Do Reported Effects of Acute Aerobic Exercise on Subsequent Higher Cognitive Performances Remain if Tested against an Instructed Self-Myofascial Release Training Control Group? A Randomized Controlled Trial

ABSTRACT Objective This study was conducted to determine the effectiveness of aerobic exercise and diet in female students with Premenstrual Syndrome Scale who were studying at the public university. Methods This randomized controlled trial was conducted in a public university in 2018. The population of the study was composed of all female first graders (N=426). The female students were followed-up for two cycles, premenstrual syndrome scale was administered to the students and premenstrual syndrome was found in 43.8% (n=187). However, 106 female students were included in the study divided in three groups (diet, aerobic exercise, control). The diet and aerobic exercise were administered during the three months. Results There was no significant difference in premenstrual syndrome scale mean scores between the post-intervention groups. However, the mean premenstrual syndrome score of the diet and aerobic exercise groups decreased significantly after the intervention. There was a significant difference in visual analogue scale score between the groups after intervention. Besides the students in exercise and diet groups experienced less dysmenorrhea intensity than the control group. Conclusion It was found that diet and aerobic exercise were effective in reducing the symptoms of premenstrual syndrome and dysmenorrhea intensity in female students with premenstrual syndrome.

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Moderators of Maintained Increase in Aerobic Exercise Among Aging Men and Women in a 4-Year Randomized Controlled Trial: The DR’s EXTRA Study

Journal of Physical Activity and Health ◽

10.1123/jpah.2014-0299 ◽

2015 ◽

Vol 12 (11) ◽

pp. 1477-1484 ◽

Cited By ~ 1

Author(s):

Leena Hakola ◽

Kai Savonen ◽

Pirjo Komulainen ◽

Maija Hassinen ◽

Rainer Rauramaa ◽

...

Keyword(s):

Randomized Controlled Trial ◽

Aerobic Exercise ◽

Controlled Trial ◽

Intervention Group ◽

Exercise Group ◽

Control Group ◽

Older Individuals ◽

Men And Women ◽

Exercise Interventions ◽

Randomized Controlled

Background:Little is known about factors that modify the effectiveness of exercise interventions in increasing exercise. We aimed to identify moderators of the effectiveness of aerobic exercise intervention in maintaining increased aerobic exercise among older individuals.Methods:The participants of a 4-year randomized controlled trial were a population sample of 1410 men and women aged 57 to 78 years. The aerobic exercise group included 185 individuals and the control group included 169 individuals who reported low aerobic exercise at baseline. Maintained increase in aerobic exercise was defined as at least 60-minute increase in moderate-to-heavy aerobic exercise per week from baseline to 2- and 4-year assessments.Results:Individuals in the aerobic exercise group were 2.5 (95% CI 1.5 to 3.9) times more likely to maintain increased aerobic exercise than those in the control group. Individuals aged < 68.5 years but not older individuals succeeded in maintaining increased aerobic exercise in the intervention group (P = .02 for interaction). Individuals who were past smokers (P = .02 for interaction), were working (P = .05 for interaction), or had symptoms of depression (P = .05 for interaction) succeeded better in maintaining increased aerobic exercise in the intervention group than other individuals.Conclusions:These findings help in more precise targeting of future exercise interventions among older individuals.

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Short-term interval aerobic exercise training does not improve memory functioning in relapsing-remitting multiple sclerosis—a randomized controlled trial

PeerJ ◽

10.7717/peerj.6037 ◽

2018 ◽

Vol 6 ◽

pp. e6037 ◽

Cited By ~ 8

Author(s):

Lisa Baquet ◽

Helge Hasselmann ◽

Stefan Patra ◽

Jan-Patrick Stellmann ◽

Eik Vettorazzi ◽

...

Keyword(s):

