Evolutionary Aspects of Bone Health: Development in Early Human Populations

2002 ◽  
Vol 1 (3-4) ◽  
pp. 169-180 ◽  
Author(s):  
Dorothy A. Nelson ◽  
Norman J. Sauer ◽  
Sabrina C. Agarwal
Author(s):  
Thomas S. Bianchi

For millennia, humans have been dependent upon rivers and their resources for food, transport, and irrigation, and by mid-Holocene times (about 5,000 years ago), humans harnessed hydraulic power that in part contributed to the rise of civilization. It is generally accepted that the earliest civilizations to develop such linkages with irrigation and cultivation of crops arose in the Old World, in Mesopotamia and the Levant, the Indus Valley, and the Central Kingdom, associated with, respectively, the Tigris, Jordan, Euphrates, and Nile; the Indus; and the Huang He (Yellow) and Changjiang (Yangtze) rivers—and, of course, their associated deltas. In this chapter, I examine the role of selected coastal deltas that were important in the development of these early Old World civiliza­tions, and how those people began to alter the shape and character of the highly productive and constantly changing deltaic environments. Before we begin, how­ever, I need to provide some basic definitions. First, I use the definition of civilization provided by Hassan, “a phenome­non of large societies with highly differentiated sectors of activities interrelated in a complex network of exchanges and obligations.” Second, I use the defini­tion of delta presented by Overeem, Syvitski, and Hutton, “a discrete shoreline protuberance formed where a river enters an ocean or lake, … a broadly lobate shape in plain view narrowing in the direction of the feeding river, and a sig­nificant proportion of the deposit … derived from the river”. Although I will at times discuss linkages between development of human settlements and river reaches upstream from the coastal delta, my primary focus in this chapter is on coastal deltaic regions, in particular those of the Nile, Indus, Yellow, and Yangtze rivers, which provide the best examples for link­ages between relatively recent early human populations and coastal deltas. I will address other deltas later in the book. My rationale for beginning this book with a discussion of the relationship between Old World civilizations and deltas is that this long- term interaction has been so dramatically altered over the past few millennia— essentially, it is a good relationship “gone bad.”


2004 ◽  
pp. 3-18
Author(s):  
Dorothy A. Nelson ◽  
Norman J. Sauer ◽  
Sabrina C. Agarwal

2021 ◽  
Author(s):  
Tomislav Domazet-Lošo

The major advantage of mRNA vaccines over more conventional approaches is their potential for rapid development and large-scale deployment in pandemic situations. In the current COVID-19 crisis the two mRNA COVID-19 vaccines have been conditionally approved and broadly applied, while others are still in clinical trials. However, there is no previous experience with the use of mRNA vaccines on the large scale in general population. This warrants a careful evaluation of mRNA vaccine safety properties by considering all available knowledge on the mRNA molecular biology and evolution. Here, I discuss the pervasive claim that mRNA-based vaccines cannot alter genomes. Surprisingly, this notion is widely stated in the mRNA vaccine literature, but never supported by referencing any primary scientific papers that would specifically address this question. This discrepancy becomes even more puzzling if one considers previous work on the molecular and evolutionary aspects of retroposition in murine and human populations that clearly documents the frequent integration of mRNA molecules into genomes, including clinical contexts. By performing basic comparisons, I showed that the sequence features of mRNA vaccines meet all known requirements for retroposition by L1 elements — the only active and the most abundant retrotransposons in the human genome. In contrast, I found an evolutionary bias in the set of known retrocopy generating genes — a pattern that might help in the future development of retroposition-resistant therapeutic mRNAs. I conclude that is unfounded to a priori assume that mRNA-based therapeutics do not impact genomes, and that the route to genome integration of vaccine mRNAs via endogenous L1 retroelements is easily conceivable. This implies that we urgently need experimental studies that would rigorously test for the potential retroposition of vaccine mRNAs. At present, the insertional mutagenesis safety of mRNA-based vaccines should be considered unresolved.


2019 ◽  
Author(s):  
Andréa Carla Bastos Andrade ◽  
José Marcelo Soriano Viana ◽  
Helcio Duarte Pereira ◽  
Vitor Batista Pinto ◽  
Fabyano Fonseca e Silva

