scholarly journals Different patterns of pneumothorax in patients with soft tissue tumors treated with pazopanib: A case series analysis

PLoS ONE ◽  
2021 ◽  
Vol 16 (7) ◽  
pp. e0254866
Author(s):  
Hisaki Aiba ◽  
Hiroaki Kimura ◽  
Satoshi Yamada ◽  
Hideki Okamoto ◽  
Katsuhiro Hayashi ◽  
...  
Keyword(s):  
Risk Factors ◽  
Soft Tissue ◽  
Time Course ◽  
Lung Tumor ◽  
Case Series ◽  
Metastatic Lesion ◽  
Soft Tissue Tumors ◽  
Visceral Pleura ◽  
Central Type ◽  
Metastatic Lesions

To investigate pneumothorax patterns in pazopanib treatment by focusing on the positional relationship between the visceral pleura and metastatic lung tumor, we examined 20 patients with advanced soft tissue tumors who developed lung metastases and underwent pazopanib treatment between 2012 and 2019. Pneumothorax was classified into two types based on the location of the metastatic lesion around the visceral pleural area before pazopanib treatment: subpleural type, within 5 mm from the pleura; and central type, >5 mm from the pleura. We investigated the rates of pneumothorax and the associated risk factors. Five patients experienced pneumothorax (three subpleural and two central types). Cavitation preceded pneumothorax in 83% of patients and led to connection of the cavitated cyst of the metastatic lesion to the chest cavity in the shorter term in patients with the subpleural type. Conversely, a more gradual increase in the cavity size and sudden cyst rupture were observed in the central type. The risk factors for pneumothorax were cavitation after initiating pazopanib and intervention before pazopanib, either ablation or surgery. The location of the metastatic lesions was not a risk factor for the occurrence of pneumothorax. In conclusion, pneumothorax is an adverse event associated with pazopanib treatment. Therefore, attention must be paid to predisposing factors such as the formation of cavitation after pazopanib initiation and previous interventions to the lungs. Moreover, because subpleural pneumothorax tends to occur earlier than the central type, a different time course can be anticipated based on the positional relationships of the metastatic lesions to the visceral pleura.

Different Patterns of Pneumothorax in Patients With Soft Tissue Tumors Treated With Pazopanib

2020 ◽  
Author(s):  
Hisaki Aiba ◽  
Hiroaki Kimura ◽  
Satoshi Yamada ◽  
Hideki Okamoto ◽  
Katsuhiro Hayashi ◽  
...  
Keyword(s):  
Risk Factors ◽  
Soft Tissue ◽  
Time Course ◽  
Lung Tumor ◽  
Lung Metastases ◽  
Metastatic Lesion ◽  
Soft Tissue Tumors ◽  
Visceral Pleura ◽  
Metastatic Lung Tumor ◽  
Central Type

Abstract Background: To investigate the patterns of pneumothorax in pazopanib treatment, focusing on the positional relationship between the visceral pleura and metastatic lung tumor. Methods: We examined 20 patients with advanced soft tissue tumor who developed lung metastases before pazopanib treatment during 2012–2019. Pneumothorax was classified into two types based on the location of the metastatic lesion around the visceral pleural area before pazopanib treatment: subpleural type, within 5 mm from the pleura; central type, > 5 mm from the pleura. We investigated the rates of pneumothorax and the risk factors. Results: Overall, 5 patients experienced pneumothorax (3 subpleural and 2 central type). Cavitation preceded pneumothorax in 80% of the patients and led to connection of the cavitated cyst of the metastatic lesion to the chest cavity in a shorter term in those with the subpleural type. Conversely, a more gradual increase in cavity and sudden cyst rupture were observed in the central type. The risk factors for pneumothorax were cavitation after the initiation of pazopanib and previous intervention before pazopanib including ablation or surgery. The locations of metastatic lesion were not risk factor for the occurrence of pneumothorax.Conclusion: Pneumothorax is an adverse event of pazopanib treatment. Therefore, attention must be paid to the predisposing factors such as the formation of cavitation after pazopanib initiation and previous interventions on the lungs. Moreover, as the subpleural pneumothorax tends to occur earlier than the central type, the different time course can be anticipated based on the positional relationships of the metastatic lesions to the visceral pleura.

scholarly journals Prevalence of Psychological Distress and Its Risk Factors in Patients with Primary Bone and Soft Tissue Tumors

Healthcare ◽  
2021 ◽  
Vol 9 (5) ◽  
pp. 566
Author(s):  
Masato Ise ◽  
Eiji Nakata ◽  
Yoshimi Katayama ◽  
Masanori Hamada ◽  
Toshiyuki Kunisada ◽  
...  
Keyword(s):  
Risk Factors ◽  
Psychological Distress ◽  
Soft Tissue ◽  
Rating Scale ◽  
Numeric Rating Scale ◽  
Soft Tissue Tumors ◽  
Number Of Patients ◽  
Primary Bone ◽  
Associated Risk Factors ◽  
Numeric Rating

