scholarly journals Assessment of pressure-volume relations in univentricular hearts: Comparison of obtainment by real-time 3D echocardiography and mini pressure-wire with conductance technology

PLoS ONE ◽  
2021 ◽  
Vol 16 (2) ◽  
pp. e0246031
Author(s):  
Katharina Linden ◽  
Christian Winkler ◽  
Johannes Breuer ◽  
Ulrike Herberg
Keyword(s):  
Single Ventricle ◽  
Intraclass Correlation ◽  
3D Echocardiography ◽  
Volume Data ◽  
Pressure Data ◽  
Hemodynamic Changes ◽  
Arterial Elastance ◽  
Pressure Wire ◽  
Measured Pressure ◽  
Good Agreement

Objectives The gold standard to obtain pressure-volume relations (PVR) of the heart, the conductance technology (PVRCond), is rarely used in children. PVR can also be obtained by 3D-echocardiography volume data combined with simultaneously measured pressure data by a mini pressure-wire (PVR3DE). We sought to investigate the feasibility of both methods in patients with univentricular hearts and to compare them, including hemodynamic changes. Methods We studied 19 patients (age 2–29 years). PVR3DE and PVRCond were assessed under baseline conditions and stimulation with dobutamine. Results Obtaining PVR3DE was successful in all patients. Obtaining PVRCond was possible in 15 patients during baseline (79%) and in 12 patients under dobutamine (63%). Both methods showed that end-systolic elastance (Ees) and arterial elastance (Ea) increased under dobutamine and that Tau showed a statistically significant decrease. Intraclass correlation (95% confidence interval) showed moderate to good agreement between methods: Ees: 0.873 (0.711–0.945), Ea: 0.709 (0.336–0.873), Tau: 0.867 (0.697–0.942). Bland-Altman analyses showed an acceptable bias with wider limits of agreement: Ees: 1.63 mmHg/ml (-3.83–7.08 mmHg/ml), Ea: 0.53 mmHg/ml (-5.23–6.28 mmHg/ml), Tau: -0,76 ms (-10.73–9.21 ms). Conclusion Changes of PVR-specific parameters under dobutamine stimulation were reflected in the same way by both methods. However, the absolute values for these parameters could vary between methods and, therefore, methods are not interchangeable. Obtaining PVR3DE in a single ventricle was easier, faster and more successful than PVRCond. PVR3DE provides a promising and needed alternative to the conductance technology for the assessment of cardiac function in univentricular hearts.

scholarly journals Repeatability of automated measurements by a new anterior segment optical coherence tomographer and biometer and agreement with standard devices

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Domenico Schiano-Lomoriello ◽  
Kenneth J. Hoffer ◽  
Irene Abicca ◽  
Giacomo Savini
Keyword(s):  
Intraclass Correlation ◽  
Anterior Segment ◽  
Consecutive Series ◽  
Optical Coherence ◽  
Limits Of Agreement ◽  
Automated Measurements ◽  
Deviation Coefficient ◽  
Corneal Diameter ◽  
High Repeatability ◽  
Good Agreement

AbstractWe assess repeatability of automatic measurements of a new anterior segment optical coherence tomographer and biometer (ANTERION) and their agreement with those provided by an anterior segment-optical coherence tomography device combined with Placido-disk corneal topography (MS-39) and a validated optical biometer (IOLMaster 500). A consecutive series of patients underwent three measurements with ANTERION and one with MS-39. A subgroup of patients underwent biometry also with IOLMaster 500. Repeatability was assessed by means of within-subject standard deviation, coefficient of variation (COV), and intraclass correlation coefficient (ICC). Agreement was investigated with the 95% limits of agreement. Paired t-test and Wilcoxon matched-pairs test were performed to compare the measurements of the different devices. Repeatability of ANTERION measurements was high, with ICC > 0.98 for all parameters except astigmatism (0.963); all parameters apart from those related to astigmatism revealed a COV < 1%. Repeatability of astigmatism improved when only eyes whose keratometric astigmatism was higher than 1.0 D were investigated. Most measurements by ANTERION and MS-39 showed good agreement. No significant differences were found between measurements by ANTERION and IOLMaster, but for corneal diameter. ANTERION revealed high repeatability of automatic measurements and good agreement with both MS-39 and IOLMaster for most parameters.