Multiple Sclerosis ◽

Randomized Controlled Trial ◽

Aerobic Exercise ◽

Controlled Trial ◽

Verbal Learning ◽

Control Group ◽

Randomized Controlled ◽

Relapsing Remitting ◽

Remitting Multiple Sclerosis ◽

Relapsing Remitting Multiple Sclerosis

Background Only few aerobic exercise intervention trials specifically targeting cognitive functioning have been performed in multiple sclerosis. Objective and Methods This randomized controlled trial with 34 patients in the intervention group (IG) (mean: 38.2 years (±9.6)) and 34 patients in the control group (CG) (mean: 39.6 years (±9.7)) aimed to determine the effects of aerobic exercise on cognition in relapsing-remitting multiple sclerosis (RRMS). The primary outcome was verbal learning assessed by the verbal learning and memory test (VLMT). Patients were randomized to an IG or a waitlist CG. Patients in the IG exercised according to an individually tailored training schedule (with two to three sessions per week for 12 weeks). The primary analysis was carried out using the intention-to-treat (ITT) sample with ANCOVA adjusting for baseline scores. Results A total of 77 patients with RRMS were screened and 68 participants randomized (CG n = 34; IG n = 34). The sample comprised 68% females, had a mean age of 39 years, a mean disease duration of 6.3 years, and a mean expanded disability status scale of 1.8. No significant effects were detected in the ITT analysis for the primary endpoint VLMT or any other cognitive measures. Moreover, no significant treatment effects were observed for quality of life, fatigue, or depressive symptoms. Conclusion This study failed to demonstrate beneficial effects of aerobic exercise on cognition in RRMS. The trial was prospectively registered at clinicaltrials.gov (NCT02005237).

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Efficacy of acupuncture based on acupoint combination theory for irritable bowel syndrome: a study protocol for a multicenter randomized controlled trial

Trials ◽

10.1186/s13063-021-05432-0 ◽

2021 ◽

Vol 22 (1) ◽

Author(s):

Jing-wen Sun ◽

Ming-liang Sun ◽

Da Li ◽

Jun Zhao ◽

Su-hua Shi ◽

...

Keyword(s):

Randomized Controlled Trial ◽

Primary Outcome ◽

Controlled Trial ◽

Control Group ◽

Randomized Controlled ◽

Multicenter Randomized Controlled Trial ◽

Group A ◽

Irritable Bowel ◽

Group B ◽

Experimental Group

Abstract Background Irritable bowel syndrome (IBS) is a chronic gastrointestinal disorder characterized by abdominal pain, diarrhea or constipation, and changes in defecation patterns. No organic disease is found to explain these symptoms by routine clinical examination. This study aims to investigate the efficacy and safety of acupuncture therapy for IBS patients compared with those of conventional treatments. We also aim to identify the optimal acupoint combination recommended for IBS and to clarify the clinical advantage of the “multiacupoint co-effect and synergistic effect.” Methods and analysis A total of 204 eligible patients who meet the Rome IV criteria for IBS will be randomly stratified into acupuncture group A, acupuncture group B, or the control group in a 1:1:1 ratio with a central web-based randomization system. The prespecified acupoints used in the control group will include bilateral Tianshu (ST25), Shangjuxu (ST37), Neiguan (PC6), and Zusanli (ST36). The prespecified acupoints used in experimental group A will include bilateral Tianshu (ST25), Shangjuxu (ST37), and Neiguan (PC6). The prespecified acupoints used in experimental group B will include bilateral Tianshu (ST25), Shangjuxu (ST37), and Zusanli (ST36). Each patient will receive 12 acupuncture treatments over 4 weeks and will be followed up for 4 weeks. The primary outcome is the IBS-Symptom Severity Scale (IBS-SSS) score. The secondary outcomes include the Bristol Stool Form Scale (BSFS), Work and Social Adjustment Score (WSAS), IBS-Quality of Life (IBS-QOL), Self-Rating Anxiety Scale (SAS), and Self-Rating Depression Scale (SDS) scores. Both the primary outcome and the secondary outcome measures will be collected at baseline, at 2 and 4 weeks during the intervention, and at 6 weeks and 8 weeks after the intervention. Ethics and dissemination The entire project has been approved by the ethics committee of the Beijing University of Chinese Medicine (2020BZYLL0903). Discussion This is a multicenter randomized controlled trial for IBS in China. The findings may shed light on the efficacy of acupuncture as an alternative to conventional IBS treatment. The results of the trial will be disseminated in peer-reviewed publications. Trial registration Chinese Clinical Trials Register ChiCTR2000041215. First registered on 12 December 2020. http://www.chictr.org.cn/.

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The effectiveness of an aerobic exercise training on patients with neck pain during a short- and long-term follow-up: a prospective double-blind randomized controlled trial

Clinical Rehabilitation ◽

10.1177/0269215520912000 ◽

2020 ◽

Vol 34 (5) ◽

pp. 617-629

Author(s):

Amira Daher ◽

Rafael S Carel ◽

Knoll Tzipi ◽

Hazan Esther ◽

Gali Dar

Keyword(s):

