Semiautomatic and fully functional electrochemical microanalyzer BO-05 suitable for scientific, didactic, and analytical applications: The use in the potentiometric analysis of  drugs

This article presents the potentiometric method of determination of chlorides using the original BO-05 electrochemical microanalyzer. The quantification of chlorides is one of the frequently performed methods, both in the indirect determination of active pharmaceutical ingredients (API) and impurities in pharmaceutical raw materials, pharmacopoeial substances or pharmaceutical formulations as well. Successfully validated method was used to the analysis of chlorides in the preparations containing verapamil hydrochloride in form of tablets Staveran® and Verapamil®. The mean content of the studied API calculated to one tablet was close to the declared and equal to 123.6±1.5 mg and 122.6±1.1 mg, respectively. The presence of excipients have no significant impact on the final results. Thus shown that the electrochemical microanalyzer BO-05 is suitable for scientific, didactic and analytical applications.

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Encapsulation of Active Pharmaceutical Ingredients in Lipid Micro/Nanoparticles for Oral Administration by Spray-Cooling

Pharmaceutics ◽

10.3390/pharmaceutics13081186 ◽

2021 ◽

Vol 13 (8) ◽

pp. 1186

Author(s):

Carmen S. Favaro-Trindade ◽

Fernando E. de Matos Junior ◽

Paula K. Okuro ◽

João Dias-Ferreira ◽

Amanda Cano ◽

...

Keyword(s):

Oral Administration ◽

Raw Materials ◽

Low Cost ◽

Pharmaceutical Formulations ◽

Spray Cooling ◽

Active Pharmaceutical Ingredients ◽

Pharmaceutical Ingredients ◽

Taste And Odor ◽

Cooling Technology ◽

Simple Technology

Nanoencapsulation via spray cooling (also known as spray chilling and spray congealing) has been used with the aim to improve the functionality, solubility, and protection of drugs; as well as to reduce hygroscopicity; to modify taste and odor to enable oral administration; and many times to achieve a controlled release profile. It is a relatively simple technology, it does not require the use of low-cost solvents (mostly associated to toxicological risk), and it can be applied for lipid raw materials as excipients of oral pharmaceutical formulations. The objective of this work was to revise and discuss the advances of spray cooling technology, with a greater emphasis on the development of lipid micro/nanoparticles to the load of active pharmaceutical ingredients for oral administration.

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Development of Analytical Profile of Lamotrigine and its API Formulation

Asian Journal of Pharmaceutical and Clinical Research ◽

10.22159/ajpcr.2022.v15i1.43396 ◽

2021 ◽

pp. 111-114

Author(s):

VISHAL CHAUDHARY ◽

VASUNDHARA SAXENA

Keyword(s):

Spectrophotometric Method ◽

Quantitative Estimation ◽

Pharmaceutical Formulations ◽

Hplc Method ◽

Active Pharmaceutical Ingredients ◽

Pharmaceutical Ingredients ◽

Rp Hplc ◽

System Suitability ◽

Bulk Drug

Objective: The objective of this review is to put a light on the development of lamotrigine and its active pharmaceutical ingredients formulation with proper demonstration. Method: In the present work, one of the most imperative spectrophotometric method which is RP-HPLC method has been developed for the quantitative estimation of lamotrigine in bulk and pharmaceutical formulations. UV spectrophotometric method which involves the determination of Lamotrigine in bulk and in bulk drug and pharmaceutical formulation has maximum absorption at 307.5nm in methanol. It obeys Beer’s and Lambert’s law in the concentration range of 5-45 µg/ml. A rapid and sensitive RP- HPLC Method with UV detection (270 nm) for routine analysis of Lamotrigine formulation was developed. Chromatography was performed with mobile phase containing a mixture of methanol and Phosphate buffer (65:35v/v) with flow rate 1.0 ml/min. In the range of 20-100 µg/ml, the linearity of lamotrigine shows a correlation co-efficient of 0.9998. The proposed method was validated by determining sensitivity and system suitability parameters.