Agreement and reliability of magnetic, angular rate, and gravity (MARG) sensors to assess multiple body segment’s external loads during off-road running

2021 ◽  
pp. 175433712199698
Author(s):  
Daniel Rojas-Valverde ◽  
José Pino-Ortega ◽  
Rafael Timón ◽  
Randall Gutiérrez-Vargas ◽  
Braulio Sánchez-Ureña ◽  
...  
Keyword(s):  
Vastus Lateralis ◽  
Angular Rate ◽  
Wearable Sensors ◽  
Intraclass Correlation ◽  
Principal Component ◽  
Test Reliability ◽  
Data Set ◽  
Body Segments ◽  
External Loads ◽  
Good Agreement

The extensive use of wearable sensors in sport medicine, exercise medicine, and health has increased the interest in their study. That is why it is necessary to test these technologies’ efficiency, effectiveness, agreement, and reliability in different settings. Consequently, the purpose of this article was to analyze the magnetic, angular rate, and gravity (MARG) sensor’s test-retest agreement and reliability when assessing multiple body segments’ external loads during off-road running. A total of 18 off-road runners (38.78 ± 10.38 years, 73.24 ± 12.6 kg, 172.17 ± 9.48 cm) ran two laps (1st and 2nd Lap) of a 12 km circuit wearing six MARG sensors. The sensors were attached to six different body segments: left (MPLeft) and right (MPRight) malleolus peroneus, left (VLLeft) and right (VLRight) vastus lateralis, lumbar (L1-L3), and thorax (T2-T4) using a special neoprene suit. After a principal component analysis (PCA) was performed, the total data set variance of all body segments was represented by 44.08%–70.64% for the 1st PCA factor considering two variables, Player LoadRT and Impacts, on L1-L3, respectively. These two variables were chosen among three total accelerometry-based external load indicators (ABELIs) to perform the agreement and reliability tests due to their relevance based on PCAs for each body segment. There were no significant differences between laps in the Player LoadRT or Impacts ( p > 0.05, trivial). The intraclass correlation and lineal correlation showed a substantial to almost perfect over-time test consistency assessed via reliability in both Player LoadRT and Impacts. Bias and t-test assessments showed good agreement between Laps. It can be concluded that MARGs sensors offer significant test re-test reliability and good agreement when assessing off-road kinematics in the six different body segments.

251 Agreement and reliability of a new polysomnography sleep staging algorithm against multiple human scorers

SLEEP ◽  
2021 ◽  
Vol 44 (Supplement_2) ◽  
pp. A101-A101
Author(s):  
Ulysses Magalang ◽  
Brendan Keenan ◽  
Bethany Staley ◽  
Peter Anderer ◽  
Marco Ross ◽  
...  
Keyword(s):  
Total Sleep Time ◽  
High Reliability ◽  
Sleep Stage ◽  
Intraclass Correlation ◽  
Sleep Time ◽  
Sleep Staging ◽  
Original Dataset ◽  
Scoring Algorithm ◽  
Scoring Algorithms ◽  
Good Agreement

