scholarly journals Encapsulation of Active Pharmaceutical Ingredients in Lipid Micro/Nanoparticles for Oral Administration by Spray-Cooling

Pharmaceutics ◽  
2021 ◽  
Vol 13 (8) ◽  
pp. 1186
Author(s):  
Carmen S. Favaro-Trindade ◽  
Fernando E. de Matos Junior ◽  
Paula K. Okuro ◽  
João Dias-Ferreira ◽  
Amanda Cano ◽  
...  
Keyword(s):  
Oral Administration ◽  
Raw Materials ◽  
Low Cost ◽  
Pharmaceutical Formulations ◽  
Spray Cooling ◽  
Active Pharmaceutical Ingredients ◽  
Pharmaceutical Ingredients ◽  
Taste And Odor ◽  
Cooling Technology ◽  
Simple Technology

Nanoencapsulation via spray cooling (also known as spray chilling and spray congealing) has been used with the aim to improve the functionality, solubility, and protection of drugs; as well as to reduce hygroscopicity; to modify taste and odor to enable oral administration; and many times to achieve a controlled release profile. It is a relatively simple technology, it does not require the use of low-cost solvents (mostly associated to toxicological risk), and it can be applied for lipid raw materials as excipients of oral pharmaceutical formulations. The objective of this work was to revise and discuss the advances of spray cooling technology, with a greater emphasis on the development of lipid micro/nanoparticles to the load of active pharmaceutical ingredients for oral administration.

scholarly journals Semiautomatic and fully functional electrochemical microanalyzer BO-05 suitable for scientific, didactic, and analytical applications: The use in the potentiometric analysis of drugs

2021 ◽  
Vol 15 (1) ◽  
pp. 64-72
Author(s):  
Włodzimierz Opoka ◽  
Marek Szlósarczyk ◽  
Adam Chojnacki ◽  
Agata Kryczyk-Poprawa ◽  
Przemysław Talik ◽  
...  
Keyword(s):  
Raw Materials ◽  
Pharmaceutical Formulations ◽  
Active Pharmaceutical Ingredients ◽  
Indirect Determination ◽  
Pharmaceutical Ingredients ◽  
Method Of Determination ◽  
Analytical Applications ◽  
Potentiometric Analysis ◽  
The Mean

This article presents the potentiometric method of determination of chlorides using the original BO-05 electrochemical microanalyzer. The quantification of chlorides is one of the frequently performed methods, both in the indirect determination of active pharmaceutical ingredients (API) and impurities in pharmaceutical raw materials, pharmacopoeial substances or pharmaceutical formulations as well. Successfully validated method was used to the analysis of chlorides in the preparations containing verapamil hydrochloride in form of tablets Staveran® and Verapamil®. The mean content of the studied API calculated to one tablet was close to the declared and equal to 123.6±1.5 mg and 122.6±1.1 mg, respectively. The presence of excipients have no significant impact on the final results. Thus shown that the electrochemical microanalyzer BO-05 is suitable for scientific, didactic and analytical applications.

scholarly journals Multiple Emulsions Able to Be Used for Oral Administration of Active Pharmaceutical Ingredients: Physico-Chemical Parameters Study of Different Phases

2020 ◽  
Vol 11 (10) ◽  
pp. 1528-1535
Author(s):  
Louis Augustin Diaga Diouf ◽  
Alphonse Rodrigue Djiboune ◽  
Mamadou Soumboundou ◽  
Sidy Mouhamed Dieng ◽  
Papa Mady Sy ◽  
...  
Keyword(s):  
Oral Administration ◽  
Active Pharmaceutical Ingredients ◽  
Chemical Parameters ◽  
Multiple Emulsions ◽  
Pharmaceutical Ingredients ◽  
Physico Chemical

scholarly journals Development of Analytical Profile of Lamotrigine and its API Formulation

2021 ◽  
pp. 111-114
Author(s):  
VISHAL CHAUDHARY ◽  
VASUNDHARA SAXENA
Keyword(s):  
Spectrophotometric Method ◽  
Quantitative Estimation ◽  
Pharmaceutical Formulations ◽  
Hplc Method ◽  
Active Pharmaceutical Ingredients ◽  
Pharmaceutical Ingredients ◽  
Rp Hplc ◽  
System Suitability ◽  
Bulk Drug

Objective: The objective of this review is to put a light on the development of lamotrigine and its active pharmaceutical ingredients formulation with proper demonstration. Method: In the present work, one of the most imperative spectrophotometric method which is RP-HPLC method has been developed for the quantitative estimation of lamotrigine in bulk and pharmaceutical formulations. UV spectrophotometric method which involves the determination of Lamotrigine in bulk and in bulk drug and pharmaceutical formulation has maximum absorption at 307.5nm in methanol. It obeys Beer’s and Lambert’s law in the concentration range of 5-45 µg/ml. A rapid and sensitive RP- HPLC Method with UV detection (270 nm) for routine analysis of Lamotrigine formulation was developed. Chromatography was performed with mobile phase containing a mixture of methanol and Phosphate buffer (65:35v/v) with flow rate 1.0 ml/min. In the range of 20-100 µg/ml, the linearity of lamotrigine shows a correlation co-efficient of 0.9998. The proposed method was validated by determining sensitivity and system suitability parameters.