Psychological distress is common in patients with soft tissue and bone tumors. We first investigated its frequency and the associated risk factors in patients with pre-operative bone and soft tissue tumors. Participants included 298 patients with bone and soft tissue tumors who underwent surgery in our institution between 2015 and 2020. Psychological distress was evaluated by the Distress and Impact Thermometer (DIT) that consists of two types of questions (questions about the severity of the patient’s distress (DIT-D) and its impact (DIT-I)). We used a cut-off point of 4 on the DIT-D and 3 on the DIT-I for screening patients with psychological distress. We therefore investigated: (1) the prevalence of psychological distress as assessed with DIT or distress thermometer (DT), which can be decided by DIT-D ≥ 4, (2) what are the risk factors for the prevalence of psychological distress, and (3) what is the number of patients who consulted a psychiatrist for psychological distress in patients with pre-operative bone and soft tissue tumors. With DIT and DT, we identified 64 patients (21%) and 95 patients (32%), respectively, with psychological distress. Multivariate logistic regression revealed that older age, sex (female), malignancy (malignant or intermediate tumor), a lower Barthel Index, and higher numeric rating scale were risk factors for psychological distress. Two patients (3%) consulted a psychiatrist after surgery. In conclusion, careful attention to psychological distress is needed, especially for female patients, older patients, and those with malignant soft or bone tissue tumors who have more than moderate pain.

scholarly journals Risk Factors for Lymphatic Metastasis of Malignant Bone and Soft-Tissue Tumors

Medicine ◽  
2014 ◽  
Vol 93 (27) ◽  
pp. e225 ◽  
Author(s):  
Takashi Yanagawa ◽  
Kenichi Saito ◽  
Kenji Takagishi
Keyword(s):  
Risk Factors ◽  
Soft Tissue ◽  
Lymphatic Metastasis ◽  
Soft Tissue Tumors

Tumors of the Foot and Ankle: Experience with 153 Cases

2009 ◽  
Vol 30 (9) ◽  
pp. 836-841 ◽  
Author(s):  
Loretta B. Chou ◽  
Yvette Y. Ho ◽  
Martin M. Malawer
Keyword(s):  
Soft Tissue ◽  
Giant Cell Tumor ◽  
Giant Cell ◽  
Case Series ◽  
Soft Tissue Tumors ◽  
Cell Tumor ◽  
Foot And Ankle ◽  
Level Of Evidence ◽  
Referral Center ◽  
Common Diagnosis

Background: Both primary and metastatic tumors in the foot and ankle have been reported as rare. The purpose of this study was to describe 153 cases of foot and ankle tumors from a 20-year experience in a tertiary referral center specializing in orthopaedic oncology. It is the largest reported series of both bone and soft tissue tumors in the foot and ankle. Materials and Methods: Between 1986 and 2006, a retrospective chart review was performed of a total of 2,660 tumors surgically treated in all anatomic sites by a single surgeon at a musculoskeletal tumor referral center. Results: One hundred fifty-three patients (5.75%) with bone and/or soft tissue tumors of the foot and ankle were treated. There were 84 women and 69 men. The patients' ages ranged from 1 to 84, with a median age of 30 and mean of 33.2. The tissue types included 80 soft tissue and 73 bone tumors. Overall, 60 (39.2%) were malignant, and 93 (60.8%) were benign. The most common diagnosis was giant cell tumor. In addition, giant cell tumor was the most common bone tumor, while pigmented villonodular synovitis and giant cell tumor of the tendon sheath were the most common soft tissue tumors. Conclusion: The incidence of tumors of the foot and ankle in this series of a single surgeon over a 20-year practice was 5.75%. The results of this study reaffirm that awareness, correctly diagnosing, and appropriately treating or referring to an orthopaedic oncologist may help with an improved outcome for patients. Level of Evidence: IV, Retrospective Case Series

Prevalence of Symptomatic Venous Thromboembolism in Patients with Malignant Bone and Soft Tissue Tumors Undergo Surgery without Chemoprophylaxis

2021 ◽  
Vol 104 (5) ◽  
pp. 728-732
Keyword(s):  
Risk Factors ◽  
Pulmonary Embolism ◽  
Venous Thromboembolism ◽  
Soft Tissue ◽  
Soft Tissue Tumor ◽  
Significant Risk ◽  
Soft Tissue Tumors ◽  
Tumor Patients ◽  
Tissue Tumor ◽  
Picture Archiving And Communication

