scholarly journals Balance rehabilitation with a virtual reality protocol for patients with hereditary spastic paraplegia: Protocol for a clinical trial

PLoS ONE ◽  
2021 ◽  
Vol 16 (4) ◽  
pp. e0249095
Author(s):  
Bianca Simone Zeigelboim ◽  
Maria Renata José ◽  
Geslaine Janaina Bueno dos Santos ◽  
Maria Izabel Rodrigues Severiano ◽  
Hélio Afonso Ghizoni Teive ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Virtual Reality ◽  
Hereditary Spastic Paraplegia ◽  
Vestibular Rehabilitation ◽  
Rehabilitation Program ◽  
Controlled Clinical Trial ◽  
Spastic Paraplegia ◽  
Post Intervention ◽  
Group I ◽  
Alternative Treatment Option

Background Neurodegenerative diseases are sporadic hereditary conditions characterized by progressive dysfunction of the nervous system. Among the symptoms, vestibulopathy is one of the causes of discomfort and a decrease in quality of life. Hereditary spastic paraplegia is a heterogeneous group of hereditary degenerative diseases involving the disorder of a single gene and is characterized by the progressive retrograde degeneration of fibers in the spinal cord. Objective To determine the benefits of vestibular rehabilitation involving virtual reality by comparing pre intervention and post intervention assessments in individuals with hereditary spastic paraplegia. Methods In this randomized controlled clinical trial from the Rebec platform RBR-3jmx67 in which allocation concealment was performed and the evaluators be blinded will be included. The participants will include 40 patients diagnosed with hereditary spastic paraplegia. The interventions will include vestibular rehabilitation with virtual reality using the Wii® console, Wii-Remote and Wii Balance Board (Nintendo), and the studies will include pre- and post intervention assessments. Group I will include twenty volunteers who performed balance games. Group II will include twenty volunteers who performed balance games and muscle strength games. The games lasted from 30 minutes to an hour, and the sessions were performed twice a week for 10 weeks (total: 20 sessions). Results This study provides a definitive assessment of the effectiveness of a virtual reality vestibular rehabilitation program in halting the progression of hereditary spastic paraplegia, and this treatment can be personalized and affordable. Conclusion The study will determine whether a vestibular rehabilitation program with the Nintendo Wii® involving virtual reality can reduce the progressive effect of hereditary spastic paraplegia and serve as an alternative treatment option that is accessible and inexpensive. Rebec platform trial: RBR-3JMX67.

scholarly journals Virtual Reality and Physiotherapy in Post-Stroke Functional Re-Education of the Lower Extremity: A Controlled Clinical Trial on a New Approach

2021 ◽  
Vol 11 (11) ◽  
pp. 1210
Author(s):  
Carlos Luque-Moreno ◽  
Pawel Kiper ◽  
Ignacio Solís-Marcos ◽  
Michela Agostini ◽  
Andrea Polli ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Virtual Reality ◽  
Lower Extremity ◽  
Combined Therapy ◽  
Functional Independence Measure ◽  
Functional Independence ◽  
Controlled Clinical Trial ◽  
Post Intervention ◽  
Trunk Control ◽  
Post Stroke

Numerous Virtual Reality (VR) systems address post-stroke functional recovery of the lower extremity (LE), most of them with low early applicability due to the gait autonomy they require. The aim of the present study was to evaluate the feasibility of a specific VR treatment and its clinical effect on LE functionality, gait, balance, and trunk control post-stroke. A controlled, prospective, clinical trial was carried out with 20 stroke patients, who were divided into two groups: the first group (VR + CP; n = 10) received combined therapy of 1 h VR and 1 h of conventional physiotherapy (CP) and the second group (CP; n = 10) received 2 h of CP (5 days/week, for 3 weeks). The following pre-post-intervention measuring scales were used: Functional Ambulatory Scale (FAC), Functional Independence Measure (FIM), Fugl-Meyer Assessment (FM), Berg Balance Scale (BBS), and Trunk Control Test (TCT). Only VR + CP showed a significant improvement in FAC. In FIM, CP presented a tendency to significance, whereas VR + CP showed significance. Both groups improved significantly in FM (especially in amplitude/pain in VR + CP and in sensitivity in CP) and in BBS. In TCT, there was a non-significant improvement in both groups. The results indicate that the intervention with VR is a feasible treatment in the post-stroke functional re-education of the LE, with the potential to be an optimal complement of CP.

