scholarly journals An outbreak of acute jaundice syndrome (AJS) among the Rohingya refugees in Cox’s Bazar, Bangladesh: Findings from enhanced epidemiological surveillance

PLoS ONE ◽  
2021 ◽  
Vol 16 (4) ◽  
pp. e0250505
Author(s):  
Md Khadimul Anam Mazhar ◽  
Flavio Finger ◽  
Egmond Samir Evers ◽  
Anna Kuehne ◽  
Melissa Ivey ◽  
...  
Keyword(s):  
Hepatitis C ◽  
Hepatitis B ◽  
Disease Surveillance ◽  
Large Scale ◽  
Hepatitis A ◽  
Hepatitis A Virus ◽  
Hepatitis E ◽  
Case Definition ◽  
Epidemiological Surveillance ◽  
Enzyme Linked Immunosorbent Assay

In the summer of 2017, an estimated 745,000 Rohingya fled to Bangladesh in what has been described as one of the largest and fastest growing refugee crises in the world. Among numerous health concerns, an outbreak of acute jaundice syndrome (AJS) was detected by the disease surveillance system in early 2018 among the refugee population. This paper describes the investigation into the increase in AJS cases, the process and results of the investigation, which were strongly suggestive of a large outbreak due to hepatitis A virus (HAV). An enhanced serological investigation was conducted between 28 February to 26 March 2018 to determine the etiologies and risk factors associated with the outbreak. A total of 275 samples were collected from 18 health facilities reporting AJS cases. Blood samples were collected from all patients fulfilling the study specific case definition and inclusion criteria, and tested for antibody responses using enzyme-linked immunosorbent assay (ELISA). Out of the 275 samples, 206 were positive for one of the agents tested. The laboratory results confirmed multiple etiologies including 154 (56%) samples tested positive for hepatitis A, 1 (0.4%) positive for hepatitis E, 36 (13%) positive for hepatitis B, 25 (9%) positive for hepatitis C, and 14 (5%) positive for leptospirosis. Among all specimens tested 24 (9%) showed evidence of co-infections with multiple etiologies. Hepatitis A and E are commonly found in refugee camps and have similar clinical presentations. In the absence of robust testing capacity when the epidemic was identified through syndromic reporting, a particular concern was that of a hepatitis E outbreak, for which immunity tends to be limited, and which may be particularly severe among pregnant women. This report highlights the challenges of identifying causative agents in such settings and the resources required to do so. Results from the month-long enhanced investigation did not point out widespread hepatitis E virus (HEV) transmission, but instead strongly suggested a large-scale hepatitis A outbreak of milder consequences, and highlighted a number of other concomitant causes of AJS (acute hepatitis B, hepatitis C, Leptospirosis), albeit most likely at sporadic level. Results strengthen the need for further water and sanitation interventions and are a stark reminder of the risk of other epidemics transmitted through similar routes in such settings, particularly dysentery and cholera. It also highlights the need to ensure clinical management capacity for potentially chronic conditions in this vulnerable population.

scholarly journals PREVALENCE OF HEPATITIS A VIRUS, HEPATITIS B VIRUS, AND HEPATITIS C VIRUS, AMONG PATIENTS WITH HEPATIC JAUNDICE IN SANA’A CITY, YEMEN: A HOSPITAL BASED STUDY

2022 ◽  
Author(s):  
Huda Zaid Al-Shami ◽  
Zaid Ali Mohammed Al-Mutawakal ◽  
Abdulwahab Ismail Mohamed Al-Kholani ◽  
Muhamed Ahmed Al-Haimi ◽  
Ahmed Mohammed Al-Haddad ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Peer Review ◽  
Hepatitis A ◽  
Hepatitis A Virus ◽  
Pharmaceutical Chemistry ◽  
Enzyme Linked Immunosorbent Assay ◽  
B Virus