Abstract Introduction Scoring algorithms have the potential to increase polysomnography (PSG) scoring efficiency while also ensuring consistency and reproducibility. We sought to validate an updated sleep staging algorithm (Somnolyzer; Philips, Monroeville PA USA) against manual sleep staging, by analyzing a dataset we have previously used to report sleep staging variability across nine center-members of the Sleep Apnea Global Interdisciplinary Consortium (SAGIC). Methods Fifteen PSGs collected at a single sleep clinic were scored independently by technologists at nine SAGIC centers located in six countries, and auto-scored with the algorithm. Each 30-second epoch was staged manually according to American Academy of Sleep Medicine criteria. We calculated the intraclass correlation coefficient (ICC) and performed a Bland-Altman analysis comparing the average manual- and auto-scored total sleep time (TST) and time in each sleep stage (N1, N2, N3, rapid eye movement [REM]). We hypothesized that the values from auto-scoring would show good agreement and reliability when compared to the average across manual scorers. Results The participants contributing to the original dataset had a mean (SD) age of 47 (12) years and 80% were male. Auto-scoring showed substantial (ICC=0.60-0.80) or almost perfect (ICC=0.80-1.00) reliability compared to manual-scoring average, with ICCs (95% confidence interval) of 0.976 (0.931, 0.992) for TST, 0.681 (0.291, 0.879) for time in N1, 0.685 (0.299, 0.881) for time in N2, 0.922 (0.791, 0.973) for time in N3, and 0.930 (0.811, 0.976) for time in REM. Similarly, Bland-Altman analyses showed good agreement between methods, with a mean difference (limits of agreement) of only 1.2 (-19.7, 22.0) minutes for TST, 13.0 (-18.2, 44.1) minutes for N1, -13.8 (-65.7, 38.1) minutes for N2, -0.33 (-26.1, 25.5) minutes for N3, and -1.2 (-25.9, 23.5) minutes for REM. Conclusion Results support high reliability and good agreement between the auto-scoring algorithm and average human scoring for measurements of sleep durations. Auto-scoring slightly overestimated N1 and underestimated N2, but results for TST, N3 and REM were nearly identical on average. Thus, the auto-scoring algorithm is acceptable for sleep staging when compared against human scorers. Support (if any) Philips.

Abstract 17209: Impaired Ventricular-Vascular Coupling in Young Adults Born Preterm

Circulation ◽  
2018 ◽  
Vol 138 (Suppl_1) ◽  
Author(s):  
Ashley Mulchrone ◽  
Alessandro Bellofiore ◽  
Arij G Beshish ◽  
Gregory Barton ◽  
Heather Shumaker ◽  
...  
Keyword(s):  
Young Adults ◽  
Preterm Birth ◽  
Right Ventricular ◽  
Very Low Birth Weight ◽  
Systolic Pressure ◽  
The United States ◽  
Pulmonary Vascular Disease ◽  
Heart Catheterization ◽  
Volume Data ◽  
Arterial Elastance

Background: Preterm birth affects 10% of live births in the United States, often requiring mechanical ventilation and oxygen supplementation. Although a known risk factor for neonatal and childhood pulmonary vascular disease, little is known regarding the long-term impact on the right ventricle (RV). Here, we utilize novel techniques to investigate RV afterload, contractility, and ventricular-vascular coupling (VVC) in young adults born preterm. Methods: Adults born premature (n=7; 4; current age 26.7±0.4 years; gestational age 28.6±1.1 weeks) born with very low birth weight (≤1500g) were recruited from the Newborn Lung Project. Control subjects (n=7; 2) from the same birth years were recruited from the general population. All subjects had no known cardiopulmonary disease. Right heart catheterization (RHC) and magnetic resonance imaging (MRI) were performed to assess right ventricular hemodynamics. Asynchronously acquired pressure and volume data (from RHC and MRI, respectively) were used to compute effective arterial elastance (Ea), end-systolic elastance (Ees), and VVC as: [ESP/SV], [(P max -ESP)/SV], and [Ees/Ea], respectively, where ESP is the end-systolic pressure, SV is the stroke volume, and P max is the maximum isovolumetric pressure estimated from a novel single-beat approach. Results were analyzed via two-sample t-test; p<0.05 was considered significant. Results: Preterm subjects had significantly increased Ea, a measure of RV afterload (Figure 1A). No difference Ees, a measure of RV contractility, was evident (Figure 1B), resulting in significantly impaired VVC in preterm subjects (Figure 1C). Conclusion: Otherwise healthy young adults born preterm have high resistance-low compliance pulmonary vascular beds with no RV adaptation, resulting in impaired right ventricular-pulmonary vascular coupling. These findings add to the growing literature that preterm birth has profound lifelong consequences that warrant further study.