Adjunctive Therapy to Manage Neuropsychiatric Symptoms in Moderate and Severe Dementia: Randomized Clinical Trial Using an Outpatient Version of Tailored Activity Program

2021 ◽  
pp. 1-12
Author(s):  
Alexandra Martini Oliveira ◽  
Marcia Radanovic ◽  
Patricia Cotting Homem de Mello ◽  
Patricia Cardoso Buchain ◽  
Adriana Dias Barbosa Vizzotto ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Sleep Disturbances ◽  
Rating Scale ◽  
Neuropsychiatric Symptoms ◽  
Caregiver Training ◽  
Controlled Clinical Trial ◽  
Post Intervention ◽  
Double Blind ◽  
Activity Program ◽  
Experimental Group

Background: Neuropsychiatric symptoms (NPS) such as aggression, apathy, agitation, and wandering may occur in up to 90%of dementia cases. International guidelines have suggested that non-pharmacological interventions are as effective as pharmacological treatments, however without the side effects and risks of medications. An occupational therapy method, called Tailored Activity Program (TAP), was developed with the objective to treat NPS in the elderly with dementia and has been shown to be effective. Objective: Evaluate the efficacy of the TAP method (outpatient version) in the treatment of NPS in individuals with dementia and in the burden reduction of their caregivers. Methods: This is a randomized, double-blind, controlled clinical trial for the treatment of NPS in dementia. Outcome measures consisted of assessing the NPS of individuals with dementia, through the Neuropsychiatric Inventory-Clinician rating scale (NPI-C), and assessing the burden on their caregivers, using the Zarit Scale. All the participants were evaluated pre-and post-intervention. Results: 54 individuals with dementia and caregivers were allocated to the experimental (n = 28) and control (n = 26) groups. There was improvement of the following NPS in the experimental group: delusions, agitation, aggressiveness, depression, anxiety, euphoria, apathy, disinhibition, irritability, motor disturbance, and aberrant vocalization. No improvement was observed in hallucinations, sleep disturbances, and appetite disorders. The TAP method for outpatient settings was also clinically effective in reducing burden between caregivers of the experimental group. Conclusion: The use of personalized prescribed activities, coupled with the caregiver training, may be a clinically effective approach to reduce NPS and caregiver burden of individuals with dementia.

A simplified rehabilitation program for patients undergoing elective colonic surgery—randomized controlled clinical trial

2010 ◽  
Vol 26 (5) ◽  
pp. 609-616 ◽  
Author(s):  
Leonardo Maciel da Fonseca ◽  
Magda Maria Profeta da Luz ◽  
Antônio Lacerda-Filho ◽  
Maria Isabel Toulson Davisson Correia ◽  
Rodrigo Gomes da Silva
Keyword(s):  
Clinical Trial ◽  
Rehabilitation Program ◽  
Controlled Clinical Trial ◽  
Colonic Surgery ◽  
Randomized Controlled Clinical Trial ◽  
Randomized Controlled

scholarly journals Effect of N-acetylcysteine on remission maintenance in patients with ulcerative colitis: A Randomized controlled clinical trial

2020 ◽  
Author(s):  
Kourosh Masnadi Shirazi ◽  
Simin Sotoudeh ◽  
Arman Masnadi Shirazi ◽  
Seyyed-Yaghoub Moaddab ◽  
Zahra Nourpanah ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Clinical Trial ◽  
Placebo Group ◽  
Fecal Calprotectin ◽  
Controlled Clinical Trial ◽  
Randomized Controlled Clinical Trial ◽  
Post Intervention ◽  
Randomized Controlled ◽  
Remission Maintenance ◽  
Hs Crp

Abstract Background: The use of antioxidant agents is suggested as a complementary therapy in UC patients for prevention of flares. Considering the potent antioxidant activity of N-acetylcysteine (NAC), in the present study we aimed to assess the effect of this supplement on remission maintenance in patients with ulcerative colitis (UC). Methods: In the present double-blind randomized controlled clinical trial, 168 volunteer UC patients who were on high dose corticosteroid for flare-up management, were recruited. The patients received 400 mg NAC or placebo twice daily for 16 weeks. Simultaneously, the prednisolone dose was tapered. The patients were followed up six more weeks post-intervention. The primary efficacy of the treatment was remaining in remission. The secondary outcomes were the endoscopic relapse, serum level of hs-CRP, hemoglobin, and fecal calprotectin level. Results: During 22 weeks follow up, 25 patients experienced relapses, six of them were in the NAC group and 19 of them were in the placebo group. There was a significant difference between the NAC and placebo groups regarding the relapse-free period (P=0.007). Compared with the NAC group, significantly more patients in the placebo group had an endoscopic relapse (p <0.001). At the end of the intervention period (16 weeks) and 6 weeks post-intervention, the mean fecal calprotectin, serum erythrocyte sedimentation rate, and hs-CRP levels were significantly lower in the NAC group compared with the placebo group (p<0.05). Conclusion: The findings indicated that NAC had a significantly more positive effect on the maintenance of remission compared with placebo in UC patients that were in the steroid-tapering phase of therapy.