Background: The prevalence and risk factors of venous thromboembolism (VTE) in malignant bone and soft tissue tumor patients that undergo surgery is reported in many studies. However, there is lack of studies on the patients without chemoprophylaxis. Objective: To evaluate the prevalence and risk factors for VTE after surgery in malignant bone and soft tissue tumor patients without chemoprophylaxis Materials and Methods: A retrospective medical chart review identified 260 cases of malignant bone and soft tissue tumor operated between 2008 and 2017. Official diagnostic reports were reviewed from the Picture Archiving and Communication System (PACs). The incidence of VTE and its risk factors were assessed using Chi-square test, t-test, and binary logistic regression. Results: The overall prevalence of symptomatic VTE was 0.8% (2/260 patients), all of which had PE. No fatal VTE was detected. Asymptomatic pulmonary embolism (PE) was identified in two patients (0.8%) Mean follow up interval of the available data was 9.5 (3 to 36) months. No significant risk factor was found. Conclusion: The authors found that patients with malignant bone and soft tissue tumors that underwent surgery without chemoprophylaxis in the authors’ center had lower prevalence of VTE when compared to most previous studies whose patient received chemoprophylaxis. Keywords: Venous thromboembolism, Sarcoma, Cancer, Deep vein thrombosis, Pulmonary embolism, Thromboprophylaxis, Chemoprophylaxis

scholarly journals Radiopathological correlations of myopericytomas of the hand: emphasis on the MRI perivascular pushing growth pattern

2020 ◽  
Vol 6 (2) ◽  
pp. 20190074
Author(s):  
Amandine Crombé ◽  
Amine Bouhamama ◽  
François Le Loarer ◽  
Michèle Kind
Keyword(s):  
Soft Tissue ◽  
Growth Pattern ◽  
Soft Tissues ◽  
Case Series ◽  
Soft Tissue Tumors ◽  
Adult Patients ◽  
Radiological Diagnosis ◽  
Imaging Features ◽  
Pathological Findings ◽  
Pre Treatment

Myopericytomas are exceedingly rare soft-tissue tumors with less than 10 cases including radiological depictions. We report three new cases of benign myopericytomas located in the soft-tissues of the hand in adult patients. A pre-treatment MRI was available for all patients and systematically evidenced well-defined, lobulated tumors closely related to the superficial palmar vascular arch and/or digital vessels with a perivascular pushing growth pattern that correlated with pathological findings. Though rare, this small case series show that myopericytomas display recurrent imaging features that could support their radiological diagnosis.

scholarly journals Scope of FNAC in the diagnosis of soft tissue tumors-A study from a tertiary cancer referral center in India

CytoJournal ◽  
2007 ◽  
Vol 4 ◽  
pp. 20 ◽  
Author(s):  
Bharat Rekhi ◽  
Biru D Gorad ◽  
Anagha C Kakade ◽  
RF Chinoy
Keyword(s):  
Soft Tissue ◽  
Predictive Value ◽  
False Positive ◽  
Spindle Cell ◽  
Soft Tissue Tumors ◽  
Diagnostic Tools ◽  
Round Cell ◽  
Cell Type ◽  
Metastatic Lesions ◽  
Spindle Cell Type

Background Fine needle aspiration cytology (FNAC) forms one of the first diagnostic tools in the evaluation of tumors. Its role in diagnosing soft tissue tumors (STT) has been fairly documented, as well as debated. Present study was aimed at evaluating its scope in diagnosing 127 cases of soft tissue tumors. Methods Conventional Pap and MGG staining was available in all the cases. Immunocytochemistry (ICC) was performed in 15 cases. Histopathological details were available in 115 cases. Results 50% cases were referred for a primary diagnosis, while 26.8% & 22.8% cases were evaluated for recurrent and metastatic lesions, respectively. Extremities were the commonest sites. On FNAC, 101 cases (79.5%) were labeled as malignant, whereas 10 cases (7.9%) were labeled as benign. The remaining 16 cases (11%) were not categorized and were labeled as ‘unsure/not specified’. Histopathological confirmation in 115 cases, gave a diagnostic accuracy of 98%, with a positive predictive value of 98% in malignant cases and a negative predictive value of 100% in benign cases. Two cases were false positive. Among the various cytological categories, 60 cases (47.2%) were of spindle cell type, followed by 32 (25.2%) of round cell type and 14 cases (11%) of lipomatous type. Other 12 cases (9.4%) were of pleomorphic type; 7 (5.5%) cases of epithelioid type and remaining 2 cases were of myxoid type. All the round cell, pleomorphic and myxoid type of tumors were sarcomas, whereas 73.3% cases of spindle cell type were labeled as ‘malignant’. Exact cytological sub typing was offered in 58 cases, with rhabdomyosarcoma (RMS) as the most frequently sub typed tumor. The two false positive malignant cases were of fibromatosis and a pigmented schwannoma, on biopsy. Out of 28 metastatic lesions, lymph nodes were the commonest site for metastasis, with epithelioid tumors that formed highest percentage of metastatic cases. Conclusion FNAC is fairly specific and sensitive in STT diagnoses for primary, recurrent and metastatic lesions. The cytological types, especially round cell and pleomorphic sarcomas, can be quickly identified. Clinicopathological correlation with ICC as an adjunct, are valuable in exact sub typing.