Should We Base Training Prescription on the Force–Velocity Profile? Exploratory Study of Its Between-Day Reliability and Differences Between Methods

2020 ◽  
pp. 1-7
Author(s):  
Pedro L. Valenzuela ◽  
Guillermo Sánchez-Martínez ◽  
Elaia Torrontegi ◽  
Javier Vázquez-Carrión ◽  
Zigor Montalvo ◽  
...  
Keyword(s):  
Coefficient Of Variation ◽  
Intraclass Correlation ◽  
Reliability Coefficient ◽  
Power Coefficient ◽  
Squat Jump ◽  
Jump Test ◽  
Force Velocity ◽  
Constrained Conditions ◽  
Vertical Jumps ◽  
Good Agreement

Purpose: To analyze the differences in the force–velocity (F–v) profile assessed under unconstrained (ie, using free weights) and constrained (ie, on a Smith machine) vertical jumps, as well as to determine the between-day reliability. Methods: A total of 23 trained participants (18 [1] y) performed an incremental load squat jump test (with ∼35%, 45%, 60%, and 70% of the subjects’ body mass) on 2 different days using free weights and a Smith machine. Nine of these participants repeated the tests on 2 other days for an exploratory analysis of between-day reliability. F–v variables (ie, maximum theoretical force [F0], velocity [v0], and power, and the imbalance between the actual and the theoretically optimal F–v profile) were computed from jump height. Results: A poor agreement was observed between the F–v variables assessed under constrained and unconstrained conditions (intraclass correlation coefficient [ICC] < .50 for all). The height attained during each single jump performed under both constrained and unconstrained conditions showed an acceptable reliability (coefficient of variation < 10%, ICC > .70). The F–v variables computed under constrained conditions showed an overall good agreement (ICC = .75–.95 for all variables) and no significant differences between days (P > .05), but a high variability for v0, the imbalance between the actual and the theoretically optimal F–v profile, and maximal theoretical power (coefficient of variation = 17.0%–27.4%). No between-day differences were observed for any F–v variable assessed under unconstrained conditions (P > .05), but all of the variables presented a low between-day reliability (coefficient of variation > 10% and ICC < .70 for all). Conclusions: F–v variables differed meaningfully when obtained from constrained and unconstrained loaded jumps, and most importantly seemed to present a low between-day reliability.

Sound Propagation in Dilute Polyatomic Gases

1972 ◽  
Vol 27 (4) ◽  
pp. 583-592
Author(s):  
H. Moraal ◽  
F. Mccourt
Keyword(s):  
Pressure Range ◽  
Sound Propagation ◽  
Plane Waves ◽  
Point Of View ◽  
Perturbation Function ◽  
Sound Waves ◽  
Polyatomic Gas ◽  
Measured Pressure ◽  
Theory And Experiment ◽  
Good Agreement

Abstract Sound propagation in dilute pure gases, both monatomic and polyatomic, has been considered from the point of view of the Waldmann-Snider equation. It is shown that the commonly employed assumption that sound propagation in gases is equivalent to the propagation of plane waves is valid only in the region where collisions restore equilibrium faster than it is perturbed by the sound waves. A systematic truncation procedure for an expansion of the perturbation function in irreducible Cartesian tensors is introduced and then illustrated in solutions for three specific kinds of molecules, helium, nitrogen and rough spheres. The agreement between theory and experiment is rather good for sound absorption in the region where the ratio of the collision and sound frequencies is greater than 1.5. The agreement in the case of dispersion is good over the whole measured pressure range. One useful result obtained is to show the polyatomic gas calculations in second approximation have as good agreement with experiment as the calculations for noble gases in third approximation. This can be related to the possession by the polyatomic gas of a bulk viscosity which dominates in sound propagation.