Effect of Liposomes on the Absorption of Water-soluble Active Pharmaceutical Ingredients via Oral Administration

2013 ◽  
Vol 19 (37) ◽  
pp. 6647-6654 ◽  
Author(s):  
Zhijun Yang ◽  
Aiping Lu ◽  
Blenda Kwan Wong ◽  
Xiaoyu Chen ◽  
Zhaoxiang Bian ◽  
...  
Keyword(s):  
Oral Administration ◽  
Water Soluble ◽  
Active Pharmaceutical Ingredients ◽  
Pharmaceutical Ingredients

Absorbable Suture Made from Rice Starch

2010 ◽  
Vol 123-125 ◽  
pp. 291-294 ◽  
Author(s):  
Sittiporn Punyanitya ◽  
Rungsarit Koonawoot ◽  
Sakdiphon Thiensem ◽  
Surasit Laosatirawong ◽  
Anirut Raksujarit
Keyword(s):  
Mechanical Properties ◽  
Polymer Films ◽  
Raw Materials ◽  
Low Cost ◽  
High Water ◽  
Hot Water ◽  
Rice Starch ◽  
Absorbable Suture ◽  
Milling Method ◽  
Simple Technology

The main objective of this work is to make an absorbable monofilament suture from Thai rice starch. The improvement of the mechanical properties of Thai rice starch polymer films were achieved by addition of small amount of gelatin, carboxymethylcellulose (CMC) and carbon nanopowders. The carbon nanopowders were produced from coconut shell in our laboratory room by milling method. The incorporation of carbon nanopowders with a high aspect ratio and/or an extremely large surface area into Thai rice starch polymer films improves their mechanical performances significantly. Additionally, the black color from carbon nanopowder is easily visualized in tissue during surgery. The manufacturing processes are very simple by blending of the raw materials in hot water and then dry heating in electric oven. The final product was characterized of microstructures and mechanical properties. The resulting Thai rice starch-carbon nanocomposites possess several advantages for manufacture of sutures: 1. high water resistance that can be uses in the human body. 2. high mechanical strength that appropriate to manufacture of sutures. 3. biocompatibility and bioabsorbable. 4. low cost. 5. Eco-friendly green nanocomposites. However, the method of size designation of sutures fibers and needle attachment are the problem which restricts our suture in really applications. The investigation of knowledge and simple technology of manufacture of suture and needle attachment will be performed.

scholarly journals ELECTROSPRAY IONIZATION MASS SPECTROMETRY FRAGMENTATION PATHWAYS OF SALTS OF SOME 1,2,4-TRIAZOLYLTHIOACETATE ACIDS, THE ACTIVE PHARMACEUTICAL INGREDIENTS

2018 ◽  
Vol 11 (10) ◽  
pp. 303
Author(s):  
Varynskyi Borys ◽  
Kaplaushenko Andriy ◽  
Parchenko Vladymyr
Keyword(s):  
Electrospray Ionization ◽  
High Performance ◽  
Pharmaceutical Formulations ◽  
Ionization Mass ◽  
Active Pharmaceutical Ingredients ◽  
Ionization Source ◽  
Fragmentation Pathways ◽  
Pharmaceutical Ingredients ◽  
Fragmentation Patterns ◽  
New Compounds

Objective: The goal of this research was to study fragmentation pathways of series salts of 1,2,4-triazolylthioacetate acids. Methods: The study was done in the Electrospray ionization source with single quadrupole mass spectrometer Agilent 6120 after elution through column Zorbax SB-C18, 30 mm × 4.6 mm, 1.8 μm at Agilent 1260 infinity high-performance liquid chromatography system. The series salts of 1,2,4-triazolylthioacetate acids were studied. These salts are active pharmaceutical ingredients of potential or registered pharmaceutical formulations. Results: The mass spectra of corresponding compounds have analyzed. The fragmentation patterns of these compounds decay have proposed. Conclusions: Studying the fragmentation of the indicated substances can be used for detecting the mentioned substances, as well as for confirming the structure of new compounds with the mass spectrum based on the patterns described above.

scholarly journals Study of the toxic effect of the drug “Incombivit”