Randomized Controlled Trial ◽

Neck Pain ◽

Aerobic Exercise ◽

Controlled Trial ◽

Cervicogenic Headache ◽

Successful Outcome ◽

Control Group ◽

Specific Exercise ◽

Randomized Controlled

Objective: To examine the effect of adding aerobic exercise (AE) to neck-specific exercise treatment for patients with neck pain (NP) to reduce pain and disability. Design: A prospective multicentre randomized controlled trial. Setting: Physiotherapy outpatient clinics. Subjects: Patients with nonspecific NP. Intervention: Patients with NP were randomly assigned to six weeks of neck-specific exercise with and without the addition of AE. Measures: Patients were classified as having a successful or non-successful outcome according to the Global Rating of Change (GROC). Outcome measures included Visual Analogue Scale (VAS), Neck Disability Index (NDI), Fear Avoidance Beliefs Questionnaire (FABQ) and cervicogenic headache. Assessments were performed at six-week, and three- and six-month follow-ups. Results: A total of 139 participants (mean age: 54.6 ± 10.5 years) were recruited ( n = 69 AE, n = 70 control). According to GROC, 77.4% of the AE group reported a successful outcome at six months vs. 40% in the control group ( P < 0.001). There was a significant reduction in VAS from baseline to six months in the AE vs. control group 6.73 (±1.69) to 1.89 (±1.37) vs. 6.65 (±1.67) to 3.32 (±1.82), respectively ( P < 0.001). Significant improvements were also obtained for NDI and FABQ from baseline to six weeks in the AE group: NDI from 16.10 (±4.53) to 7.78 (±4.78) vs. 17.01 (±4.84) to 11.09 (±5.64) in the control group ( P = 0.003); FABQ from 33.53 (±9.31) to 20.94 (±841) in the AE vs. 33.45 (±10.20) to 26.83 (±10.79) in the control group ( P < 0.001). The AE group also demonstrated significant reduction in cervicogenic headache from baseline to six months ( P = 0.003). Conclusion: Adding AE to long-term neck-specific exercises is an effective treatment for reducing NP and headache in patients with NP.

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Effects of Traditional vs. iPad-Enhanced Aerobic Exercise on Wayfinding Efficacy and Cognition: A Pilot Randomized Controlled Trial

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph16183495 ◽

2019 ◽

Vol 16 (18) ◽

pp. 3495 ◽

Cited By ~ 1

Author(s):

Daniel Palac ◽

Tiffany Bullard ◽

Jason D. Cohen ◽

Lydia T. Nguyen ◽

Raksha A. Mudar ◽

...

Keyword(s):

At Risk ◽

Randomized Controlled Trial ◽

Cognitive Impairment ◽

Aerobic Exercise ◽

Cognitive Functioning ◽

Self Efficacy ◽

Controlled Trial ◽

Control Group ◽

Randomized Controlled ◽

Experimental Group

The purpose of this pilot study was to test the feasibility and efficacy of an iPad-enhanced aerobic exercise intervention designed to enhance wayfinding efficacy and performance and relevant cognitive functioning among middle-aged adults at risk for cognitive impairment. Twenty-seven low active adults (21 females) aged 45 to 62 years (51.22 ± 5.20) participated in a ten-week randomized controlled trial. Participants were randomized to an iPad-enhanced aerobic exercise group (experimental group) or an aerobic exercise-only group (control group) following baseline assessment. Both groups exercised at 50% to 75% of age-predicted heart rate maximum for 30 to 50 min/d, 2 d/wk for 10 weeks. During aerobic exercise, the experimental group engaged in virtual tours delivered via iPad. Baseline and post-intervention assessments of wayfinding self-efficacy, wayfinding task performance, cognitive functioning, electroencephalogram (EEG), and psychosocial questionnaires were administered. The results suggest that ten weeks of iPad-enhanced, moderately intense aerobic exercise had specific effects on wayfinding self-efficacy; however, no statistical differences were found between groups on the behavioral wayfinding task or spatial memory performance at follow-up. Performance scores on an inhibitory attentional-control cognitive assessment revealed significant differences between groups, favoring the experimental group (p < 0.05). Virtual reality-enhanced aerobic exercise may prove to be an effective method for improving cognitive function and increasing confidence to navigate real-world scenarios among individuals at risk of cognitive impairment.

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Sport injury prevention in individuals with chronic ankle instability: Fascial Manipulation® versus control group: A randomized controlled trial

Journal of Bodywork and Movement Therapies ◽

10.1016/j.jbmt.2019.01.001 ◽

2019 ◽

Vol 23 (2) ◽

pp. 316-323 ◽

Cited By ~ 2

Author(s):

Simone Brandolini ◽

Giacomo Lugaresi ◽

Antonio Santagata ◽

Andrea Ermolao ◽

Marco Zaccaria ◽

...

Keyword(s):

Randomized Controlled Trial ◽

Injury Prevention ◽

Sport Injury ◽

Ankle Instability ◽

Controlled Trial ◽

Chronic Ankle Instability ◽

Control Group ◽

Randomized Controlled ◽

Group A ◽

Sport Injury Prevention

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Potential mechanisms underpinning aerobic exercise-induced analgesia in primary dysmenorrhea: a controlled non-randomized pilot trial

10.21203/rs.2.15666/v1 ◽

2019 ◽

Author(s):

Priya Kannan ◽

Kwok-Kuen Cheung ◽

Chan Sheung Chi ◽

Lam King Yan ◽

Law Yee Xi ◽

...

