Serum 25-hydroxyvitamin D, serum calcium and vitamin D receptor (VDR) polymorphisms in a selected population with lumbar disc herniation—A case control study

Purpose: To compare serum total calcium and phosphate levels in patients with non-severe COVID-19 with age, sex, and serum 25-hydroxyvitamin D level matched healthy adult cohort.Methods: In this retrospective case-control study, medical records of patients (≥18 years) diagnosed as non-severe COVID-19 admitted at and discharged from our tertiary care institution during the period from April 10, 2020 and June 20, 2020 were retrieved. Baseline investigations, notably, serum calcium, phosphate, albumin, magnesium, 25-hydroxyvitamin D, and C-reactive protein (CRP), were performed at admission before any form of calcium or vitamin D supplementation were considered. The biochemical parameters were compared with age, sex, and 25-hydroxyvitamin D matched healthy adult controls (1:1 ratio) derived from the Chandigarh Urban Bone Epidemiological Study (CUBES).Results: After exclusion, 72 patients with non-severe COVID-19 (63 mild and 9 moderate disease) and an equal number of healthy controls were included in the final analysis. Age, sex, serum 25-hydroxyvitamin D, and albumin levels were matched between the 2 groups. Hypovitaminosis D and hypocalcemia were seen in 97 and 67% of the patients, respectively. The patients had lower serum calcium (P value <0.001) and phosphate (P = 0.007) compared with the controls. There was no statistically significant correlation between serum calcium and CRP.Conclusions: Hypocalcemia is highly prevalent even in COVID-19 patients with non-severe disease probably implying that hypocalcemia is intrinsic to the disease. Prospective studies with larger number of patients are required to prove this hypothesis and unravel the underlying pathophysiological mechanisms.

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Serum 25-hydroxyvitamin D level in psoriasis patients: a case-control study

International Journal of Research in Dermatology ◽

10.18203/issn.2455-4529.intjresdermatol20185500 ◽

2019 ◽

Vol 5 (1) ◽

pp. 27

Author(s):

Surinder Gupta ◽

Preeti Garg ◽

Nakul Gupta

Keyword(s):

Vitamin D ◽

Case Control Study ◽

Treatment Resistance ◽

Case Control ◽

The Body ◽

North India ◽

Hydroxyvitamin D ◽

25 Hydroxyvitamin D ◽

Differentiation And Proliferation ◽

Control Study

Background: Sufficient level of vitamin D in blood is required for proper regulation of cell differentiation and proliferation. Unchecked proliferation of cells leads to various disease states. Vitamin D also has immunomodulatory effects in the body. Psoriasis is a chronic inflammatory and hyperproliferative disease with vitamin D having an impact on it. This case – control study was done to judge the levels of vitamin D in patients of psoriasis compared to age and sex matched controls.Methods: A case control study was conducted including 50 patients (35 females and 15 males) of chronic plaque psoriasis from dermatology outpatient department of Maharaja Agrasen Medical College (MAMC), Agroha, Haryana, representing patients from north India and 50 healthy controls. Both urban and rural background patients were included.Results: The mean serum 25-hydroxyvitamin D (25-OHD) level in psoriasis patients was 22.865±11.386 ng/ml, whereas in controls it was 35.116±11.048 ng/ml (p<0.001). Serum level of 25-OHD in psoriatic patients was deficient (<20 ng/ml) in 26 (52%), insufficient (20-30 ng/ml) in 8 (16%) psoriatic patients.Conclusions: High prevalence of low vitamin D level was found in this study. We infer that vitamin D does play a role in the pathogenesis, precipitation, exacerbation, or treatment resistance of psoriasis.

