scholarly journals Short chain fatty acids enriched fermentation metabolites of soluble dietary fibre from Musa paradisiaca drives HT29 colon cancer cells to apoptosis

PLoS ONE ◽  
2019 ◽  
Vol 14 (5) ◽  
pp. e0216604 ◽  
Author(s):  
Arun K. B. ◽  
Aravind Madhavan ◽  
Reshmitha T. R. ◽  
Sithara Thomas ◽  
P. Nisha
Keyword(s):  
Fatty Acids ◽  
Colon Cancer ◽  
Cancer Cells ◽  
Dietary Fibre ◽  
Short Chain Fatty Acids ◽  
Short Chain ◽  
Colon Cancer Cells ◽  
Musa Paradisiaca ◽  
Soluble Dietary Fibre ◽  
Chain Fatty Acids

Short-chain fatty acids inhibit intestinal trefoil factor gene expression in colon cancer cells

1998 ◽  
Vol 275 (1) ◽  
pp. G85-G94 ◽  
Author(s):  
Chau P. Tran ◽  
Mary Familari ◽  
Lorraine M. Parker ◽  
Robert H. Whitehead ◽  
Andrew S. Giraud
Keyword(s):  
Gene Expression ◽  
Fatty Acids ◽  
Colon Cancer ◽  
Cancer Cells ◽  
Short Chain Fatty Acids ◽  
Short Chain ◽  
Trefoil Factor ◽  
Colon Cancer Cells ◽  
Intestinal Trefoil Factor ◽  
Response Element

Intestinal trefoil factor (ITF) gene expression was detected in five colon cancer cell lines. ITF was synthesized by mucous cells of LIM 1215 and LIM 1863 lines, from which it is secreted constitutively. The ITF mRNA transcript was estimated to be 0.6 kb. In LIM 1215 cells, the expression of ITF was potently and dose-dependently inhibited by short-chain fatty acids (butyrate > propionate > acetate) within 8 h of application. The inhibitory effect of butyrate was ablated by actinomycin D and preceded its effects on differentiation of LIM 1215 cells as indicated by induction of alkaline phosphatase activity and counting of periodic acid-Schiff-positive cells. The human ITF promoter contained an 11-residue consensus sequence with high homology to the butyrate response element of the cyclin D1 gene. Mobility shift assays show specific binding of this response element to nuclear protein extracts of LIM 1215 cells. We conclude that butyrate inhibits ITF expression in colon cancer cells and that this effect may be mediated transcriptionally and independently of its effects on differentiation.

scholarly journals The relationship between gut microbiota, short-chain fatty acids and type 2 diabetes mellitus: the possible role of dietary fibre

2021 ◽  
Author(s):  
Dominic Salamone ◽  
Angela Albarosa Rivellese ◽  
Claudia Vetrani
Keyword(s):  
Type 2 Diabetes ◽  
Fatty Acids ◽  
Gut Microbiota ◽  
Dietary Fibre ◽  
Short Chain Fatty Acids ◽  
Short Chain ◽  
Microbiota Composition ◽  
The Relationship ◽  
Chain Fatty Acids

AbstractGut microbiota and its metabolites have been shown to influence multiple physiological mechanisms related to human health. Among microbial metabolites, short-chain fatty acids (SCFA) are modulators of different metabolic pathways. On the other hand, several studies suggested that diet might influence gut microbiota composition and activity thus modulating the risk of metabolic disease, i.e. obesity, insulin resistance and type 2 diabetes. Among dietary component, dietary fibre may play a pivotal role by virtue of its prebiotic effect on fibre-fermenting bacteria, that may increase SCFA production. The aim of this review was to summarize and discuss current knowledge on the impact of dietary fibre as modulator of the relationship between glucose metabolism and microbiota composition in humans. More specifically, we analysed evidence from observational studies and randomized nutritional intervention investigating the relationship between gut microbiota, short-chain fatty acids and glucose metabolism. The possible mechanisms behind this association were also discussed.

A proteomic analysis of differential cellular responses to the short-chain fatty acids butyrate, valerate and propionate in colon epithelial cancer cells

2012 ◽  
Vol 8 (4) ◽  
pp. 1146-1156 ◽  
Author(s):  
Josephine Kilner ◽  
Jennifer S. Waby ◽  
Joanna Chowdry ◽  
Abdul Q. Khan ◽  
Josselin Noirel ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Cancer Cells ◽  
Proteomic Analysis ◽  
Cellular Responses ◽  
Short Chain Fatty Acids ◽  
Short Chain ◽  
Epithelial Cancer ◽  
Chain Fatty Acids
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