Background: Hepatic jaundice results from abnormal metabolism of bilirubin in the liver. The main hepatic jaundice causes are severe damage to hepatocytes due to autoimmune diseases, infectious diseases, drugs/ medication induced, or, less commonly, hereditary genetic diseases. Aim: The aim of this study is to determine the prevalence of hepatitis B Virus (HBV), hepatitis A virus (HAV), and hepatitis C virus (HCV), in patients with hepatic jaundice as causes of acute viral hepatitis (AVH) in Sana'a city, Yemen. Subjects and Methods: Data of patients with hepatic jaundice tested for hepatitis B surface antigen, total anti-HCV antibody, and anti-HAV immunoglobulin M (IgM) by enzyme-linked immunosorbent assay were collected from Class I Viral Diagnostic Laboratories in Sana'a for 3 years. Then the statistical analysis of the data was used where the descriptive analysis was calculated: frequency and percentage, as well as the association of infection with sex and age group by means of detection odds ratio, 95% CI and X2 more than 3.9 and P<0.05 were considered statistically significant. Results: The study included 644 males (43.8%) and 826 females (56.2%), while most patients were less than 21 years old. The rate of Hepatitis viruses positive was 27.6% positive. Hepatitis A virus infection was the most common virus diagnosed accounting for 259 cases (17.6% of the total), while HBV was less common with 104 (7.1%) and HCV only 42 cases (2.9%). The highest incidence of hepatitis B was in 11-20 years patients (18.2%), with an associated OR 9.3 (p < 0.0001). The highest incidence of hepatitis C was in 31-40 years patients (7.3%), with an associated OR 3.3 (p<0.0001). Conclusion:  Alarmingly changing the epidemiology and dynamics of hepatitis A-C viruses in Yemen, a detailed study is required to understand the definite disease problem caused by these viruses. It is noticeable in this study the high prevalence of hepatitis A virus and hepatitis B virus in the Yemeni population with hepatic jaundice. Also, to our knowledge, this study is the first to report epidemiological transformation of hepatitis A virus in Sana'a, Yemen.                     Peer Review History: Received: 13 November 2021; Revised: 11 December; Accepted: 30 December, Available online: 15 January 2022 Academic Editor: Dr. Nuray Arı, Ankara University, Turkiye, [email protected] UJPR follows the most transparent and toughest ‘Advanced OPEN peer review’ system. The identity of the authors and, reviewers will be known to each other. This transparent process will help to eradicate any possible malicious/purposeful interference by any person (publishing staff, reviewer, editor, author, etc) during peer review. As a result of this unique system, all reviewers will get their due recognition and respect, once their names are published in the papers. We expect that, by publishing peer review reports with published papers, will be helpful to many authors for drafting their article according to the specifications. Auhors will remove any error of their article and they will improve their article(s) according to the previous reports displayed with published article(s). The main purpose of it is ‘to improve the quality of a candidate manuscript’. Our reviewers check the ‘strength and weakness of a manuscript honestly’. There will increase in the perfection, and transparency.  Received file:                Reviewer's Comments: Average Peer review marks at initial stage: 5.5/10 Average Peer review marks at publication stage: 7.0/10 Reviewers: Dr. Gulam Mohammed Husain,, National Research Institute of Unani Medicine for Skin Disorders, Hyderabad, India, [email protected] Dr. Salfarina Ramli, Department of Pharmacology and Pharmaceutical Chemistry, Faculty of Pharmacy, Universiti Teknologi MARA, 42300 Puncak Alam, Selangor, Malaysia. [email protected]   Similar Articles: PREVALENCE OF DIFFERENT HEPATITIS B VIRUS GENOTYPES AND RISK FACTORS ASSOCIATED AMONG SELECTED YEMENI PATIENTS WITH CHRONIC HEPATITIS B INFECTION SERO-EPIDEMIOLOGICAL STUDY OF HEPATITIS B, C, HIV AND TREPONEMA PALLIDUM AMONG BLOOD DONORS IN HODEIDA CITY- YEMEN EXPLOSION OF HEPATITIS B AND C VIRUSES AMONG HEMODIALYSIS PATIENTS AS A RESULT OF HEMODIALYSIS CRISIS IN YEMEN

scholarly journals Hepatitis viral en la gestación

1996 ◽  
Vol 47 (1) ◽  
pp. 47-50
Author(s):  
Pío Iván Gómez Sánchez
Keyword(s):  
Hepatitis C ◽  
Hepatitis B ◽  
Hepatitis A ◽  
Hepatitis E ◽  
Hepatitis Delta

La primera causa de ictericia en el embarazo es la hepatitis viral que puede ser causada por lo menos por cinco virus (A, B, C, D y E). El descubrimiento del virus de la hepatitis C y Delta prácticamente eliminó las antes denominadas Hepatitis No A No B y aún existe la posibilidad de descubrir nuevos virus.En este artículo se presenta un caso clínico de hepatitis B y se revisa etiología, diagnóstico, profilaxis y tratamiento de las diferentes hepatitis virales, haciendo énfasis en el diagnóstico, tratamiento y profilaxis del hijo de madre con hepatitis B, por la morbimortalidad que representa. Se revisa la hepatitis Delta, importante en Colombia, por tener zonas endémicas de este virus que requiere la infección previa o simultánea de hepatitis B. Por último se revisa la hepatitis E, de características similares a la hepatitis A, pero que afecta preferencialmente a la mujer gestante y en ella tiene mayor índice de morbimortalidad.