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Serum Levels of 25-Hydroxyvitamin D in Patients with Seborrheic Dermatitis: A Case-Control Study

Dermatology Research and Practice ◽

10.1155/2021/6623271 ◽

2021 ◽

Vol 2021 ◽

pp. 1-5

Author(s):

Siavash Rahimi ◽

Negar Nemati ◽

Seyedeh Sareh Shafaei-Tonekaboni

Keyword(s):

Vitamin D ◽

Healthy Subjects ◽

Case Control Study ◽

Seborrheic Dermatitis ◽

Case Control ◽

Lower Serum ◽

Hydroxyvitamin D ◽

Control Subjects ◽

25 Hydroxyvitamin D ◽

Control Study

Several autoimmune papulosquamous skin conditions such as psoriasis, systemic lupus erythematous, and lichen planus have been associated with vitamin D deficiency or correlated with serum vitamin D level. This study was aimed at comparing the 25-hydroxyvitamin D (25(OH)D) status in patients with facial or scalp seborrheic dermatitis with healthy subjects. This case-control study included 289 patients (118 with psoriasis and 171 sex- and age-matched control subjects) from the outpatient clinic of two hospital dermatology departments in the west of Mazandaran province, Iran. All patients and control subjects were studied during one season to avoid seasonal variations in vitamin D levels. Serum mean ± standard deviation of 25(OH)D levels were signiﬁcantly lower in seborrheic dermatitis patients than in control subjects (20.71 ± 8.16 vs. 23.91 ± 7.78, P = 0.007). Serum 25(OH)D levels were negatively associated with the risk of developing seborrheic dermatitis (odds ratio (OR): 0.898, 95% confidence interval (Cl): 0.840–0.960, P = 0.002). Also, vitamin D under 30 ng/ml was associated with OR: 4.22 (95% Cl: 1.077–16.534, P = 0.039) for seborrheic dermatitis. The severity of scalp disease was significantly associated with serum 25(OH)D level ( P = 0.003). Cases with severe scalp scores had significantly lower serum 25(OH)D level compared to moderate OR score ( P = 0.036). A similar trend was not seen in the facial disease. The 25(OH)D values are signiﬁcantly lower in seborrheic dermatitis patients than in healthy subjects. Furthermore, the scalp disease severity was associated with lower serum 25(OH)D level. Our results may suggest that vitamin D may play a role in the pathogenesis of seborrheic dermatitis.

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Serum 25-hydroxyvitamin D status in chinese children with vitiligo: a case-control study

Clinical Pediatrics ◽

10.1177/0009922817734362 ◽

2017 ◽

Vol 57 (7) ◽

pp. 802-805 ◽

Cited By ~ 7

Author(s):

Xianhui Zhang ◽

Wei Wang ◽

Yuanjun Li ◽

Hui Wang ◽

Runtao Liu ◽

...

Keyword(s):

Vitamin D ◽

Family History ◽

Autoimmune Diseases ◽

Case Control Study ◽

Serum Vitamin ◽

Case Control ◽

Hydroxyvitamin D ◽

Serum Vitamin D ◽

25 Hydroxyvitamin D ◽

Control Study

Background. Vitamin D can play a vital role in autoimmune diseases. Epidemiologic evidence demonstrates vitamin D deficiency excited in adult patients with vitiligo. Objectives. To investigate 25-hydroxyvitamin D (25(OH)D) levels in children with vitiligo and explore possible relevant factors. Methods. A total of 114 patients and 100 controls were included in our case-control study. We analyzed the required data collected by the questionnaire and examination to reveal the correlation with 25(OH)D levels. Results. The mean serum 25(OH)D levels in patients and controls were 43.62 ± 19.23 and 67.87 ± 19.45 nmol/L, respectively. The rate of deficient in patients and controls are 14.9% and 2%, respectively. There was significant difference between the 2 groups. Significant differences also existed on different ages comparing serum vitamin D levels of patients with controls ( P < .001). Age was an independent factor affecting 25(OH)D level ( P = .032). Two (1.8%) and 4 (3.5%) of children with vitiligo have comorbid autoimmune diseases and family history, respectively. There was no correlation between sex, duration of disease, type of vitiligo, skin lesion location, stage, family history, and comorbid autoimmune diseases with 25(OH)D levels. Conclusion. Serum vitamin D level was associated with onset vitiligo children. More sunshine and vitamin D fortified foods are necessary among children with age. The rates of children vitiligo with family history has decreased in China.

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