scholarly journals Control strategies against COVID-19 in China: Significance of effective testing in the long run

PLoS ONE ◽  
2021 ◽  
Vol 16 (7) ◽  
pp. e0253901
Author(s):  
Yatang Lin ◽  
Fangyuan Peng

The COVID-19 pandemic has become a long-term crisis that calls for long-term solutions. We combined an augmented SEIR simulation model with real-time human mobility data to decompose the effects of lockdown, travel bans and effective testing measures in the curtailment of COVID-19 spread in China over different time horizons. Our analysis reveals that the significant growth in the detection rate of infectious cases, thanks to the expansion in testing efficiency, were as effective as city lockdowns in explaining the reduction in new infections up to mid-March. However, as we extended the analysis to July, increasing the detection rate to at least 50% is the only reliable way to bring the spread under control.

2020 ◽  
Author(s):  
Yatang Lin ◽  
Fangyuan Peng

The coronavirus disease 2019 (COVID-19) outbreak is reasonably contained in China. In this paper, we evaluated the effectiveness of different containment strategies in halting the pandemic spread in both short- and long-term. We combined a networked metapopulation SEIR model featuring undocumented infections, actual mobility data and Bayesian inference to simulate the counterfactual outbreak scenarios removing each one or a combination of the following three policies in place: i) city lockdowns, ii) intercity travel bans, and iii) testing, detection, and quarantine. Our estimates revealed that 11.4% [95% credible interval (CI): 9.7-13.0%] of the infected cases were unidentified before January 23, 2020. The rate grew to 92.5% [95% credible interval (CI): 85.9-94.5%] in early March, thanks to the boost in coronavirus testing capacity. We show that increasing the detection rate of infections from 11.4% to 92.5% alone would explain 75% of the reduction in infections from a no-policy baseline by March 15, 2020. The most pronounced policy implication is that city lockdowns appeared to be the more effective intervention in the short-run but effective testing is essential in containing the COVID-19 spread in the long run. By March 15, restoring within-city personal contact to its 2019 level would lead to a 678% growth in infections with all the other interventions remaining unaffected. Removing intercity travel restrictions and effective detection measures would lead to 3% and 477% growth, respectively. Extending the time horizon to July 15, the counterfactual increase in infections would become 581%, 3% and 30000% had the three classes of interventions been lifted individually.


2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Shaobin Wang ◽  
Yun Tong ◽  
Yupeng Fan ◽  
Haimeng Liu ◽  
Jun Wu ◽  
...  

AbstractSince spring 2020, the human world seems to be exceptionally silent due to mobility reduction caused by the COVID-19 pandemic. To better measure the real-time decline of human mobility and changes in socio-economic activities in a timely manner, we constructed a silent index (SI) based on Google’s mobility data. We systematically investigated the relations between SI, new COVID-19 cases, government policy, and the level of economic development. Results showed a drastic impact of the COVID-19 pandemic on increasing SI. The impact of COVID-19 on human mobility varied significantly by country and place. Bi-directional dynamic relationships between SI and the new COVID-19 cases were detected, with a lagging period of one to two weeks. The travel restriction and social policies could immediately affect SI in one week; however, could not effectively sustain in the long run. SI may reflect the disturbing impact of disasters or catastrophic events on the activities related to the global or national economy. Underdeveloped countries are more affected by the COVID-19 pandemic.


2020 ◽  
Author(s):  
Kathy Leung ◽  
Joseph T Wu ◽  
Gabriel M Leung

AbstractDigital proxies of human mobility and physical mixing have been used to monitor viral transmissibility and effectiveness of social distancing interventions in the ongoing COVID-19 pandemic. We developed a new framework that parameterizes disease transmission models with age-specific digital mobility data. By fitting the model to case data in Hong Kong, we were able to accurately track the local effective reproduction number of COVID-19 in near real time (i.e. no longer constrained by the delay of around 9 days between infection and reporting of cases) which is essential for quick assessment of the effectiveness of interventions on reducing transmissibility. Our findings showed that accurate nowcast and forecast of COVID-19 epidemics can be obtained by integrating valid digital proxies of physical mixing into conventional epidemic models.


