scholarly journals Different domains of dengue research in the Philippines: A systematic review and meta-analysis of questionnaire-based studies

PLoS ONE ◽  
2021 ◽  
Vol 16 (12) ◽  
pp. e0261412
Author(s):  
Rhanye Mac Guad ◽  
Rogie Royce Carandang ◽  
Judilynn N. Solidum ◽  
Andrew W. Taylor-Robinson ◽  
Yuan Seng Wu ◽  
...  
Keyword(s):  
Systematic Review ◽  
Meta Analysis ◽  
Clinical Signs ◽  
Reliability And Validity ◽  
The Philippines ◽  
Healthcare Personnel ◽  
Extensive Literature ◽  
Comprehensive Overview ◽  
Awareness Campaigns ◽  
Preventive Practices

Background Dengue is the most rapidly spreading mosquito-borne viral disease of humans worldwide, including southeast Asia region. This review provides a comprehensive overview of questionnaire-related dengue studies conducted in the Philippines and evaluates their reliability and validity in these surveys. Methods A review protocol constructed by a panel of experienced academic reviewers was used to formulate the methodology, research design, search strategy and selection criteria. An extensive literature search was conducted between March–June 2020 in various major electronic biomedical databases including PubMed, EMBASE, MEDLINE and ScienceDirect. A systematic review and meta-analysis (PRISMA) were selected as the preferred item reporting method. Results Out of a total of 34 peer-reviewed dengue-related KAP studies that were identified, 15 published from 2000 to April 2020 met the inclusion criteria. Based on the meta-analysis, a poor mean score was obtained for each of knowledge (68.89), attitude (49.86) and preventive practice (64.69). Most respondents were equipped with a good knowledge of the major clinical signs of dengue. Worryingly, 95% of respondents showed several negative attitudes towards dengue prevention, claiming that this was not possible and that enacting preventive practices was not their responsibility. Interestingly, television or radio was claimed as the main source of gaining dengue information (range 50–95%). Lastly, only five articles (33.3%) piloted or pretested their questionnaire before surveying, of which three reported Cronbach’s alpha coefficient (range 0.70 to 0.90). Conclusion This review indicates that to combat the growing public health threat of dengue to the Philippines, we need the active participation of resident communities, full engagement of healthcare personnel, promotion of awareness campaigns, and access to safe complementary and alternative medicines. Importantly, the psychometric properties of each questionnaire should be assessed rigorously.

scholarly journals Different Domains of Dengue Research in Malaysia: A Systematic Review and Meta-Analysis of Questionnaire-Based Studies

2021 ◽  
Vol 18 (9) ◽  
pp. 4474
Author(s):  
Rhanye Mac Guad ◽  
Yuan Seng Wu ◽  
Yin Nwe Aung ◽  
Shamala Devi Sekaran ◽  
André Barretto Bruno Wilke ◽  
...  
Keyword(s):  
Meta Analysis ◽  
Reliability And Validity ◽  
Health Belief ◽  
Healthcare Personnel ◽  
Extensive Literature ◽  
Complementary Medicines ◽  
Modes Of Transmission ◽  
Health Clinics ◽  
Dengue Control ◽  
Belief Model

This review provided a systematic overview of the questionnaire-related dengue studies conducted in Malaysia and evaluated their reliability and validity used in the questionnaires. An extensive literature search was conducted using various electronic databases, including PubMed, EMBASE, Medline, and ScienceDirect. Systematic reviews and meta-analysis (PRISMA) were selected as the preferred item reporting method. Out of 88 identified dengue-related, 57 published from 2000 to April 2020 met the inclusion criteria and were included. Based on the meta-analysis, a poor mean score was obtained for knowledge (49%), attitude (44%), and preventive practice (55%). The study showed that the level of knowledge on cardinal signs and modes of transmission for dengue virus were highest among health care workers, followed by students (international and local) and lastly community residents. In treatment-seeking behaviours, only half of the respondents (50.8%) would send their child to the nearest health clinics or hospitals when a child became restless or lethargic. The acceptance rate for dengue vaccine, bacteria (Wolbachia), as a vector for dengue control and self-test diagnostic kit for dengue showed considerably high (88.4%, 70%, and 44.8%, respectively). Health belief model (HBM) constructs, such as perceived barriers, perceived severity, perceived susceptibility, self-efficacy, and perceived benefit influence prevention practices. Lastly, only 23 articles (40.3%) had piloted or pretested the questionnaire before surveying, in which three reported Cronbach’s alpha coefficient (0.70–0.90). A need for active participation of communities and healthcare personnel, promotion of awareness, and safe complementary medicines, as well as assessment of psychometric properties of questionnaire use in dengue surveys in Malaysia, in order for assessing dengue reliably and valid.