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Stability Indicating LC Method for Rapid Determination of Related Substances of O-Desmethyl Venlafaxine in Active Pharmaceutical Ingredients and Pharmaceutical Formulations

Journal of Chromatographic Science ◽

10.1093/chromsci/bmt207 ◽

2014 ◽

Vol 52 (10) ◽

pp. 1247-1254 ◽

Cited By ~ 1

Author(s):

Karri Visweswara Rao ◽

Kesareddy Padmaja Reddy ◽

Yelavarthi Ravindra Kumar

Keyword(s):

Rapid Determination ◽

Pharmaceutical Formulations ◽

Active Pharmaceutical Ingredients ◽

Stability Indicating ◽

Pharmaceutical Ingredients ◽

Related Substances

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Spectrophotometric flow injection procedure to indirect determination of paracetamol in pharmaceutical formulations using o-tolidine as reagent

Eclética Química Journal ◽

10.26850/1678-4618eqj.v33.2.2008.p47-53 ◽

2018 ◽

Vol 33 (2) ◽

pp. 47

Author(s):

Orlando Fatibello-Filho ◽

Heberth Juliano Vieira

Keyword(s):

Standard Deviation ◽

Detection Limit ◽

Flow Injection ◽

Pharmaceutical Formulations ◽

Injection Method ◽

Indirect Determination ◽

Analytical Curve ◽

Relative Standard ◽

Injection Procedure

A spectrophotometric flow injection method for the determination of paracetamol in pharmaceutical formulations is proposed. The procedure was based on the oxidation of paracetamol by sodium hypochloride and the determination of the excess of this oxidant using o-tolidine dichloride as chromogenic reagent at 430 nm. The analytical curve was linear in the paracetamol concentration range from 8.50 x 10-6 to 2.51 x 10-4 mol L-1 with a detection limit of 5.0 x 10-6 mol L-1. The relative standard deviation was smaller than 1.2% for 1.20 x 10-4 mol L-1 paracetamol solution (n = 10). The results obtained for paracetamol in pharmaceutical formulations using the proposed flow injection method and those obtained using a USP Pharmacopoeia method are in agreement at the 95% confidence level.

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Fast and Accurate Quantitative Determination of Prednisolone and Chlorpheniramine in Active Pharmaceutical Ingredients and Parenteral Dosage Forms

10.26538/tjnpr/v5i11.5 ◽

2021 ◽

Vol 5 (11) ◽

pp. 1922-1926

Keyword(s):

Quantitative Determination ◽

Dosage Forms ◽

Active Pharmaceutical Ingredients ◽

Pharmaceutical Ingredients

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Simultaneous Determination of Emtricitabine and Tenofovir disoproxil fumarate in Pharmaceutical Dosage by Reverse Phase High Performance Liquid Chromatography

Asian Journal of Research in Chemistry ◽

10.52711/0974-4150.2021.00070 ◽

2021 ◽

pp. 412-416

Author(s):

Rajan V. Rele ◽

Sandip P. Patil

Keyword(s):

High Performance Liquid Chromatography ◽

Liquid Chromatography ◽

Simultaneous Determination ◽

Tenofovir Disoproxil Fumarate ◽

High Performance ◽

Phosphoric Acid Solution ◽

Active Pharmaceutical Ingredients ◽

Chromatography Method ◽

Pharmaceutical Ingredients

A simple, rapid and accurate high performance liquid chromatography method is described for simultaneous determination of emtricitabine and tenofovir disoproxil fumarate from active pharmaceutical ingredients. The separation of drug was achieved on Hypersil BDS C18 (150 x 4.6 mm i.d.) with 5 µ particle size column showed most favorable chromatographic pattern over the other columns. The mobile phase consisted of a mixture of buffer and methanol (85:15 % v/v). The buffer was mixtures of 0.1 % (v/v) ortho-phosphoric acid solution adjusted the pH 3.5 with tri-ethyl amine. The detection was carried out at wavelength 260 nm. The mixture of buffer of pH 3.5 and methanol (85:15% v/v) was used as a diluent. The method was validated for system suitability, linearity, accuracy, precision, robustness, stability of sample solution. The method has been successfully used to analyze emtricitabine and tenofovir disoproxil fumarate from active pharmaceutical ingredients.

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