PERANCANGAN SISTEM PENDIAGNOSA PENYAKIT HEPATITIS DENGAN METODE CASE BASED REASONING (CBR)

2019 ◽  
Vol 1 (2) ◽  
Author(s):  
Darsin Darsin ◽  
Mira Febriana Sesunan
Keyword(s):  
Hepatitis C ◽  
Hepatitis B ◽  
Hepatitis A ◽  
Hepatitis E ◽  
Case Based Reasoning ◽  
Virus Hepatitis ◽  
Case Based

Penyakit Hepatitis adalah penyakit yang disebabkan oleh beberapa jenis virus yang menyerang dan menyebabkan peradangan serta merusak sel-sel organ hati manusia. Hepatitis dikategorikan dalam beberapa golongan, diantaranya hepatitis A, B, C, D dan E. Hepatitis dibagi menjadi 2 yaitu hepatitis akut yang  berlangsung kurang dari 6 bulan ditularkan melalui fecal oral lewat makanan dan hepatitis kronis yang berlangsung lebih dari 6 bulan ditularkan lewat cairan parenrral, seksual, plasenta. Hepatitis akut terdiri dari virus hepatitis A dan virus hepatitis E, sedangkan hepatitis kronis terdiri dari virus hepatitis B dan virus hepatitis C. Di Indonesia penyakit Hepatitis yang paling banyak di derita adalah hepatitis A, B dan hepatitis C. Sedangkan mengidentifikasi serangan penyakit pemyakit hepatitis, dapat dilakukan dengan cara melihat fisik secara langsung pada setiap bagian tubuh, baik kulit, mata, air seni. Dalam penelitian ini, dilakukan identifikasi penyakit hepatitis A, B, C, D, E. Sistem penalaran komputer berbasis kasus case based reasoning (CBR) merupakan sistem yang bertujuan untuk menyelesaikan suatu kasus baru dengan cara mengadaptasi solusi-solusi yang terdapat kasus-kasus sebelumnya yang mirip dengan kasus baru tersebut.

scholarly journals Biochemical Parameters in Common Viral Hepatitis

1970 ◽  
Vol 11 (1) ◽  
pp. 42-45 ◽  
Author(s):  
Md Ashraf-Uz-Zaman ◽  
Bilquis Ara Begum ◽  
Humaira Binte Asad ◽  
Shafia Sharmin Moutoshi ◽  
Md Nasiruddin
Keyword(s):  
Hepatitis C ◽  
Hepatitis B ◽  
Viral Hepatitis ◽  
Biochemical Parameters ◽  
Hepatitis A ◽  
Serum Alkaline Phosphatase ◽  
Hepatitis E ◽  
Mean Value ◽  
Serum Bilirubin Level ◽  
Hepatitis D

Viral hepatitis is the inflammation of the liver caused by hepatitis viruses. The most common causes of viral hepatitis are the five unrelated hepatotropic viruses Hepatitis A, Hepatitis B, Hepatitis C, Hepatitis D, and Hepatitis E. The aim of this study is to assess the biochemical parameters in viral hepatitis which varies with respect to the different types of viral hepatitis. Sex of the patient affected by Hepatitis A was almost similar in male and female, being 9 (45%) and 11 (55%) in respectively. But in contrast, more than eighty per cent (85%) Hepatitis-E affected population was male. Similar scenario was found in Hepatitis B And C infection (Male- 75%,67%, Female 25,35%). Mean value with standard deviation (±SD) of serum bilirubin level was highest in Hepatitis E (251 ± 125.19 ìmol/l). Value of serum ALT in hepatitis E was found to be 1794 U/l (highest), hepatitis B 1362 U/l hepatitis C are 135.45 U/L,. Serum aspartate aminotransferase (S.AST) is also raised in all types of vira hepatitis but more in Hepatitis E (765 U/l) and Hepatitis B (430 U/l). Serum Alkaline Phosphatase (ALP) was raised significantly in Hepatitis B (240 U/l). The prothombin time was more altered in Hepatitis-E (22.7seconds) and Hepatitis-B (18.5 seconds). There was no significant alteration in serum protein level. So, it can be concluded that derangement of biochemical parameters in patients suffering from common types of viral hepatitis is more in HEV and HBV and comparatively less in HAV and HCV. Keywords: Viral hepatitis, hepatitis A, hepatitis B, hepatitis C, hepatitis D, hepatitis E DOI:10.3329/jom.v11i1.4268 J Medicine 2010: 11: 42-45

scholarly journals Seroprevalence of Hepatitis Virus Antibodies in Newly Admitted Students of Sylhet MAG Osmani Medical College