scholarly journals COVID-19 in People Living with HIV: A Systematic Review and Meta-Analysis

2021 ◽  
Vol 18 (7) ◽  
pp. 3554
Author(s):  
Kai Wei Lee ◽  
Sook Fan Yap ◽  
Yun Fong Ngeow ◽  
Munn Sann Lye
Keyword(s):  
Systematic Review ◽  
Laboratory Testing ◽  
Meta Analysis ◽  
Clinical Signs ◽  
Adverse Outcomes ◽  
People Living With Hiv ◽  
Common Symptom ◽  
Chest Imaging ◽  
Wide Range ◽  
Epidemiological Characteristics

COVID-19 is a global health emergency. People living with human immunodeficiency virus (PLHIV) have concerns about whether they have a higher risk of getting the infection and suffer worse COVID-19 outcomes. Findings from studies on these questions have largely been inconsistent. We aimed to determine the epidemiological characteristics, clinical signs and symptoms, blood parameters, and clinical outcomes among PLHIV who contracted COVID-19. Relevant studies were identified through Medline, Cinahl, and PubMed databases. A random-effects model was used in meta-analyses with a 95% confidence interval. Eighty-two studies were included in the systematic review and sixty-seven studies for the meta-analysis. The pooled incidence proportion of COVID-19 among PLHIV was 0.9% (95% CI 0.6%, 1.1%) based on the data from seven cohort studies. Overall, 28.4% were hospitalised, of whom, 2.5% was severe-critical cases and 3.5% needed intensive care. The overall mortality rate was 5.3%. Hypertension was the most commonly reported comorbidity (24.0%). Fever (71.1%) was the most common symptom. Chest imaging demonstrated a wide range of abnormal findings encompassing common changes such as ground glass opacities and consolidation as well as a spectrum of less common abnormalities. Laboratory testing of inflammation markers showed that C-reactive protein, ferritin, and interleukin-6 were frequently elevated, albeit to different extents. Clinical features as well as the results of chest imaging and laboratory testing were similar in highly active antiretroviral therapy (HAART)-treated and non-treated patients. PLHIV were not found to be at higher risk for adverse outcomes of COVID-19. Hence, in COVID-19 management, it appears that they can be treated the same way as HIV negative individuals. Nevertheless, as the pandemic situation is rapidly evolving, more evidence may be needed to arrive at definitive recommendations.

scholarly journals Clinical Anatomy of the Posterior Meniscofemoral Ligament of Wrisberg: An Original MRI Study, Meta-analysis, and Systematic Review

2021 ◽  
Vol 9 (2) ◽  
pp. 232596712097319
Author(s):  
Przemysław A. Pękala ◽  
Dominik P. Łazarz ◽  
Mateusz A. Rosa ◽  
Jakub R. Pękala ◽  
Adam Baginski ◽  
...  
Keyword(s):  
Systematic Review ◽  
Quality Assessment ◽  
Meta Analysis ◽  
Lateral Meniscus ◽  
Lower Limbs ◽  
Clinical Anatomy ◽  
Extensive Literature ◽  
Anatomic Structure ◽  
Meniscofemoral Ligament ◽  
The Mean