AbstractLinkage disequilibrium (LD) analysis provides information on evolutionary aspects of the populations and allows selecting populations and single nucleotide polymorphisms (SNPs) for association studies. Recently, haplotype blocks have been used to increase the power of quantitative trait loci detection in genome-wide association studies and the prediction accuracy with genomic selection. The objectives of this study were to compare the degree of LD, the LD decay, the LD decay extent, and the number and length of haplotype blocks in the populations and to elaborate the first LD map for maize, for elucidating if the maize chromosomes also had a pattern of interspaced regions of high and low rates of recombination. We used a biparental temperate population, a tropical synthetic, and a tropical breeding population, genotyped for approximately 75,000 SNPs. The level of LD expressed by the r2 values is surprisingly low (0.02, 0.04, and 0.04), but comparable to some non-isolated human populations. The general evidence is that the synthetic is the population with higher LD. It is not expected a significant advantage of haplotype-based association study and along generations genomic selection due to the reduced number of SNPs in the haplotype blocks (2 to 3). The results concerning LD decay (rapid decay after 5-10 kb) and LD decay extent (along up to 300 kb) are in the range observed with maize inbred line panels. Our most important result is that maize chromosomes had a pattern of regions of extensive LD interspaced with regions of low LD. However, our simple simulated LD map provides evidence that this pattern can reflect regions with differences of allele frequencies and LD level (expressed by D’) and not regions with high and low rates of recombination.


2000 ◽  
Vol 65 (1) ◽  
pp. 43-66 ◽  
Author(s):  
David G. Anderson ◽  
J. Christopher Gillam

AbstractGIS-based, least-cost analyses employing continental scale elevation data, coupled with information on the late glacial location of ice sheets and pluvial lakes, suggest possible movement corridors used by initial human populations in colonizing the New World. These routes, demographic evidence, and the location of Paleoindian archaeological assemblages, support the possibility of a rapid spread and diversification of founding populations. Initial dispersal, these analyses suggest, would have been most likely in coastal and riverine settings, and on plains. The analyses suggest areas where evidence for early human settlement may be found in North and South America. In some cases, these areas have received little prior archaeological survey. The method can be used to explore patterns of human migration and interaction at a variety of geographic scales.


Author(s):  
Thomas S. Bianchi

Humans have had a long relationship with the ebb and flow of tides on river deltas around the world. The fertile soils of river deltas provided early human civilizations with a means of farming crops and obtaining seafood from the highly productive marshes and shallow coastal waters associated with deltas. However, this relationship has at times been both nurturing and tumultuous for the development of early civilizations. The vicissitudes of seasonal changes in river flooding events as well as frequently shifting deltaic soils made life for these early human settlements challenging. These natural transient processes that affect the supply of sediments to deltas today are in many ways very similar to what they have been over the millennia of human settlements. But something else has been altered in the natural rhythm of these cycles. The massive expansion of human populations around the world in both the lower and upper drainage basins of these large rivers have changed the manner in which sediments and water are delivered to deltas. Because of the high density of human populations found in these regions, humans have developed elaborate hydrological engineering schemes in an attempt to "tame" these deltas. The goal of this book is to provide information on the historical relationship between humans and deltas that will hopefully encourage immediate preparation for coastal management plans in response to the impending inundation of major cities, as a result of global change around the world.


Author(s):  
Candace S. Alcorta ◽  
Richard Sosis

This chapter, which discusses the association between religion and violence, also addresses why suicide terrorists are willing to offer their lives for their life-affirming religions. Religious violence and “sacred pain” have long been significant components in the mythology and ritual of Western religious traditions. Religious rituals differ widely across cultures. Music intensifies the ritual experience itself, transforming the ordinary into the extraordinary and laying the foundation for creation of the sacred. Religious ritual is an efficient tool for altering group cooperation and cohesion. The evolution of religion is closely linked with the emergence of large social groups in early human populations. It can be stated that understanding both the proximate and evolutionary mechanisms which link religion and violence is an important first step in understanding, and hopefully eradicating, the religious violence that has become so prevalent in the modern world.


2001 ◽  
Vol 66 (3) ◽  
pp. 530-535 ◽  
Author(s):  
David G. Anderson ◽  
J. Christopher Gillam

How early human populations in North America maintained reproductive viability is a question that has shaped our research for over a decade. The concept of staging areas, mechanisms for band-macroband interaction, and an examination of how interaction networks could have formed and evolved over the course of the Paleoindian era are all solutions that we have presented.


1970 ◽  
Vol 1 (1) ◽  
pp. 59-71 ◽  
Author(s):  
Cynthia Irwin-Williams ◽  
C. Vance Haynes

It is becoming increasingly apparent that the pattern of early human occupation of the Southwestern United States was strongly influenced by the major paleoclimatic events of the period 9500 B.C. to A.D. 700. The size of human populations and the distribution of human settlement at both the regional-topographic and large-scale areal level, known from archaeological research, are directly correlated to climatic change documented by the evidence of geology and palynology.The effect of climatic change is felt through the actions and reactions of the economic subsystem and its linkages with other subsystems. These reactions reflect not only the character of the climatic stimulus but also the existing state of the cultural system. Alternate reactions include direct systemic readaptation to the changed environment (through changed technologies, methods of population control, etc.); or small scale or large scale relocation of populations in different local niches, regions, or areas whose character most closely approximates the conditions to which the cultural system was initially adapted.


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