2009 ◽  
Vol 3 (1) ◽  
pp. 20-26
Author(s):  
Muhammad Shamsher Ahmed ◽  
Osul Ahmed Chowdhury ◽  
Mohsina Khatoon ◽  
Fahmin Kabir ◽  
Ahmed Riad Chowdhury ◽  
...  
Keyword(s):  
Hepatitis C ◽  
Hepatitis B ◽  
Hepatitis A ◽  
Hepatitis Virus ◽  
Intervention Strategy ◽  
Hepatitis E ◽  
First Year ◽  
Hepatitis Viruses ◽  
Medical College ◽  
B Virus

Blood samples from randomly selected 100 newly admitted first year MBBS students of Sylhet MAG Osmani Medical College were tested to find the seroprevalence of antibodies against Hepatitis A, Hepatitis B, Hepatitis C and Hepatitis E viruses. The study revealed a lower seroprevalence of HAV antibodies than the common perception of their age group. The rate of vaccination against hepatitis B virus was found not very high, considering the affluence of their parents. Also there were lack of awareness about risk factors of viral hepatitis and many of the students were in habit of taking food outside. Institutionalized vaccination policy for 1st year medical students against Hepatitis A and Hepatitis B along with awareness building measures regarding the professional risk among the new entrants are suggested. Policy planners and other stakeholders in the field should come up with a comprehensive intervention strategy to protect the future caregivers from the scourge of hepatitis viruses. Keywords: Hepatitis A, Hepatitis B, Hepatitis C, Hepatitis E, Seroprevalence   doi: 10.3329/bjmm.v3i1.2967 Bangladesh J Med Microbiol 2009; 03 (01): 20-26

scholarly journals Seroprevalence of anti-HEV and HEV RNA among volunteer blood donors and patients with Hepatitis B and C in Iran

1970 ◽  
Vol 1 (1) ◽  
pp. 34-37 ◽  
Author(s):  
Hossein Keyvani ◽  
Mahmood Shamsi Shamabadi ◽  
Saeed Najafifard ◽  
Bashir Hajibeigi ◽  
Farahnaz Fallahian ◽  
...  
Keyword(s):  
Hepatitis C ◽  
Hepatitis B ◽  
Hepatitis E Virus ◽  
Blood Donors ◽  
Hepatitis E ◽  
Positive Control ◽  
Enzyme Linked Immunosorbent Assay ◽  
Rt Pcr ◽  
Blood Transfusion Center ◽  
Infected Cells

Aim: To assess seroprevalence of antibodies to hepatitis E virus (HEV) in healthy blood donors and hepatitis B, C patients. Methods: 450 subjects consisted of 200 blood donors in Tehran blood transfusion center, 100 subjects with hepatitis C and 150 subjects with hepatitis B infection enrolled in this study. The A549 cell line was grown in mixed medium. Cells were infected with hepatitis E virus that was purified from stool sample of a patient confirmed for hepatitis E infection by reverse transcription-polymerase chain reaction (RT-PCR) method. Supernatant of infected cells was used as positive control in our RT- PCR assay. Results: In a total of 450 subjects, 33 (7.3%) had positive anti-HEV by enzyme-linked immunosorbent assay (ELISA). Anti-HEV was seen in (9/200) 4.5%, (7/100) 7%, and (17/150) 11.3% of healthy blood donors, hepatitis C, and hepatitis B subjects, respectively. Difference between two groups was statistically significance (P = 0.028). Difference between frequency of anti-HEV in hepatitis B in relation to healthy blood donors was significant (P = 0.014). Conclusions: HEV infection is more common in subjects with hepatitis B. Keywords: Hepatitis E virus, Seroprevalence, Transmission, Iran   doi: 10.3329/blj.v1i1.2623 Bangladesh Liver Journal Vol.1(1) 2009 p.34-37 

scholarly journals Need for Increasing Hepatitis A Virus Vaccination Among Patients Infected With Hepatitis B Virus and Hepatitis C Virus

2018 ◽  
Vol 154 (8) ◽  
pp. 2015-2017 ◽  
Author(s):  
Anne C. Moorman ◽  
Jian Xing ◽  
Noele P. Nelson ◽  
Scott D. Holmberg ◽  
Eyasu H. Teshale ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Hepatitis A ◽  
Hepatitis A Virus ◽  
Virus Vaccination ◽  
B Virus

scholarly journals Prevalence of hepatitis E virus infection in West Bengal, India: a hospital-based study