2020 ◽  
Vol 22 (99) ◽  
pp. 24-28
Author(s):  
T. M. Kaliuzhna ◽  
H. A. Fotina
Keyword(s):  
Body Weight ◽  
Oral Administration ◽  
Water Soluble ◽  
Biologically Active ◽  
Standard Diet ◽  
Active Pharmaceutical Ingredients ◽  
Combination Drug ◽  
Pharmaceutical Ingredients ◽  
White Rats ◽  
Single Oral Administration

Modern veterinary medicine has made great strides in the prevention and treatment of various diseases, largely through the availability of highly effective drugs. One of the major challenges to development of effective, safe, competitive drugs in Ukraine is the creation of an effective system of pre-clinical trials that meet international standards. The toxicity study is a mandatory phase trials of new drugs. The drug “Inkombivit” accommodates only available endogenous biologically active substances, which are natural feed ingredients for animals and are naturally present in animal tissues. All active pharmaceutical ingredients used in drug “Inkombivit”, by the EU regulation No. 37/2010 related to non-hazardous for animals and people compounds. The LD50 of most active pharmaceutical ingredients included in the drug “Incombivit” for mice when administered orally ranges from 5000 to 10000 mg/kg body weight, except for some active pharmaceutical ingredients when they are contained in milligram amounts in 1 liter of the drug, for which LD50 less than 1000 mg/kg body weight of animals. Incombivit is a combination drug that contains fat- and water-soluble vitamins, trace elements and amino acids that normalize metabolism, increase overall resistance, improve productivity, safety and reproductive functions of animals. Acute toxicity of the drug was studied on 50 white mice weighing 19–21 g and on 20 white rats weighing 250–295 g. The animals were kept in accordance with sanitary norms and rules on a standard diet (compound feed) adopted in the vivarium. The acute LD50 of Incombivit for a single oral administration is 7500 ± 229.95 mg/kg body weight for mice and 6250 ± 375.50 mg/kg body weight for rats. Incombivit can be classified as hazard class 4 according to the International Standard GOST 12.1.007-76 and to category 5 according to the International Global Harmonized System (GHS) classification, as its LD50 for mice and rats with a single oral administration exceeds 5000 mg/kg body weight.

scholarly journals Primaquine-based ionic liquids as a novel class of antimalarial hits

RSC Advances ◽  
2016 ◽  
Vol 6 (61) ◽  
pp. 56134-56138 ◽  
Author(s):  
Ricardo Ferraz ◽  
Joana Noronha ◽  
Fernanda Murtinheira ◽  
Fátima Nogueira ◽  
Marta Machado ◽  
...  
Keyword(s):  
Ionic Liquids ◽  
Low Cost ◽  
Antimalarial Drugs ◽  
Active Pharmaceutical Ingredients ◽  
Pharmaceutical Ingredients

Ionic liquids derived from active pharmaceutical ingredients may open new perspectives towards low-cost rescuing of classical antimalarial drugs.

scholarly journals Stability of Pharmaceutical Co-Crystals at Humid Conditions Can Be Predicted

Pharmaceutics ◽  
2021 ◽  
Vol 13 (3) ◽  
pp. 433
Author(s):  
Heiner Veith ◽  
Maximilian Zaeh ◽  
Christian Luebbert ◽  
Naír Rodríguez-Hornedo ◽  
Gabriele Sadowski
Keyword(s):  
Pharmaceutical Formulations ◽  
Active Pharmaceutical Ingredient ◽  
Storage Conditions ◽  
Pharmaceutical Products ◽  
Active Pharmaceutical Ingredients ◽  
Statistical Associating Fluid Theory ◽  
Pharmaceutical Ingredients ◽  
Soluble Solid ◽  
Fluid Theory ◽  
The Stability

Knowledge of the stability of pharmaceutical formulations against relative humidity (RH) is essential if they are to become pharmaceutical products. The increasing interest in formulating active pharmaceutical ingredients as stable co-crystals (CCs) triggers the need for fast and reliable in-silico predictions of CC stability as a function of RH. CC storage at elevated RH can lead to deliquescence, which leads to CC dissolution and possible transformation to less soluble solid-state forms. In this work, the deliquescence RHs of the CCs succinic acid/nicotinamide, carbamazepine/nicotinamide, theophylline/citric acid, and urea/glutaric acid were predicted using the Perturbed-Chain Statistical Associating Fluid Theory (PC-SAFT). These deliquescence RH values together with predicted phase diagrams of CCs in water were used to determine critical storage conditions, that could lead to CC instability, that is, CC dissolution and precipitation of its components. The importance of CC phase purity on RH conditions for CC stability is demonstrated, where trace levels of a separate phase of active pharmaceutical ingredient or of coformer can significantly decrease the deliquescence RH. The use of additional excipients such as fructose or xylitol was predicted to decrease the deliquescence RH even further. All predictions were successfully validated by stability measurements at 58%, 76%, 86%, 93%, and 98% RH and 25 °C.

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