Background: The posterior meniscofemoral ligament (pMFL) of Wrisberg attaches to the posterior horn of the lateral meniscus and the lateral intercondylar aspect of the medial femoral condyle and passes posteriorly to the posterior cruciate ligament (PCL). The pMFL plays a role in recovery after PCL injuries and offers stability to the lateral meniscus, promoting normal knee function. Purpose/Hypothesis: The aim of the magnetic resonance imaging (MRI) arm of this study was to evaluate the prevalence of the pMFL in Polish patients. The purpose of the systematic review and meta-analysis was to evaluate the clinical relevance of the pMFL in knee surgery. It was hypothesized that extensive variability exists in reports on the prevalence, function, and clinical significance of the pMFL. Study Design: Cross-sectional study and systematic review; Level of evidence, 3. Methods: A retrospective MRI investigation was conducted on 100 randomly selected lower limbs of Polish patients (56 male, 44 female) performed in 2019 to determine the prevalence of the pMFL. Additionally, an extensive literature search of major online databases was performed to evaluate all reported data on the pMFL. Assessments of article eligibility and data extraction were completed independently by 2 reviewers, and all disagreements were resolved via a consensus. A quality assessment of the included articles was performed using the Anatomical Quality Assessment tool. Results: In the MRI arm of this study, the pMFL was observed in 73 of the 100 limbs. In the meta-analysis, 47 studies were included, totaling 4940 lower limbs. The pooled prevalence of the pMFL was found to be 70.4% (95% CI, 63.4%-76.9%); the mean length was 27.7 mm (95% CI, 24.8-30.5 mm) and the mean widths were 4.5, 6.1, and 4.1 mm for the meniscal and femoral attachments and midportion, respectively. The mean pMFL thickness was 2.3 mm (95% CI, 1.8-2.7 mm). Conclusion: Despite the variability in the literature, the pMFL was found to be a prevalent and large anatomic structure in the knee joint. The shared features of this ligament with the PCL necessitate the consideration of its value in planning and performing arthroscopic procedures of the knee.

scholarly journals Florfenicol - pharmacodynamic, pharmacokinetics and clinical efficacy of oral formulations in domestic animals: A systematic review

2005 ◽  
Vol 59 (5-6) ◽  
pp. 635-654 ◽  
Author(s):  
Leon Scuka
Keyword(s):  
Systematic Review ◽  
Clinical Efficacy ◽  
Meta Analysis ◽  
Clinical Signs ◽  
Domestic Animals ◽  
Oral Solution ◽  
Favorable Effect ◽  
Respiratory Pathogens ◽  
Oral Formulations

Porcine respiratory disease complex (PRDC) is a major economic problem for swine producers world-wide. Pharmacodynamic, pharmacokinetics and clinical efficacy of florfenicol oral formulations in domestic animals were evaluated. For this purpose the systematic review and meta-analysis were done. In vitro efficacy of florfenicol showed that this drug is highly effective against most important respiratory pathogens. All these facts are shown in our survey. Three studies in pigs were relevant to include in the meta-analysis, which showed that results in the florfenicol group were better than in comparative control groups in all observed parameters: clinical signs, lung lesions and resolution of Actinobacillus pleuropneumoniae (P<0,001). A second meta-analysis with 7 studies showed that the usage of florfenicol reduces mortality in pig herds with PRDC (P<0.05). Other field trials in pigs using florfenicol oral forms where reviewed. After treatment with florfenicol oral solution there was a significant drop of mortality in both groups of pigs (P<0.01); eg. one using florfenicol oral solution in treating PRDC (n=85) and another mixed pneumoenteric infection (n=54). Analysis of data when using premix in pigs (n=118) also suggests that a medicated premix has a favorable anti-infectious effect on pigs, irrespective of the group of animals or the evolution stage of the disease. Finally, favorable effect of florfenicol in treating swine ileitis was also presented. Regarding their pharmacokinetics, in vitro and clinical efficacy of florfenicol oral forms, they should be considered as a powerful tool for combating complex infections that are frequently met in intensive animal production.

