scholarly journals Correlation of host inflammatory cytokines and immune-related metabolites, but not viral NS1 protein, with disease severity of dengue virus infection

PLoS ONE ◽  
2020 ◽  
Vol 15 (8) ◽  
pp. e0237141
Author(s):  
Hui Jen Soe ◽  
Rishya Manikam ◽  
Chandramathi Samudi Raju ◽  
Mohammad Asif Khan ◽  
Shamala Devi Sekaran
Keyword(s):  
Virus Infection ◽  
Dengue Virus ◽  
Disease Severity ◽  
Inflammatory Cytokines ◽  
Ns1 Protein ◽  
Dengue Virus Infection

scholarly journals Current Understanding of the Pathogenesis of Dengue Virus Infection

2020 ◽  
Author(s):  
Puneet Bhatt ◽  
Sasidharan Pillai Sabeena ◽  
Muralidhar Varma ◽  
Govindakarnavar Arunkumar
Keyword(s):  
Immune Response ◽  
T Cells ◽  
Virus Infection ◽  
Dengue Virus ◽  
Genetic Factors ◽  
Host Immune Response ◽  
Severe Dengue ◽  
Ns1 Protein ◽  
Dengue Virus Infection ◽  
Antibody Dependent Enhancement

AbstractThe pathogenesis of dengue virus infection is attributed to complex interplay between virus, host genes and host immune response. Host factors such as antibody-dependent enhancement (ADE), memory cross-reactive T cells, anti-DENV NS1 antibodies, autoimmunity as well as genetic factors are major determinants of disease susceptibility. NS1 protein and anti-DENV NS1 antibodies were believed to be responsible for pathogenesis of severe dengue. The cytokine response of cross-reactive CD4+ T cells might be altered by the sequential infection with different DENV serotypes, leading to further elevation of pro-inflammatory cytokines contributing a detrimental immune response. Fcγ receptor-mediated antibody-dependent enhancement (ADE) results in release of cytokines from immune cells leading to vascular endothelial cell dysfunction and increased vascular permeability. Genomic variation of dengue virus and subgenomic flavivirus RNA (sfRNA) suppressing host immune response are viral determinants of disease severity. Dengue infection can lead to the generation of autoantibodies against DENV NS1antigen, DENV prM, and E proteins, which can cross-react with several self-antigens such as plasminogen, integrin, and platelet cells. Apart from viral factors, several host genetic factors and gene polymorphisms also have a role to play in pathogenesis of DENV infection. This review article highlights the various factors responsible for the pathogenesis of dengue and also highlights the recent advances in the field related to biomarkers which can be used in future for predicting severe disease outcome.

scholarly journals Detection of Proteinuria by Colorimetric Method and Correlation with Disease Severity in Patients Dengue

2021 ◽  
Vol 27 (3) ◽  
pp. 244
Author(s):  
Acivrida Mega Charisma ◽  
Elis Anita Farida ◽  
Farida Anwari
Keyword(s):  
Virus Infection ◽  
Dengue Virus ◽  
Disease Severity ◽  
Dengue Infection ◽  
Urine Samples ◽  
P Value ◽  
Urine Protein ◽  
Dengue Virus Infection ◽  
Chi Square ◽  
Chi Square Test

Severe dengue virus infection often causes proteinuria through several mechanisms, such as leakage of plasma proteins caused by higher protein filtering in the kidneys. The condition of proteinuria in patients with dengue shock syndrome will affect the management, prognosis, and mortality of patients with dengue virus infection. The objectives of this study were to determine the presence of protein in urine samples in patients in which IgG/IgM dengue was detected, to determine the presence of protein in urine samples in patients without dengue infection, and to determine the relationship between proteinuria in dengue patients and the degree of disease severity. The study was conducted in March-June 2020 at the Clinical Laboratory and Inpatient Clinic of Vita Medika Kepung, Kediri Regency. The method used was the consecutive sampling technique. The minimum sample size was 100 respondents with criteria for suspected dengue infection, onset fever > 4 days, age > 2 years, and no indication of other infectious diseases (blood and urine), divided into two groups, group with positive dengue infection and non-dengue group. The results showed that proteinuria was detected in 26% of respondents, secondary dengue infection and positive serological test of IgG, IgM only IgG were detected in 24 (92.3%) respondents and positive IgG and IgM were found in 2 (7.7%) respondents, this was shown by the p-value = 0.000 in the Chi-Square test with a Prevalence Ratio (PR) value of 11,987. In addition, Chi-Square test results indicated that a higher urine protein/albumin led to more severe disease, with p-value = 0.012 and 0.025 (p <0.05) and PR values of 3.333 and 2.800. The results of this study concluded that there was a close relationship between high levels of protein/albumin in the urine with the degree of disease severity in patients with dengue infection. In addition, an increase in urine protein/albumin levels is always followed by a decrease in serum protein/albumin levels.

scholarly journals Interleukin-6: A promising disease severity index for dengue virus infection

2017 ◽  
Vol 7 (5) ◽  
pp. 266-269 ◽  
Author(s):  
Fariha Kanwal ◽  
◽  
Changrui Lu ◽  
Ishtiaq Qadri ◽  
Muhammad Sohail ◽  
...  
Keyword(s):  
Virus Infection ◽  
Dengue Virus ◽  
Disease Severity ◽  
Interleukin 6 ◽  
Severity Index ◽  
Disease Severity Index ◽  
Dengue Virus Infection

scholarly journals Effect of freeze-dried Carica papaya leaf juice on inflammatory cytokines production during dengue virus infection in AG129 mice

2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Nor Azrina Norahmad ◽  
Mohd Ridzuan Mohd Abd Razak ◽  
Norazlan Mohmad Misnan ◽  
Nur Hana Md Jelas ◽  
Umi Rubiah Sastu ◽  
...  
Keyword(s):  
Virus Infection ◽  
Dengue Virus ◽  
Inflammatory Cytokines ◽  
Carica Papaya ◽  
Dengue Virus Infection ◽  
Freeze Dried ◽  
Leaf Juice

scholarly journals Immune cell phenotypes associated with disease severity and long-term neutralizing antibody titers after natural dengue virus infection

2021 ◽  
Vol 2 (5) ◽  
pp. 100278
Author(s):  
Angeline Rouers ◽  
Melissa Hui Yen Chng ◽  
Bernett Lee ◽  
Menaka P. Rajapakse ◽  
Kaval Kaur ◽  
...  
Keyword(s):  
Virus Infection ◽  
Dengue Virus ◽  
Disease Severity ◽  
Immune Cell ◽  
Neutralizing Antibody ◽  
Dengue Virus Infection ◽  
Antibody Titers ◽  
Cell Phenotypes

scholarly journals Interleukin-33 contributes to disease severity in Dengue virus infection in mice

Immunology ◽  
2018 ◽  
Vol 155 (4) ◽  
pp. 477-490 ◽  
Author(s):  
Rafael E. Marques ◽  
Anne-Gaëlle Besnard ◽  
Isabelle Maillet ◽  
Caio T. Fagundes ◽  
Danielle G. Souza ◽  
...  
Keyword(s):  
Virus Infection ◽  
Dengue Virus ◽  
Disease Severity ◽  
Dengue Virus Infection ◽  
Interleukin 33
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