scholarly journals Mesenchymal Chondrosarcoma: Clinicopathologic Study of 20 Cases

2012 ◽  
Vol 136 (1) ◽  
pp. 61-75 ◽  
Author(s):  
Rachel J Shakked ◽  
David S Geller ◽  
Richard Gorlick ◽  
Howard D Dorfman
Keyword(s):  
Soft Tissue ◽  
Case Series ◽  
Disease Free Survival ◽  
Soft Tissue Tumors ◽  
Mesenchymal Chondrosarcoma ◽  
Multicenter Studies ◽  
Clinicopathologic Study ◽  
Sample Error ◽  
Multiple Challenges ◽  
Grade Malignancy

Context.—Mesenchymal chondrosarcoma is a rare, high-grade malignancy of bone or soft tissue with a unique, biphasic histology and poor prognosis. Because of its rarity and variable length of disease-free survival, the natural history of the disease remains poorly understood. Objective.—To present clinical, radiographic, and histopathologic features of mesenchymal chondrosarcoma from one of the largest case series collected by a single, senior-level bone pathologist. Design.—Twenty cases were reviewed in consultations spanning 45 years. Results.—Eighteen tumors (90%) originated in bone, and 2 tumors (10%) were of extraskeletal origin. Of the skeletal tumors, locations included craniofacial bones (n  =  9; 50%), ribs and chest wall (n  =  4; 22%), sacrum and spinal elements (n  =  3; 17%), and lower extremities (n  =  2; 11%), whereas soft tissue tumors were located about the scapula (n  =  1; 50%) and lower extremity (n  =  1; 50%). Plain radiographs demonstrated calcified, osteolytic lesions with extraosseous extension. Typical histologic features were identified consisting of small, round or spindled cells, interspersed with hyaline cartilage islands. Seventeen patients (85%) were treated surgically, and 8 patients (40%) received adjuvant treatment. Seven patients (35%) were living at last follow-up, 1.8 to 12.5 years after diagnosis, and 8 patients (40%) died between 1.2 and 21.8 years after diagnosis. Conclusions.—Mesenchymal chondrosarcoma presents multiple challenges. Diagnostic pitfalls include inadequate biopsy samples, which may result in sample error. Sox9 has been proposed as a unique marker for mesenchymal chondrosarcoma which may improve diagnostic specificity. Treatment and prognosis vary considerably. Patients who receive surgery and chemotherapy seem to fare better. Multicenter studies with higher sample numbers may improve our understanding of this malignancy.

scholarly journals Inflammatory Myofibroblastic Tumor in the Inguinal canal: A Rare Case Report

2022 ◽  
Author(s):  
Arpankumar Patel ◽  
Rutikbhai Desai ◽  
Hilloni Shah ◽  
Laseena Vaisyambath ◽  
Manozna Karri ◽  
...  
Keyword(s):  
Risk Factors ◽  
Soft Tissue ◽  
Inflammatory Myofibroblastic Tumor ◽  
Case Reports ◽  
Symptomatic Treatment ◽  
Soft Tissue Tumors ◽  
Anaplastic Lymphoma ◽  
Rare Case Report ◽  
Inflammatory Pseudotumors ◽  
Specific Symptoms

Abstract Background Inflammatory myofibroblastic tumors, previously known as inflammatory pseudotumors, are rare soft tissue carcinomas with variable presentation and location. Due to non-specific symptoms and location, the diagnosis of this condition is often clinically challenging. Only a handful of case reports have been published in the literature describing this tumor, and there is still a lack of consensus on pathogenesis, risk factors, and treatment strategy. Most tumors have shown mutation in the anaplastic lymphoma receptor tyrosine kinase (ALK) gene. In this article, we describe a case of ALK-negative malignant inflammatory myofibroblastic tumor. Case A 46 years old male with no risk factors presented with a mass in the inguinal region. The ultrasound was suggestive of a mixed echoic mass suggestive of inguinal hernia, which led to surgical repair with resection of the tumor segment. Subsequently, histopathology and immunohistochemistry confirmed that the mass was an inflammatory myofibroblastic tumor which then recurred in a few years and failed to respond to multiple chemotherapy regimens, and over time, it progressively metastasized to the anterior abdominal wall and lungs. The patient is currently receiving palliative chemotherapy and symptomatic treatment. Conclusion This rare soft tissue tumor has not received much attention, and clinicians often miss the diagnosis. We stress that further study should be carried out on these soft tissue tumors, and adequate diagnostic and therapy recommendations should be developed.

Sign in / Sign up

Export Citation Format

Share Document