scholarly journals Mixed milk feeding: a systematic review and meta-analysis of its prevalence and drivers

2020 ◽  
Vol 78 (11) ◽  
pp. 914-927
Author(s):  
Carmen Monge-Montero ◽  
Liandré F van der Merwe ◽  
Katerina Papadimitropoulou ◽  
Carlo Agostoni ◽  
Paola Vitaglione
Keyword(s):  
Systematic Review ◽  
Data Extraction ◽  
Meta Analysis ◽  
Formula Feeding ◽  
Nutrition Status ◽  
Feeding Practice ◽  
Extensive Literature ◽  
Analysis Model ◽  
Term Infants ◽  
Milk Feeding

Abstract Context Extensive literature is available on exclusive breastfeeding and formula-feeding practices and health effects. In contrast, limited and unstructured literature exists on mixed milk feeding (MMF), here defined as the combination of breastfeeding and formula feeding during the same period in term infants &gt; 72 hours old (inclusion criterion). Objective A systematic review and meta-analysis were performed, following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, on the global prevalence of MMF (primary outcome) and related drivers and practices (secondary outcomes). Data Sources The search of MMF in generally healthy populations was conducted across 6 databases, restricted to publications from January 2000 to August 2018 in English, Spanish, French, and Mandarin. Data Extraction Two reviewers independently performed screenings and data extraction according to a priori inclusion and exclusion criteria. Data Analysis Of the 2931 abstracts identified, 151 full-text publications were included for data extraction and 96 of those were included for data synthesis (the majority of those were cross-sectional and cohort studies). The authors summarized data across 5 different categories (feeding intention prenatally, and 4 age intervals between &gt; 72 hours and &gt; 6–23 months) and 5 regional subgroups. The overall prevalence of MMF across different age intervals and regions varied between 23% and 32%; the highest rate was found for the age group 4–6 months (32%; 95% confidence interval, 27%–38%); regional comparisons indicated highest MMF rates in Asia (34%), North and South America (33%), and Middle East and Africa together (36%), using a random effects meta-analysis model for proportions. Some drivers and practices for MMF were identified. Conclusion MMF is a widespread feeding reality. A shared and aligned definition of MMF will help shed light on this feeding practice and evaluate its influence on the duration of total breastfeeding, as well as on infants’ nutrition status, growth, development, and health status in the short and long terms. PROSPERO registration number CRD42018105337.

scholarly journals Proton pump inhibitors do not increase the risk of dementia: a systematic review and meta-analysis of prospective studies

2020 ◽  
Vol 33 (10) ◽  
Author(s):  
Madhav Desai ◽  
Venkat Nutalapati ◽  
Sachin Srinivasan ◽  
Jihan Fathallah ◽  
Chandra Dasari ◽  
...  
Keyword(s):  
Systematic Review ◽  
Proton Pump ◽  
Prospective Studies ◽  
Case Reports ◽  
Meta Analysis ◽  
Case Series ◽  
Extensive Literature ◽  
Meta Regression

SUMMARY Published studies have reported variable results on the association between duration of proton pump inhibitor (PPI) use and the risk of dementia. An extensive literature search was performed in PubMed, Embase, Google Scholar, and Cochrane for studies examining the risk of cognitive decline and dementia among PPI users versus non-PPI users in prospective studies. Retrospective database linkage studies, case reports, case series, editorials, uncontrolled cohort studies, cross-sectional studies, and review articles were excluded. Primary outcome was pooled hazard rate (HR) of any dementia among PPI users compared with non-PPI users. Secondary outcomes were pooled HR of Alzheimer’s dementia (AD) and risk with long-term PPI follow-up (more than 5 years) studies. Meta-analysis outcomes, heterogeneity (I2), and meta-regression (for the effect of covariates) were derived by statistical software R and Open meta-analyst. A total of six studies (one RCT and five prospective) with 308249 subjects, average age of 75.8 ± 5.2 years, and follow-up of 5 (range 1.5–11) years were included in the analysis. Pooled HR of any dementia was 1.16 (n = 6, 95% confidence interval (CI) = 0.86–1.47). Results remained unchanged when only studies with long-term PPI use (more than 5 years) were analyzed (n = 4, pooled HR 1.10, 95% CI 0.66–1.53). Finally, the pooled HR for AD was 1.06 (n = 3, 95% CI 0.70–1.41). There was substantial heterogeneity among inclusion studies (I2 = 93%). Meta-regression did not demonstrate a significant role of age at study start (P = 0.1) or duration of PPI use (P = 0.62) to incident dementia. The results of this systematic review and meta-analysis do not show a significant relationship between PPI use and dementia in prospective studies with at least a 5-year follow-up.

