Tissue Engineering and Cell-Populated Collagen Matrices

2003 ◽  
pp. 287-293
Author(s):  
Paul D. Kemp
Keyword(s):  
Tissue Engineering ◽  
Collagen Matrices

Influence of Collagen Status on Microstructures of Porous Collagen/TCP Composites

2007 ◽  
Vol 330-332 ◽  
pp. 495-498
Author(s):  
Chao Zou ◽  
Wen Jian Weng ◽  
Xu Liang Deng ◽  
Kui Cheng ◽  
Pi Yi Du ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Cell Growth ◽  
Tricalcium Phosphate ◽  
Freeze Drying ◽  
Alkali Treatment ◽  
Test Results ◽  
Collagen Matrices ◽  
The Difference ◽  
Porous Composites ◽  
Better Than

Two starting collagens, sponge and floc collagen, were used to prepare collagen/tricalcium phosphate (TCP) composites. The resulting composites were porous and had 200μm pore size. However, there was a difference in the microstructure of the pore walls for the composites derived from the two collagens, the pore walls in sponge collagen/TCP composite were still porous and had 200 nm micropores size, TCP particles were trapped in collagen matrices. While floc collagen/TCP composite had smooth and dense walls in which TCP particles were embedded. The difference could be attributed to the starting collagen with different status. Sponge collagen has a soft structure, which easily becomes disassembled fibrils during alkali treatment, the disassembled fibrils are integrated again to form a dense morphology for pore walls after freeze-drying. While floc collagen has already a low disassembly degree, the alkali treatment could not be able to separate the fibrils, this remains as micropores in pore walls after freeze-drying. Both porous composites are significant in bone tissue engineering or regeneration. MTT test results showed the two composites had good cytocompatibility, and sponge collagen/TCP composite was somewhat better than floc collagen/TCP composite, which could result from that micropores derived roughness in pore walls of sponge collagen/TCP composite is suitable for cell growth.

Properties of Porcine and Recombinant Human Collagen Matrices for Optically Clear Tissue Engineering Applications

2006 ◽  
Vol 7 (6) ◽  
pp. 1819-1828 ◽  
Author(s):  
Y. Liu ◽  
M. Griffith ◽  
M. A. Watsky ◽  
J. V. Forrester ◽  
L. Kuffová ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Engineering Applications ◽  
Collagen Matrices ◽  
Human Collagen

Tissue engineering of bone: effects of mechanical strain on osteoblastic cells in type I collagen matrices

Biomaterials ◽  
2005 ◽  
Vol 26 (3) ◽  
pp. 311-318 ◽  
Author(s):  
A IGNATIUS ◽  
H BLESSING ◽  
A LIEDERT ◽  
C SCHMIDT ◽  
C NEIDLINGERWILKE ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Type I Collagen ◽  
Mechanical Strain ◽  
Osteoblastic Cells ◽  
Type I ◽  
Collagen Matrices

Morphology of collagen matrices for tissue engineering (biocompatibility, biodegradation, tissue response)

2015 ◽  
Vol 77 (6) ◽  
pp. 29 ◽  
Author(s):  
A. B. Shekhter ◽  
A. E. Guller ◽  
L. P. Istranov ◽  
E. V. Istranova ◽  
D. V. Butnaru ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Tissue Response ◽  
Collagen Matrices ◽  
Matrices For Tissue Engineering

scholarly journals Engineered Collagen Matrices

2020 ◽  
Vol 7 (4) ◽  
pp. 163
Author(s):  
Vaidehi A. Patil ◽  
Kristyn S. Masters
Keyword(s):  
Mechanical Properties ◽  
Tissue Engineering ◽  
De Novo ◽  
Synthetic Polymers ◽  
Chemical Modifications ◽  
Collagen Matrices ◽  
Wide Range ◽  
History Of ◽  
The Creation ◽  
Range Of Values

Collagen is the most abundant protein in mammals, accounting for approximately one-third of the total protein in the human body. Thus, it is a logical choice for the creation of biomimetic environments, and there is a long history of using collagen matrices for various tissue engineering applications. However, from a biomaterial perspective, the use of collagen-only scaffolds is associated with many challenges. Namely, the mechanical properties of collagen matrices can be difficult to tune across a wide range of values, and collagen itself is not highly amenable to direct chemical modification without affecting its architecture or bioactivity. Thus, many approaches have been pursued to design scaffold environments that display critical features of collagen but enable improved tunability of physical and biological characteristics. This paper provides a brief overview of approaches that have been employed to create such engineered collagen matrices. Specifically, these approaches include blending of collagen with other natural or synthetic polymers, chemical modifications of denatured collagen, de novo creation of collagen-mimetic chains, and reductionist methods to incorporate collagen moieties into other materials. These advancements in the creation of tunable, engineered collagen matrices will continue to enable the interrogation of novel and increasingly complex biological questions.

Medical Applications of Collagen and Collagen-Based Materials

2019 ◽  
Vol 26 (3) ◽  
pp. 506-516 ◽  
Author(s):  
Anatoly B. Shekhter ◽  
Alexey L. Fayzullin ◽  
Marina N. Vukolova ◽  
Tatyana G. Rudenko ◽  
Varvara D. Osipycheva ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
General Surgery ◽  
Chronic Wounds ◽  
Published Data ◽  
Medical Applications ◽  
Therapeutic Effects ◽  
Collagen Matrices ◽  
Further Development ◽  
And Cartilage

Collagen and collagen-based materials have been successfully used in medicine for over 50 years. The number of scientific articles about the role of collagen in the construction of scaffolds for tissue engineering has risen precipitously in recent years. The review contains materials about historic and modern applications of collagen in medicine such as soluble collagen injections, solid constructs reconstructed from solution, and decellularized collagen matrices. The analysis of published data proves the efficacy of collagen material in the treatment of chronic wounds, burns, venous and diabetic ulcers, in plastic, reconstructive and general surgery, urology, proctology, gynecology, ophthalmology, otolaryngology, neurosurgery, dentistry, cardiovascular and bone and cartilage surgery, as well as in cosmetology. Further development of collagenoplasty requires addressing the problems of allergic complications, improvement of structure and maximizing therapeutic effects against pathological processes.

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