2014 ◽  
Vol 63 (7) ◽  
pp. 975-980 ◽  
Author(s):  
Nidhi S. Chandra ◽  
Durbadal Ojha ◽  
Sanjoy Chatterjee ◽  
Debprasad Chattopadhyay
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Hepatitis E Virus ◽  
Hepatitis A ◽  
West Bengal ◽  
Hepatitis A Virus ◽  
Hepatitis E ◽  
Viral Marker ◽  
Sporadic Hepatitis ◽  
Acute Sporadic Hepatitis

India is an endemic zone for hepatitis E virus (HEV), which is associated with both epidemic and sporadic infections. In West Bengal, only two hepatitis E outbreaks have been studied to date. However, sporadic cases of HEV infection also occur during inter-epidemic periods. The aim of this hospital-based study was to detect the prevalence of HEV infection in patients with acute sporadic hepatitis in West Bengal, India. Blood samples and clinical information were collected from 285 patients of both sexes and different ages with acute viral hepatitis (AVH) at Calcutta Medical College, Kolkata, a tertiary-care centre. Samples were tested for hepatitis B virus (HBV) surface antigen, anti-hepatitis C virus antibodies, anti-hepatitis A virus IgM and anti-HEV antibodies (IgM and IgG) by ELISA. Only those patients with AVH who were in their first week of illness and negative for all hepatotropic viral antibodies were tested for HEV RNA by reverse transcriptase nested PCR. HEV was identified as the most common cause of AVH (41.8 % of patients), followed by HBV (21.4 %), hepatitis A virus (17.2 %) and hepatitis C virus (4.6 %). Co-infections with more than one virus were found in 22 patients, with HBV–HEV the most common co-infection (3.8 %). Only 14.7 % of patients had no viral marker. To the best of our knowledge, this is the first documented epidemiological study of acute sporadic hepatitis with HEV in the state of West Bengal, India, indicating that this state is an endemic zone for HEV infection.

scholarly journals Seroprevalência do Anticorpo do Vírus na Hepatite A em Viajantes Portugueses: Um Novo Paradigma

2017 ◽  
Vol 30 (7-8) ◽  
pp. 534
Author(s):  
Sónia Rocha ◽  
Sandra Tejo ◽  
Eugénia Ferreira ◽  
Luís Trindade ◽  
Eduardo Rabadão ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Virus Infection ◽  
Hepatitis B ◽  
Hepatitis A ◽  
Hepatitis A Virus ◽  
Age Groups ◽  
Sub Saharan Africa ◽  
Immunodeficiency Virus

Introduction: In Portugal, the prevalence of hepatitis A virus infection has decreased in the past decades, especially in young adults. The aim of this study was to detect the prevalence of antibody to hepatitis A virus in a population observed in our Travel Clinic.Material and Methods: Antibodies against hepatitis A, hepatitis B, hepatitis C and human immunodeficiency virus were tested using standard enzyme immunoassay in patients older than 18. The exclusion criteria were: prior vaccination for hepatitis A virus, previous diagnosis of infection with hepatitis B virus, hepatitis C virus and/or human immunodeficiency virus, foreign travelers and long-term expatriates. We applied an epidemiological survey and data was statistically analyzed with SPSS® 18.0.Results: In the 665 travelers studied, natural immunity to hepatitis A virus was present in 57.6% (n = 383). They were stratified into 8 age groups and for each one hepatitis A immunity was clarified: 5.0% (n = 1) in 18 - 25 years, 32.3% (n = 21) in 26 - 30 years, 40.9% (n = 47) in 31 - 35 years, 45.8% (n = 54) in 36 - 40 years, 68.7% (n = 79) in 41 - 45 years, 70.1% (n = 68) in 46 - 50 years, 80.8% (n = 63) in 51 - 55 years and 87.7% (n = 50) over 56 years old. In those who accepted further screening, positivity for hepatitis B core antibody was found in 0.6% (n = 3) travelers, hepatitis C virus infection in 1.1% (n = 6) and human immunodeficiency virus infection in 0.5% (n = 3) whose previous status was unknown. The most frequent travel destination was sub-Saharan Africa (72.6%; n = 483).Discussion: We found 49.1% (n = 260) travelers under 50 years old susceptible to hepatitis A virus infection and for those between 40 and 50 years, 30.7% (n = 65) still need vaccine protection.Conclusion: Across age groups there is a trend towards lower prevalence of hepatitis A virus antibody, in particular among youngsters, when compared with older Portuguese studies.

Sign in / Sign up

Export Citation Format

Share Document