The reliability and validity of radiological assessment for patellar instability. A systematic review and meta-analysis

2010 ◽  
Vol 40 (4) ◽  
pp. 399-414 ◽  
Author(s):  
Toby O. Smith ◽  
Leigh Davies ◽  
Andoni P. Toms ◽  
Caroline B. Hing ◽  
Simon T. Donell
Keyword(s):  
Systematic Review ◽  
Patellar Instability ◽  
Meta Analysis ◽  
Reliability And Validity ◽  
Radiological Assessment

scholarly journals Prevalence and Determinants of Trachomatous Trichiasis towards Elimination of Trachoma in Ethiopia: A Systematic Review and Meta- Analysis

2021 ◽  
Author(s):  
Daniel Geleta ◽  
Netsanet Workneh
Keyword(s):  
Systematic Review ◽  
Meta Analysis ◽  
Adult Population ◽  
Comprehensive Overview ◽  
Cross Sectional ◽  
Pooled Prevalence ◽  
The Status ◽  
The Individual ◽  
Study Participants ◽  
Trachomatous Trichiasis

Abstract Background: Trachomatous Trichiasis is a preventable and treatable late stage of trachoma infection, mainly exacerbating the condition of poor and marginalized people. Given the hurtful nature of the infection, many countries, including Ethiopia, lack coherent data on the status of the problem toward its targeted time of elimination. Hence, this systematic review and meta-analysis aimed to provide a comprehensive overview of the prevalence and determinants of trachomatous trichiasis towards the elimination of trachoma in Ethiopia.Methods: Based on the predefined criteria, electronic database searches on the peer-reviewed journal papers of an English version were reviewed on the prevalence and determinants of trachomatous trichiasis among the adult population in Ethiopia from January 2015 to December 2020. After reviewing the quality of the individual sources of evidence by three reviewers, the data items were extracted using a locally devised charting form. Data were synthesized qualitatively and quantitatively in terms of publication year, design, study participants, and outcome of interest. Finally, quantitative results were pooled, explored for sources of variation, tested for a potential source of influence of prevalence estimates and publication bias in the statistical meta-analysis using STATA version-16 software.Result: After the exclusion of 121 duplicates, 108 extraneous titles & abstracts, and removal of three articles for the reasons detected on full-text screening, ten eligible studies were included for analysis. All the included studies were cross-sectional studies that took prevalence as the main outcome of interest. Accordingly, the overall pooled prevalence of Trachomatous trichiasis was 1.80 % (95%CI=1.15, 2.44) while an individual prevalence estimate of the studies ranged from 0.5% (95%CI= 0.42, 0.60) to 3.9 % (95%CI=3.82, 3.98). On subgroup analysis, the highest [3.76% (95% CI = 3.20, 4.41)] and the lowest [0.5% (95%CI= 0.42, 0.60)] prevalence were respectively reported in Gambella and Somalia. The trend of the prevalence has demonstrated unstable pattern, while there were no published studies on the determinants of trachoma trichiasis among adult over the specified period of the review.Conclusion: The prevalence of TT was significantly higher than the elimination threshold in all regions of Ethiopia, needing further implementation to facilitate roads toward the elimination.Trail registration: CRD42021260802

scholarly journals Preventive practices towards Sexually Transmitted Infection and its determinants among young people in Ethiopia: a protocol for a systematic review and Meta-analysis