New Relationship Between Resistivity Index and Relative Permeability

2015 ◽  
Vol 137 (3) ◽  
Author(s):  
Dong Ma ◽  
Changwei Liu ◽  
Changhui Cheng
Keyword(s):  
Capillary Pressure ◽  
Relative Permeability ◽  
Pressure Data ◽  
Two Phase ◽  
Resistivity Index ◽  
Proposed Model ◽  
Petrophysical Parameter ◽  
Oil Water ◽  
Better Than ◽  
Good Agreement

Relative permeability as an important petrophysical parameter is often measured directly in the laboratory or obtained indirectly from the capillary pressure data. However, the literature on relationship between relative permeability and resistivity is lacking. To this end, a new model of inferring two-phase relative permeability from resistivity index data was derived on the basis of Poiseuille's law and Darcy's law. The wetting phase tortuosity ratio was included in the proposed model. The relative permeabilities computed from the capillary pressure data, as well as the experimental data measured in gas–water and oil–water flow condition, were compared with the proposed model. Both results demonstrated that the two-phase permeability obtained by proposed model were generally in good agreement with the data computed from capillary pressure and measured in the laboratory. The comparison also showed that our model was much better than Li model at matching the relative permeability data.

scholarly journals Reproducibility and validity of portable haemoglobinometer for the diagnosis of anaemia in children under the age of 5 years

2020 ◽  
Vol 9 ◽  
Author(s):  
Alessandra da Silva Pereira ◽  
Inês Rugani Ribeiro de Castro ◽  
Flávia Fioruci Bezerra ◽  
José Firmino Nogueira Neto ◽  
Ana Carolina Feldenheimer da Silva
Keyword(s):  
Venous Blood ◽  
Intraclass Correlation ◽  
Age Groups ◽  
Capillary Blood ◽  
Test Method ◽  
Automated System ◽  
Accuracy Rate ◽  
Predictive Values ◽  
Sensitivity Specificity ◽  
Good Agreement

Abstract Portable haemoglobinometers have been used in order to estimate the prevalence of anaemia in diverse settings. However, few studies have been conducted to evaluate their performance in children of different age groups in distinct epidemiological contexts. To evaluate the reproducibility and reliability of a portable haemoglobinometer for the diagnosis of anaemia in children <5 years Hb was measured in the venous blood of 351 children <5 years by an automated system (standard method) and in three capillary blood samples, using a portable haemoglobinometer (HemoCue®; test method). The reproducibility of the device and of the test method was evaluated using the intraclass correlation coefficient (ICC) (Hb in its continuous form), κ and prevalence-adjusted bias-adjusted κ (PABAK) (categorised variable: anaemia: yes/no). For test method validation, Bland–Altman analyses were performed and sensitivity, specificity, accuracy rate, positive predictive value (PPV) and negative predictive values (NPV) were calculated. The haemoglobinometer presented good device reproducibility (ICC = 0·79) and reasonable method reproducibility (puncture, collection and reading) (ICC = 0·71). Superficial and fair agreement (κ) and good agreement (PABAK) were observed among the diagnoses obtained through the test method. The prevalence of anaemia was 19·1 and 19·7 % using the standard and the test method, respectively, with no statistically significant differences. The test method presented higher specificity (87·7 %) and NPV (88·3 %) than sensitivity (50·7 %) and PPV (49·3 %), and intermediary accuracy rate (57·8 %). HemoCue® showed good device reproducibility and reasonable method reproducibility, as well as good performance in estimating the prevalence of anaemia. Nevertheless, it showed a fair reliability and low individual diagnostic accuracy.