Keyword(s):

Randomized Controlled Trial ◽

Aerobic Exercise ◽

Controlled Trial ◽

Exercise Group ◽

Control Group ◽

Primary Dysmenorrhea ◽

Beneficial Effects ◽

Randomized Controlled ◽

Tnf Α ◽

Exercise Induced

Abstract BackgroundAerobic exercise has been shown to alleviate the pain of primary dysmenorrhea in several studies however, no study has yet identified the physiological mechanisms underlying the beneficial effects of aerobic exercise-induced pain relief in primary dysmenorrhea. The objectives of the study are: (1) To evaluate the feasibility of the protocol for a randomized controlled trial to investigate the physiological mechanisms underlying the beneficial effects of aerobic exercise on the pain associated with primary dysmenorrhea and (2) to obtain preliminary results (effect size) to estimate the sample size for the future randomized controlled trial.MethodsTwenty women aged 18–29 years were divided into two groups (high-intensity aerobic-exercise group and no-exercise control group) in a 1:1 ratio. Women assigned to the exercise group performed high-intensity treadmill-based aerobic exercise for three days a week, at 70–85% of maximum heart rate for 30 minutes for 4 weeks. The control group did not receive trial intervention but provided blood for estimation of plasma variables. Blood plasma levels of progesterone, metabolites of prostaglandin (PG) F2-alpha (13,14-dihydro-15-keto-prostaglandin F2 alpha [KDPGF2α]) and PGE2 (13,14-dihydro-15-keto-prostaglandin E2 [KDPGE2]), and tumor necrosis factor-alpha (TNF-α) were measured at 4-weeks post-intervention.ResultsWith respect to feasibility outcomes, 90% of the required number of participants were recruited in 3-4 weeks. Adherence to the intervention was 97% and the retention rate was 90%. There was an increase in progesterone levels (d = 0.36) and decreases in KDPGF2α (d = 0.35), KDPGE2 (d = 0.47), and TNF-α (d = 0.33) from baseline to week 4 in the exercise group compared with the control group.ConclusionThe study methodology appears to be feasible for conducting a full-scale randomized controlled trial. The findings indicated a trend towards an increase in progesterone levels and decreases in inflammatory pain mediators, including KDPGF2α, KDPGE2, and TNF-α, in the exercise group compared with the control group, suggesting the possibility that aerobic exercise may be effective for primary dysmenorrhea via its influence on progesterone and inflammatory pain mediators. Trial Registration Our trial is registered in the Australian New Zealand Clinical Trials Registry (ACTRN12618000784213). The date of registration is 09 May 2018. Trial registration was completed prior to enrollment of the first participant.

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Short-term aerobic training does not improve memory functioning in relapsing remitting multiple sclerosis – a randomized controlled trial

10.1101/366161 ◽

2018 ◽

Author(s):

L Baquet ◽

H Hasselmann ◽

S Patra ◽

JP Stellmann ◽

E Vettorazzi ◽

...

Keyword(s):

Randomized Controlled Trial ◽

Aerobic Exercise ◽

Verbal Memory ◽

Exercise Intervention ◽

Controlled Trial ◽

Verbal Learning ◽

Intervention Group ◽

Control Group ◽

Randomized Controlled ◽

Relapsing Remitting

AbstractBackgroundOnly few aerobic exercise intervention trials specifically targeting cognitive functioning have been performed in MS.Objective and methodsThis randomized controlled trial aimed to determine the effects of aerobic exercise on cognition in relapsing-remitting MS. The primary outcome was verbal memory (Verbal learning and memory test, VLMT). Patients were randomized to an intervention group (IG) program or a waitlist control group (CG). Patients in the IG exercised according to an individually tailored training schedule (with 2-3 sessions per week for 12 weeks). The primary analysis was carried out using the intention-to-treat (ITT) sample with ANCOVA adjusting for baseline scores.Results77 RRMS patients were screened and 68 participants randomized (CG n=34; IG n=34). The sample comprised 68% females, had a mean age of 39 years, a mean disease duration of 6.3 years, and a mean EDSS of 1.8. No significant effects were detected in the ITT analysis for the primary endpoint VLMT or any other cognitive measures. Moreover, no significant treatment effects were observed for quality of life, fatigue, or depressive symptoms.ConclusionThis study failed to demonstrate beneficial effects of aerobic exercise on cognition in RRMS.The trial was prospectively registered at clinicaltrials.gov (NCT02005237).

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