclusions: Elderly and those with comorbidities, in particular hypertension and diabetes, have higher risk for poor outcomes and therefore should receive more attention in the clinical setting. Preventive measures should also be prioritized to protect those groups in order to reduce the severe cases and deaths-associated COVID-19 in armed-conflict.

scholarly journals Regional Variability in COVID-19 Case Fatality Rate in Canada, February–December 2020

2021 ◽  
Vol 18 (4) ◽  
pp. 1839
Author(s):  
Eunha Shim
Keyword(s):  
British Columbia ◽  
Case Fatality Rate ◽  
Case Reports ◽  
Case Fatality ◽  
Health Interventions ◽  
Fatality Rate ◽  
Older Individuals ◽  
Regional Variability ◽  
Provincial Level ◽  
Mortality Burden

A total of 475,214 COVID-19 cases, including 13,659 deaths, had been recorded in Canada as of 15 December 2020. The daily reports of confirmed cases and deaths in Canada prior to 15 December 2020 were obtained from publicly available sources and used to examine regional variations in case fatality rate (CFR). Based on a factor of underestimation and the duration of time from symptom onset to death, the time-delay adjusted CFR for COVID-19 was estimated in the four most affected provinces (Quebec, Ontario, Alberta, and British Columbia) and nationwide. The model-based adjusted CFR was higher than the crude CFR throughout the pandemic, primarily owing to the incorporation in our estimation of the delay between case reports and deaths. The adjusted CFR in Canada was estimated to be 3.36% nationwide. At the provincial level, the adjusted CFR was the highest in Quebec (5.13%)—where the proportion of deaths among older individuals was also the highest among the four provinces—followed by Ontario (3.17%), British Columbia (1.97%), and Alberta (1.13%). Provincial-level variations in CFR were considerable, suggesting that public health interventions focused on densely populated areas and elderly individuals can ameliorate the mortality burden of the COVID-19 pandemic.

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