Prehospital Vital Signs Accurately Predict Initial Emergency Department Vital Signs

2020 ◽  
Vol 35 (3) ◽  
pp. 254-259
Author(s):  
Marc D. Trust ◽  
Morgan Schellenberg ◽  
Subarna Biswas ◽  
Kenji Inaba ◽  
Vincent Cheng ◽  
...  
Keyword(s):  
Emergency Department ◽  
Intraclass Correlation ◽  
Vital Signs ◽  
Correlation Coefficients ◽  
Trauma Team ◽  
Urban Setting ◽  
Trauma Patients ◽  
Level I ◽  
Gcs Score ◽  
Good Agreement

AbstractIntroduction:Prehospital vital signs are used to triage trauma patients to mobilize appropriate resources and personnel prior to patient arrival in the emergency department (ED). Due to inherent challenges in obtaining prehospital vital signs, concerns exist regarding their accuracy and ability to predict first ED vitals.Hypothesis/Problem:The objective of this study was to determine the correlation between prehospital and initial ED vitals among patients meeting criteria for highest levels of trauma team activation (TTA). The hypothesis was that in a medical system with short transport times, prehospital and first ED vital signs would correlate well.Methods:Patients meeting criteria for highest levels of TTA at a Level I trauma center (2008-2018) were included. Those with absent or missing prehospital vital signs were excluded. Demographics, injury data, and prehospital and first ED vital signs were abstracted. Prehospital and initial ED vital signs were compared using Bland-Altman intraclass correlation coefficients (ICC) with good agreement as >0.60; fair as 0.40-0.60; and poor as <0.40).Results:After exclusions, 15,320 patients were included. Mean age was 39 years (range 0-105) and 11,622 patients (76%) were male. Mechanism of injury was blunt in 79% (n = 12,041) and mortality was three percent (n = 513). Mean transport time was 21 minutes (range 0-1,439). Prehospital and first ED vital signs demonstrated good agreement for Glasgow Coma Scale (GCS) score (ICC 0.79; 95% CI, 0.77-0.79); fair agreement for heart rate (HR; ICC 0.59; 95% CI, 0.56-0.61) and systolic blood pressure (SBP; ICC 0.48; 95% CI, 0.46-0.49); and poor agreement for pulse pressure (PP; ICC 0.32; 95% CI, 0.30-0.33) and respiratory rate (RR; ICC 0.13; 95% CI, 0.11-0.15).Conclusion:Despite challenges in prehospital assessments, field GCS, SBP, and HR correlate well with first ED vital signs. The data show that these prehospital measurements accurately predict initial ED vitals in an urban setting with short transport times. The generalizability of these data to settings with longer transport times is unknown.

An App to Assess Young Children’s Perceptions of Movement Competence

2018 ◽  
Vol 6 (s2) ◽  
pp. S252-S263 ◽  
Author(s):  
Lisa M. Barnett ◽  
Owen Makin
Keyword(s):  
Intraclass Correlation ◽  
Correlation Coefficients ◽  
Future Research ◽  
Children's Perceptions ◽  
Intraclass Correlation Coefficients ◽  
Children’S Perceptions ◽  
Digital Assessment ◽  
Android App ◽  
Test Retest Reliability ◽  
Good Agreement

Assessing young children’s perceptions is commonly done one on one with an interviewer. An app enables several children to complete the scale at once. The objective was to describe an app to assess children’s perceptions of movement competence and then present consistency of child responses. The Pictorial Scale of Perceived Movement Skill Competence (PMSC) has fundamental movement skill (FMS; e.g., catch) and play items (e.g., cycling). The PMSC android app has the same items and images but children complete it independently with audio. Intraclass correlation coefficients (ICC) assessed i) test-retest reliability using the PMSC app on 18 items in 42 children (M = 6.8 yrs) and ii) consistency between measures for 13 FMS items in 44 children (M = 8.5 yrs). Over time (M = 6.9 days, SD = 0.35) the full PMSC had good consistency (ICC = 0.79, 95% CI 0.64–0.88) and the FMS items had moderate consistency (ICC = 0.68, 95% CI 0.47–0.81). There was good agreement between the app and interview for FMS items (ICC = 0.86, 95% CI 0.76–0.92). Locomotor items were less consistent. The PMSC app can generally be recommended. Future research could investigate how different forms of digital assessment affect children’s perception.

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