2006 ◽  
Vol 53 (4-5) ◽  
pp. 225-234 ◽  
Author(s):  
K.V. Gernaey ◽  
C. Rosen ◽  
U. Jeppsson

Intensive use of the benchmark simulation model No. 1 (BSM1), a protocol for objective comparison of the effectiveness of control strategies in biological nitrogen removal activated sludge plants, has also revealed a number of limitations. Preliminary definitions of the long-term benchmark simulation model No. 1 (BSM1_LT) and the benchmark simulation model No. 2 (BSM2) have been made to extend BSM1 for evaluation of process monitoring methods and plant-wide control strategies, respectively. Influent-related disturbances for BSM1_LT/BSM2 are to be generated with a model, and this paper provides a general overview of the modelling methods used. Typical influent dynamic phenomena generated with the BSM1_LT/BSM2 influent disturbance model, including diurnal, weekend, seasonal and holiday effects, as well as rainfall, are illustrated with simulation results. As a result of the work described in this paper, a proposed influent model/file has been released to the benchmark developers for evaluation purposes. Pending this evaluation, a final BSM1_LT/BSM2 influent disturbance model definition is foreseen. Preliminary simulations with dynamic influent data generated by the influent disturbance model indicate that default BSM1 activated sludge plant control strategies will need extensions for BSM1_LT/BSM2 to efficiently handle 1 year of influent dynamics.


2017 ◽  
Vol 22 (02) ◽  
pp. 1750013 ◽  
Author(s):  
LORENA CADAVID ◽  
LUISA DÍEZ-ECHAVARRÍA ◽  
ALEJANDRO VALENCIA

One of the main thoughts about the development of spin-off activities at higher educational institutions is the need for money and time resources, at the expense of some resources invested for educational purposes. We analyzed the short- and long-run implications for higher educational institutions of investing time and money in spin-off activities from several perspectives: income, number of students and number of professors. To do that, we developed a simulation model at the aggregated level, which represents the phenomenon like a flow of two resources between two competing purposes: spin-off and educational activities. We also designed four scenarios according to different strategies to be implemented: high investment of time and money, low investment of time and money, high investment of time but low investment of money and low investment of time but high investment of money. The model was calibrated for the Colombian case. We concluded that proportional investment of time and money increases the performance in the long term, but decreases it on the short term. In addition, money investment without a proportional investment in time means a waste of resources, while time investment without a proportional investment of money could be a more effective strategy.


Sensors ◽  
2021 ◽  
Vol 21 (24) ◽  
pp. 8282
Author(s):  
Yinghao Liu ◽  
Zipei Fan ◽  
Xuan Song ◽  
Ryosuke Shibasaki

The prediction of human mobility can facilitate resolving many kinds of urban problems, such as reducing traffic congestion, and promote commercial activities, such as targeted advertising. However, the requisite personal GPS data face privacy issues. Related organizations can only collect limited data and they experience difficulties in sharing them. These data are in “isolated islands” and cannot collectively contribute to improving the performance of applications. Thus, the method of federated learning (FL) can be adopted, in which multiple entities collaborate to train a collective model with their raw data stored locally and, therefore, not exchanged or transferred. However, to predict long-term human mobility, the performance and practicality would be impaired if only some models were simply combined with FL, due to the irregularity and complexity of long-term mobility data. Therefore, we explored the optimized construction method based on the high-efficient gradient-boosting decision tree (GBDT) model with FL and propose the novel federated voting (FedVoting) mechanism, which aggregates the ensemble of differential privacy (DP)-protected GBDTs by the multiple training, cross-validation and voting processes to generate the optimal model and can achieve both good performance and privacy protection. The experiments show the great accuracy in long-term predictions of special event attendance and point-of-interest visits. Compared with training the model independently for each silo (organization) and state-of-art baselines, the FedVoting method achieves a significant accuracy improvement, almost comparable to the centralized training, at a negligible expense of privacy exposure.