scholarly journals Voices 2: Improving Prosodic Recognition in Schizophrenia With an Online Rehabilitation Program

2021 ◽  
Vol 12 ◽  
Author(s):  
María Lado-Codesido ◽  
Rosa María Rey Varela ◽  
Marina Larios Quiñones ◽  
Luis Martínez Agulleiro ◽  
Julieta Ossa Basanes ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Emotion Recognition ◽  
Intervention Group ◽  
Rehabilitation Program ◽  
Clinical State ◽  
Control Group ◽  
Post Intervention ◽  
Clinical Trial Registration ◽  
Training Tool ◽  
On Line

Introduction: Emotion recognition of voices may play an important role in interpersonal communication and patients with schizophrenia present alterations in this regard. Several on-line rehabilitation tools have been developed for treatment in this area. Voices is an on-line prosodic recognition program consisting of identifying different emotional tones in neutral phrases, in different sessions of gradually increasing difficulty. This training tool has previously reported benefits, and a new version has been created called Voices 2. The main aim of this study is to test the capacity of the Voices 2 program to improve emotion recognition through prosody for adults with schizophrenia. Secondly, it seeks to observe durability effects 1 month after intervention.Method: A randomized, single-blind, multicenter clinical trial was conducted with 44 outpatients diagnosed with schizophrenia or schizoaffective disorder. The intervention group (also called Voices) was treated with Voices 2, whereas the control group was treated with auditory training that was not related to emotions. Sociodemographic and clinical data, clinical state (PANSS), Intelligence Quotient and prosodic recognition (RMV-SV) were measured at baseline. After intervention, RMV-SV and PANSS were assessed. One month later, the RMV-SV measure was repeated.Results: The control group (n = 19) and the Voices group (n = 22) did not differ on χ2, t or U tests in sociodemographic, clinical and psychometric variables at baseline or post-intervention (all p-values &gt; 0.05). In the Voices group, statistically significant differences were observed in the RMV-SV scale applied post-intervention vs. that applied pre-intervention (Z = 2.47, p = 0.013). Similar results were observed in the 1-month follow-up RMV-SV vs. the pre-intervention RMV-SV (Z = 1.97, p = 0.049). PANSS scale was also assessed with no significant differences between pre vs. post measures in both groups. Lastly, Voices 2 was rated relatively higher, based on its ease of understanding, entertainment value, usefulness and the appropriateness of use of its emotional glossary.Discussion: Improvements were observed in prosodic recognition following intervention with Voices 2 in the Voices group. Although these results are similar to other clinical trial rehabilitation programs, specific research on the matter remains scarce. Certain aspects, such as the durability of effects or adherence should be thoroughly studied and clarified.Clinical Trial Registration: [https://doi.org/10.17605/OSF.IO/G95C4].

scholarly journals Diode Laser as an Adjunctive to Nonsurgical Periodontal Therapy during Maintenance Phase: A Randomized Controlled Clinical Trial

2016 ◽  
Vol 6 (1) ◽  
pp. 12-17
Author(s):  
SS Suprith ◽  
Swati Setty ◽  
Srinath Thakur
Keyword(s):  
Clinical Trial ◽  
Diode Laser ◽  
Maintenance Phase ◽  
Periodontal Therapy ◽  
Controlled Clinical Trial ◽  
Randomized Controlled Clinical Trial ◽  
Attachment Loss ◽  
Randomized Controlled ◽  
Group I ◽  
Nonsurgical Periodontal Therapy

ABSTRACT Aim The aim of the study was to determine and compare the pocket depths (PD), relative attachment levels (RAL), bleeding on probing (BOP) and plaque indices (PI) in patients treated with scaling and root planning (SRP) alone and along with diode laser. Materials and methods The study was carried out on 30 subjects who fulfill the inclusion and exclusion criteria. Group I: 15 patients treated with SRP along with diode laser irradiation. Group II: 15 patients treated only with SRP. The clinical parameters were probing PD, RAL, BOP and PI which were recorded at base line, 7 days and after 1 month. Statistical analysis was done using Kolmogorov-Smirnov, Shapiro-Wilk, t-test, chi-square test. Results The use of diode lasers as an adjunct to SRP during maintenance phase showed better results when compared to SRP alone. Moderate periodontal pockets with moderate attachment loss showed significant improvement in group I than in group II. There was no change in deep pockets with severe attachment loss in both groups. Clinical significance The study shows that the specified laser parameter and the modality of application of the same results in faster healing. This can be recommended as an appropriate treatment for moderate pockets. How to cite this article Suprit SS, Setty S, Thakur S. Diode Laser as an Adjunctive to Nonsurgical Periodontal Therapy during Maintenance Phase: A Randomized Controlled Clinical Trial. Int J Laser Dent 2016;6(1):12-17.

Sign in / Sign up

Export Citation Format

Share Document