2021 ◽  
Author(s):  
Etsay Woldu Anbesu ◽  
Setognal Birara Aychiluhm ◽  
Mussie Alemayehu
Keyword(s):  
Systematic Review ◽  
Young People ◽  
Sexually Transmitted Infections ◽  
Sexually Transmitted Infection ◽  
Meta Analysis ◽  
Transmitted Infection ◽  
Sexually Transmitted ◽  
Preventive Practices ◽  
Pooled Prevalence ◽  
Statistical Heterogeneity

Abstract Background Globally, about 178.5 million new cases of curable sexually transmitted infections occur among young people aged 15–24 years. There are fragmented and inconsistent findings on preventive practices of sexually transmitted infection and there is no national representative data on preventive practices of sexually transmitted infection in Ethiopia. Thus, this systematic review and meta-analysis aimed to estimate the pooled prevalence of good preventive practices of sexually transmitted infection and identify its determinants among young people in Ethiopia. Methods The Preferred Reporting Items for Systematic review and Meta-analyses (PRISMA) guideline was employed to develop the review protocol. Databases such as PubMed, CINAH, Google, and Google Scholar were used to search published and unpublished studies from May 15 − 12 August/2021. Joanna Briggs Institute Meta-Analysis of Statistics Assessment and Review Instrument will be used to assess the quality of the studies. Statistical heterogeneity will be checked using I2 statistics. Subgroup analyses and meta-regression will be done based on regions to identify the sources of heterogeneity at a p-value < 0.05. The statistical analysis will be done using STATA version-14 software. A random-effects model will be employed to estimate the pooled prevalence and identify determinants of preventive practices of sexually transmitted infections. Discussion Young people have a high unmet need for sexual and reproductive health services and poor preventive practices toward sexually transmitted infection. Despite different interventions implemented to enhance the preventive practice of sexually transmitted infection among young people, the problem is still a challenge in low-income countries, including Ethiopia

scholarly journals Preventive practices towards Sexually Transmitted Infection and its determinants among young people in Ethiopia: a protocol for a systematic review and Meta-analysis

2021 ◽  
Author(s):  
Etsay Woldu Anbesu ◽  
Setognal Birara Aychiluhm ◽  
Mussie Alemayehu
Keyword(s):  
Systematic Review ◽  
Young People ◽  
Sexually Transmitted Infections ◽  
Sexually Transmitted Infection ◽  
Meta Analysis ◽  
Transmitted Infection ◽  
Sexually Transmitted ◽  
Preventive Practices ◽  
Pooled Prevalence ◽  
Statistical Heterogeneity

Abstract Background Globally, about 178.5 million new cases of curable sexually transmitted infections occur among young people aged 15–24 years. There are fragmented and inconsistent findings on preventive practices of sexually transmitted infection and there is no national representative data on preventive practices of sexually transmitted infection in Ethiopia. Thus, this systematic review and meta-analysis aimed to estimate the pooled prevalence of good preventive practices of sexually transmitted infection and identify its determinants among young people in Ethiopia. Methods The Preferred Reporting Items for Systematic review and Meta-analyses (PRISMA) guideline was employed to develop the review protocol. Databases such as PubMed, CINAH, Google, and Google Scholar were used to search published and unpublished studies from May 15 − 12 August/2021. Joanna Briggs Institute Meta-Analysis of Statistics Assessment and Review Instrument will be used to assess the quality of the studies. Statistical heterogeneity will be checked using I2 statistics. Subgroup analyses and meta-regression will be done based on regions to identify the sources of heterogeneity at a p-value < 0.05. The statistical analysis will be done using STATA version-14 software. A random-effects model will be employed to estimate the pooled prevalence and identify determinants of preventive practices of sexually transmitted infections. Discussion Young people have a high unmet need for sexual and reproductive health services and poor preventive practices toward sexually transmitted infection. Despite different interventions implemented to enhance the preventive practice of sexually transmitted infection among young people, the problem is still a challenge in low-income countries, including Ethiopia

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