2020 ◽  
Vol 34 (01) ◽  
pp. 394-402
Author(s):  
Brian Dickinson ◽  
Gourab Ghoshal ◽  
Xerxes Dotiwalla ◽  
Adam Sadilek ◽  
Henry Kautz

Nighttime lights satellite imagery has been used for decades as a uniform, global source of data for studying a wide range of socioeconomic factors. Recently, another more terrestrial source is producing data with similarly uniform global coverage: anonymous and aggregated smart phone location. This data, which measures the movement patterns of people and populations rather than the light they produce, could prove just as valuable in decades to come. In fact, since human mobility is far more directly related to the socioeconomic variables being predicted, it has an even greater potential. Additionally, since cell phone locations can be aggregated in real time while preserving individual user privacy, it will be possible to conduct studies that would previously have been impossible because they require data from the present. Of course, it will take quite some time to establish the new techniques necessary to apply human mobility data to problems traditionally studied with satellite imagery and to conceptualize and develop new real time applications. In this study we demonstrate that it is possible to accelerate this process by inferring artificial nighttime satellite imagery from human mobility data, while maintaining a strong differential privacy guarantee. We also show that these artificial maps can be used to infer socioeconomic variables, often with greater accuracy than using actual satellite imagery. Along the way, we find that the relationship between mobility and light emissions is both nonlinear and varies considerably around the globe. Finally, we show that models based on human mobility can significantly improve our understanding of society at a global scale.


2014 ◽  
Vol 2014 ◽  
pp. 1-12 ◽  
Author(s):  
Maria Kopsakangas-Savolainen ◽  
Rauli Svento

Production structure in markets with a significant role of hydropower is sensitive to the production profile of hydropower. In this paper we utilize a long-run oriented real-time price based simulation model to analyze through scenarios the impact of different hydropower production profiles on the total annual energy consumed, prices, and capacity structure. We also show the relation between different hydropower production profiles and emissions, costs, and windfall profits. There seems to be no superior scenario under which all socially desirable goals are achieved as there is a clear tradeoff between allowing high windfall profits with highest cost efficiency and achieving the target for lower emissions.


2021 ◽  
Author(s):  
Anne-Sophie Ruget ◽  
Christopher J. Banks ◽  
Jessica Enright ◽  
Rowland R. Kao

Abstract Background In the context of an outbreak the natural boundaries of islands can allow for control of movements between populations. We estimate the risk of introduction of COVID-19 to each of the Hebridean islands situated off the west coast of mainland Scotland due to individual movements, and explore control strategies to mitigate this risk.Methods We use a combination of real human mobility data and census data to generate seasonally varying patterns of human movements amongst the Hebrides and from elsewhere. We consider three distinct periods: each of summer and winter 2019, illustrating a year prior to the pandemic, and summer 2020 illustrating a "pandemic summer". Movements during these periods serve as input to simulate COVID-19 transmission from the mainland to the archipelago in a stochastic meta-population model allowing us to explore the impact of seasonal variations on the risk of introduction and the effectiveness of non-pharmaceutical interventions.Results Despite strong seasonality in movement patterns, partly driven by tourism, for islands closely connected to the mainland there is evidence of substantial risk of disease introduction even over winter. In summer, when the risk is the highest, some islands can delay the introduction of COVID-19 by over six weeks, i.e. beyond the summer holiday period, through a 70% reduction of movements. Conclusion A high introduction risk in winter will be of particular concern if COVID-19 becomes a seasonal respiratory infection affecting temperate areas in winter concomitantly with other seasonal infections such as flu.For some islands, control of movements in peak summer tourist season has the potential for delaying the introduction risk beyond the summer holiday period, i.e. beyond a period of high mobility of people, potentially inducing a risk for rapid spread. Such measures would be particularly relevant in the occurrence of a variant escaping the vaccine given the current progress of the vaccine roll-out. However, such restrictions must be balanced against indirect negative economic impacts that might result.


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