Reconstructed and neo-slave narratives in French: Filling the gap through literature and archives

2021 ◽  
Vol 24 (1-2) ◽  
pp. 29-48
Author(s):  
Holly Collins

This article examines Rebecca J. Scott and Jean M. Hébrard’s Freedom Papers and Marie-Célie Agnant’s novel Le livre d’Emma as two important contributions geared towards filling the lacunae that exist in the historical record given the lack of slave narratives in French. This study argues that these narratives are important because they approach slavery in the French empire from a fresh angle. Freedom Papers reconstructs the existence of a woman named Rosalie from her entry into the slave trade through her life in Haiti. Such a biographical approach allows researchers to put an individual face on what has mostly been studied as an abstract institution. Similarly, Agnant traces the family history of Emma back to her first ancestor to make the transatlantic journey. Although Agnant’s contribution is fictional, Emma’s story captures a perspective similar to the experience of many whose ancestors were enslaved. Both stories stress the importance of writing – veritable ink on paper. It was through writing that biased historical narrative was created by former empires. It is therefore through writing that Rosalie succeeded in injecting herself into the historical record, and through writing that Emma ensures her ancestors’ story is never forgotten.

2021 ◽  
Vol 22 (9) ◽  
pp. 4700
Author(s):  
Michelle M. Monasky ◽  
Emanuele Micaglio ◽  
Giuseppe Ciconte ◽  
Ilaria Rivolta ◽  
Valeria Borrelli ◽  
...  

Genetic testing in Brugada syndrome (BrS) is still not considered to be useful for clinical management of patients in the majority of cases, due to the current lack of understanding about the effect of specific variants. Additionally, family history of sudden death is generally not considered useful for arrhythmic risk stratification. We sought to demonstrate the usefulness of genetic testing and family history in diagnosis and risk stratification. The family history was collected for a proband who presented with a personal history of aborted cardiac arrest and in whom a novel variant in the SCN5A gene was found. Living family members underwent ajmaline testing, electrophysiological study, and genetic testing to determine genotype-phenotype segregation, if any. Patch-clamp experiments on transfected human embryonic kidney 293 cells enabled the functional characterization of the SCN5A novel variant in vitro. In this study, we provide crucial human data on the novel heterozygous variant NM_198056.2:c.5000T>A (p.Val1667Asp) in the SCN5A gene, and demonstrate its segregation with a severe form of BrS and multiple sudden deaths. Functional data revealed a loss of function of the protein affected by the variant. These results provide the first disease association with this variant and demonstrate the usefulness of genetic testing for diagnosis and risk stratification in certain patients. This study also demonstrates the usefulness of collecting the family history, which can assist in understanding the severity of the disease in certain situations and confirm the importance of the functional studies to distinguish between pathogenic mutations and harmless genetic variants.


2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Hyo Geun Choi ◽  
Wook Chun ◽  
Kuk Hyun Jung

2014 ◽  
Vol 8 (11-12) ◽  
pp. 783 ◽  
Author(s):  
Richard Walker ◽  
Alyssa Louis ◽  
Alejandro Berlin ◽  
Sheri Horsburgh ◽  
Robert G. Bristow ◽  
...  

Introduction: The prostate-specific antigen (PSA) era and resultant early detection of prostate cancer has presented clinicians with the challenge of distinguishing indolent from aggressive tumours. Mutations in the BRCA1/2 genes have been associated with prostate cancer risk and prognosis. We describe the prostate cancer screening characteristics of BRCA1/2 mutation carriers, who may be classified as genetically-defined high risk, as compared to another high-risk cohort of men with a family history of prostate cancer to evaluate the utility of a targeted screening approach for these men.Methods: We reviewed patient demographics, clinical screening characteristics, pathological features, and treatment outcomes between a group of BRCA1 or BRCA2 mutation carriers and age-matched men with a family history of prostate cancer followed at our institutional Prostate Cancer Prevention Clinic from 1995 to 2012.Results: Screening characteristics were similar between the mutation carriers (n = 53) and the family history group (n = 53). Some cancers would be missed in both groups by using a PSA cut-off of >4 ug/L. While cancer detection was higher in the family history group (21% vs. 15%), the mutation carrier group was more likely to have intermediate- or high-risk disease (88% vs. 36%). BRCA2 mutation carriers were more likely to have aggressive disease, biological recurrence, and distant metastasis.Conclusions: In our cohort, regular screening appears justified for detecting prostate cancer in BRCA1 and BRCA2 carriers and other high-risk populations. Lowering PSA cut-offs and defining monitoring of PSA velocity as part of the screening protocol may be useful. BRCA2 is associated with more aggressive disease, while the outcome for BRCA1 mutation carriers requires further study. Large multinational studies will be important to define screening techniques for this unique high-risk population.


PEDIATRICS ◽  
1957 ◽  
Vol 19 (5) ◽  
pp. 908-915
Author(s):  
Eugene F. Diamond

A study of cases of rheumatic fever admitted to La Rabida Sanitarium over a 5-year period was carried out to evaluate heredity and environment as etiologic factors in rheumatic disease. The incidence of rheumatic fever was shown to be higher in families where one or both parents were known to have a positive family history of rheumatic fever. The incidence of rheumatic fever was compared in environmental groups. A totally unfavorable environment was shown to increase the incidence of rheumatic fever. No single unfavorable environmental factor changed the incidence of rheumatic fever. The incidence of rheumatic fever in each environmental group was higher when there was a positive family history for rheumatic fever, indicating an hereditary factor in the family incidence of rheumatic fever. Analysis of the various mating types in the families with a positive rheumatic trait was carried out. Agreement with a simple autosomal recessive gene inheritance was obtained in families where both parents had a definite family history, but no agreement was obtained in cases where only one parent gave a positive family history.


2019 ◽  
pp. 3-10
Author(s):  
Con Chapman

This chapter provides data regarding Cornelius Hodges’s birth and traces his family history to his grandparents’ generation. Confusion as to the exact spelling of his last name (“Hodges,” not “Hodge”) is resolved by reference to his birth certificate. Census records reveal that, contrary to prior accounts of his life, he had not one sister but three, all older. The change in his name from “Cornelius” to “Johnny” is discussed, along with the seven nicknames that he was given by colleagues. The chapter also details the history of the Cambridge, Massachusetts, neighborhood where he was born—Cambridgeport—and of the South End of Boston, to which the family would move when he was twelve, after a stop in North Cambridge that has been overlooked in prior accounts of his life.


Author(s):  
J. Andrew Dearman

This chapter explores plot and theme in the book of Ruth as an example of narrative analysis. The book is identified as a short story with a dilemma facing the family of Elimelech from the town of Bethlehem and the tribe of Judah. The family history of Elimelech and the role of the Moabite Ruth in it are examined first as a self-contained narrative and then in the context of Israel’s national history. The family dilemma is resolved with the birth of an heir for the family of Elimelech and the contribution of the family to the tribe of Judah to Israel’s national storyline is further revealed in the kingship of David, a descendant of Elimelech and Ruth.


2019 ◽  
Vol 14 (10) ◽  
pp. S524-S525
Author(s):  
J. Li ◽  
C. Li ◽  
B. Cheng ◽  
J. He ◽  
W. Liang

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